Cited by 1,752interferon and immune responsesImmune Response and InflammationDNA Repair Mechanisms

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

cGAS surveillance of micronuclei links genome instability to innate immunity

Open access

Mackenzie, Karen J., Carroll, Paula, Martin, Carol-Anne, Murina, Olga, Fluteau, Adeline, Simpson, Daniel J., Olova, Nelly, Sutcliffe, Hannah, Rainger, Jacqueline K., Leitch, Andrea, Osborn, Ruby T., Wheeler, Ann P., Nowotny, Marcin, Gilbert, Nick, Chandra, Tamir, Reijns, Martin A. M., Jackson, Andrew P.·2017·Nature

DOI 10.1038/nature23449PMC PMC5870830

Open this paper in CoChat — free account

Abstract

DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage. Precisely how cellular DNA gains access to the cytoplasm remains to be determined. Here, we report that cGAS localizes to micronuclei arising from genome instability in a mouse model of monogenic autoinflammation, after exogenous DNA damage and spontaneously in human cancer cells. Such micronuclei occur after mis-segregation of DNA during cell division and consist of chromatin surrounded by its own nuclear membrane. Breakdown of the micronuclear envelope, a process associated with chromothripsis, leads to rapid accumulation of cGAS, providing a mechanism by which self-DNA becomes exposed to the cytosol. cGAS is activated by chromatin, and consistent with a mitotic origin, micronuclei formation and the proinflammatory response following DNA damage are cell-cycle dependent. By combining live-cell laser microdissection with single cell transcriptomics, we establish that interferon-stimulated gene expression is induced in micronucleated cells. We therefore conclude that micronuclei represent an important source of immunostimulatory DNA. As micronuclei formed from lagging chromosomes also activate this pathway, recognition of micronuclei by cGAS may act as a cell-intrinsic immune surveillance mechanism that detects a range of neoplasia-inducing processes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature23449

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
Full-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574
The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
Liao, Y., Smyth, G. K., & Shi, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt214 · Cited by 3,064
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333
Tumor spectrum analysis in p53-mutant mice
Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.017 · Cited by 1,917
Scater: Pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R
McCarthy, D. J., Campbell, K. R., Lun, A. T. L., & Wills, Q. F. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw777 · Cited by 1,852

Flagged first, then by citations

Show all 56 references

Sorted by citations

Items 601–700 of 1,000

Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer
Parkes, E. E., Savage, K. I., Lioe, T. F., Boyd, C., Halliday, S. R., Walker, S. M., Lowry, K., Knight, L. A., Buckley, N. E., Grogan, A., et al. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01599-0 · Cited by 36
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
Uchihara, Y., Permata, T. B. M., Sato, H., Kawabata‐Iwakawa, R., Katada, S., Gu, W., Kakoti, S., Yamauchi, M., Kato, R., Gondhowiardjo, S. A., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.04.030 · Cited by 36
Double-checking chromosome segregation
Maiato, H., & Silva, S. D. R. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202301106 · Cited by 37
Strategies involving STING pathway activation for cancer immunotherapy: Mechanism and agonists
Pan, X., Zhang, W., Guo, H., Wang, L., Wu, H., Ding, L., & Yang, B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115596 · Cited by 36
Photoactivated DNA Assembly and Disassembly for On‐Demand Activation and Termination of cGAS‐STING Signaling
Yu, F., Li, X., Zhao, J., Zhao, Y., & Li, L. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202305837 · Cited by 35
cGAS-STING signalling regulates microglial chemotaxis in genome instability
Talbot, E., Joshi, L., Thornton, P., Dezfouli, M., Tsafou, K., Perkinton, M. S., & Khoronenkova, S. V. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad1184 · Cited by 39
Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
Zhang, J., Yu, S., Peng, Q., Wang, P., & Fang, L. (2024) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0440 · Cited by 38
A noncanonical cGAS–STING pathway drives cellular and organismal aging
de Faria, R. C., Silva, L. N. D. E., Teodoro-Castro, B., McCommis, K. S., Shashkova, E. V., & Gonzalo, S. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2424666122 · Cited by 35
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Yan, Y., Tan, X., Song, B., Yi, M., Chu, Q., & Wu, K. (2025) · 癌症：英文版 · doi:10.1002/cac2.70067 · Cited by 35
Targeting STING to generate therapeutic anti-tumor immunity
Fahey, C. G., Cordova, A. F., Gedeon, P. C., & Barbie, D. A. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.12.002 · Cited by 36
Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma
Brownstein, J. M., Wisdom, A. J., Castle, K. D., Mowery, Y. M., Guida, P. M., Lee, C., Tommasino, F., Tessa, C. L., Scifoni, E., Gao, J., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0965 · Cited by 35
DNA Repair and Signaling in Immune-Related Cancer Therapy
Kakoti, S., Sato, H., Laskar, S. S., Yasuhara, T., & Shibata, A. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00205 · Cited by 36
High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells
Permata, T. B. M., Sato, H., Gu, W., Kakoti, S., Uchihara, Y., YOSHIMATSU, Y., Sato, I., Kato, R., Yamauchi, M., Suzuki, K., et al. (2021) · Journal of Radiation Research · doi:10.1093/jrr/rrab050 · Cited by 38
Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer
Jungles, K. M., Holcomb, E. A., Pearson, A. N., Jungles, K. R., Bishop, C. R., Pierce, L. J., Green, M. D., & Speers, C. W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1022542 · Cited by 36
KIF2C is a prognostic biomarker associated with immune cell infiltration in breast cancer
Liu, S., Ye, Z., Xue, V. W., Sun, Q., Li, H., & Lu, D. (2023) · BMC Cancer · doi:10.1186/s12885-023-10788-4 · Cited by 35
Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis
Shriki, A., Lanton, T., Sonnenblick, A., Levkovitch-Siany, O., Eidelshtein, D., Abramovitch, R., Rosenberg, N., Pappo, O., Elgavish, S., Nevo, Y., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0321 · Cited by 34
Enhancing immunotherapy outcomes by targeted remodeling of the tumor microenvironment via combined cGAS-STING pathway strategies
Huang, M., Cha, Z., Liu, R., Lin, M., Gafoor, N. A., Kong, T., Ge, F., & Chen, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1399926 · Cited by 36
DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance
Wang, L., Li, S., Wang, K., Wang, N., Liu, Q., Sun, Z., Wang, L., Wang, L., Liu, Q., Song, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34858-6 · Cited by 34
Small molecule inhibitors for cancer immunotherapy and associated biomarkers – the current status
Schlicher, L., Green, L. G., Romagnani, A., & Renner, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1297175 · Cited by 34
Activation and regulation of cGAS-STING signaling in cancer cells
Shim, A., Chen, Y., & Maciejowski, J. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.08.030 · Cited by 37
Filament-like Assemblies of Intracellular Nucleic Acid Sensors: Commonalities and Differences
Cadena, C., & Hur, S. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.023 · Cited by 34
The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance
Liao, W., Du, C., & Wang, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573915 · Cited by 34
Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic‐Like Behaviors
Zhang, D., Liu, C., Li, H., & Jiao, J. (2020) · Advanced Science · doi:10.1002/advs.202002117 · Cited by 35
Immune modulating activity of the CHK1 inhibitor prexasertib and anti-PD-L1 antibody LY3300054 in patients with high-grade serous ovarian cancer and other solid tumors
Do, K. T., Manuszak, C., Thrash, E. M., Giobbie‐Hurder, A., Hu, J., Kelland, S., Powers, A., de Jonge, A., Shapiro, G. I., & Severgnini, M. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-02910-x · Cited by 34
MYO10 drives genomic instability and inflammation in cancer
Pozo, F. M., Geng, X., Tamagno, I., Jackson, M. W., Heimsath, E. G., Hammer, J. A., Cheney, R. E., & Zhang, Y. (2021) · Science Advances · doi:10.1126/sciadv.abg6908 · Cited by 36
The multifaceted functions of cGAS
Liu, H., Wang, F., Cao, Y., Dang, Y., & Ge, B. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac031 · Cited by 38
Single-Cell Transcriptome Analysis of Radiation Pneumonitis Mice
Yang, M., Fan, Q., Hei, T. K., Chen, G., Cao, W., Meng, G., & Han, W. (2022) · Antioxidants · doi:10.3390/antiox11081457 · Cited by 34
Targeting the loss of cGAS / STING signaling in cancer
Sasaki, N., Homme, M., & Kitajima, S. (2023) · Cancer Science · doi:10.1111/cas.15913 · Cited by 34
cGAS-STING signaling in cardiovascular diseases
Zhang, Q., Shen, L., Ruan, H., & Huang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1402817 · Cited by 33
ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I
Li, C., Wang, B., Tu, J., Liu, C., Wang, Y., Chen, J., Huang, Y., Liu, B., & Yuan, X. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06911-3 · Cited by 35
Mitochondria-targeted manganese-based mesoporous silica nanoplatforms trigger cGAS-STING activation and sensitize anti PD-L1 therapy in triple-negative breast cancer
Zhong, N., Zu, Z., Lu, Y., Sha, X., Li, Y., Liu, Y., Lu, S., Luo, X., Zhou, Y., Tao, J., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.04.040 · Cited by 33
Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation
Chao, H., Karagounis, I. V., Thomas, C. G., François, N., Facciabene, A., Koumenis, C., & Maity, A. M. (2020) · Oncogene · doi:10.1038/s41388-020-1300-x · Cited by 34
DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signaling
Katsuki, Y., Jeggo, P. A., Uchihara, Y., Takata, M., & Shibata, A. (2020) · Genome Instability & Disease · doi:10.1007/s42764-020-00017-8 · Cited by 38
Chemical Insights into Liquid-Liquid Phase Separation in Molecular Biology
Kamimura, Y. R., & Kanai, M. (2020) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.20200397 · Cited by 34
Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application
Pu, F., Chen, F., Liu, J., Zhang, Z., & Shao, Z. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s298958 · Cited by 34
Interplay of cGAS with chromatin
Wischnewski, M., & Ablasser, A. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.05.011 · Cited by 35
Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation
López‐Peláez, M., Young, L. A., Vázquez–Chantada, M., Nelson, N., Durant, S. T., Wilkinson, R. W., Poon, E., Gaspar, M., Valge-Archer, V., Smith, P. D., et al. (2022) · OncoImmunology · doi:10.1080/2162402x.2022.2117321 · Cited by 37
The DNA damage induced immune response: Implications for cancer therapy
Barros, E. M., McIntosh, S., & Savage, K. I. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103409 · Cited by 37
Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence
Haarer, E. L., Theodore, C. J., Guo, S., Frier, R. B., & Campellone, K. G. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010045 · Cited by 33
Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response
Du, H., Xiao, N., Zhang, S., Zhou, X., Zhang, Y., Lu, Z., Fu, Y., Huang, M., Xu, S., & Chen, Q. (2023) · iScience · doi:10.1016/j.isci.2023.107090 · Cited by 33
Radiopharmaceuticals as combinatorial partners for immune checkpoint inhibitors
Pouget, J., Chan, T. A.-T., Galluzzi, L., & Constanzo, J. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.07.014 · Cited by 32
Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15
Moro, R. N., Biswas, U., Kharat, S. S., Duzanic, F. D., Das, P., Stavrou, M., Raso, M. C., Freire, R., Chaudhuri, A. R., Sharan, S. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41801-w · Cited by 35
DNA repair-dependent immunogenic liabilities in colorectal cancer: opportunities from errors
Amodio, V., Vitiello, P. P., Bardelli, A., & Germano, G. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02848-8 · Cited by 33
The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy
Ribeiro, A. R. S., Neuper, T., & Horejs‐Hoeck, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s477320 · Cited by 33
Balancing STING in antimicrobial defense and autoinflammation
Landman, S. L., Ressing, M. E., & van der Veen, A. G. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.06.004 · Cited by 32
Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma
Li, J., Ko, J. M. Y., Dai, W., Yu, V. Z., Ng, H. Y., Hoffmann, J., & Lung, M. L. (2021) · Cancers · doi:10.3390/cancers13133204 · Cited by 35
Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA
Fermaintt, C. S., Takahashi‐Ruiz, L., Liang, H., Mooberry, S. L., & Risinger, A. L. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000297 · Cited by 33
Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induction in Mendelian Disease
Lepelley, A., Wai, T., & Crow, Y. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729763 · Cited by 33
Regulation of cGAS Activity and Downstream Signaling
Joshi, B., Joshi, J. C., & Mehta, D. (2022) · Cells · doi:10.3390/cells11182812 · Cited by 33
Innate immune recognition against SARS-CoV-2
Yamada, T., & Takaoka, A. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00259-5 · Cited by 33
Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies
Andrade, J., Gallagher, A., Maharaj, J., & McClelland, S. E. (2023) · Chromosome Research · doi:10.1007/s10577-023-09737-5 · Cited by 35
Barrier-to-autointegration factor: a first responder for repair of nuclear ruptures
Halfmann, C. T., & Roux, K. J. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1892320 · Cited by 33
The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers
Yan, H., Lü, W., & Wang, F. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01328-4 · Cited by 35
Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence
Yue, X., Cui, J., Sun, Z., Liu, L., Li, Y., Shao, L., Feng, Q., Wang, Z., Hambright, W. S., Cui, Y., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01467-1 · Cited by 32
Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy
Wang, Y., Liu, Y., Zhang, J., Peng, Q., Wang, X., Xiao, X., & Shi, K. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.008 · Cited by 31
RETRACTED ARTICLE: Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma
Wu, S., Wang, B., Li, H., Wang, H., Du, S., Huang, X., Fan, Y., Gao, Y., Gu, L., Huang, Q., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03013-4 · Cited by 32
Retracted
Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells
Huang, X., Liang, N. N., Fuming, Z., Lin, W., & Ma, W. (2024) · Antioxidants · doi:10.3390/antiox13060679 · Cited by 31
MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
Técher, H., Gopaul, D., Heuzé, J., Bouzalmad, N., Leray, B., Vernet, A., Mettling, C., Moreaux, J., Pasero, P., & Lin, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-49740-w · Cited by 33
Chromothripsis in cancer
Simovic-Lorenz, M., & Ernst, A. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00769-5 · Cited by 33
The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders
Matz, K. M., Guzman, R. M., & Goodman, A. G. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.08.002 · Cited by 32
Expanding roles of cell cycle checkpoint inhibitors in radiation oncology
Hauge, S., Mariampillai, A. E., Rødland, G. E., Bay, L. T. E., Landsverk, H. B., & Syljuåsen, R. G. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1913529 · Cited by 35
Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse
Haimovici, A., Höfer, C., Badr, M. T., Haghighi, E. B., Amer, T., Boerries, M., Bronsert, P., Glavynskyi, I., Fanfone, D., Ichim, G., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04768-y · Cited by 34
Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis
Klaasen, S. J., & Kops, G. J. P. L. (2022) · Cells · doi:10.3390/cells11223564 · Cited by 36
cGAS in nucleus: The link between immune response and DNA damage repair
Song, J.-X., Villagomes, D., Zhao, H., & Zhu, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1076784 · Cited by 33
DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy
Gilmore, E. S., McCabe, N., Kennedy, R. D., & Parkes, E. E. (2019) · Journal of Oncology · doi:10.1155/2019/4325105 · Cited by 32
Immune Dysfunction from Radiation Exposure
Hollingsworth, B. A., Aldrich, J. T., Case, C. M., DiCarlo, A. L., Hoffman, C. M., Jakubowski, A. A., Liu, Q., Loelius, S. G., PrabhuDas, M., Winters, T. A., et al. (2023) · Radiation Research · doi:10.1667/rade-22-00004.1 · Cited by 32
The DNA damage response in immunotherapy and radiation
Samstein, R. M., & Riaz, N. (2018) · Advances in Radiation Oncology · doi:10.1016/j.adro.2018.08.017 · Cited by 30
Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies
Pereira, S. M., Ribeiro, R., & Logarinho, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040938 · Cited by 31
Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection
Gusho, E., & Laimins, L. A. (2021) · Viruses · doi:10.3390/v13071390 · Cited by 30
Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection
Dörflinger, B., Badr, M. T., Haimovici, A., Fischer, L., Vier, J., Metz, A., Eisele, B., Bronsert, P., Aumann, K., Höppner, J., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01009-9 · Cited by 32
Recent advances in the activation and regulation of the cGAS-STING pathway
Fang, R., Jiang, Q., Yu, X., Zhao, Z., & Jiang, Z. (2022) · Advances in immunology · doi:10.1016/bs.ai.2022.09.003 · Cited by 30
Discovery of Podofilox as a Potent cGAMP–STING Signaling Enhancer with Antitumor Activity
Han, J., Hu, S., Hu, Y., Xu, Y., Hou, Y., Yang, Y., Su, H., Zhang, Z., Liu, P., Sun, X., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0483 · Cited by 33
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis
Luo, J., Lu, C., Chen, Y., Wu, X., Zhu, C., Cui, W., Yu, S., Li, N., Pan, Y., Zhao, W., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112328 · Cited by 30
Mapping the landscape of genetic dependencies in chordoma
Sharifnia, T., Wawer, M. J., Goodale, A. B., Lee, Y., Kazachkova, M., Dempster, J. M., Muller, S., Levy, J. B., Freed, D. M., Sommer, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37593-8 · Cited by 30
Novel Mechanisms and Future Opportunities for the Management of Radiation Necrosis in Patients Treated for Brain Metastases in the Era of Immunotherapy
Vaios, E., Winter, S. F., Shih, H. A., Dietrich, J., Peters, K. B., Floyd, S., Kirkpatrick, J. P., & Reitman, Z. J. (2023) · Cancers · doi:10.3390/cancers15092432 · Cited by 31
Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
Kumar, V., Bauer, C., & Stewart, J. H. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151338 · Cited by 33
Combining Heavy-Ion Therapy with Immunotherapy: An Update on Recent Developments
Helm, A., Ebner, D. K., Tinganelli, W., Simoniello, P., Bisio, A., Marchesano, V., Durante, M., Yamada, S., & Shimokawa, T. (2018) · International Journal of Particle Therapy · doi:10.14338/ijpt-18-00024.1 · Cited by 31
Site occupancy calibration of taxane pharmacology in live cells and tissues
Pineda, J. J., Miller, M. A., Song, Y., Kuhn, H., Mikula, H., Tallapragada, N. P., Weissleder, R., & Mitchison, T. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800047115 · Cited by 30
Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity
Zhang, Y., Ma, Z., Wang, Y., Boyer, J. A., Ni, G., Cheng, L., Su, S., Zhang, Z., Zhu, Z., Qian, J., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101463 · Cited by 32
Oncolytic HSV Therapy Modulates Vesicular Trafficking Inducing Cisplatin Sensitivity and Antitumor Immunity
Hong, B., Chapa, V. A., Saini, U., Modgil, P., Cohn, D. E., He, G., Siddik, Z. H., Sood, A. K., Yan, Y., Selvendiran, K., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2210 · Cited by 30
Cell-Cycle Cross Talk with Caspases and Their SubstratesPreprint
Connolly, P. F., García-Carpio, I., & Villunger, A. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036475 · Cited by 32
Alpha Particle–Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery
Coll, R. P., Bright, S. J., Martinus, D. K. J., Georgiou, D. K., Sawakuchi, G. O., & Manning, H. C. (2023) · Molecular Imaging and Biology · doi:10.1007/s11307-023-01857-y · Cited by 30
Targeting TREX1 Induces Innate Immune Response in Drug-Resistant Small-Cell Lung Cancer
Murayama, T., Mahadevan, N. R., Meador, C. B., Ivanova, E. V., Pan, Y., Knelson, E. H., Tani, T., Nakayama, J., Ma, X., Thai, T. C., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0360 · Cited by 29
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy
Lu, D., Li, W., Tan, J., Li, Y., Mao, W., Zheng, Y., Yang, M., Wang, J., Wang, W., Wang, S., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c09825 · Cited by 29
Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)
Wang, H., Zang, C., Ren, M., Shang, M., Wang, Z., Peng, X., Zhang, Q., Wen, X., Xi, Z., & Zhou, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-72393-w · Cited by 29
Critical DNA damaging pathways in tumorigenesis
Kloeber, J. A., & Lou, Z. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.012 · Cited by 30
Viral Modulation of the DNA Damage Response and Innate Immunity: Two Sides of the Same Coin
Lopez, A., Doyle, R. N., Sandoval, C., Nisson, K., Yang, V. B., & Fregoso, O. I. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167327 · Cited by 31
The pleiotropic roles of cGAS–STING signaling in the tumor microenvironment
Li, J., & Bakhoum, S. F. W. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac019 · Cited by 30
The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability
Hintzen, D. C., Soto, M., Schubert, M., Bakker, B., Spierings, D. C. J., Szuhai, K., Lansdorp, P. M., Kluin, R. J. C., Foijer, F., Medema, R. H., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268579 · Cited by 29
The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles
Meng, X., Yang, S., & Camp, V. J. A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01538 · Cited by 30
DNA double-strand break repair and nucleic acid-related immunity
Zhang, H., Chen, Y., Jiang, Y., & Mao, Z. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022061 · Cited by 28
At the Crossroads of the cGAS-cGAMP-STING Pathway and the DNA Damage Response: Implications for Cancer Progression and Treatment
Korneenko, T. V., Pestov, N. B., Nevzorov, I. A., Daks, A. A., Николаевич, Т. К., Солопова, О. Н., & Barlev, N. A. (2023) · Pharmaceuticals · doi:10.3390/ph16121675 · Cited by 29
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
Guanizo, A. C., Luong, Q., Jayasekara, W. S. N., de Geus, E. D., Inampudi, C., Xue, V. S., Chen, J., de Weerd, N. A., Matthews, A. Y., Gantier, M. P., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-02014-5 · Cited by 28
Unveiling the mysteries of extrachromosomal circular DNA: from generation to clinical relevance in human cancers and health
Wang, Z., Yu, J., Zhu, W., Hong, X., Xu, Z., Mao, S., Huang, L., Han, P., He, C., Song, C., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02187-5 · Cited by 28
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP)
En, A., Takauji, Y., Ayusawa, D., & Fujii, M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111927 · Cited by 30
Atezolizumab in the treatment of metastatic triple-negative breast cancer
Pérez-García, J. M., Soberino, J., Racca, F., Gión, M., Stradella, A., & Cortés, J. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1769063 · Cited by 29
Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
Hart, M., Adams, S. D., & Draviam, V. M. (2021) · Communications Biology · doi:10.1038/s42003-021-01979-5 · Cited by 29
Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies
Garcia-Fabiani, M. B., Haase, S., Comba, A., Carney, S. V., McClellan, B. L., Banerjee, K., Alghamri, M. S., Faisal, S. M., Kadiyala, P., Núñez, F. J., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.631037 · Cited by 30
Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study
Reece, A. S., & Hulse, G. K. (2021) · BMC Cancer · doi:10.1186/s12885-021-08598-7 · Cited by 28
Pharmacological Targeting of STING-Dependent IL-6 Production in Cancer Cells
Al-Asmari, S. S., Rajapakse, A., Ullah, T. R., Pépin, G., Croft, L. V., & Gantier, M. P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.709618 · Cited by 28

Authors: Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., Osborn, R. T., Wheeler, A. P., Nowotny, M., Gilbert, N., Chandra, T., Reijns, M. A. M., & Jackson, A. P.
Affiliations: Institute of Genetics and Cancer (GB)
International Institute of Molecular and Cell Biology (PL)
Corresponding author: Reijns, Martin A. M.
Jackson, Andrew P.
ORCID: Mackenzie, Karen J.
Martin, Carol-Anne
Murina, Olga
Simpson, Daniel J.
Olova, Nelly
Osborn, Ruby T.
Wheeler, Ann P.
Nowotny, Marcin
Gilbert, Nick
Chandra, Tamir
Reijns, Martin A. M.
Jackson, Andrew P.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2017-07-24
Volume: 548
Issue: 7668
Pages: 461-465
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature23449
PMC: PMC5870830
OpenAlex: W2738136165
Cited by: 1,752
References: 56
Citations by year: 2026: 208 · 2025: 196 · 2024: 225 · 2023: 233 · 2022: 216 · 2021: 231 · 2020: 193 · 2019: 125 · 2018: 99 · 2017: 26
FWCI: 54.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: Howard Hughes Medical Institute
Wellcome Trust
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (158709)
Medical Research Council (1805075, MR/K01563X/1, MC_PC_15075)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: cGAS, micronuclei, genomic instability, innate immunity, cytosolic DNA sensing, autoinflammation, chromothripsis, DNA damage, interferon-stimulated genes, cancer, mitosis, lagging chromosomes, immunostimulatory DNA
MeSH terms: Chromothripsis, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Animals, Cell Cycle, Chromatin, Cytoplasm, DNA, DNA Damage, Female, Humans, Immunity, Innate, Inflammation, Lasers, Male, Mitosis, Nuclear Envelope, Nucleotidyltransferases, Microdissection, Genomic Instability, Cell Line, Tumor, Micronuclei, Chromosome-Defective, Mice, Single-Cell Analysis, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

cGAS surveillance of micronuclei links genome instability to innate immunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks