Cell Senescence: Role in Aging and Age-Related Diseases
Open accessAbstract
Cell senescence is one of the major paradigms of aging research. It started with the demonstration by L. Hayflick of the limited number of divisions by normal, nontransformed cells, not shown by transformed malignant cells, this processes being largely regulated by the telomere-telomerase system. A complete renewal of this discipline came from the demonstration that cells can enter senescence at any time by an anti-oncogene-triggered pathway, enabling them to escape malignancy. The senescent cell became a major actor of the aging process, among others, by the acquisition of the senescence-associated secretory phenotype. This chapter is devoted to the regulatory process involved in the acquisition of the senescent cell phenotype and its role in organismal aging.
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Senescent cells secrete inflammatory and other factors that can disrupt normal cellular functions, damage tissues and promote carcinogenesis.
“they also secrete inflammatory and other factors that can disrupt normal cellular functions, damage tissues and promote carcinogenesis61,62.”
From Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) · cites this paper as [61]
Senescent cells accumulate with age and in many diseases, potentially contributing to pathology.
“Senescent cells produce a distinct inflammatory secretome and have been found to accumulate with age and in many diseases; potentially contributing to pathology [17–21].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [19]
Senescent cells produce a distinct inflammatory secretome.
“Senescent cells produce a distinct inflammatory secretome and have been found to accumulate with age and in many diseases; potentially contributing to pathology [17–21].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [19]
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- Authors
- Campisi, J., & Robert, L.
- Affiliations
- Buck Institute for Research on Aging (US)
- Hôtel-Dieu de Paris (FR)
- ORCID
- Campisi, Judith
- Venue
- Interdisciplinary Topics in Gerontology and Geriatrics
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 39
- Pages
- 45-61
- ISSN
- 2297-3486 (ISSN-L)
- 2297-3508
- PMC
- PMC4211612
- OpenAlex
- W1497413135
- Cited by
- 240
- References
- 66
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 23 · 2023: 21 · 2022: 19 · 2021: 30 · 2020: 25 · 2019: 25 · 2018: 20 · 2017: 18 · 2016: 28 · 2015: 20 · 2014: 1
- FWCI
- 57.47
- Type
- book chapter
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Interdisciplinary topics in gerontology and geriatrics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R37AG009909, P01AG041122, P01AG017242)
- National Cancer Institute (R21CA170610)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, aging, age-related diseases, Hayflick limit, telomeres, telomerase, replicative senescence, oncogene-induced senescence, senescence-associated secretory phenotype, senescence regulation
- MeSH terms
- Aging, Cell Division, Cells, Cultured, DNA Damage, Humans, Models, Biological, Neoplasms, Cellular Senescence, Oxidative Stress, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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