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RIPK1 inhibits ZBP1-driven necroptosis during development
Abstract
Receptor-interacting protein kinase 1 (RIPK1) promotes cell survival-mice lacking RIPK1 die perinatally, exhibiting aberrant caspase-8-dependent apoptosis and mixed lineage kinase-like (MLKL)-dependent necroptosis. However, mice expressing catalytically inactive RIPK1 are viable, and an ill-defined pro-survival function for the RIPK1 scaffold has therefore been proposed. Here we show that the RIP homotypic interaction motif (RHIM) in RIPK1 prevents the RHIM-containing adaptor protein ZBP1 (Z-DNA binding protein 1; also known as DAI or DLM1) from activating RIPK3 upstream of MLKL. Ripk1 RHIM/RHIM mice that expressed mutant RIPK1 with critical RHIM residues IQIG mutated to AAAA died around birth and exhibited RIPK3 autophosphorylation on Thr231 and Ser232, which is a hallmark of necroptosis, in the skin and thymus. Blocking necroptosis with catalytically inactive RIPK3(D161N), RHIM mutant RIPK3, RIPK3 deficiency, or MLKL deficiency prevented lethality in Ripk1 RHIM/RHIM mice. Loss of ZBP1, which engages RIPK3 in response to certain viruses but previously had no defined role in development, also prevented perinatal lethality in Ripk1 RHIM/RHIM mice. Consistent with the RHIM of RIPK1 functioning as a brake that prevents ZBP1 from engaging the RIPK3 RHIM, ZBP1 interacted with RIPK3 in Ripk1 RHIM/RHIM Mlkl-/- macrophages, but not in wild-type, Mlkl-/- or Ripk1 RHIM/RHIM Ripk3 RHIM/RHIM macrophages. Collectively, these findings indicate that the RHIM of RIPK1 is critical for preventing ZBP1/RIPK3/MLKL-dependent necroptosis during development.
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“or (2) ZBP1, which operates as a sensor for cytosolic DNA-promoting type I interferon (IFN) synthesis and NF-κB activation [439–441].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [441]
In the citing paper
“Moreover, mice expressing a variant of RIPK1 mutated in the RHIM domain die perinatally, a phenotype that can be rescued by concurrent Ripk3, Mlkl, or Zbp1 (but not Ticam1) deletion, as well as by the knock-in of catalytically inactive RIPK3 or RIPK3 mutated in the RHIM domain [440, 441].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [441]
In the citing paper
“ZBP1 acts at the initial steps of necroptosis by mediating the sequential activation of RIPK3 and MLKL.”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [441]
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Metadata
- Authors
- Newton, K., Wickliffe, K. E., Maltzman, A., Dugger, D. L., Strasser, A., Pham, V. C., Lill, J. R., Roose-Girma, M., Warming, S., Solon, M., Ngu, H., Webster, J. D., & Dixit, V. M.
- Affiliations
- Genentech (US)
- The University of Melbourne (AU)
- Corresponding author
- Newton, Kim
- Dixit, Vishva M.
- ORCID
- Venue
- Nature
- Published
- 2016-11-07
- Volume
- 540
- Issue
- 7631
- Pages
- 129-133
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2547118804
- Cited by
- 390
- References
- 32
- Citations by year
- 2026: 29 · 2025: 47 · 2024: 42 · 2023: 37 · 2022: 42 · 2021: 49 · 2020: 52 · 2019: 36 · 2018: 38 · 2017: 17 · 2016: 1
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Genentech
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- RIPK1, ZBP1, necroptosis, RIPK3, MLKL, RHIM domain, perinatal lethality, developmental cell death, innate immunity, thymus, DAI
- MeSH terms
- Animals, Animals, Newborn, Embryo, Mammalian, Female, Glycoproteins, Macrophages, Male, Mutation, Necrosis, Phosphorylation, Protein Binding, Protein Kinases, Tumor Necrosis Factor-alpha, RNA-Binding Proteins, Apoptosis, Amino Acid Motifs, Adaptor Proteins, Vesicular Transport, Mice, Caspase 8, Receptor-Interacting Protein Serine-Threonine Kinases
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