Cited by 1,851Nerve injury and regenerationSpinal Cord Injury ResearchNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.

Astrocyte scar formation aids central nervous system axon regeneration

Open access

Anderson, Mark A., Burda, Joshua E., Ren, Yilong, Ao, Yan, O’Shea, Timothy M., Kawaguchi, Riki, Coppola, Giovanni, Khakh, Baljit S., Deming, Timothy J., Sofroniew, Michael V.·2016·Nature

DOI 10.1038/nature17623PMC PMC5243141

Open this paper in CoChat — free account

Abstract

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte scar formation, attenuating scar-forming astrocytes, or ablating chronic astrocytic scars all failed to result in spontaneous regrowth of transected corticospinal, sensory or serotonergic axons through severe spinal cord injury (SCI) lesions. By contrast, sustained local delivery via hydrogel depots of required axon-specific growth factors not present in SCI lesions, plus growth-activating priming injuries, stimulated robust, laminin-dependent sensory axon regrowth past scar-forming astrocytes and inhibitory molecules in SCI lesions. Preventing astrocytic scar formation significantly reduced this stimulated axon regrowth. RNA sequencing revealed that astrocytes and non-astrocyte cells in SCI lesions express multiple axon-growth-supporting molecules. Our findings show that contrary to the prevailing dogma, astrocyte scar formation aids rather than prevents central nervous system axon regeneration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature17623

Cites

104 of 104 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
Degeneration and Regeneration of the Nervous System.
(1929) · JAMA · doi:10.1001/jama.1929.02710220063037 · Cited by 2,908
Genomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404
Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats
David, S., & Aguayo, A. J. (1981) · Science · doi:10.1126/science.6171034 · Cited by 1,698

Flagged first, then by citations

Show all 104 references

Sorted by citations

Items 401–500 of 1,002

Chondroitin Sulfate Glycosaminoglycan Matrices Promote Neural Stem Cell Maintenance and Neuroprotection Post-Traumatic Brain Injury
Betancur, M. I., Mason, H. D., Alvarado‐Velez, M., Holmes, P. V., Bellamkonda, R. V., & Karumbaiah, L. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00805 · Cited by 60
Crosstalk of Astrocytes and Other Cells during Ischemic Stroke
He, T., Yang, G., & Zhang, Z. (2022) · Life · doi:10.3390/life12060910 · Cited by 63
Mapping astrogliosis in the individual human brain using multidimensional MRI
Benjamini, D., Priemer, D. S., Perl, D. P., Brody, D. L., & Basser, P. J. (2022) · Brain · doi:10.1093/brain/awac298 · Cited by 60
Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury
Zhang, H., Zhou, Z., Xie, H., Xiao-bo, T., Xu, H., Li, W., & Yao, S. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.357912 · Cited by 62
Size- and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood–brain barrier
Liu, X., Sui, B., & Sun, J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb01314k · Cited by 61
Systemic administration of epothilone D improves functional recovery of walking after rat spinal cord contusion injury
Ruschel, J., & Bradke, F. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.12.001 · Cited by 63
The role of neuro-epithelial-like and radial-glial stem and progenitor cells in development, plasticity, and repair
Lindsey, B. W., Hall, Z. J., Heuzé, A., Joly, J., Tropepe, V., & Kaslin, J. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.004 · Cited by 62
Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming
Fang, J., Hsueh, Y., Soto, J., Sun, W., Wang, J., Gu, Z., Khademhosseini, A., & Li, S. (2020) · ACS Nano · doi:10.1021/acsnano.9b04837 · Cited by 61
Stability and biodegradation of silk fibroin/hyaluronic acid nerve conduits
Hu, Z., Das, S. K., Yan, S., You, R., Li, X., Luo, Z., Li, M., Zhang, Q., & Kaplan, D. L. (2020) · Composites Part B Engineering · doi:10.1016/j.compositesb.2020.108222 · Cited by 61
Cellular responses and functions of α7 nicotinic acetylcholine receptor activation in the brain: A narrative review
Xu, Z.-Q., Zhang, W.-J., Su, D.-F., Zhang, G.-Q., & Miao, C.-Y. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-273 · Cited by 60
The roles of astrocytic phagocytosis in maintaining homeostasis of brains
Lee, S. Y., & Chung, W. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.12.007 · Cited by 60
Non-invasive approaches to functional recovery after spinal cord injury: Therapeutic targets and multimodal device interventions
Pizzolato, C., Gunduz, M. A., Palipana, D. B., Wu, J., Grant, G. D., Hall, S., Dennison, R., ZAFONTE, R. D., Lloyd, D. G., & Teng, Y. D. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113612 · Cited by 64
Impact of aging immune system on neurodegeneration and potential immunotherapies
Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D., & Zhao, Y. L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.07.006 · Cited by 64
Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection
Lima, R., Monteiro, S., Lopes, J., Barradas, P. S., Vasconcelos, N., Gomes, E. D., Assunção-Silva, R. C., Teixeira, F. G., Morais, M., Sousa, N., et al. (2017) · Pharmaceuticals · doi:10.3390/ph10040083 · Cited by 62
Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes
Hackett, A. R., Yahn, S. L., Lyapichev, K. A., Dajnoki, A., Lee, D.-H., Rodriguez, M., Cammer, N. C., Pak, J., Mehta, S. T., Bodamer, O. A., et al. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.001 · Cited by 60
The Functional Role of Spinal Interneurons Following Traumatic Spinal Cord Injury
Zavvarian, M.-M., Hong, J., & Fehlings, M. G. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00127 · Cited by 59
Recent advances in nanomaterials for the treatment of spinal cord injury
Gong, W., Zhang, T., Che, M., Wang, Y., He, C., Liu, L., Lv, Z., Xiao, C., Wang, H., & Zhang, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100524 · Cited by 60
Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model
Wen, J., Maxwell, R. R., Wolf, A. J., Spira, M., Gulinello, M. E., & Cole, P. D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.007 · Cited by 58
Human GNPTAB stuttering mutations engineered into mice cause vocalization deficits and astrocyte pathology in the corpus callosum
Han, T., Root, J. T., Reyes, L. D., Huchinson, E. B., du Hoffmann, J., Lee, W., Barnes, T. D., & Drayna, D. T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901480116 · Cited by 60
Zeb2 Is a Regulator of Astrogliosis and Functional Recovery after CNS Injury
Vivinetto, A. L., Kim, I., Goldberg, D. C., Fones, L., Brown, E., Tarabykin, V. S., Hill, C. E., Cho, S., & Cave, J. W. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107834 · Cited by 56
Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model
Mizuno, G. O., Wang, Y., Shi, G., Wang, Y., Sun, J., Papadopoulos, S., Broussard, G. J., Unger, E. K., Deng, W., Weick, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.033 · Cited by 58
Mechanisms of Axon Growth and Regeneration: Moving between Development and Disease
Bradke, F. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1131-22.2022 · Cited by 60
Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury
Cieri, M. B., & Ramos, A. J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-02091 · Cited by 66
Lactate promotes microglial scar formation and facilitates locomotor function recovery by enhancing histone H4 lysine 12 lactylation after spinal cord injury
Hu, X., Huang, J., Li, Z., Li, J., Ouyang, F., Chen, Z., Li, Y., Zhao, Y., Wang, J., Yu, S., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03186-5 · Cited by 58
DNA methylation controls stemness of astrocytes in health and ischaemia
Kremer, L. P. M., Cerrizuela, S., El‐Sammak, H., Shukairi, M. E. A., Ellinger, T., Straub, J., Korkmaz, A., Volk, K., Brunken, J., Kleber, S., et al. (2024) · Nature · doi:10.1038/s41586-024-07898-9 · Cited by 61
Determinants of Axon Growth, Plasticity, and Regeneration in the Context of Spinal Cord Injury
Filous, A. R., & Schwab, J. M. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.09.005 · Cited by 61
Don't forget astrocytes when targeting Alzheimer's disease
Sadick, J. S., & Liddelow, S. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14568 · Cited by 60
AP-1cFos/JunB/miR-200a regulate the pro-regenerative glial cell response during axolotl spinal cord regeneration
Sabin, K. Z., Jiang, P., Gearhart, M. D., Stewart, R. M., & Echeverri, K. (2019) · Communications Biology · doi:10.1038/s42003-019-0335-4 · Cited by 59
Hypothalamic deep brain stimulation augments walking after spinal cord injury
Cho, N., Squair, J. W., Aureli, V., James, N. D., Bole-Feysot, L., Dewany, I., Hankov, N., Baud, L., Leonhartsberger, A., Sveistyte, K., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03306-x · Cited by 62
Self-citation
Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
Wang, L., Xia, J., Li, J., Hagemann, T. L., Jones, J. R., Fraenkel, E., Weitz, D. A., Zhang, S., Messing, A., & Feany, M. Β. (2018) · Nature Communications · doi:10.1038/s41467-018-04269-7 · Cited by 62
The Drama of Wallerian Degeneration: The Cast, Crew, and Script
Zhang, K., Jiang, M., & Fang, Y. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-071819-103917 · Cited by 59
Role of glia in optic nerve
Yazdankhah, M., Shang, P., Ghosh, S., Hose, S., Liu, H., Weiss, J., Fitting, C. S., Bhutto, I. A., Zigler, J. S., Qian, J. X., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100886 · Cited by 57
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice
Danjo, Y., Shigetomi, E., Hirayama, Y. J., Kobayashi, K., Ishikawa, T., Fukazawa, Y., Shibata, K., Takanashi, K., Parajuli, B., Shinozaki, Y., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20210989 · Cited by 56
Hydrogel scaffolds in the treatment of spinal cord injury: a review
Cai, M., Chen, L., Wang, T., Liang, Y., Zhao, J., Zhang, X., Li, Z., & Wu, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1211066 · Cited by 56
Electrospun Fibers for Drug Delivery after Spinal Cord Injury and the Effects of Drug Incorporation on Fiber Properties
Johnson, C. D. L., D’Amato, A. R., & Gilbert, R. J. (2016) · Cells Tissues Organs · doi:10.1159/000446621 · Cited by 58
Employing Endogenous NSCs to Promote Recovery of Spinal Cord Injury
Liu, S., & Chen, Z. (2019) · Stem Cells International · doi:10.1155/2019/1958631 · Cited by 56
Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes
Ma, M., Li, H., Wu, J., Zhang, Y., Shen, H., Li, X., Wang, Z., & Chen, G. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01990-7 · Cited by 58
Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery
Joshi, C. R., Labhasetwar, V., & Ghorpade, A. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9724-3 · Cited by 55
Neuronal Redevelopment and the Regeneration of Neuromodulatory Axons in the Adult Mammalian Central Nervous System
Cooke, P., Janowitz, H. N., & Dougherty, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.872501 · Cited by 61
Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice
O’Shea, T. M., Ao, Y., Wang, S., Wollenberg, A. L., Kim, J. H., Espinoza, R. A. R., Czechanski, A., Reinholdt, L. G., Deming, T. J., & Sofroniew, M. V. (2022) · Nature Communications · doi:10.1038/s41467-022-33382-x · Cited by 54
Self-citation
Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
Zheng, J., Wu, H., Wang, X., Zhang, G., Lü, J., Xu, W., Xu, S., Fang, Y., Zhang, A., Shao, A., et al. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.02.007 · Cited by 56
Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS
Chen, M., Geoffroy, C. G., Meves, J. M., Narang, A., Li, Y., Nguyen, M. T., Khai, V. S., Kong, X., Steinke, C. L., Carolino, K. I., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.102 · Cited by 56
Biomaterials and glia: Progress on designs to modulate neuroinflammation
Tsui, C. T., Koss, K. M., Churchward, M. A., & Todd, K. G. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.008 · Cited by 57
Keep an eye on adenosine: Its role in retinal inflammation
Santiago, A. R., Madeira, M. H., Boia, R., Aires, I. D., Rodrigues‐Neves, A. C., Santos, P. F., & Ambrósio, A. F. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107513 · Cited by 58
The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System
Sutherland, T. C., & Geoffroy, C. G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00190 · Cited by 56
Injectable Gelatin Hydrogel Suppresses Inflammation and Enhances Functional Recovery in a Mouse Model of Intracerebral Hemorrhage
Xu, J., Duan, Z., Qi, X., Ou, Y., Guo, X., Zi, L., Yang, W., Liu, H., Ma, L., Li, H., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00785 · Cited by 55
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking
Schiweck, J., Murk, K., Ledderose, J. M. T., Münster‐Wandowski, A., Ornaghi, M., Vida, I., & Eickholt, B. J. (2021) · Nature Communications · doi:10.1038/s41467-021-21662-x · Cited by 57
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders
Liddelow, S. A., Olsen, M. L., & Sofroniew, M. V. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041356 · Cited by 55
Self-citation
Contusion brain damage in mice for modelling of post-traumatic epilepsy with contralateral hippocampus sclerosis: Comprehensive and longitudinal characterization of spontaneous seizures, neuropathology, and neuropsychiatric comorbidities
Golub, V. M., & Reddy, D. S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113946 · Cited by 54
3D Gelatin Microsphere Scaffolds Promote Functional Recovery after Spinal Cord Hemisection in Rats
Ke, H., Yang, H., Zhao, Y., Li, T., Xin, D., Gai, C., Jiang, Z., & Wang, Z. (2022) · Advanced Science · doi:10.1002/advs.202204528 · Cited by 54
Glial Na+‐dependent ion transporters in pathophysiological conditions
Boscia, F., Begum, G., Pignataro, G., Sirabella, R., Cuomo, O., Casamassa, A., Sun, D., & Annunziato, L. (2016) · Glia · doi:10.1002/glia.23030 · Cited by 56
Brain repair from intrinsic cell sources
Torper, O., & Götz, M. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2016.12.010 · Cited by 56
Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis
Blochet, C., Buscemi, L., Clément, T., Gehri, S., Badaut, J., & Hirt, L. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18806893 · Cited by 55
Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition
Kárová, K., Wainwright, J. V., Urdzíková, L. M., Pisal, R. V., Schmidt, M. H., Jendelová, P., & Jhanwar‐Uniyal, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1394-7 · Cited by 54
The Potential of Astrocytes as Immune Modulators in Brain Tumors
Priego, N., & Valiente, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01314 · Cited by 59
Walking with Salamanders: From Molecules to Biorobotics
Ryczko, D., Simon, A., & Ijspeert, A. J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.006 · Cited by 53
Human menstrual blood-derived stem cells promote functional recovery in a rat spinal cord hemisection model
Wu, Q., Wang, Q., Li, Z., Li, X., Zang, J., Wang, Z., Chen, X., Gong, Y., Cheng, J., Li, H., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0847-8 · Cited by 53
Integrated, Transparent Silicon Carbide Electronics and Sensors for Radio Frequency Biomedical Therapy
Nguyen, T., Yadav, S., Truong, T., Han, M., Barton, M., Leitch, M., Guzmán, P., Dinh, T., Ashok, A., Vu, H., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c03188 · Cited by 53
Astrocytic modulation of neuronal signalling
Purushotham, S. S., & Buskila, Y. (2023) · Frontiers in Network Physiology · doi:10.3389/fnetp.2023.1205544 · Cited by 56
Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer
Cigliola, V., Shoffner, A. R., Lee, N., Ou, J., Gonzalez, T. J., Hoque, J., Becker, C. J., Han, Y., Shen, G. R., Faw, T. D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40486-5 · Cited by 51
Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats
Jea, A. H., Palejwala, A., Fridley, J., Mata, J., Samuel, E. G., Luerssen, T. G., Perlaky, L., Kent, T., & Tour, J. (2016) · Surgical Neurology International · doi:10.4103/2152-7806.188905 · Cited by 53
Mechanism of Neuroprotection Against Experimental Spinal Cord Injury by Riluzole or Methylprednisolone
Sámano, C., & Nistri, A. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2459-6 · Cited by 53
miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway
Zhang, Y., Meng, T., Chen, J., Zhang, Y., Kang, J., Li, X., Yu, G., Tian, L., Jin, Z., Dong, H., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60509 · Cited by 53
Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
Maïer, B., & Kubis, N. (2019) · Neural Plasticity · doi:10.1155/2019/6843895 · Cited by 58
Activation of both transforming growth factor-β and bone morphogenetic protein signalling pathways upon traumatic brain injury restrains pro-inflammatory and boosts tissue reparatory responses of reactive astrocytes and microglia
Divolis, G., Stavropoulos, A., Manioudaki, M., Apostolidou, A. C., Doulou, A., Gavriil, A., Dafnis, I., Chroni, A., Mummery, C. L., Xilouri, M., et al. (2019) · Brain Communications · doi:10.1093/braincomms/fcz028 · Cited by 51
Biomimetic Scaffolds for Spinal Cord Applications Exhibit Stiffness‐Dependent Immunomodulatory and Neurotrophic Characteristics
Woods, I., O’Connor, C., Frugoli, L., Kerr, S., Gonzalez, J. G., Stasiewicz, M., McGuire, T. K., Cavanagh, B., Hibbitts, A., Dervan, A. G., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101663 · Cited by 53
Heterogeneity of white matter astrocytes in the human brain
Bugiani, M., Plug, B. C., Man, J. H. K., Breur, M., & van der Knaap, M. S. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02391-3 · Cited by 55
The evolving role of extracellular vesicles (exosomes) as biomarkers in traumatic brain injury: Clinical perspectives and therapeutic implications
Khan, N. A., Asim, M., El-Menyar, A. A., Biswas, K. H., Rizoli, S. B., & Al-Thani, H. A. S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.933434 · Cited by 52
Neuroinflammation and Autophagy in Parkinson’s Disease—Novel Perspectives
Minchev, D. S., Kazakova, M., & Sarafian, V. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314997 · Cited by 55
Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy
Yu, T., Yang, L., Zhou, Y. Y., Wu, M., & Jiao, J. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03614-y · Cited by 54
The Importance of Phosphoinositide 3-Kinase in Neuroinflammation
Wright, B., King, S. P., & Suphioglu, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111638 · Cited by 55
Neuroinflammation: targeting microglia for neuroprotection and repair after spinal cord injury
Cavalcanti, R. R., de Almeida, F. M., Martinez, A. M. B., & Freria, C. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1670650 · Cited by 55
The role of glia in protein aggregation
Li, Q., & Haney, M. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105015 · Cited by 54
Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration
Puhl, D. L., Funnell, J. L., Nelson, D. W., Gottipati, M. K., & Gilbert, R. J. (2020) · Bioengineering · doi:10.3390/bioengineering8010004 · Cited by 54
Astrocytes usurp neurons as a disease focus
Liddelow, S. A., & Sofroniew, M. V. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0367-6 · Cited by 50
Self-citation
Recent trends in the development of peptide and protein-based hydrogel therapeutics for the healing of CNS injury
Mukherjee, N., Adak, A., & Ghosh, S. (2020) · Soft Matter · doi:10.1039/d0sm00885k · Cited by 53
Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease
Jiwaji, Z., & Hardingham, G. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.020 · Cited by 53
Not everything is scary about a glial scar
Liddelow, S. A., & Barres, B. A. (2016) · Nature · doi:10.1038/nature17318 · Cited by 51
Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery
Wollenberg, A. L., O’Shea, T. M., Kim, J. H., Czechanski, A., Reinholdt, L. G., Sofroniew, M. V., & Deming, T. J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.057 · Cited by 51
Self-citation
History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair
Walker, M. J., & Xu, X. (2018) · Brain Sciences · doi:10.3390/brainsci8060109 · Cited by 51
The Neuroprotective Role of Reactive Astrocytes after Central Nervous System Injury
Boghdadi, A. G., Teo, L., & Bourne, J. A. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6938 · Cited by 52
Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke
Hernandez, V. G., Lechtenberg, K. J., Peterson, T. C., Zhu, L., Lucas, T. A., Bradshaw, K. P., Owah, J. O., Dorsey, A. I., Gentles, A. J., & Buckwalter, M. S. (2023) · Glia · doi:10.1002/glia.24377 · Cited by 51
Are We Close to Targeting Enteric Glia in Gastrointestinal Diseases and Motility Disorders?
Gulbransen, B. D., & Christofi, F. L. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.050 · Cited by 50
Alexander disease: models, mechanisms, and medicine
Hagemann, T. L. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.10.002 · Cited by 50
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway
Li, Z., Yu, S., Liu, Y., Hu, X., Li, Y., Xiao, Z., Chen, Y., Tian, D., Xu, X., Cheng, L., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02449-3 · Cited by 49
Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke
Li, W., Mandeville, E. T., Durán‐Laforet, V., Fukuda, N., Yu, Z., Zheng, Y., Held, A., Park, J., Nakano, T., Tanaka, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35498-6 · Cited by 53
The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage
Li, H., Ghorbani, S., Ling, C., Yong, V. W., & Xue, M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106282 · Cited by 52
Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia
Žucha, D., Abaffy, P., Kirdajová, D., Jirák, D., Kubista, M., Anděrová, M., & Valihrach, L. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404203121 · Cited by 56
Regulation of adult neural progenitor cell functions by purinergic signaling
Tang, Y., & Illés, P. (2016) · Glia · doi:10.1002/glia.23056 · Cited by 51
Transplantation of human bone marrow‐derived clonal mesenchymal stem cells reduces fibrotic scar formation in a rat spinal cord injury model
Kim, M., Kim, K. H., Song, S. U., Yi, T., Yoon, S. H., Park, S. R., & Choi, B. H. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2425 · Cited by 50
Immunobiology of spinal cord injuries and potential therapeutic approaches
Ahmed, A., Patil, A.-A., & Agrawal, D. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3184-9 · Cited by 51
Role of immune responses for extracellular matrix remodeling in the ischemic brain
Dzyubenko, E., Manrique‐Castano, D., Kleinschnitz, C., Faissner, A., & Hermann, D. M. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418818092 · Cited by 55
Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease
Marchetti, B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101664 · Cited by 52
Altered astrocytic function in experimental neuroinflammation and multiple sclerosis
das Neves, S. P., Sousa, J. C., Sousa, N., Cerqueira, J., & Marques, F. (2020) · Glia · doi:10.1002/glia.23940 · Cited by 49
Human Cerebral Organoid Implantation Alleviated the Neurological Deficits of Traumatic Brain Injury in Mice
Bao, Z., Fang, K.-H., Miao, Z., Li, C., Yang, C., Yu, Q., Zhang, C., Miao, Z., Liu, Y., & Ji, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6338722 · Cited by 51
Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats
Liu, Q., Zhou, S., Wang, X. D., Gu, C., Guo, Q., Li, X., Zhang, C., Zhang, N., Zhang, L., & Huang, F. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02518-7 · Cited by 50
Pathophysiology of Traumatic Spinal Cord Injury
Couillard‐Després, S., Bieler, L., & Vogl, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-46293-6_19 · Cited by 53
Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats
Zhong, K., Wang, R., Qian, X.-D., Yu, P., Zhu, X., Zhang, Q., & Ye, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110041 · Cited by 47
Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury
Yang, T., Xing, L., Yu, W., Cai, Y., Cui, S., & Chen, G. (2020) · The FASEB Journal · doi:10.1096/fj.202001657rr · Cited by 48
Neural Tissue Homeostasis and Repair Is Regulated via CS and DS Proteoglycan Motifs
Hayes, A. J., & Melrose, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.696640 · Cited by 52

Authors: Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V.
Affiliations: Tongji University (CN)
University of California, Los Angeles (US)
Corresponding author: Sofroniew, Michael V.
ORCID: Anderson, Mark A.
Burda, Joshua E.
Ren, Yilong
O’Shea, Timothy M.
Kawaguchi, Riki
Coppola, Giovanni
Khakh, Baljit S.
Deming, Timothy J.
Sofroniew, Michael V.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-03-30
Volume: 532
Issue: 7598
Pages: 195-200
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature17623
PMC: PMC5243141
OpenAlex: W2335534790
Cited by: 1,851
References: 104
Citations by year: 2026: 116 · 2025: 163 · 2024: 180 · 2023: 159 · 2022: 234 · 2021: 250 · 2020: 224 · 2019: 159 · 2018: 162 · 2017: 136 · 2016: 62
FWCI: 97.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: National Institute of Mental Health (R01MH099559, MH104069, MH099559A, DP1MH104069)
National Institute of Neurological Disorders and Stroke (NS084030, NS057624, NS060677, R01NS060677, R01NS057624, P30NS062691, R01NS084030)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: axon regeneration, spinal cord injury, central nervous system injury, corticospinal axons, sensory axons, serotonergic axons, hydrogel delivery, laminin, axon growth inhibition, astrocytes
MeSH terms: Animals, Astrocytes, Axons, Central Nervous System, Cicatrix, Female, Models, Biological, Nerve Regeneration, Chondroitin Sulfate Proteoglycans, Spinal Cord Injuries, Reproducibility of Results, Genomics, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Astrocyte scar formation aids central nervous system axon regeneration

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks