Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

limma powers differential expression analyses for RNA-sequencing and microarray studies

Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,015 · see citing works

MetaboAnalyst 3.0—making metabolomics more meaningful

Xia, J., Sinelnikov, I. V., Han, B., & Wishart, D. S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv380 · Cited by 2,680 · see citing works

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J. I., Scott, L. J., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 2,217 · see citing works

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works

Lamin A Truncation in Hutchinson-Gilford Progeria

Sandre‐Giovannoli, A. D., Bernard, R., Cau, P., Navarro, C. L., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Münnich, A., Merrer, M. F. L., et al. (2003) · Science · doi:10.1126/science.1084125 · Cited by 1,472 · see citing works

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works

Lamin A-Dependent Nuclear Defects in Human Aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.052 · Cited by 988 · see citing works

Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial

Heilbronn, L. K., de Jonge, L., Frisard, M. I., DeLany, J. P., Larson-Meyer, D. E., Rood, J., Nguyen, T., Martin, C. K., Volaufova, J., Most, M. M., et al. (2006) · JAMA · doi:10.1001/jama.295.13.1539 · Cited by 969 · see citing works

Metabolic control of autophagy

Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855 · see citing works

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works

Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance

Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R. E., & Smith‐Wheelock, M. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00152.x · Cited by 734 · see citing works

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works

Endogenous hydrogen sulfide production is essential for dietary restriction benefits

Hine, C., Harputlugil, E., Zhang, Y., Ruckenstuhl, C., Lee, B. C., Brace, L., Longchamp, A., Treviño-Villarreal, J. H., Mejia, P., Ozaki, C. K., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.048 · Cited by 558 · see citing works

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice

Pendás, A. M., Zhou, Z., Cadiñanos, J., Freije, J. M. P., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., et al. (2002) · Nature Genetics · doi:10.1038/ng871 · Cited by 554 · see citing works

AMPK at the Nexus of Energetics and Aging

Burkewitz, K., Zhang, Y., & Mair, W. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.002 · Cited by 483 · see citing works

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

Varela, I., Cadiñanos, J., Pendás, A. M., Gutiérrez-Fernández, A., Folgueras, A. R., Sánchez, L. M., Zhou, Z., Rodríguez, F. J., Stewart, C. L., Vega, J. A., et al. (2005) · Nature · doi:10.1038/nature04019 · Cited by 466 · see citing works

Essential role for autophagy in life span extension

Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73946 · Cited by 464 · see citing works

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.027 · Cited by 451 · see citing works

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

Dunn, S. E., Kari, F. W., French, J. E., Leininger, J. R., Travlos, G. S., Wilson, R., & Barrett, J. C. (1997) · PubMed · Cited by 439 · see citing works

Splicing-directed therapy in a new mouse model of human accelerated aging

Osorio, F. G., Navarro, C. L., Cadiñanos, J., López-Mejía, I. C., Quirós, P. M., Bartoli, C., Rivera, J., Tazi, J., Guzmán, G., Varela, I., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002847 · Cited by 432 · see citing works

Progeria syndromes and ageing: what is the connection?

Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works

Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort

Schmidt, J. A., Rinaldi, S., Scalbert, A., Ferrari, P., Achaintre, D., Gunter, M. J., Appleby, P. N., Key, T. J., & Travis, R. C. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.144 · Cited by 349 · see citing works

The metabolic regulation of aging

Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works

Of mice and men: the benefits of caloric restriction, exercise, and mimetics

Mercken, E. M., Carboneau, B. A., Krzysik-Walker, S. M., & de Cabo, R. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.11.005 · Cited by 318 · see citing works

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., et al. (2016) · Nature · doi:10.1038/nature19329 · Cited by 315 · see citing works

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

Igarashi, M., & Guarente, L. (2016) · Cell · doi:10.1016/j.cell.2016.05.044 · Cited by 302 · see citing works

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors

Navarro, C. L., Cadiñanos, J., Sandre‐Giovannoli, A. D., Bernard, R., Courrier, S., Boccaccio, I., Boyer, A., Kleijer, W. J., Wagner, A., Giuliano, F., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi159 · Cited by 299 · see citing works

Progeria: A Paradigm for Translational Medicine

Gordon, L. B., Rothman, F. G., López-Otı́n, C., & Misteli, T. (2014) · Cell · doi:10.1016/j.cell.2013.12.028 · Cited by 276 · see citing works

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

Osorio, F. G., Bárcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. P., & López-Otín, C. (2012) · Genes & Development · doi:10.1101/gad.197954.112 · Cited by 276 · see citing works

Caloric restriction mimetics: towards a molecular definition

Madeo, F., Pietrocola, F., Eisenberg, T., & Kroemer, G. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4391 · Cited by 264 · see citing works

Protein and amino acid restriction, aging and disease: from yeast to humans

Mirzaei, H., Suarez, J. A., & Longo, V. D. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.002 · Cited by 248 · see citing works

Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, and IGF-1 Binding Proteins

Breese, C. R., Ingram, R. L., & Sonntag, W. E. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.5.b180 · Cited by 237 · see citing works

Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

van der Pluijm, I., Garinis, G. A., Brandt, R. M. C., Gorgels, T. G. M. F., Wijnhoven, S., Diderich, K. E. M., de Wit, J., Mitchell, J. R., van Oostrom, C., Beems, R. B., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0050002 · Cited by 237 · see citing works

Comparative and meta‐analytic insights into life extension via dietary restriction

Nakagawa, S., Lagisz, M., Hector, K. L., & Spencer, H. G. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00798.x · Cited by 219 · see citing works

Statistical methods for testing effects on “maximum lifespan”

Wang, C., Li, Q., Redden, D. T., Weindruch, R., & Allison, D. B. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.003 · Cited by 208 · see citing works

Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice

Solon-Biet, S. M., Mitchell, S. J., Coogan, S. C. P., Cogger, V. C., Gokarn, R., McMahon, A. C., Raubenheimer, D., de Cabo, R., Simpson, S. J., & Le Couteur, D. G. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.007 · Cited by 207 · see citing works

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

Stenesen, D., Suh, J. M., Seo, J. H., Yu, K., Lee, K., Kim, J.-S., Min, K., & Graff, J. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.006 · Cited by 203 · see citing works

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Balmus, G., Larrieu, D., Barros, A. C., Collins, C., Abrudan, M. I., Demir, M., Geisler, N. J., Lelliott, C. J., White, J. K., Karp, N. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03770-3 · Cited by 203 · see citing works

Cytochrome P450s in the synthesis of cholesterol and bile acids – from mouse models to human diseases

Lorbek, G., Lewińska, M., & Rozman, D. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08432.x · Cited by 195 · see citing works

Effects of 2‐year calorie restriction on circulating levels of IGF‐1, IGF‐binding proteins and cortisol in nonobese men and women: a randomized clinical trial

Fontana, L., Villareal, D. T., Das, S. K., Smith, S. R., Meydani, S. N., Pittas, A. G., Klein, S., Bhapkar, M. V., Rochon, J., Ravussin, É., et al. (2015) · Aging Cell · doi:10.1111/acel.12400 · Cited by 174 · see citing works

nVenn: generalized, quasi-proportional Venn and Euler diagrams

Pérez-Silva, J. G., Araujo‐Voces, M., & Quesada, V. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty109 · Cited by 154 · see citing works

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

Mariño, G., Ugalde, A. P., Fernández, Á. F., Osorio, F. G., Fueyo, A., Freije, J. M. P., & López-Otı́n, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002696107 · Cited by 145 · see citing works

Premature aging in mice activates a systemic metabolic response involving autophagy induction

Mariño, G., Ugalde, A. P., Salvador-Montoliu, N., Varela, I., Quirós, P. M., Cadiñanos, J., van der Pluijm, I., Freije, J. M. P., & López-Otı́n, C. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn120 · Cited by 143 · see citing works

The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy

McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.07.044 · Cited by 137 · see citing works

Alterations in xenobiotic metabolism in the long‐lived Little mice

Amador‐Noguez, D., Dean, A., Huang, W., Setchell, K., Moore, D., & Darlington, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00300.x · Cited by 134 · see citing works

The effect of diet on plasma homocysteine concentrations in healthy male subjects

Mann, N. J., Li, D., Sinclair, A., Dudman, N. P. B., Guo, X., Elsworth, G., Wilson, A., & Kelly, F. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600874 · Cited by 118 · see citing works

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Goldberg, A. A., Richard, V. R., Kyryakov, P., Bourque, S. D., Beach, A., Burstein, M. T., Glebov, A., Koupaki, O., Boukh‐Viner, T., Gregg, C., et al. (2010) · Aging · doi:10.18632/aging.100168 · Cited by 115 · see citing works

SIRT 1 but not its increased expression is essential for lifespan extension in caloric‐restricted mice

Mercken, E. M., Hu, J. H., Krzysik-Walker, S. M., Wei, M., Li, Y., McBurney, M. W., de Cabo, R., & Longo, V. D. (2013) · Aging Cell · doi:10.1111/acel.12151 · Cited by 112 · see citing works

The Impact of Dietary Methionine Restriction on Biomarkers of Metabolic Health

Orgeron, M., Stone, K. P., Wanders, D., Cortez, C. C., Van, N. T., & Gettys, T. W. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00011-9 · Cited by 107 · see citing works

Interruption of progerin–lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

Lee, S.-J., Jung, Y., Yoon, M.-H., Kang, S., Oh, A.-Y., Lee, J.-H., Jun, S.-Y., Woo, T.-G., Chun, H.-Y., Kim, S. K., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84164 · Cited by 102 · see citing works

The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans

Magner, D. B., Wollam, J., Shen, Y., Hoppe, C., Li, D., Latza, C., Rottiers, V., Hutter, H., & Antebi, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.007 · Cited by 98 · see citing works

Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia

Elshorbagy, A. K., Valdivia‐Garcia, M., Refsum, H., Smith, A. D., Mattocks, D. A. L., & Perrone, C. E. (2010) · Nutrition · doi:10.1016/j.nut.2009.09.017 · Cited by 96 · see citing works

Effect of Chronic Caloric Restriction on the Circadian Regulation of Physiological and Behavioral Variables in Old Male B6C3F1Mice

Duffy, P. H., Feuers, R. J., & Hart, R. W. (1990) · Chronobiology International · doi:10.1080/07420529009064635 · Cited by 81 · see citing works

Lipid Profiles and Signals for Long Life

Schroeder, E. A., & Brunet, A. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.08.007 · Cited by 40 · see citing works

Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan

Arlia‐Ciommo, A., Piano, A., Leonov, A., Svistkova, V., & Titorenko, V. I. (2014) · Cell Cycle · doi:10.4161/15384101.2014.965063 · Cited by 38 · see citing works

Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo

Enot, D. P., Niso‐Santano, M., Durand, S., Chery, A., Pietrocola, F., Vacchelli, E., Madeo, F., Galluzzi, L., & Kroemer, G. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1064206 · Cited by 31 · see citing works

Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast

Leonov, A., Arlia‐Ciommo, A., Bourque, S. D., Koupaki, O., Kyryakov, P., Dakik, P., McAuley, M., Medkour, Y., Mohammad, K., Maulo, T. D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16766 · Cited by 18 · see citing works

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Bárcena, C., Valdés-Mas, R., Mayoral, P., Garabaya, C., Durand, S., Rodríguez, F., Fernández-García, M. T., Salazar, N., Nogacka, A. M., Garatachea, N., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0504-5 · Cited by 661 · see citing works

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sanderson, S. M., Gao, X., Dai, Z., & Locasale, J. W. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0187-8 · Cited by 572 · see citing works

Molecular physiology of bile acid signaling in health, disease, and aging

Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481 · see citing works

Chronic inflammation and the hallmarks of aging

Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471 · see citing works

B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease

Lyon, P. D., Strippoli, V., Fang, B., & Cimmino, L. (2020) · Nutrients · doi:10.3390/nu12092867 · Cited by 450 · see citing works

Biomarkers of aging

Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works

Lipid metabolism and lipid signals in aging and longevity

Mutlu, A. S., Duffy, J. D., & Wang, M. C. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.03.034 · Cited by 311 · see citing works

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

Parkhitko, A. A., Jouandin, P., Mohr, S. E., & Perrimon, N. (2019) · Aging Cell · doi:10.1111/acel.13034 · Cited by 276 · see citing works

Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice

Richardson, N. E., Konon, E. N., Schuster, H. S., Mitchell, A. T., Boyle, C., Rodgers, A. C., Finke, M., Haider, L. R., Yu, D., Flores, V., et al. (2021) · Nature Aging · doi:10.1038/s43587-020-00006-2 · Cited by 264 · see citing works

Importance of circadian timing for aging and longevity

Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 249 · see citing works

Venn diagrams in bioinformatics

Jia, A., Xu, L., & Wang, Y. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab108 · Cited by 243 · see citing works

Methionine Restriction and Cancer Biology

Wanders, D., Hobson, K., & Ji, X. (2020) · Nutrients · doi:10.3390/nu12030684 · Cited by 185 · see citing works

Ageing, metabolism and the intestine

Funk, M. C., Zhou, J., & Boutros, M. (2020) · EMBO Reports · doi:10.15252/embr.202050047 · Cited by 166 · see citing works

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Grajeda-Iglesias, C., Durand, S., Daillère, R., Iribarren, K., Lemaitre, F., Derosa, L., Aprahamian, F., Bossut, N., Nirmalathasan, N., Madeo, F., et al. (2021) · Aging · doi:10.18632/aging.202739 · Cited by 161 · see citing works

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Shi, L., Jin, L., & Huang, W. (2023) · Cells · doi:10.3390/cells12141888 · Cited by 148 · see citing works

Sensing and Signaling of Methionine Metabolism

Lauinger, L., & Kaiser, P. (2021) · Metabolites · doi:10.3390/metabo11020083 · Cited by 128 · see citing works

Impacts of essential amino acids on energy balance

Xiao, F., & Guo, F. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101393 · Cited by 130 · see citing works

Dietary methionine restriction improves the gut microbiota and reduces intestinal permeability and inflammation in high-fat-fed mice

Yang, Y., Zhang, Y., Xu, Y., Luo, T., Ge, Y., Jiang, Y., Shi, Y., Sun, J., & Le, G. (2019) · Food & Function · doi:10.1039/c9fo00766k · Cited by 112 · see citing works

The Molecular Link from Diet to Cancer Cell Metabolism

Bose, S., Allen, A. E., & Locasale, J. W. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.018 · Cited by 93 · see citing works

Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects

Chu, C., Yu, L., Qi, G., Mi, Y., Wu, W., Lee, Y. K., Zhai, Q., Tian, F., & Chen, W. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104556 · Cited by 85 · see citing works

The hallmarks of aging as a conceptual framework for health and longevity research

Tartiere, A. G., Freije, J. M. P., & López-Otı́n, C. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1334261 · Cited by 97 · see citing works

Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress

Kitada, M., Ogura, Y., Monno, I., Xu, J., & Koya, D. (2021) · Biomedicines · doi:10.3390/biomedicines9020130 · Cited by 75 · see citing works

Host and microbiota metabolic signals in aging and longevity

Zhou, Y., Hu, G., & Wang, M. C. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00837-z · Cited by 70 · see citing works

Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Xiao, Y., Feng, Y., Zhao, J., Chen, W., & Lu, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.005 · Cited by 75 · see citing works

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

Suzuki, K., Yamamoto, M., Hernández‐Benítez, R., Li, Z., Wei, C., Soligalla, R. D., Aizawa, E., Hatanaka, F., Kurita, M., Reddy, P., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0213-0 · Cited by 69 · see citing works

Methionine restriction - Association with redox homeostasis and implications on aging and diseases

Zhang, Y., Jelleschitz, J., Grune, T., Chen, W., Zhao, Y., Jia, M., Wang, Y., Liu, Z., & Höhn, A. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102464 · Cited by 69 · see citing works

Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

Li, J., Yang, H. Z., Lei, M., Zhu, W., Su, Y., Li, K.-Y., Zhu, W.-Y., Wang, J., Zhang, L., Qu, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01017-8 · Cited by 63 · see citing works

The metabolomic signature of extreme longevity: naked mole rats versus mice

Viltard, M., Durand, S., Pérez-Lanzón, M., Aprahamian, F., Lefevre, D., Leroy, C., Madeo, F., Kroemer, G., & Friedlander, G. (2019) · Aging · doi:10.18632/aging.102116 · Cited by 62 · see citing works

Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence

Wu, Q., Chen, X., Li, J., & Sun, S. (2020) · Aging and Disease · doi:10.14336/ad.2020.0314 · Cited by 62 · see citing works

Amino acid variability, tradeoffs and optimality in human diet

Dai, Z.-W., Zheng, W.-Y., & Locasale, J. (2021) · bioRxiv · doi:10.1038/s41467-022-34486-0 · Cited by 53 · see citing works

Methionine restriction alleviates high-fat diet-induced obesity: Involvement of diurnal metabolism of lipids and bile acids

Wang, L., Ren, B., Zhang, Q., Chu, C., Zhao, Z., Wu, J., Zhao, W., Liu, Z., & Liu, X. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165908 · Cited by 57 · see citing works

Global Analysis of Protein Arginine Methylation

Zhang, F., Kerbl-Knapp, J., Colman, M. J. R., Meinitzer, A., Macher, T., Vujić, N., Fasching, S., Jany-Luig, E., Korbelius, M., Kuentzel, K. B., et al. (2021) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100016 · Cited by 56 · see citing works

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

Correia‐Melo, C., Kamrad, S., Tengölics, R., Messner, C. B., Trébulle, P., Townsend, S., Varma, S. J., Freiwald, A., Heineike, B. M., Campbell, K., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.007 · Cited by 55 · see citing works

Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species

Fan, J., & Xu, Y. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1771707 · Cited by 56 · see citing works

Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action

Sharma, S., Dixon, T., Jung, S., Graff, E. C., Forney, L. A., Gettys, T. W., & Wanders, D. (2019) · Obesity · doi:10.1002/oby.22534 · Cited by 54 · see citing works

Energy Metabolism and Aging

Bartke, A., Brannan, S., Hascup, E. R., Hascup, K. N., & Darcy, J. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.200112 · Cited by 48 · see citing works

Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights

Jonsson, W. O., Margolies, N., & Anthony, T. G. (2019) · Nutrients · doi:10.3390/nu11061349 · Cited by 50 · see citing works

Molecular pathology of rare progeroid diseases

Rieckher, M., Garinis, G. A., & Schumacher, B. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.06.011 · Cited by 48 · see citing works

Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish

Maï, M. E., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J., Kang, D., Pourcher, T., Yue, J., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00401-5 · Cited by 57 · see citing works

Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial

Bannitz, R. F., Beraldo, R. A., Peluso, A. A., Dall, M., Babaei, P., Foglietti, R., Martins, L. M., Gomes, P. M., Marchini, J. S., Suen, V. M. M., et al. (2022) · Nutrients · doi:10.3390/nu14132670 · Cited by 47 · see citing works

Bile acid metabolism in health and ageing-related diseases

Li, X., Fang, C., Zhao, R., Zou, L., Miao, H., & Zhao, Y. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116313 · Cited by 49 · see citing works

Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome

Kreienkamp, R., & Gonzalo, S. (2020) · Cells · doi:10.3390/cells9020395 · Cited by 45 · see citing works

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

Vernier, M., McGuirk, S., Dufour, C. R., Wan, L., Audet‐Walsh, É., St‐Pierre, J., & Giguère, V. (2020) · Oncogene · doi:10.1038/s41388-020-01438-1 · Cited by 43 · see citing works

Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application

Liu, C., Ji, L., Hu, J., Zhao, Y., Johnston, L. J., Zhang, X., & Ma, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111427 · Cited by 41 · see citing works

Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer

Montégut, L., de Cabo, R., Zitvogel, L., & Kroemer, G. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0504 · Cited by 38 · see citing works

Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle

Rajabian, N., Ikhapoh, I. A., Shahini, S., Choudhury, D., Thiyagarajan, R., Shahini, A., Kulczyk, J., Breed, K., Saha, S., Mohamed, M. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36483-3 · Cited by 38 · see citing works

Caloric restriction maintains stem cells through niche and regulates stem cell aging

Maharajan, N., Vijayakumar, K. A., Jang, C. H., & Cho, G. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01846-1 · Cited by 38 · see citing works

The role of dietary strategies in the modulation of hallmarks of aging

de França, N. A. G., Rolland, Y., Guyonnet, S., & Barreto, P. D. S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101908 · Cited by 38 · see citing works

Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery

Cappuccilli, M. L., Bergamini, C., Giacomelli, F. A., Cianciolo, G., Donati, G., Conte, D., Natali, T., Manna, G. L., & Capelli, I. (2020) · Nutrients · doi:10.3390/nu12051234 · Cited by 39 · see citing works

The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality

Bray, C., Balcells, C. D., McNeish, I. A., & Keun, H. C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1264785 · Cited by 38 · see citing works

The Cutting Edge: The Role of mTOR Signaling in Laminopathies

Chiarini, F., Evangelisti, C., Cenni, V., Fazio, A., Paganelli, F., Martelli, A. M., & Lattanzi, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040847 · Cited by 35 · see citing works

The Aged Intestine: Performance and Rejuvenation

Wang, Q., Qi, Y., Shen, W., Xu, J., Wang, L., Chen, S., Hou, T., & Si, J. (2021) · Aging and Disease · doi:10.14336/ad.2021.0202 · Cited by 35 · see citing works

The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

Ungvari, A., Gulej, R., Csík, B., Mukli, P., Negri, S., Tarantini, S., Yabluchanskiy, A., Benyó, Z., Csiszár, A., & Ungvari, Z. I. (2023) · Nutrients · doi:10.3390/nu15214662 · Cited by 34 · see citing works

Autophagy-mediated metabolic effects of aspirin

Castoldi, F., Humeau, J. F., Martins, I., Lachkar, S., Loew, D., Dingli, F., Durand, S., Enot, D. P., Bossut, N., Chery, A., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00365-0 · Cited by 33 · see citing works

Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet

Xu, K., Guo, Y., Wang, Y., Ren, Y., Low, V., Cho, S., Ping, L., Peng, K., Li, X., Qiu, Y., et al. (2022) · Aging Cell · doi:10.1111/acel.13760 · Cited by 31 · see citing works

Progress and trends in the development of therapies for Hutchinson–Gilford progeria syndrome

Lai, W., & Wong, W. (2020) · Aging Cell · doi:10.1111/acel.13175 · Cited by 33 · see citing works

SLC43A2 and NFκB signaling pathway regulate methionine/cystine restriction-induced ferroptosis in esophageal squamous cell carcinoma via a feedback loop

Peng, H., Yan, Y., He, M., Li, J., Wang, L., Jia, W. P., Yang, L., Jiang, J., Chen, Y., Li, F., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05860-7 · Cited by 32 · see citing works

Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals

Liu, W., Zhu, P., Li, M., Li, Z., Yu, Y., Liu, G., Du, J., Wang, X., Yang, J., Tian, R., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112740 · Cited by 29 · see citing works

A nutrigeroscience approach: Dietary macronutrients and cellular senescence

Calubag, M. F., Robbins, P. D., & Lamming, D. W. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.025 · Cited by 32 · see citing works

H3K4 Methylation in Aging and Metabolism

Hsu, C.-L., Lo, Y., & Kao, C.-F. (2021) · Epigenomes · doi:10.3390/epigenomes5020014 · Cited by 30 · see citing works

Universal transcriptomic hallmarks of mammalian ageing and mortality

Tyshkovskiy, A., Kholdina, D., Davitadze, M., Molière, A., Moldakozhayev, A., Tongu, Y., Kasahara, T., Glubokov, D., Eames, A., Kats, L., et al. (2026) · Nature · doi:10.1038/s41586-026-10542-3 · Cited by 37 · see citing works

Dietary Methionine Restriction Alleviates Choline-Induced Tri-Methylamine-N-Oxide (TMAO) Elevation by Manipulating Gut Microbiota in Mice

Lu, M., Yang, Y., Xu, Y., Wang, X., Li, B., Le, G., & Xie, Y. (2023) · Nutrients · doi:10.3390/nu15010206 · Cited by 32 · see citing works

Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet

Swaminathan, A., Fokin, A., Venckūnas, T., & Degens, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-81037-6 · Cited by 28 · see citing works

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and RejuvenationPreprint

Tyshkovskiy, A., Kholdina, D., Ying, K., Davitadze, M., Molière, A., Tongu, Y., Kasahara, T., Kats, L., Vladimirova, A., Moldakozhayev, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.04.601982 · Cited by 30 · see citing works

Differences in cell death in methionine versus cysteine depletion

Wallis, K., Morehead, L. C., Bird, J. T., Byrum, S. D., & Miousse, I. R. (2021) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22428 · Cited by 26 · see citing works

Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder

Zolkipli‐Cunningham, Z., Naviaux, J. C., Nakayama, T., Hirsch, C. M., Monk, J. M., Li, K., Wang, L., Le, T. P., Meinardi, S., Blake, D. R., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248771 · Cited by 26 · see citing works

Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan

Almendáriz-Palacios, C., Mousseau, D. D., Eskiw, C. H., & Gillespie, Z. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239220 · Cited by 28 · see citing works

Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?

Bárcena, C., López-Otı́n, C., & Kroemer, G. (2018) · Autophagy · doi:10.1080/15548627.2018.1533059 · Cited by 24 · see citing works

Dietary restriction and ageing: Recent evolutionary perspectives

Auley, M. T. M. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111741 · Cited by 22 · see citing works

Bile-ology: from bench to bedside

Jin, L., Fang, Z., Fan, M.-J., & Huang, W. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900158 · Cited by 22 · see citing works

Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess Desulfovibrio through gut–liver axis

Zhou, L., Lu, G., Nie, Y., Ren, Y., Shi, J., Xue, Y., Xu, Z., & Geng, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2370634 · Cited by 21 · see citing works

Long term methionine restriction: Influence on gut microbiome and metabolic characteristics

Nagarajan, A., Lasher, A. T., Morrow, C. D., & Sun, L. Y. (2024) · Aging Cell · doi:10.1111/acel.14051 · Cited by 21 · see citing works

Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

Saxena, S., & Kumar, S. (2020) · GeroScience · doi:10.1007/s11357-020-00167-3 · Cited by 22 · see citing works

The Protective Effect of Roseburia faecis Against Repeated Water Avoidance Stress-induced Irritable Bowel Syndrome in a Wister Rat Model

Choi, S. I., Kim, N., Nam, R. H., Jang, J. Y., Kim, E. H., Ha, S., Kang, K. S., Lee, W., Choi, H., Kim, Y.-R., et al. (2023) · Journal of Cancer Prevention · doi:10.15430/jcp.2023.28.3.93 · Cited by 20 · see citing works

Comparison between the effects of selenomethionine and S-adenosylmethionine in preventing cholestasis-induced rat liver damage

Brzački, V., Mladenović, B., Dimić, D., Jeremic, L. M., Živanović, D., Djukić, D., Stojanović, N. M., & Sokolovic, D. T. (2019) · Amino Acids · doi:10.1007/s00726-019-02716-3 · Cited by 20 · see citing works

Nutrient Sensing and Redox Balance: GCN2 as a New Integrator in Aging

Falcón, P., Escandón, M., Brito, Á., & Matus, S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5730532 · Cited by 20 · see citing works

Identification of common cardiometabolic alterations and deregulated pathways in mouse and pig models of aging

Fanjul, V., Jorge, I., Camafeita, E., Macías, Á., González‐Gómez, C., Barettino, A., Dorado, B., Andrés‐Manzano, M. J., Rivera, J., Vázquez, J., et al. (2020) · Aging Cell · doi:10.1111/acel.13203 · Cited by 20 · see citing works

Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases

Wu, G., Xu, J., Wang, Q., Fang, Z., Fang, Y., Jiang, Y., Zhang, X., Cheng, X., Sun, J., & Le, G. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05829 · Cited by 17 · see citing works

High methionine intake alters gut microbiota and lipid profile and leads to liver steatosis in mice

Zhou, L., Yan, Z., Yang, S., Lu, G., Nie, Y., Ren, Y., Xue, Y., Shi, J., Xu, Z., & Geng, Y. (2024) · Food & Function · doi:10.1039/d4fo01613k · Cited by 18 · see citing works

Effects of High and Low Protein Diets on Inflammatory Profiles in People with Morbid Obesity: A 3-Week Intervention Study

Koelman, L., Markova, M., Seebeck, N., Hornemann, S., Rosenthal, A., Lange, V., Pivovarova‐Ramich, O., & Aleksandrova, K. (2020) · Nutrients · doi:10.3390/nu12123636 · Cited by 17 · see citing works

Perspective: Methionine Restriction–Induced Longevity—A Possible Role for Inhibiting the Synthesis of Bacterial Quorum Sensing Molecules

Bin, P., Zhu, C., Liu, S., Li, Z., Ren, W., & Zhu, G. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa028 · Cited by 16 · see citing works

Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice

Feng, C., Jiang, Y., Li, S., Ge, Y., Shi, Y., Xue Ming, T. A. N. G., & Le, G. (2022) · Nutrients · doi:10.3390/nu14214503 · Cited by 15 · see citing works

Senolytics Enhance the Longevity of Caenorhabditis elegans by Altering Betaine Metabolism

Lan, W., Xiao, X., Nian, J., Wang, Z., Zhang, X., Wu, Y., Zhang, D., Chen, J., Bao, W., Li, C., et al. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae221 · Cited by 14 · see citing works

Metabolic Rewiring by Human Placenta-Derived Mesenchymal Stem Cell Therapy Promotes Rejuvenation in Aged Female Rats

Kim, K., & Lee, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010566 · Cited by 14 · see citing works

Fecal Microbiota Transplantation from Methionine-Restricted Diet Mouse Donors Improves Alzheimer’s Learning and Memory Abilities Through Short-Chain Fatty Acids

Yu, R., Zhang, H., Chen, R., Lin, Y., Xu, J., Fang, Z., Ru, Y., Fan, C., & Wu, G. (2025) · Foods · doi:10.3390/foods14010101 · Cited by 15 · see citing works

Methionine increases yolk production to offset the negative effect of caloric restriction on reproduction without affecting longevity in C. elegans

Zhou, G., Huang, C., Liu, X., Li, L., Jiang, Y. Y., & Wei, Y. (2020) · Aging · doi:10.18632/aging.102770 · Cited by 14 · see citing works

Preclinical Advances of Therapies for Laminopathies

Benarroch, L., Cohen, E., Atalaia, A., Yaou, R. B., Bonne, G., & Bertrand, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214834 · Cited by 15 · see citing works

Homocysteine promotes cardiac fibrosis by regulating the Akt/FoxO3 pathway

Shi, Y., Zhao, L., Zhang, Y., Qin, Q., Cong, H., & Guo, Z. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-5602 · Cited by 14 · see citing works

Dietary Methionine Restriction Improves Gut Health and Alters the Plasma Metabolomic Profile in Rats by Modulating the Composition of the Gut Microbiota

Yang, M., Xie, Q., Xiao, Y., Xia, M., Chen, J., Tan, B., & Yin, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073657 · Cited by 13 · see citing works

Mechanistic target of rapamycin signaling in mouse models of accelerated aging

Lee, J. Y., Kennedy, B. K., & Liao, C. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz059 · Cited by 13 · see citing works

Metabolomics Based on 1H-NMR Reveal the Regulatory Mechanisms of Dietary Methionine Restriction on Splenic Metabolic Dysfunction in Obese Mice

Yang, Y., Qian, J., Li, B., Lu, M., Le, G., & Xie, Y. (2021) · Foods · doi:10.3390/foods10102439 · Cited by 13 · see citing works

Prebiotic roles and anti-aging effects of xylo-oligosaccharide: Keystone responsive bacteria and their metabolic interactions

Feng, Y., Xiao, Y., Li, X., Guo, M., Huang, L., Lu, W., Zhao, J., & Chen, W. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116673 · Cited by 12 · see citing works

The Metabolic Relationship Between Viral Infection and Cancer

Mullen, P. J., & Christofk, H. R. (2021) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070120-090423 · Cited by 13 · see citing works

Streptococcus anginosus -derived methionine promotes gastric cancer progression

Zhou, C., Zhao, L., Qin, Y., Yu, J., Li, W., Feng, Q., Tong, X., Abuduaini, R., Lu, S., Tang, H., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-336966 · Cited by 11 · see citing works

Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets

Aissa, A. F., Tryndyak, V., de Conti, A., Machado, A. R. T., Tuttis, K., Machado, C. D. S., Hernandes, L. C., dos Santos, P. W. D. S., Serpeloni, J. M., Pogribny, I. P., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112938 · Cited by 11 · see citing works

Methionine and H2S alter cancer–immune dialogue

Joulia, E., & Metallo, C. M. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00862-3 · Cited by 11 · see citing works

Organelle dysfunction and its contribution to metabolic impairments in aging and age-related diseases

Heiby, J. C., & Ori‬‬, A. (2022) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2022.100416 · Cited by 11 · see citing works

Identification potential biomarkers for diagnosis, and progress of breast cancer by using high-pressure photon ionization time-of-flight mass spectrometry

Zhang, J., He, X., Guo, X., Wang, J., Gong, X., Jiao, D., Chen, H., & Liu, Z. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342883 · Cited by 10 · see citing works

The role of the gut-liver axis in modulating non-alcoholic fatty liver disease through dietary patterns and microecological agents

Fang, Y., Fang, Z., Li, Z., Yu, R., Zhang, H., Wang, Q., Cheng, X., Le, G., & Wu, G. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103335 · Cited by 9 · see citing works

Tissue-specific roles of GCN2 in aging and autosomal dominant retinitis pigmentosa

Kim, K., Park, J.-E., Yeom, J., Park, N., Trần, T.-X. T., & Kang, M. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.09.120 · Cited by 9 · see citing works

Less methionine means more health

Nelson, C. (2018) · Lab Animal · doi:10.1038/s41684-018-0170-0 · Cited by 1 · see citing works

Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?

Bárcena, C., López-Otı́n, C., & Kroemer, G. (2018) · Autophagy · doi:10.1080/15548627.2018.1533059 · Cited by 24 · see citing works

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

Perrone, C. E., Malloy, V. L., Orentreich, D. S., & Orentreich∥, N. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.005 · Cited by 76 · see citing works

Methionine restriction and life‐span control

Lee, B. C., Kaya, A., & Gladyshev, V. N. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12973 · Cited by 108 · see citing works

Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

Sánchez-Román, I., & Barja, G. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.021 · Cited by 142 · see citing works