Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumPreprint

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From endoplasmic-reticulum stress to the inflammatory response

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Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

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mTORC1-IRE1α pathway activation contributes to palmitate-elicited triglyceride secretion and cell death in hepatocytes

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Endoplasmic reticulum stress-induced cell death mechanism

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Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis

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Nuclear fragile X mental retardation-interacting protein 1-mediated ribophagy protects T lymphocytes against apoptosis in sepsis

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Linking the unfolded protein response to bioactive lipid metabolism and signalling in the cell non‐autonomous extracellular communication of ER stress

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Establishment and Validation of a Model for Fetal Neural Ischemia Using Necrotic Core-Free Human Spinal Cord Organoids

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Decoding contextual crosstalk: revealing distinct interactions between non-coding RNAs and unfolded protein response in breast cancer

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Unraveling the Connection: Pain and Endoplasmic Reticulum Stress

Kawanaka, R., Jin, H., & Aoe, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094995 · Cited by 18

Endoplasmic reticulum stress mechanisms and exercise intervention in type 2 diabetes mellitus

Chen, Q., Zhao, X., Xu, Z., & Liu, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117122 · Cited by 18

Mechanisms, assessment, and exercise interventions for skeletal muscle dysfunction post-chemotherapy in breast cancer: from inflammation factors to clinical practice

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ERp44 depletion exacerbates ER stress and aggravates diabetic nephropathy in db/db mice

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A phosphorescent iridium probe for sensing polarity in the endoplasmic reticulum and in vivo

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Copper Induces Apoptosis Through Endoplasmic Reticulum Stress in Skeletal Muscle of Broilers

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Diagnostic and Prognostic Values of MANF Expression in Hepatocellular Carcinoma

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High expression of spliced X-Box Binding Protein 1 in lung tumors is associated with cancer aggressiveness and epithelial-to-mesenchymal transition

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Thyroid hormone synthesis continues despite biallelic thyroglobulin mutation with cell death

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Principles of brain aging: Status and challenges of modeling human molecular changes in mice

Kluever, V., & Fornasiero, E. F. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101465 · Cited by 18

The unfolded protein response: An emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinoma

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Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms

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Deep Learning-Based Morphological Classification of Endoplasmic Reticulum Under Stress

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Cocoa Extract Provides Protection against 6-OHDA Toxicity in SH-SY5Y Dopaminergic Neurons by Targeting PERK

Vestuto, V., Amodio, G., Pepe, G., Basilicata, M. G., Belvedere, R., Napolitano, E., Guarnieri, D., Pagliara, V., Paladino, S., Rodriquez, M., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10082009 · Cited by 18

Neuroprotection Targeting Protein Misfolding on Chronic Cerebral Hypoperfusion in the Context of Metabolic Syndrome

Herrera, M. I., Udovin, L., Toro-Urrego, N., Kusnier, C. F., Luaces, J. P., Losada, M. E. O., & Capani, F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00339 · Cited by 18

The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP

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Patient-derived models of UBA5- associated encephalopathy identify defects in neurodevelopment and highlight potential therapeutic avenues

Chen, H., LaFlamme, C. W., Wang, Y., Blan, A. W., Koehler, N., Moraes, R. M., Olszewski, A. R., Fuerte, E. P. A., Bonkowski, E. S., Bajpai, R., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adn8417 · Cited by 17

External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics

Chen, Z., Chen, P., Li, J., Landao‐Bassonga, E., Papadimitriou, J. M., Gao, J., Liu, D., Tai, A. C. P., Ma, J., Lloyd, D. G., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads6132 · Cited by 17

Protein Kinase-Mediated Decision Between the Life and Death

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TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis

Zhang, L., Su, N., Luo, Y., Chen, S., & Zhao, T. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00786-5 · Cited by 17

Targeting EDEM protects against ER stress and improves development and survival in C. elegans

Ghenea, S., Chiritoiu‐Butnaru, M., Tăcutu, R., Miranda‐Vizuete, A., & Petrescu, S. M. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010069 · Cited by 19

Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response

Andeen, N. K., Kung, V. L., Robertson, J. A., Gurley, S. B., Avasare, R. S., & Sitaraman, S. (2022) · Glomerular Diseases · doi:10.1159/000525542 · Cited by 17

Pazopanib restricts small cell lung cancer proliferation via reactive oxygen species‐mediated endoplasmic reticulum stress

Li, Y., Chen, C., Liu, H., Li, C., Zhang, Z., & Wang, C. (2022) · Thoracic Cancer · doi:10.1111/1759-7714.14543 · Cited by 17

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Mizumoto, T., Yoshizawa, T., Sato, Y., Ito, T., Tsuyama, T., Satoh, A., Araki, S., Tsujita, K., Tamura, M., Oike, Y., et al. (2022) · Cells · doi:10.3390/cells11223609 · Cited by 18

4-PBA Attenuates Fat Accumulation in Cultured Spotted Seabass Fed High-Fat-Diet via Regulating Endoplasmic Reticulum Stress

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Heat stress induced hepatocyte apoptosis in largemouth bass Micropterus salmoides via IRE1α/TRAF2/ASK1/JNK pathway

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Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells

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Mild hypothermia protects rat neuronal injury after intracerebral hemorrhage via attenuating endoplasmic reticulum response induced neuron apoptosis

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Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

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Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin β1

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Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis

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The potential immunotoxicity of fine particulate matter based on SD rat spleen

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Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats

Xiong, G., Chen, H., Wan, Q., Dai, J., Sun, Y. L., Wang, J., & Li, X. (2019) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-019-1357-9 · Cited by 17

Modulation of endoplasmic reticulum stress response in gut-origin encephalopathy: Impact of vascular endothelial growth factor receptor-2 manipulation

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Microtubules and Gαo-signaling modulate the preferential secretion of young insulin secretory granules in islet β cells via independent pathways

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One-step synthesized amphiphilic carbon dots for the super-resolution imaging of endoplasmic reticulum in live cells

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The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress

Ünlü, I., Lu, Y., & Wang, X. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004872 · Cited by 17

Mutations in unfolded protein response regulator ATF6 cause hearing and vision loss syndrome

Lee, E.-J., Kim, K., Diaz‐Aguilar, M. S., Min, H., Chávez, E., Steinbergs, K. J., Safarta, L. A., Zhang, G., Ryan, A. F., & Lin, J. H. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175562 · Cited by 16

Targeting p38 MAPK: A potential bridge between ER stress and age-related bone loss

Yin, M., Zheng, X., & Shi, L. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111549 · Cited by 16

Engineered Electrotherapy Platforms: Integrating Electroactive Materials for Precision Cancer Therapy

Cai, Y., Sun, S., Nie, J., Yang, N., & Cheng, L. (2026) · Advanced Materials · doi:10.1002/adma.72763 · Cited by 16

Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer

Blomain, E. S., Merlino, D. J., Pattison, A. M., Snook, A. E., & Waldman, S. A. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.103192 · Cited by 16

Emerging role of protein modification in inflammatory bowel disease

Wang, G., Yuan, J., Luo, J., Ocansey, D. K. W., Zhang, X., Qian, H., Xu, W., & Mao, F. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2100114 · Cited by 16

Norketamine, the Main Metabolite of Ketamine, Induces Mitochondria-Dependent and ER Stress-Triggered Apoptotic Death in Urothelial Cells via a Ca2+-Regulated ERK1/2-Activating Pathway

Lin, J.-W., Lin, Y., Liu, J., Liu, S., Fang, K., Hsu, R., Huang, C.-F., Chang, K.-Y., Lee, K.-I., Chang, K.-C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094666 · Cited by 16

A journey in UPR modelling

Pontisso, I., Guevara, R. O., Combettes, L., & Dupont, G. (2023) · Biology of the Cell · doi:10.1111/boc.202200111 · Cited by 16

β‐Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control

Liu, J., Fu, H., Kang, F., Ning, G., Ni, Q., Wang, W., & Wang, Q. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13380 · Cited by 16

Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma

Fan, R., Wang, S., Wu, Y., Feng, Y., Gao, M., Cao, Y., Ma, X., Xie, S., Wang, C., Gao, L., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7933 · Cited by 16

Research progress on the activation mechanism of NLRP3 inflammasome in septic cardiomyopathy

Wen, Y., Liu, Y., Liu, W., Liu, W., Dong, J., Liu, Q., Hao, H., & Ren, H. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.1039 · Cited by 16

Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma

Xiong, S., Zhou, J., Tan, T. K., Chung, T., Tan, T. Z., Toh, S. H. M., Tang, N. X. N., Jia, Y., See, Y. X., Fullwood, M. J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50910-z · Cited by 19

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

Zuazo-Gaztelu, I., Lawrence, D. A., Oikonomidi, I., Marsters, S. A., Pechuan-Jorge, X., Gaspar, C. J., Kan, D., Segal, E., Clark, K., Beresini, M. H., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003086 · Cited by 16

A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease

Gerakis, Y., & Hetz, C. A. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.012 · Cited by 16

Exploring Cellular Stress Response and Chaperones

Stacchiotti, A. (2019) · Cells · doi:10.3390/cells8050408 · Cited by 16

Consequences of mutations in the genes of the ER export machinery COPII in vertebrates

Lu, C., & Kim, J. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-019-01062-3 · Cited by 16

C6-ceramide induces salivary adenoid cystic carcinoma cell apoptosis via IP3R-activated UPR and UPR-independent pathways

Qiu, L., Liu, Z., Wu, C., Chen, W., Chen, Y., Zhang, B., Li, J., Liu, H., Huang, N. K., Jiang, Z., et al. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.164 · Cited by 16

miR-512-3p Overcomes Resistance to Cisplatin in Retinoblastoma by Promoting Apoptosis Induced by Endoplasmic Reticulum Stress

Kong, M., Han, Y., Zhao, Y., & Zhang, H. (2020) · Medical Science Monitor · doi:10.12659/msm.923817 · Cited by 16

Autophagy, unfolded protein response and lung disease

Akhter, M. S., Uddin, M. A., Kubra, K., & Barabutis, N. (2020) · Current Research in Cell Biology · doi:10.1016/j.crcbio.2020.100003 · Cited by 17

Hypercapnia Induces Inositol-Requiring Enzyme 1α–Driven Endoplasmic Reticulum–associated Degradation of the Na,K-ATPase β-Subunit

Kryvenko, V., Wessendorf, M., Tello, K., Herold, S., Morty, R. E., Seeger, W., & Vadász, I. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0114oc · Cited by 16

The gut metabolite, trimethylamine N-oxide inhibits protein folding by affecting cis–trans isomerization and induces cell cycle arrest

Kumari, K., Warepam, M., Bansal, A. K., Dar, T. A., Uversky, V. N., & Singh, L. R. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04087-z · Cited by 16

Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy

Wang, H., Karnati, S., & Madhusudhan, T. (2022) · Pharmaceuticals · doi:10.3390/ph15040401 · Cited by 18

Implication of hyperoxaluria on osteopontin and ER stress mediated apoptosis in renal tissue of rats

Bhardwaj, R., Bhardwaj, A., Tandon, C., Dhawan, D. K., Bijarnia, R. K., & Kaur, T. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.04.002 · Cited by 16

Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece

CHARONIS, A. S., Michalak, M., Groenendyk, J., & Agellon, L. B. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13413 · Cited by 16

Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts

Mpoyi, E. N., Cantini, M., Sin, Y. Y., Fleming, L., Zhou, D. W., Costell, M., Lu, Y., Kadler, K. E., Garcı́a, A. J., Agtmael, T. V., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120090 · Cited by 16

Stress-induced cell depolarization through the MAP kinase–Cdc42 axis

Salat-Canela, C., Pérez, P., Ayté, J., & Hidalgo, E. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.06.004 · Cited by 16

Chrysin protects cardiac H9c2 cells against H2O2-induced endoplasmic reticulum stress by up-regulating the Nrf2/PERK pathway

Yuvaraj, S., Ajeeth, A. K., Puhari, S. S. M., Abhishek, A., Ramprasath, T., Vasudevan, V., Narasimman, V., & Selvam, G. S. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04531-z · Cited by 15

A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress

Dalton, H. M., Viswanatha, R., Brathwaite, R., Zuno, J. S., Berman, A. R., Rushforth, R., Mohr, S. E., Perrimon, N., & Chow, C. Y. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010430 · Cited by 15

Mechanical Ventilation-Related High Stretch Mainly Induces Endoplasmic Reticulum Stress and Thus Mediates Inflammation Response in Cultured Human Primary Airway Smooth Muscle Cells

Yang, C., Guo, J., Ni, K., Wen, K., Qin, Y., Gu, R., Wang, C., Liu, L., Pan, Y., Li, J., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043811 · Cited by 15

The mitochondrial‐endoplasmic reticulum co‐transfer in dental pulp stromal cell promotes pulp injury repair

Zhang, X., Wang, C., Zhou, Z., & Zhang, Q. (2023) · Cell Proliferation · doi:10.1111/cpr.13530 · Cited by 15

Multi-omics analysis of oxidative stress and apoptosis in hepatopancreas cells induced by Polyascus gregaria parasitizing the Eriocheir sinensis

Zhao, S., Hu, Q., Jiang, H., Zhao, Y., Wang, Y., Feng, C., & Li, X. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109180 · Cited by 15

Crosstalk between protein misfolding and endoplasmic reticulum stress during ageing and their role in age-related disorders

Hemagirri, M., Chen, Y., Gopinath, S. C. B., Sahreen, S., Adnan, M., & Sasidharan, S. (2023) · Biochimie · doi:10.1016/j.biochi.2023.10.019 · Cited by 15

Dyschromatopsia: a comprehensive analysis of mechanisms and cutting-edge treatments for color vision deficiency

Yang, Z., Yan, L., Zhang, W., Jia, Q., An, W., & Yao, K. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1265630 · Cited by 16

Spotlight on necroptosis: Role in pathogenesis and therapeutic potential of intervertebral disc degeneration

Ran, R., Zhang, S.-B., Shi, Y., Song, W., Song, W., Dong, Y.-B., Zhou, K., & Zhang, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112616 · Cited by 15

Roles of X-box binding protein 1 in liver pathogenesis

Tak, J., Kim, Y. S., & Kim, S. G. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0441 · Cited by 15

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

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