Paleoproterozoic sterol biosynthesis and the rise of oxygen

MrBayes 3: Bayesian phylogenetic inference under mixed models

Ronquist, F., & Huelsenbeck, J. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg180 · Cited by 28,956 · see citing works

RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models

Stamatakis, A. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl446 · Cited by 15,582 · see citing works

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

Sievers, F., Wilm, A., Dineen, D., Gibson, T., Karplus, K., Li, W.-Z., Lopez, R., McWilliam, H., Remmert, M., Söding, J., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.75 · Cited by 15,576 · see citing works

Bayesian Phylogenetics with BEAUti and the BEAST 1.7

Drummond, A. J., Suchard, M. A., Xie, D., & Rambaut, A. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss075 · Cited by 9,991 · see citing works

The Pfam protein families database: towards a more sustainable future

Finn, R. D., Coggill, P., Eberhardt, R. Y., Eddy, S. R., Mistry, J., Mitchell, A. L., Potter, S. C., Punta, M., Qureshi, M., Sangrador-Vegas, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1344 · Cited by 5,975 · see citing works

The rise of oxygen in Earth's early ocean and atmosphere

Lyons, T. W., Reinhard, C. T., & Planavsky, N. J. (2014) · Nature · doi:10.1038/nature13068 · Cited by 2,810 · see citing works

Palaeontologia electronica

(2017) · Palaeontologia Electronica · doi:10.26879/suffix · Cited by 2,540 · see citing works

Atmospheric Influence of Earth's Earliest Sulfur Cycle

Farquhar, J., Bao, H., & Thiemens, M. (2000) · Science · doi:10.1126/science.289.5480.756 · Cited by 1,805 · see citing works

Dating the rise of atmospheric oxygen

Bekker, A., Holland, H. D., Wang, P.-L., Rumble, D., Stein, H. J., Hannah, J. L., Coetzee, L. L., & Beukes, N. J. (2004) · Nature · doi:10.1038/nature02260 · Cited by 1,435 · see citing works

Archean Molecular Fossils and the Early Rise of Eukaryotes

Brocks, J. J., Logan, G. A., Buick, R., & Summons, R. E. (1999) · Science · doi:10.1126/science.285.5430.1033 · Cited by 1,275 · see citing works

Proterozoic Ocean Chemistry and Evolution: A Bioinorganic Bridge?

Anbar, A. D., & Knoll, A. H. (2002) · Science · doi:10.1126/science.1069651 · Cited by 1,191 · see citing works

The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa.

Cavalier‐Smith, T. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-2-297 · Cited by 995 · see citing works

Estimating the timing of early eukaryotic diversification with multigene molecular clocks

Parfrey, L. W., Lahr, D. J. G., Knoll, A. H., & Katz, L. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110633108 · Cited by 899 · see citing works

The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils?

Douzery, E. J. P., Snell, E. A., Bapteste, E., Delsuc, F., & Philippe, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403984101 · Cited by 638 · see citing works

Biomarker evidence for green and purple sulphur bacteria in a stratified Palaeoproterozoic sea

Brocks, J. J., Love, G. D., Summons, R. E., Knoll, A. H., Logan, G. A., & Bowden, S. A. (2005) · Nature · doi:10.1038/nature04068 · Cited by 607 · see citing works

Rapid oxygenation of Earth’s atmosphere 2.33 billion years ago

Luo, G., Ono, S., Beukes, N. J., Wang, D. T., Xie, S., & Summons, R. E. (2016) · Science Advances · doi:10.1126/sciadv.1600134 · Cited by 371 · see citing works

Steroids, triterpenoids and molecular oxygen

Summons, R. E., Bradley, A. S., Jahnke, L. L., & Waldbauer, J. R. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1837 · Cited by 364 · see citing works

Reappraisal of hydrocarbon biomarkers in Archean rocks

French, K. L., Hallmann, C., Hope, J. M., Schoon, P. L., Zumberge, J. A., Hoshino, Y., Peters, C. A., George, S. C., Love, G. D., Brocks, J. J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419563112 · Cited by 307 · see citing works

Phylogenomics of Sterol Synthesis: Insights into the Origin, Evolution, and Diversity of a Key Eukaryotic Feature

Quéméner, E. D., & Gribaldo, S. (2009) · Genome Biology and Evolution · doi:10.1093/gbe/evp036 · Cited by 293 · see citing works

Constraints on the timescale of animal evolutionary history

Benton, M., Donoghue, P., Vinther, J., Asher, R., Friedman, M., & Near, T. (2015) · Palaeontologia Electronica · doi:10.26879/424 · Cited by 284 · see citing works

Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus

Pearson, A., Budin, M., & Brocks, J. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536559100 · Cited by 251 · see citing works

Sponge grade body fossil with cellular resolution dating 60 Myr before the Cambrian

Yin, Z., Zhu, M., Davidson, E. H., Bottjer, D. J., Zhao, F., & Tafforeau, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414577112 · Cited by 230 · see citing works

An Alternative Root for the Eukaryote Tree of Life

He, D., Fiz-Palacios, O., Fu, C., Fehling, J., Tsai, C.-C., & Baldauf, S. L. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.036 · Cited by 226 · see citing works

A molecular time-scale for eukaryote evolution recalibrated with the continuous microfossil record

Berney, C., & Pawlowski, J. (2006) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2006.3537 · Cited by 212 · see citing works

Distinctive hydrocarbon biomarkers from fossiliferous sediment of the Late Proterozoic Walcott Member, Chuar Group, Grand Canyon, Arizona

Summons, R. E., Brassell, S. C., Eglinton, G., Evans, E., Horodyski, R. J., Robinson, N., & Ward, D. M. (1988) · Geochimica et Cosmochimica Acta · doi:10.1016/0016-7037(88)90031-2 · Cited by 205 · see citing works

Bacterial proteins pinpoint a single eukaryotic root

Derelle, R., Torruella, G., Klimeš, V., Brinkmann, H., Kim, E., Vlček, Č., Lang, B. F., & Eliáš, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420657112 · Cited by 187 · see citing works

Sterol Synthesis in Diverse Bacteria

Wei, J. H., Yin, X., & Welander, P. V. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00990 · Cited by 182 · see citing works

Sterol and genomic analyses validate the sponge biomarker hypothesis

Gold, D. A., Grabenstatter, J., de Mendoza, A., Riesgo, A., Ruiz-Trillo, I., & Summons, R. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512614113 · Cited by 145 · see citing works

Early sponges and toxic protists: possible sources of cryostane, an age diagnostic biomarker antedating Sturtian Snowball Earth

Brocks, J. J., Jarrett, A. J. M., Sirantoine, E., Kenig, F., Moczydłowska, M., Porter, S., & Hope, J. (2016) · Geobiology · doi:10.1111/gbi.12165 · Cited by 109 · see citing works

Ancestral state reconstruction of ontogeny supports a bilaterian affinity for <i>Dickinsonia</i>

Gold, D. A., Runnegar, B., Gehling, J. G., & Jacobs, D. K. (2015) · Evolution &amp; Development · doi:10.1111/ede.12168 · Cited by 99 · see citing works

A distinct pathway for tetrahymanol synthesis in bacteria

Banta, A. B., Wei, J. H., & Welander, P. V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511482112 · Cited by 82 · see citing works

Airborne hydrocarbon contamination from laboratory atmospheres

Illing, C. J., Hallmann, C., Miller, K. E., Summons, R. E., & Strauss, H. (2014) · Organic Geochemistry · doi:10.1016/j.orggeochem.2014.07.006 · Cited by 37 · see citing works

A Protocol for Diagnosing the Effect of Calibration Priors on Posterior Time Estimates: A Case Study for the Cambrian Explosion of Animal Phyla

Battistuzzi, F. U., Billing-Ross, P., Murillo, O., Filipski, A., & Kumar, S. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv075 · Cited by 34 · see citing works

Analysis of Molecular Biomarkers Covalently Bound Within Neoproterozoic Sedimentary Kerogen

Love, G. D., Stalvies, C., Grosjean, E., Meredith, W., & Snape, C. E. (2008) · The Paleontological Society Papers · doi:10.1017/s1089332600001613 · Cited by 33 · see citing works

The timetable of evolution

Knoll, A. H., & Nowak, M. A. (2017) · Science Advances · doi:10.1126/sciadv.1603076 · Cited by 277 · see citing works

Theoretical Foundation of the RelTime Method for Estimating Divergence Times from Variable Evolutionary Rates

Tamura, K., Tao, Q., & Kumar, S. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy044 · Cited by 260 · see citing works

Cyanobacteria evolution: Insight from the fossil record

Demoulin, C., Lara, Y. J., Cornet, L., François, C., Baurain, D., Wilmotte, A., & Javaux, E. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.007 · Cited by 239 · see citing works

Oxygenation, Life, and the Planetary System during Earth's Middle History: An Overview

Lyons, T. W., Diamond, C. W., Planavsky, N. J., Reinhard, C. T., & Li, C. (2021) · Astrobiology · doi:10.1089/ast.2020.2418 · Cited by 211 · see citing works

The Paleoproterozoic fossil record: Implications for the evolution of the biosphere during Earth's middle-age

Javaux, E. J., & Lepot, K. (2018) · Earth-Science Reviews · doi:10.1016/j.earscirev.2017.10.001 · Cited by 158 · see citing works

Early Archean origin of Photosystem <scp>II</scp>

Cardona, T., Sánchez‐Baracaldo, P., Rutherford, A. W., & Larkum, A. W. (2019) · Geobiology · doi:10.1111/gbi.12322 · Cited by 144 · see citing works

Lost world of complex life and the late rise of the eukaryotic crown

Brocks, J. J., Nettersheim, B. J., Adam, P., Schaeffer, P., Jarrett, A. J. M., Güneli, N., Liyanage, T., van Maldegem, L. M., Hallmann, C., & Hope, J. M. (2023) · Nature · doi:10.1038/s41586-023-06170-w · Cited by 135 · see citing works

Metagenomes Reveal Global Distribution of Bacterial Steroid Catabolism in Natural, Engineered, and Host Environments

Holert, J., Cardenas, E., Bergstrand, L. H., Zaikova, E., Hahn, A. S., Hallam, S., & Mohn, W. W. (2018) · mBio · doi:10.1128/mbio.02345-17 · Cited by 120 · see citing works

Lipid biomarkers: molecular tools for illuminating the history of microbial life

Summons, R. E., Welander, P. V., & Gold, D. A. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00636-2 · Cited by 115 · see citing works

Squalene monooxygenase: a journey to the heart of cholesterol synthesis

Chua, N. K., Coates, H. W., & Brown, A. J. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101033 · Cited by 110 · see citing works

Insights into eukaryogenesis from the fossil record

Porter, S. M. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0105 · Cited by 105 · see citing works

A conceptual framework of evolutionary novelty and innovation

Erwin, D. H. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12643 · Cited by 105 · see citing works

Pervasive aerobic nitrogen cycling in the surface ocean across the Paleoproterozoic Era

Kipp, M. A., Stüeken, E. E., Yun, M., Bekker, A., & Buick, R. (2018) · Earth and Planetary Science Letters · doi:10.1016/j.epsl.2018.08.007 · Cited by 104 · see citing works

Wasteful, essential, evolutionary stepping stone? The multiple personalities of the photorespiratory pathway

Fernie, A. R., & Bauwe, H. (2020) · The Plant Journal · doi:10.1111/tpj.14669 · Cited by 94 · see citing works

Evolution of bacterial steroid biosynthesis and its impact on eukaryogenesis

Hoshino, Y., & Gaucher, E. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2101276118 · Cited by 83 · see citing works

A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis

Pollier, J., Vancaester, E., Kuzhiumparambil, U., Vickers, C., Vandepoele, K., Goossens, A., & Fabris, M. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0305-5 · Cited by 71 · see citing works

The Paradigms They Are a-Changin’: past, present and future of PVC bacteria research

Rivas‐Marín, E., & Devos, D. P. (2017) · Antonie van Leeuwenhoek · doi:10.1007/s10482-017-0962-z · Cited by 73 · see citing works

Origin and Evolution of Polycyclic Triterpene Synthesis

Santana‐Molina, C., Rivas‐Marín, E., Rojas, A. M., & Devos, D. P. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa054 · Cited by 64 · see citing works

Free and kerogen‐bound biomarkers from late Tonian sedimentary rocks record abundant eukaryotes in mid‐Neoproterozoic marine communities

Zumberge, J. A., Rocher, D., & Love, G. D. (2020) · Geobiology · doi:10.1111/gbi.12378 · Cited by 73 · see citing works

The earliest history of eukaryotic life: uncovering an evolutionary story through the integration of biological and geological data

COHEN, P. A., & Kodner, R. B. (2021) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2021.11.005 · Cited by 65 · see citing works

C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis

Lee, A. K., Banta, A. B., Wei, J. H., Kiemle, D. J., Feng, J., Giner, J., & Welander, P. V. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802930115 · Cited by 63 · see citing works

Absence of biomarker evidence for early eukaryotic life from the Mesoproterozoic Roper Group: Searching across a marine redox gradient in mid‐Proterozoic habitability

Nguyen, K. D., Love, G. D., Zumberge, J. A., Kelly, A. E., Owens, J. D., Rohrssen, M., Bates, S. M., Cai, C., & Lyons, T. W. (2019) · Geobiology · doi:10.1111/gbi.12329 · Cited by 55 · see citing works

Organic geochemical approaches to understanding early life

Alléon, J., & Summons, R. E. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.005 · Cited by 53 · see citing works

The oxygen cycle and a habitable Earth

Huang, J., Liu, X., Shen, S., Shen, S., Hou, Z., Li, C., Li, C., Yao, L., & Huang, J. (2021) · Science China Earth Sciences · doi:10.1007/s11430-020-9747-1 · Cited by 53 · see citing works

Sterol Metabolism and Transport in Atherosclerosis and Cancer

Yamauchi, Y., & Rogers, M. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00509 · Cited by 48 · see citing works

Oxygen and the Energetic Requirements of the First Multicellular Animals

Leys, S. P., & KAHN, A. S. (2018) · Integrative and Comparative Biology · doi:10.1093/icb/icy051 · Cited by 46 · see citing works

Four billion years of microbial terpenome evolution

Hoshino, Y., & Villanueva, L. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad008 · Cited by 44 · see citing works

Viral histones: pickpocket’s prize or primordial progenitor?

Talbert, P. B., Armache, K., & Henikoff, S. (2022) · Epigenetics & Chromatin · doi:10.1186/s13072-022-00454-7 · Cited by 42 · see citing works

Reconciling discrepant minor sulfur isotope records of the Great Oxidation Event

Uveges, B. T. I., Izon, G., Ono, S., Beukes, N. J., & Summons, R. E. (2023) · Nature Communications · doi:10.1038/s41467-023-35820-w · Cited by 40 · see citing works

Nitrogenase resurrection and the evolution of a singular enzymatic mechanism

Garcia, A. K., Harris, D. F., Rivier, A. J., Carruthers, B. M., Pinochet-Barros, A., Seefeldt, L. C., & Kaçar, B. (2023) · eLife · doi:10.7554/elife.85003 · Cited by 38 · see citing works

Mission to Planet Earth: The First Two Billion Years

Stüeken, E. E., Som, S. M., Claire, M. W., Rugheimer, S., Scherf, M., Sproß, L., Tosi, N., Ueno, Y., & Lammer, H. (2020) · Space Science Reviews · doi:10.1007/s11214-020-00652-3 · Cited by 36 · see citing works

The Physalis floridana genome provides insights into the biochemical and morphological evolution of Physalis fruits

Lu, J., Luo, M., Wang, L., Li, K., Yu, Y., Yang, W., Gong, P., Gao, H., Li, Q., Zhao, J., et al. (2021) · Horticulture Research · doi:10.1038/s41438-021-00705-w · Cited by 37 · see citing works

Phytosterol Profiles, Genomes and Enzymes – An Overview

Darnet, S. H., Blary, A., Chevalier, Q., & Schaller, H. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.665206 · Cited by 36 · see citing works

De novo cholesterol biosynthesis in bacteria

Lee, A. K., Wei, J. H., & Welander, P. V. (2023) · Nature Communications · doi:10.1038/s41467-023-38638-8 · Cited by 36 · see citing works

Transcending membrane barriers: advances in membrane engineering to enhance the production capacity of microbial cell factories

Wu, T., Jiang, J., Zhang, H., Liu, J., & Ruan, H. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02436-8 · Cited by 34 · see citing works

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model

Zuniga-Hertz, J. P., & Patel, H. H. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01340 · Cited by 32 · see citing works

Levels of Diatom Minor Sterols Respond to Changes in Temperature and Salinity

Jaramillo-Madrid, A. C., Ashworth, J. R., & Ralph, P. J. (2020) · Journal of Marine Science and Engineering · doi:10.3390/jmse8020085 · Cited by 31 · see citing works

The unique sterol biosynthesis pathway of three model diatoms consists of a conserved core and diversified endpoints

Jaramillo-Madrid, A. C., Ashworth, J. R., Fabris, M., & Ralph, P. J. (2020) · Algal Research · doi:10.1016/j.algal.2020.101902 · Cited by 28 · see citing works

Overexpression of Key Sterol Pathway Enzymes in Two Model Marine Diatoms Alters Sterol Profiles in Phaeodactylum tricornutum

Jaramillo-Madrid, A. C., Abbriano, R. M., Ashworth, J., Fabris, M., Pernice, M., & Ralph, P. J. (2020) · Pharmaceuticals · doi:10.3390/ph13120481 · Cited by 28 · see citing works

Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes

Castellana, S., Mazza, T., Kappler, M., Генов, Н., Genov, N., Biagini, T., Fusilli, C., Scholkmann, F., Relógio, A., Hogenesch, J. B., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01178 · Cited by 25 · see citing works

The anaerobic survival mechanism of Schizophyllum commune 20R‐7‐F01 , isolated from deep sediment 2 km below the seafloor

Arifeen, M. Z. U., Chu, C., Yang, X., Liu, J., Huang, X., Ma, Y., Liu, X., Xue, Y., & Liu, C. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15332 · Cited by 26 · see citing works

New chronological and paleontological evidence for Paleoproterozoic eukaryote distribution and stratigraphic correlation between the Yanliao and Xiong’er basins, North China Craton

Lyu, D., Deng, Y., Wang, X., Ye, Y., Pang, K., Miao, L., Luo, Z., Zhang, F., Lu, Y., Deng, S., et al. (2022) · Precambrian Research · doi:10.1016/j.precamres.2022.106577 · Cited by 26 · see citing works

RelTime Relaxes the Strict Molecular Clock throughout the Phylogeny

Battistuzzi, F. U., Tao, Q., Jones, L., Tamura, K., & Kumar, S. (2018) · Genome Biology and Evolution · doi:10.1093/gbe/evy118 · Cited by 25 · see citing works

Reconstructing Early Microbial Life

Kaçar, B. (2024) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041522-103400 · Cited by 25 · see citing works

Engineering membrane architecture for biotechnological applications

Jin, Z., Vighi, A., Dong, Y., Bureau, J.-A., & Ignea, C. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108118 · Cited by 25 · see citing works

Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii

Zhou, W., Warrilow, A. G. S., Thomas, C. D., Ramos, E., Parker, J. E., Price, C. L., Vanderloop, B. H., Fisher, P. M., Loftis, M. D., Kelly, D. E., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.07.004 · Cited by 24 · see citing works

Role of stellar physics in regulating the critical steps for life

Lingam, M., & Loeb, A. (2019) · International Journal of Astrobiology · doi:10.1017/s1473550419000016 · Cited by 25 · see citing works

Mechanisms and climatic-ecological effects of the Great Oxidation Event in the early Proterozoic

Luo, G., Zhu, X., Wang, S., Zhang, S., & Jiao, C. (2022) · Science China Earth Sciences · doi:10.1007/s11430-021-9934-y · Cited by 20 · see citing works

Earth’s surface oxygenation and the rise of eukaryotic life: Relationships to the Lomagundi positive carbon isotope excursion revisited

Fakhraee, M., Tarhan, L. G., Reinhard, C. T., Crowe, S. A., Lyons, T. W., & Planavsky, N. J. (2023) · Earth-Science Reviews · doi:10.1016/j.earscirev.2023.104398 · Cited by 20 · see citing works

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

Wu, X., Niculite, C. M., Preda, M. B., Rossi, A., Tebaldi, T., Butoi, E. D., White, M. K., Tudoran, O. M., Petrusca, D. N., Jannasch, A. S. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18411-x · Cited by 19 · see citing works

Origin and Early Evolution of the Eukaryotes: Perspectives from the Fossil Record

Agić, H. (2021) · Advances in astrobiology and biogeophysics · doi:10.1007/978-3-030-81039-9_11 · Cited by 18 · see citing works

Zinc enrichment and isotopic fractionation in a marine habitat of the c. 2.1 Ga Francevillian Group: A signature of zinc utilization by eukaryotes?

Ossa, F. O., Pons, M., Bekker, A., Hofmann, A., Poulton, S. W., Andersen, M. B., Agangi, A., Gregory, D. D., Reinke, C., Steinhilber, B., et al. (2023) · Earth and Planetary Science Letters · doi:10.1016/j.epsl.2023.118147 · Cited by 18 · see citing works

Distinctive microfossil supports early Paleoproterozoic rise in complex cellular organisation

Barlow, E. V., House, C. H., Liu, M., Wetherington, M., & Kranendonk, M. J. V. (2023) · Geobiology · doi:10.1111/gbi.12576 · Cited by 18 · see citing works

Terpenoids and membrane dynamics evolution

Hoshino, Y. (2024) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2024.1345733 · Cited by 11 · see citing works

Paleozoic diversification of terrestrial chitin-degrading bacterial lineages

Gruen, D. S., Wolfe, J. M., & Fournier, G. P. (2019) · BMC Evolutionary Biology · doi:10.1186/s12862-019-1357-8 · Cited by 17 · see citing works

Sterol synthesis is essential for viability in the planctomycete bacteriumGemmata obscuriglobus

Gudde, L. R., Hulce, M., Largen, A. H., & Franke, J. D. (2019) · FEMS Microbiology Letters · doi:10.1093/femsle/fnz019 · Cited by 17 · see citing works

Effect of oxygen concentrations and branched‐chain amino acids on the growth and development of sub‐seafloor fungus, Schizophyllum commune 20R‐7‐F01

Arifeen, M. Z. U., Ma, Z., Wu, S., Liu, J., Xue, Y., & Liu, C. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15738 · Cited by 16 · see citing works

The slow rise of complex life as revealed through biomarker genetics

Gold, D. A. (2018) · Emerging Topics in Life Sciences · doi:10.1042/etls20170150 · Cited by 16 · see citing works

Chromium evidence for protracted oxygenation during the Paleoproterozoic

Mänd, K., Planavsky, N. J., Porter, S. M., Robbins, L. J., Wang, C., Kreitsmann, T., Paiste, K., Paiste, P., Romashkin, A. E., Deines, Y. E., et al. (2022) · Earth and Planetary Science Letters · doi:10.1016/j.epsl.2022.117501 · Cited by 15 · see citing works

Taming chlorophylls by early eukaryotes underpinned algal interactions and the diversification of the eukaryotes on the oxygenated Earth

Kashiyama, Y., Yokoyama, A., Shiratori, T., Hess, S., Not, F., Bachy, C., Gutiérrez-Rodríguez, A., Kawahara, J., Suzaki, T., Nakazawa, M., et al. (2019) · The ISME Journal · doi:10.1038/s41396-019-0377-0 · Cited by 11 · see citing works

Macroscopic fossils from the Chuanlinggou Formation of North China: evidence for an earlier origin of multicellular algae in the late Palaeoproterozoic

Liu, J., Zhang, Y., Shi, X., Chen, A., Tang, D., & Yang, T. (2023) · Palaeontology · doi:10.1111/pala.12685 · Cited by 12 · see citing works

Deciphering the evolutionary history of microbial cyclic triterpenoids

Welander, P. V. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.002 · Cited by 13 · see citing works

A diverse Palaeoproterozoic microbial ecosystem implies early eukaryogenesis

Javaux, E. (2025) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2024.0092 · Cited by 11 · see citing works

A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity

Zhou, W., Fisher, P. M., Vanderloop, B. H., Shen, Y., Shi, H., Maldonado, A. J., Leaver, D. J., & Nes, W. D. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000317 · Cited by 11 · see citing works

A detour to sterol synthesis

Baker, M. A. B., & Brown, A. J. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0347-8 · Cited by 11 · see citing works

Did high temperature rather than low O2 hinder the evolution of eukaryotes in the Precambrian?

Zhang, F., Wang, H., Ye, Y., Liu, Y., Lyu, Y., Deng, Y., Lyu, D., Wang, X., Wu, H., Deng, S., et al. (2022) · Precambrian Research · doi:10.1016/j.precamres.2022.106755 · Cited by 11 · see citing works

Impact of steroid biosynthesis on the aerobic adaptation of eukaryotes

Hoshino, Y., & Gaucher, E. A. (2024) · Geobiology · doi:10.1111/gbi.12612 · Cited by 10 · see citing works

Proterozoic microfossils continue to provide new insights into the rise of complex eukaryotic life

Anderson, R. P., Mughal, S., & Wedlake, G. O. (2024) · Royal Society Open Science · doi:10.1098/rsos.240154 · Cited by 9 · see citing works

Regional and global proxies for varying ocean redox conditions at ∼1.57 Ga: A causal connection with volcanism-induced weathering

Ye, Y., Wang, H., Wang, X., Li, J., Wu, C., & Zhang, S. (2022) · Geosystems and Geoenvironment · doi:10.1016/j.geogeo.2022.100173 · Cited by 10 · see citing works

氧循环与宜居地球

黄, 建., 刘, 晓., 何, 永., 沈, 树., 侯, 增., 李, 曙., 李, 昶., 姚, 丽., & 黄, 季. (2021) · SCIENTIA SINICA Terrae · doi:10.1360/n072020-0399 · Cited by 8 · see citing works

Oceanic Ba removal improved marine habitability for the oldest-known animals at ca. 600 Ma

Sui, P., Wei, W., Zhang, S., Zhao, Y.-Y., & Huang, F. (2025) · Global and Planetary Change · doi:10.1016/j.gloplacha.2025.104790 · Cited by 8 · see citing works

The bacterial origin of mitochondria: Incorrect phylogenies and the importance of metabolic traits

Esposti, M. D. (2023) · International review of cytology · doi:10.1016/bs.ircmb.2022.11.001 · Cited by 7 · see citing works

Physicochemical origins of prokaryotic and eukaryotic organisms

Spitzer, J. J. (2023) · The Journal of Physiology · doi:10.1113/jp284428 · Cited by 7 · see citing works

Photostable and high-brightness aggregation-induced emission of iridium luminogen achieving reliable and sensitive continuous luminescent quantification of molecular oxygen

Cao, Q., Xing, Y., Di, L., Yang, Z., Chen, X., Xia, Z., Ling, J., & Wang, H. (2023) · Talanta · doi:10.1016/j.talanta.2023.125059 · Cited by 6 · see citing works

Lipids of Geochemical Interest in Microalgae

Volkman, J. K. (2018) · Springer eBooks · doi:10.1007/978-3-319-54529-5_10-1 · Cited by 6 · see citing works

The Evolutionary Journey of Sterol Synthesis Pathways in Eukaryotes

Ferreira-Guerra, M., Coleto‐Alcudia, V., Mora‐García, S., & Caño‐Delgado, A. I. (2025) · Plant and Cell Physiology · doi:10.1093/pcp/pcaf016 · Cited by 5 · see citing works

Bacterial estrogenesis without oxygen: Wood–Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere

Wang, P., Wu, T.-Y., Chen, Y., Gicana, R. G., Lee, T., Chen, M., Hsiao, T., Lu, M. J., Lai, Y.-L., Wang, T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422930122 · Cited by 5 · see citing works

Division of labour in a matrix, rather than phagocytosis or endosymbiosis, as a route for the origin of eukaryotic cells

Bateman, A. (2020) · Biology Direct · doi:10.1186/s13062-020-00260-9 · Cited by 4 · see citing works

The Evolutionary History and Modern Diversity of Triterpenoid Cyclases

McShea, H. S., Viens, R. A., Olagunju, B. O., Giner, J., & Welander, P. V. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf203 · Cited by 3 · see citing works

A geranylgeranyl reductase homolog required for cholesterol production in Myxococcota

Lee, A. K., & Welander, P. V. (2025) · Journal of Bacteriology · doi:10.1128/jb.00495-24 · Cited by 3 · see citing works

Lipids of Geochemical Interest in Microalgae

Volkman, J. K. (2020) · Springer eBooks · doi:10.1007/978-3-319-90569-3_10 · Cited by 3 · see citing works

元古宙早期大氧化事件的成因机制与气候生态效应

Luo, G., 朱, 祥., Wang, S., 张, 世., & 焦, 超. (2022) · SCIENTIA SINICA Terrae · doi:10.1360/sste-2021-0297 · Cited by 3 · see citing works

Chapter 12 With a Little Help from My Friends: The Central Role of Photorespiration and Related Metabolic Processes in the Acclimation and Adaptation of Plants to Oxygen and to Low-CO2 Stress

Bauwe, H., & Fernie, A. R. (2021) · Advances in photosynthesis and respiration · doi:10.1007/978-3-030-64926-5_12 · Cited by 3 · see citing works

Sterol Biosynthetic Pathways and Their Function in Bacteria

Franke, J. D. (2021) · Springer eBooks · doi:10.1007/978-3-030-77595-7_9 · Cited by 3 · see citing works

Overexpression of key sterol pathway enzymes in two model marine diatoms alters sterol profiles in Phaeodactylum tricornutumPreprint

Jaramillo-Madrid, A. C., Abbriano, R. M., Ashworth, J., Fabris, M., & Ralph, P. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.30.228171 · Cited by 3 · see citing works

Infancy of sterol biosynthesis hints at extinct eukaryotic species

Kenig, F. (2023) · Nature · doi:10.1038/d41586-023-01816-1 · Cited by 2 · see citing works

De novo cholesterol biosynthesis in the bacterial domainPreprint

Lee, A. K., Wei, J. H., & Welander, P. V. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.03.510737 · Cited by 2 · see citing works

The Eukaryotic Last Common Ancestor Was Bifunctional for Hopanoid and Sterol ProductionPreprint

Francis, W. R. (2022) · Preprints.org · doi:10.20944/preprints202004.0186.v5 · Cited by 2 · see citing works

Archaeal lineages related to eukaryotes encode functional diterpenoid cyclasesPreprint

McShea, H. S., Anda, V. D., Brocks, J. J., Welander, P. V., & Baker, B. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.07.637177 · Cited by 2 · see citing works

Horizontal transfer of matrix metalloproteinase genes links early animal and microbial evolution

Parsons, C., & Fournier, G. P. (2025) · Biology Direct · doi:10.1186/s13062-025-00700-4 · Cited by 1 · see citing works

Origins of Archean organic matter

Alléon, J., & Summons, R. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95547-8.00033-1 · Cited by 1 · see citing works

ARCH × Φ: Sterols and the evolution of gated biological execution

Rahman, T., & Zorumski, C. F. (2026) · Biosystems · doi:10.1016/j.biosystems.2026.105812 · Cited by 1 · see citing works

Precambrian Organic Matter

Summons, R. E. (2018) · Encyclopedia of earth sciences series/Encyclopedia of earth sciences · doi:10.1007/978-3-319-39312-4_191 · Cited by 1 · see citing works

Gene transfer history of carbon fixation proteins constrains marine cyanobacteria divergence times

Betts, M. N. (2018) · DSpace@MIT (Massachusetts Institute of Technology)

Biogeochemical and phylogenetic signals of Proterozoic and Phanerozoic microbial metabolisms

Gruen, D. S. (2018) · doi:10.1575/1912/10645

The Eukaryotic Last Common Ancestor Was Bifunctional for Hopanoid and Sterol ProductionPreprint

Francis, W. R. (2021) · Preprints.org · doi:10.20944/preprints202004.0186.v2

Isolation and Identification of Exiguobacterium Profundum Strain from Cholesterol-Enriched Fetal Sample

Yuan, H., Fu, H., Wu, C., Li, Y., Guorong, Y., & Ding, B. (2020) · Frontiers in Medical Science Research · doi:10.25236/fmsr.2020.020410

Tracing molecular properties throughout evolution: A chemoinformatic approach

Otero, M., Sarno, S., Acebedo, S. L., & Ramirez, J. A. (2021) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2021.110601

A Chemoinformatic Exploration of the Chemical Space of Natural Steroids.Preprint

Otero, M., Sarno, S., Acebedo, S. L., & Ramirez, J. A. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12654512.v1

Common origin of sterol biosynthesis points to a feeding strategy shift in Neoproterozoic animals

Brunoir, T. N., Mulligan, C., Sistiaga, A., Vuu, K. M., Shih, P. M., O’Reilly, S. S., Summons, R. E., & Gold, D. A. (2023) · Nature Communications · doi:10.1038/s41467-023-43545-z · Cited by 14 · see citing works

Infancy of sterol biosynthesis hints at extinct eukaryotic species

Kenig, F. (2023) · Nature · doi:10.1038/d41586-023-01816-1 · Cited by 2 · see citing works

Sterol biosynthesis and prokaryotes-to-eukaryotes evolution

Chen, L., Wang, G., & Zhang, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.093 · Cited by 52 · see citing works

The Origin of Sterol Biosynthesis: A Time-Point for the Evolution of Eukaryotes and the Presence of O2

Pearson, A. J., Budin, M., & Brocks, J. J. (2003) · AGU Fall Meeting Abstracts

Steroids, triterpenoids and molecular oxygen

Summons, R. E., Bradley, A. S., Jahnke, L. L., & Waldbauer, J. R. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1837 · Cited by 364 · see citing works