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Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response

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Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity

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Overcoming Immune Resistance With Radiation Therapy in Prostate Cancer

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Size-optimized nuclear-targeting phototherapy enhances the type I interferon response for “cold” tumor immunotherapy

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Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

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Enhancing nano-immunotherapy of cancer through cGAS–STING pathway modulation

Fu, G., Zhao, Y., Mao, C., & Liu, Y. (2025) · Biomaterials Science · doi:10.1039/d4bm01532k · Cited by 17

[Mitochondrial DNA and cGAS-STING Innate Immune Signaling Pathway: Latest Research Progress].

Li, Y.-X., Cui, S.-F., Meng, W., Hu, H., & Wang, C. (2021) · 四川大学学报：医学版 · doi:10.12182/20210560501 · Cited by 17

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Marzano, S., Miglietta, G., Morigi, R., Marinello, J., Arleo, A., Procacci, M., Locatelli, A., Leoni, A., Pagano, B., Randazzo, A., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00772 · Cited by 18

cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer

Ge, H., Dan, Q., & Yang, Y. (2022) · Current Cancer Drug Targets · doi:10.2174/1568009623666221115095114 · Cited by 17

Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation

Zhou, L., Ho, B. M., Chan, H. Y. E., Tong, Y., Du, L., He, J. N., Ng, D. S., Tham, C. C. Y., Pang, C. P., & Chu, W. K. (2023) · Journal of Innate Immunity · doi:10.1159/000533897 · Cited by 18

Carbon ion irradiation exerts antitumor activity by inducing cGAS–STING activation and immune response in prostate cancer‐bearing mice

Hu, W., Zhang, Z., Xue, Y., Ning, R., Guo, X., Sun, Y., & Zhang, Q. (2024) · Cancer Medicine · doi:10.1002/cam4.6950 · Cited by 17

Cancer Radiosensitization Nanoagent to Activate cGAS‐STING Pathway for Molecular Imaging Guided Synergistic Radio/Chemo/Immunotherapy

Wu, Z., Li, Q., Zhu, K., Zheng, S., Hu, H., Hou, M., Li, Q., Chen, S., Xu, Y., Zhao, B., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303626 · Cited by 18

The Regulation of Cellular Senescence in Cancer

Zhang, X., Gao, Y., Zhang, S., Wang, Y., Du, Y., Hao, S., & Ni, T. (2025) · Biomolecules · doi:10.3390/biom15030448 · Cited by 17

The Regulation of cGAS

Xiong, M.-G., Wang, S., Wang, Y., & Ran, Y. (2018) · Virologica Sinica · doi:10.1007/s12250-018-0005-6 · Cited by 17

Apoptotic mitochondria prime anti-tumour immunity

McArthur, K., & Kile, B. T. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00335-6 · Cited by 19

Immunofluorescence microscopy-based assessment of cytosolic DNA accumulation in mammalian cells

Sato, A., Buqué, A., Yamazaki, T., Bloy, N., Petroni, G., & Galluzzi, L. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100488 · Cited by 17

An update on post‐transcriptional regulation of retrotransposons

Warkocki, Z. (2022) · FEBS Letters · doi:10.1002/1873-3468.14551 · Cited by 19

Application of individualized multimodal radiotherapy combined with immunotherapy in metastatic tumors

Ji, X., Jiang, W., Wang, J., Zhou, B., Ding, W., Liu, S., Huang, H., Chen, G., & Sun, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1106644 · Cited by 18

Molecular pathobiology of scleritis and its therapeutic implications

Das, U. N. (2019) · International Journal of Ophthalmology · doi:10.18240/ijo.2020.01.23 · Cited by 17

Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway

Bai, Z., Peng, Y., Xia, X., Li, Y., Zhong, Y., Chen, L., Guan, Q., Liu, W., Zhou, Y., & Ma, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216695 · Cited by 17

Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

Ng, I.-I., Zhang, Z., Xiao, K., Ye, M., Tian, T., Zhu, Y., He, Y.-D., Chu, L., & Tang, H. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115733 · Cited by 16

Longitudinal and multisite sampling reveals mutational and copy number evolution in tumors during metastatic dissemination

Zhao, K., Vos, J. L., Lam, S. Z., Boe, L. A., Muldoon, D. M., Han, C. Y., Valero, C., Lee, M., Fitzgerald, C. W. R., Lee, A. S., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02204-3 · Cited by 17

cGAS Conducts Micronuclei DNA Surveillance

Mann, C. C. D. O., & Kranzusch, P. J. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.08.007 · Cited by 71

DNA damage-induced immune response: Micronuclei provide key platform

Gekara, N. O. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201708069 · Cited by 88

Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING

Takaki, T., Millar, R., Hiley, C. T., & Boulton, S. J. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.04.017 · Cited by 101

Arrayed whole-genome CRISPR screen identifies novel regulators of cGAS biology in response to DNA damage

Millar, R. (2025) · UCL Discovery (University College London)

A microscopy reporter for cGAMP reveals rare cGAS activation following DNA damage, and a lack of correlation with micronuclear cGAS enrichmentPreprint

Lebrec, V., Afshar, N., Davies, L. R., Kujirai, T., Κανέλλου, Α., Tidu, F., & Zierhut, C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.13.593978 · Cited by 12