Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumPreprint

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From endoplasmic-reticulum stress to the inflammatory response

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Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

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Emerging magic bullet: subcellular organelle-targeted cancer therapy

Yan, Y., Zhang, Y., Liu, J., Chen, B., & Wang, Y. (2024) · Medical Review · doi:10.1515/mr-2024-0044 · Cited by 14

SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis

Shi, J., Chen, L., Wang, X., & Ma, X. (2025) · Inflammation Research · doi:10.1007/s00011-025-01998-6 · Cited by 14

SIRT5 modulates mitochondria function via mitophagy and antioxidant mechanisms to facilitate oocyte maturation in mice

Yan, J.-J., Wang, Y., Shi, Z.-Y., Ding, Y.-Y., Wen, H.-Q., Wu, M., Sun, S., Cai, Y., & Zhang, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141488 · Cited by 14

Exploring Endoplasmic Reticulum Dysfunction on Protein Phase Separation Using Viscosity-Sensitive Fluorescent Lifetime Probe

Wei, Y., Zi, X., Zhai, J., Zhang, M., Li, J., Sun, Z., Ju, M., Zhang, X., & Shen, B. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c01131 · Cited by 14

Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances?

Pinto, B., França, L. M., Laurindo, F. R. M., & Paes, A. M. D. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-11488-6_5 · Cited by 14

A crucial role of endoplasmic reticulum stress in cellular responses during pulmonary arterial hypertension.

Pan, T. S., Zhang, L., Miao, K., & Wang, Y. (2020) · PubMed Central · Cited by 14

Surface functionalized red fluorescent dual-metallic Au/Ag nanoclusters for endoplasmic reticulum imaging

Cui, L., Li, C., Chen, B., Huang, H. H., Xia, Q., Li, X., Shen, Z., Ge, Z., & Wang, Y. (2020) · Microchimica Acta · doi:10.1007/s00604-020-04585-0 · Cited by 14

Dietary ω-3 fatty acids reduced atrial fibrillation vulnerability via attenuating myocardial endoplasmic reticulum stress and inflammation in a canine model of atrial fibrillation

Tu, T., Li, B., Li, X., Zhang, B., Xiao, Y., Li, J., Qin, F., Liu, N., Sun, C., Liu, Q., et al. (2021) · Journal of Cardiology · doi:10.1016/j.jjcc.2021.08.012 · Cited by 14

Lipid Metabolism and Immune Checkpoints

Liao, Q., Zhou, Y., Xia, L., & Cao, D. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6785-2_12 · Cited by 14

Agonal Factors Distort Gene-Expression Patterns in Human Postmortem Brains

Dai, R., Chen, Y., Dai, R., Jiang, Y. W., Tian, J., Liu, S., Xu, M. M., Li, M., Zhou, J., Liu, C., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.614142 · Cited by 14

A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3)

Gong, S., Duan, Y., Wu, C., Osterhoff, G., Schopow, N., & Kallendrusch, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189903 · Cited by 14

Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice

Xie, X., Tie, Y., Lai, S., Zhang, Y., Li, H., & Liu, Y. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04282-7 · Cited by 14

Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases

Kuribara, T., & Totani, K. (2022) · Biology · doi:10.3390/biology11020199 · Cited by 14

Cancer and COVID-19: unravelling the immunological interplay with a review of promising therapies against severe SARS-CoV-2 for cancer patients

Leyfman, Y., Emmanuel, N., Menon, G. P., Joshi, M., Wilkerson, W. B., Cappelli, J., Erick, T. K., Park, C. H., & Sharma, P. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01432-6 · Cited by 14

Subcellular localization and relevant mechanisms of human cancer‐related micropeptides

Deng, J., Xu, W., Jie, Y., & Chong, Y. (2023) · The FASEB Journal · doi:10.1096/fj.202301019rr · Cited by 14

Amyloid and immune homeostasis

Wang, Y., & Zhang, Y.-G. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.10.038 · Cited by 14

Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes

Chen, Y., Griffiths, A., Wang, J., Zhang, T., Song, Q., & Song, Z. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00165.2020 · Cited by 14

NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response

Borrello, M. T., Emma, M. R., Listì, A., Rubis, M., Coslet, S., Augello, G., Cusimano, A., Cabibi, D., Porcasi, R., Giannitrapani, L., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002413rr · Cited by 14

Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection

Wang, X., Yuan, J., Wang, H., Gan, N., Zhang, Q., Liu, B., Wang, J., Shu, Z., Rao, L., Gou, X., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900248 · Cited by 14

Sensing molecular carbon dioxide: a translational focus for respiratory disease

Vadász, I., Cummins, E. P., Brotherton, D. H., Casalino-Matsuda, S. M., Dada, L. A., Green, O., King, D. T., Kryvenko, V., Shigemura, M., Sporn, P. H. S., et al. (2025) · Physiological Reviews · doi:10.1152/physrev.00022.2024 · Cited by 13

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Yang, X., Huijie, B., & Chen, Z. (2025) · Advanced Science · doi:10.1002/advs.202518884 · Cited by 13

The role and therapeutic implication of endoplasmic reticulum stress in inflammatory cancer transformation.

Li, Y., Lu, L., Zhang, G., Ji, G., & Xu, H. (2022) · PubMed Central · Cited by 13

Short-term air pollution and temperature exposure and changes in the extracellular microRNA profile of Normative Aging Study (NAS) participants

Yazdi, M. D., Nassan, F. L., Кошелева, А., Wang, C., Xu, Z., Di, Q., Réquia, W. J., Comfort, N. T., Wu, H., Laurent, L. C., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.107735 · Cited by 13

Multitranscript analysis reveals an effect of 2-deoxy-d-glucose on gene expression linked to unfolded protein response and integrated stress response in primary human monocytes and monocyte-derived macrophages

Tamayo-Molina, Y. S., Velilla, P. A., Hernández-Sarmiento, L. J., & Inchima, S. U. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130397 · Cited by 13

Investigation into Molecular Brain Aging in Senescence-Accelerated Mouse (SAM) Model Employing Whole Transcriptomic Analysis in Search of Potential Molecular Targets for Therapeutic Interventions

Fujiwara, M., Ferdousi, F., & Isoda, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813867 · Cited by 13

Novel Targeted Therapies for Rheumatoid Arthritis Based on Intracellular Signalling and Immunometabolic Changes: A Narrative Review

Rahmati, M., Kwesiga, M. P., Lou, J., Tan, A. L., & McDermott, M. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2901042 · Cited by 13

Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model

Braun, M., Ashkenazi, A., Beveridge, R. E., Castanedo, G. M., Wallweber, H. A., Beresini, M. H., Clark, K., Bruyn, T. D., Fu, L., Gibbons, P., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02425 · Cited by 13

Recent progress on the organelle targeted AlEgens for bioimaging and treatment of diseases

Ding, Q., Luo, Y., Hu, J. P., Zhang, S., Zhang, W., Feng, Y., Qian, K., Li, X., Cheng, Z., & Gu, M. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153395 · Cited by 13

Fluorescence lifetime imaging: A novel approach to simultaneous visualizing lipid droplets and endoplasmic reticulum polarity in live cells and fatty liver

Zhan, Z., Huang, R., Chai, L., Yang, H., Dai, Y.-C., Chen, M., Gu, G., & Lv, Y. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136699 · Cited by 13

Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation

Ji, F., Zhang, J., Mao, L., Tan, Y., Ye, M., He, X., Zhao, Y., Liu, J., Zhang, Y., Zhang, N., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55745-2 · Cited by 13

When Proteins Go Berserk: The Unfolded Protein Response and ER Stress

Meiseles, D., Arbeli, N., & Dvela‐Levitt, M. (2025) · The Nephron journals/Nephron journals · doi:10.1159/000544971 · Cited by 14

Endoplasmic Reticulum Stress Induces Liquid–Liquid Phase Separation of GRP78 and Modulates Protein Aggregation Dynamics

Li, J., Zi, X., Fang, J., Liang, M., Ju, M., Sun, Z., Shen, B., & Zhang, X. (2025) · ACS Sensors · doi:10.1021/acssensors.5c00807 · Cited by 13

11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids

Zhang, H., Zhou, F., Zhenyu, P., Bu, X., Wang, Y., & Chen, F. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.046 · Cited by 13

Integration of quantitative proteomics and metabolomics reveals tissue hypoxia mechanisms in an ischemic-hypoxic rat model

He, R., Kong, Y., Peng, F., Li, L., Shi, H., & Liu, Z. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103924 · Cited by 13

IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis

Dai, Q., Han, S., Liu, T., Zheng, J., Liu, C., Li, J., & Li, S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00274 · Cited by 13

Periplocin and cardiac glycosides suppress the unfolded protein response

Tokugawa, M., Inoue, Y., Ishiuchi, K., Kujirai, C., Matsuno, M., Ri, M., Itoh, Y., Miyajima, C., Morishita, D., Ohoka, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89074-x · Cited by 13

MicroRNA-494 Regulates Endoplasmic Reticulum Stress in Endothelial Cells

Chatterjee, N., Fraile‐Bethencourt, E., Baris, A. M., Espinosa‐Díez, C., & Anand, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.671461 · Cited by 13

The role of XBP-1-mediated unfolded protein response in colorectal cancer progression-a regulatory mechanism associated with lncRNA-miRNA-mRNA network

Wang, Y., Zhang, J., & Zheng, S. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02167-5 · Cited by 13

Elucidation of ER stress and UPR pathway in sialic acid‐deficient cells: Pathological relevance to GNEM

Chaudhary, P., Sharma, S., Singh, R., & Arya, R. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30148 · Cited by 13

Dexmedetomidine alleviates traumatic spinal cord injury in rats via inhibiting apoptosis induced by endoplasmic reticulum stress

Liu, Y., Liu, W.-F., Chen, W.-C., Li, W., Lin, Y.-L., Xu, C., & He, H. (2021) · Neurological Research · doi:10.1080/01616412.2021.1979750 · Cited by 13

Human Amnion Membrane-Derived Mesenchymal Stem Cells and Conditioned Medium Can Ameliorate X-Irradiation-Induced Testicular Injury by Reducing Endoplasmic Reticulum Stress and Apoptosis

Cetinkaya-Un, B., Ün, B., Akpolat, M., Andiç, F., & Yazır, Y. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00753-6 · Cited by 13

Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice

Feng, Y., Lang, J., Sun, B., Yan, Z., Zhao, Z., & Sun, G. (2023) · Neurological Research · doi:10.1080/01616412.2023.2170905 · Cited by 13

Particle-induced osteolysis is mediated by endoplasmic reticulum stress-associated osteoblast apoptosis

Yu, X., Ding, H., Wang, D., Ren, Z., Chen, B., Wu, Q., Yuan, T., Liu, Y., Zhang, L., Zhao, J., et al. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110686 · Cited by 13

Hepatitis B surface antigen expression impairs endoplasmic reticulum stress-related autophagic flux by decreasing LAMP2

Liang, Y., Luo, X., Schefczyk, S., Muungani, L. T., Deng, H., Wang, B., Baba, H. A., Lu, M., Wedemeyer, H. H., Schmidt, H., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101012 · Cited by 13

Real-Time and Non-invasive Monitoring of the Activation of the IRE1α-XBP1 Pathway in Individuals with Hemodynamic Impairment

Fohlen, B., Tavernier, Q., Huynh, T. M., Caradeuc, C., Corre, D. L., Bertho, G., Cholley, B., & Pallet, N. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.023 · Cited by 14

A2a adenosine receptor agonist improves endoplasmic reticulum stress in MIN6 cell line through protein kinase A/ protein kinase B/ Cyclic adenosine monophosphate response element‐binding protein/ and Growth Arrest And DNA‐Damage‐Inducible 34/ eukaryotic Initiation Factor 2α pathways

Arasi, F. P., Shahrestanaki, M. K., & Aghaei, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27719 · Cited by 13

Decitabine shows synergistic effects with arsenic trioxide against myelodysplastic syndrome cells via endoplasmic reticulum stress-related apoptosis

Huang, L., Liu, Z., Jiang, H., Li, L., & Fu, R. (2019) · Journal of Investigative Medicine · doi:10.1136/jim-2018-000953 · Cited by 13

UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis

Bedi, B., Lin, K.-C., Maurice, N., Yuan, Z.-H., Bijli, K. M., Koval, M., Hart, C., Goldberg, J., Stecenko, A., & Sadikot, R. (2020) · Clinical science · doi:10.1042/cs20200066 · Cited by 11

T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation

Chen, M., Li, S., Hao, M.-L., Chen, J., Zhao, Z., Hong, S., Min, J., Tang, J., Hu, M., & Li, H. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12965 · Cited by 13

Aging alters the metabolic flux signature of the ER‐unfolded protein response in vivo in mice

Ward, C., Peng, L., Yuen, S., Halstead, J., Palacios, H. H., Nyangau, E., Mohammed, H., Ziari, N., Dandan, M., Frakes, A. E., et al. (2022) · Aging Cell · doi:10.1111/acel.13558 · Cited by 13

Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop

Németh, B. C., Demcsák, A., Geisz, A., & Sahin‐Tóth, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-09595-x · Cited by 14

Hijacking the unfolded protein response (UPR) pathway: Balancing viral infection and host cell survival

Chen, H., Liu, D., Hua, J., Wu, M., Hua, Y., Feng, C., He, Z., Moffett, P., & Zhang, K. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.111040 · Cited by 13

Light‐Induced Chiral Iron Copper Selenide Nanoparticles Prevent β‐Amyloidopathy In Vivo

Zhang, H., Hao, C., Qu, A., Sun, M., Xu, L., Xu, C., & Kuang, H. (2020) · Angewandte Chemie · doi:10.1002/ange.202002028 · Cited by 12

Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress

Zhao, W., Li, G., Zhang, Q., Chen, M., He, L., Wu, Z., Zhang, Y., Fan, M., Liang, Y., Zhang, W., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115453 · Cited by 15

Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis

Tukacs, V., Mittli, D., Hunyadi‐Gulyás, É., Hlatky, D., Medzihradszky, K. F., Darula, Z., Nyitrai, G., Czurkó, A., Juhász, G., Kardos, J., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03215-z · Cited by 13

Non-Genomic Hallmarks of Aging—The Review

Holmannová, D., Borský, P., Kovaříková, H., Štveráková, T., Vošmik, M., Hruška, L., Fiala, Z., & Borská, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015468 · Cited by 13

The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans

Ma, Z., Horrocks, J., Mir, D. A., Cox, M., Ruzga, M. N., Rollins, J. A., & Rogers, A. N. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1263344 · Cited by 12

Endoplasmic Reticulum Stress and Unfolded Protein Response in Vernal Keratoconjunctivitis

Leonardi, A., Donato, A. C., Rosani, U., Stefano, A. D., Cavarzeran, F., & Brun, P. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.4.23 · Cited by 12

Role of Fibroblast Growth Factors in Neurological Disorders: Insight into Therapeutic Approaches and Molecular Mechanisms

Upadhayay, S., Soni, D., Dhureja, M., Temgire, P., Kumar, V., Arthur, R., & Kumar, P. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04962-x · Cited by 12

Ginsenoside Rh2 Mitigates Endoplasmic Reticulum Stress-Induced Apoptosis and Inflammation and Through Inhibition of Hepatocyte–Macrophage Inflammatory Crosstalk

Park, S., Jeong, I., & Kim, O. (2025) · Nutrients · doi:10.3390/nu17101682 · Cited by 12

Chronic fructose intake does not induce liver steatosis and inflammation in female Sprague–Dawley rats, but causes hypertriglyceridemia related to decreased VLDL receptor expression

Sangüesa, G., Montañés, J. C., Baena, M., Sánchez, R. M., Roglans, N., Alegret, M., & Laguna, J. C. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1654-9 · Cited by 13

cAMP-dependent protein kinase A in grass carp Ctenopharyngodon idella: Molecular characterization, gene structure, tissue distribution and mRNA expression in endoplasmic reticulum stress-induced adipocyte lipolysis

Ji, S., Sun, J. H., Bian, C., Huang, X., Chang, Z., Yang, M., Lu, R., & Ji, H. (2020) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2020.110479 · Cited by 12

Expression liabilities in a four‐chain bispecific molecule

Guo, C., Chen, F., Xiao, Q. F., Catterall, H. B., Robinson, J. H., Wang, Z., Mock, M. L., & Hubert, R. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27850 · Cited by 12

ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes

Ward, C., Peng, L., Yuen, S., Chang, M., Karapetyan, R., Nyangau, E., Mohammed, H., Palacios, H. H., Ziari, N., Joe, L. K., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031073 · Cited by 12

RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway

Luo, R., Liang, H., Zhang, W., Li, G., Zhao, K., Hua, W., Song, Y., & Cao, Y. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022024 · Cited by 12

Pitavastatin protects against neomycin-induced ototoxicity through inhibition of endoplasmic reticulum stress

Wu, Y., Meng, W., Guan, M., Zhao, X., Zhang, C., Fang, Q., Zhang, Y., Sun, Z., Cai, M., Huang, D., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.963083 · Cited by 12

Referential modification strategy based on phenolic hydroxyl-containing KSA luminogens for ER-targeting probe construction

Deng, Q., Ding, K., Li, Y., Jiao, Y., Hu, R., Zhang, T., Wang, Z., & Tang, B. Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121767 · Cited by 12

Hepatocellular Carcinoma

Ettorre, G. M. (2022) · Updates in surgery/Updates in surgery series · doi:10.1007/978-3-031-09371-5 · Cited by 12

Microvascular lung injury and endoplasmic reticulum stress in systemic lupus erythematosus-associated alveolar hemorrhage and pulmonary vasculitis

Zhuang, H., Hudson, E., Han, S., Arja, R. D., Hui, W. W. Y., Lu, L., & Reeves, W. H. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00051.2022 · Cited by 12

TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells’ killing

Feng, X., Yang, G., Zhang, L., Tao, S., Shim, J. S., Chen, L., & Wu, Q. (2022) · Investigational New Drugs · doi:10.1007/s10637-022-01306-7 · Cited by 12

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Park, E., Kim, H. S., Lee, D.-H., Kim, S., Yoon, J.-S., Lee, J.-M., Im, S. J., Lee, H., Lee, M.-W., & Lee, C. (2023) · Nature Communications · doi:10.1038/s41467-023-36836-y · Cited by 12

Chlorogenic acid alleviates oxidative damage in hepatocytes by regulating miR-199a-5p/GRP78 axis

Li, J., Ge, H., Xu, Y., Xie, J., Karim, N., Yan, F., Mo, J., & Chen, W. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102595 · Cited by 12

Natural products modulate cell apoptosis: a promising way for treating endometrial cancer

Zhou, X., Zeng, Y., Zheng, R., Wang, Y., Li, T., Song, S., Zhang, S., Huang, J., & Ren, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1209412 · Cited by 12

Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease

Zeng, X., Geng, W.-S., Zhang, Y., Yin, J., Xu, G., Yu, M., Li, L., & Jia, J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102000 · Cited by 12

Deoxynivalenol and T-2 toxin cause liver damage and egg quality degradation through endoplasmic reticulum stress in summer laying hens

Guo, H., Hongyan, W., Lou, W., Khan, R. U., You, J., Huang, B., Shu, H., Li, G., & Dai, S. (2024) · International Journal of Biometeorology · doi:10.1007/s00484-024-02674-w · Cited by 12

Pimpinelol, a novel atypical Sesquiterpene lactone from Pimpinella haussknechtii fruits with evaluation of endoplasmic reticulum stress in breast cancer cells

Aghaei, M., Ghanadian, M., Sajjadi, S. E., Saghafian, R., & Shahrestanaki, M. K. (2018) · Fitoterapia · doi:10.1016/j.fitote.2018.06.024 · Cited by 12

Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections

Ren, S., Ding, C., & Sun, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103689 · Cited by 13

Manganese-induced neurotoxicity in cerebellar granule neurons due to perturbation of cell network pathways with potential implications for neurodegenerative disorders

Hernández, R. B., Carrascal, M., Abián, J., Michalke, B., Farina, M., González, Y. R., Iyirhiaro, G. O., Moteshareie, H., Burnside, D. J., Golshani, A., et al. (2020) · Metallomics · doi:10.1039/d0mt00085j · Cited by 13

Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway

Wang, M., Liu, C. X., Li, Y., Zhang, Q., Zhu, L., Fang, Z., & Jin, L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01781 · Cited by 12

The Role of the Signaling Pathways Involved in the Effects of Hydrogen Sulfide on Endoplasmic Reticulum Stress

Zhao, S., Li, X., Lu, P., Li, X., Ming-fei, S., & Wang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646723 · Cited by 12

Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei

Ooi, C., Smith, T., Gluenz, E., Wand, N. V., Vaughan, S., & Rudenko, G. (2018) · Traffic · doi:10.1111/tra.12561 · Cited by 13

ER stress-related molecules induced by Hantaan virus infection in differentiated THP-1 cells

Li, Z., Shen, Y., Song, Y. J., Zhang, Y., Zhang, C., Ma, Y., Zhang, F., & Chen, L. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01150-9 · Cited by 12

Tannic acid alleviates lipopolysaccharide‑induced H9C2 cell apoptosis by suppressing reactive oxygen species‑mediated endoplasmic reticulum stress

Yang, Y., Zhao, J., Gao, H.-B., Li, J.-J., Li, X., Niu, X., Lei, Y., & Li, X. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12174 · Cited by 12

The unfolded protein response and the biology of uveal melanoma

Zhang, S., Wang, K., Zhu, X., Cherepanoff, S., Conway, R. M., Madigan, M. C., Zhu, L., Murray, M. T., & Zhou, F. (2022) · Biochimie · doi:10.1016/j.biochi.2022.01.017 · Cited by 11

α-Hederin induces human colorectal cancer cells apoptosis through disturbing protein homeostasis

Wang, Q., Feng, H., Li, Z., Wu, Q., Li, L., Sun, D., Tan, J., Fan, M., Yu, C., Xu, C., et al. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110785 · Cited by 11

Ortho-silicic Acid Prevents Glucocorticoid-Induced Femoral Head Necrosis by Promoting Akt Phosphorylation to Inhibit Endoplasmic Reticulum Stress-Mediated Apoptosis and Enhance Angiogenesis and Osteogenesis

Sun, Z., Wang, J., Ji, Z., Ma, J., Chen, Y., & Jiao, G. (2024) · Biological Trace Element Research · doi:10.1007/s12011-023-04048-6 · Cited by 11

Post-treatment with maropitant reduces oxidative stress, endoplasmic reticulum stress and neuroinflammation on peripheral nerve injury in rats

Niella, R. V., Corrêa, J. M. X., dos Santos, J. F. R., Lima, L. F., Marques, C. S. D. C., Santos, L. C., Santana, L. R., Silva, Á. J. C., Farias, K. S., Pirovani, C. P., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0287390 · Cited by 11

Puerarin attenuates myocardial ischemic injury and endoplasmic reticulum stress by upregulating the Mzb1 signal pathway

Xue, J., Ren, H., Zhang, Q., Gu, J., Xu, Q., Sun, J., Zhang, L., & Zhou, M.-S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1442831 · Cited by 11

A stress paradox: the dual role of the unfolded protein response in the placenta

Chowdhury, D., Jang, C. E., Lajoie, P., & Renaud, S. J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1525189 · Cited by 12

Triphenylamine-Naphthalimide-Based “On–Off–On” AIEgen for Imaging Golgi Apparatus and Endoplasmic Reticulum

Kumar, P., Mishra, T., Sanyam, S., Mondal, A., & Basu, S. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01722 · Cited by 11

Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response

Poothong, J., Tirasophon, W., & Kaufman, R. J. (2017) · Bioscience Reports · doi:10.1042/bsr20160574 · Cited by 11

Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α–RIG-I Antiviral Signaling

Han, S., Mao, L., Liao, Y., Sun, S., Zhang, Z., Mo, Y., Liu, H., Zhi, X., Lin, S., Seo, H. S., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801546 · Cited by 11

Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells

Snyder, J. T., Darko, C., Sharma, R. B., & Alonso, L. C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.734079 · Cited by 12

The cardiotoxicity of asthmatic rats after traffic-related PM2.5 and water-soluble components exposure mediated by endoplasmic reticulum stress and autophagy

Tian, J., Shi, H., Wang, X., Wu, H., Wang, C., Liu, N., Wang, D., Shi, D., Zhang, H., & Zhang, Z. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19496-1 · Cited by 11

Illuminating Sub‐Cellular Organelles by Small Molecule AIEgens

Ingle, J., Sengupta, P., & Basu, S. (2022) · ChemBioChem · doi:10.1002/cbic.202200370 · Cited by 11

Fluoride-Induced Cortical Toxicity in Rats: the Role of Excessive Endoplasmic Reticulum Stress and Its Mediated Defective Autophagy

Zhang, J., Tang, Y., Xu, W., Hu, Z., Xu, S., & Niu, Q. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03463-5 · Cited by 11

ATF5 is a regulator of ER stress and β-cell apoptosis in different mouse models of genetic- and diet-induced obesity and diabetes mellitus

Ma, J., Liu, Y., Valladolid‐Acebes, I., Recio-López, P., Peng, G., Li, J., Berggren, P., Juntti‐Berggren, L., & Tong, N. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110535 · Cited by 11

Non-alcoholic fatty liver disease and liver secretome

Khan, M. S., Lee, C.-H., & Kim, S. G. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01419-w · Cited by 13

Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway

Cendron, L., Rothenberger, S., Cassari, L., Dettin, M., & Pasquato, A. (2022) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2022.10.001 · Cited by 12

Role of the endoplasmic reticulum in the search for early biomarkers of meat quality

González‐Blanco, L., Sierra, V., Diñeiro, Y., Coto‐Montes, A. M., & Oliván, M. (2023) · Meat Science · doi:10.1016/j.meatsci.2023.109224 · Cited by 11

Endoplasmic Reticulum Stress in Disease

Kaufman, R. J., & Popolo, L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.20053-9 · Cited by 1

Endoplasmic Reticulum Stress in Disease Pathogenesis

Lin, J. H., Walter, P., & Yen, T. S. B. (2007) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151434 · Cited by 843

Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

Dufey, E., Sepúlveda, D., Rivera, D. R., & Hetz, C. A. (2014) · Universidad de Chile · Cited by 29

Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response

Zhang, K., & Kaufman, R. J. (2005) · Handbook of Experimental Pharmacology · doi:10.1007/3-540-29717-0_3 · Cited by 152

The endoplasmic reticulum and the unfolded protein response

Malhotra, J. D., & Kaufman, R. J. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.09.003 · Cited by 1,014