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cGAS surveillance of micronuclei links genome instability to innate immunity
Open accessAbstract
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage. Precisely how cellular DNA gains access to the cytoplasm remains to be determined. Here, we report that cGAS localizes to micronuclei arising from genome instability in a mouse model of monogenic autoinflammation, after exogenous DNA damage and spontaneously in human cancer cells. Such micronuclei occur after mis-segregation of DNA during cell division and consist of chromatin surrounded by its own nuclear membrane. Breakdown of the micronuclear envelope, a process associated with chromothripsis, leads to rapid accumulation of cGAS, providing a mechanism by which self-DNA becomes exposed to the cytosol. cGAS is activated by chromatin, and consistent with a mitotic origin, micronuclei formation and the proinflammatory response following DNA damage are cell-cycle dependent. By combining live-cell laser microdissection with single cell transcriptomics, we establish that interferon-stimulated gene expression is induced in micronucleated cells. We therefore conclude that micronuclei represent an important source of immunostimulatory DNA. As micronuclei formed from lagging chromosomes also activate this pathway, recognition of micronuclei by cGAS may act as a cell-intrinsic immune surveillance mechanism that detects a range of neoplasia-inducing processes.
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“Besides the exogenous dsDNA released by virus or bacterial, intrinsic self-dsDNA released into the cytosol from nucleus or mitochondrion due to cellular or mitochondrial stress can also bind to cGAS and activate cGAS-STING pathway.400,401”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [400]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We found a striking localization of cGAS to approximately half of all micronuclei as previously observed22,23.”
From Chromosomal instability drives metastasis through a cytosolic DNA response (2018) · cites this paper as [23]
Experimental — accuracy not yet measuredIn the citing paper
“Type I IFN is produced by cancer cells succumbing to ICD by a mechanism involving the detection of endogenous dsRNA by TLR3 [873], or double-stranded DNA (dsDNA) by cGAS [854, 905, 906].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [905]
In the citing paper
“Moreover, recent data indicate that cancer cells escaping mitotic catastrophe efficiently promote the secretion of type I IFN following the detection of cytosolic dsDNA by cGAS, potentially resulting in their elimination by immunological mechanisms [905, 906].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [905]
In the citing paper
“this strategy may also impair signaling of MN-initiated cell-intrinsic immune surveillance and tumor suppression (Harding et al., 2017; Mackenzie et al., 2017)”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Mackenzie et al., 2017
In the citing paper
“Mechanistically, cytoplasmic DNA in early senescent cells can originate from micronuclei produced due to chromosome segregation errors during mitosis [175,176].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [176]
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Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
Full-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574
The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
Liao, Y., Smyth, G. K., & Shi, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt214 · Cited by 3,064
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333
Tumor spectrum analysis in p53-mutant mice
Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.017 · Cited by 1,917
McCarthy, D. J., Campbell, K. R., Lun, A. T. L., & Wills, Q. F. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw777 · Cited by 1,852
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Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis
Zhong, L., Hu, M., Bian, L., Liu, Y., Chen, Q., & Shu, H. (2020) · Cell Discovery · doi:10.1038/s41421-020-0162-2 · Cited by 139
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
Kim, C., Wang, X.-D., & Yu, Y. (2020) · eLife · doi:10.7554/elife.60637 · Cited by 136
Leveraging the replication stress response to optimize cancer therapy
Cybulla, E., & Vindigni, A. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00518-6 · Cited by 144
The abscopal effect 67 years later: from a side story to center stage
Demaria, S., & Formenti, S. C. (2020) · British Journal of Radiology · doi:10.1259/bjr.20200042 · Cited by 140
Targeting DNA repair pathway in cancer: Mechanisms and clinical application
Wang, M., Chen, S., & Ao, D. (2021) · MedComm · doi:10.1002/mco2.103 · Cited by 140
Chromosomal instability as a driver of cancer progression
Chen, X., Agustinus, A. S., Li, J., Bona, M. D., & Bakhoum, S. F. W. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00761-7 · Cited by 146
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Vietri, M., Schultz, S. W., Bellanger, A., Jones, C. M., Petersen, L. I., Raiborg, C., Skarpen, E., Pedurupillay, C. R. J., Kjos, I., Kip, E., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0537-5 · Cited by 137
The cGAS‐STING pathway: The role of self‐DNA sensing in inflammatory lung disease
Ma, R., Serrano, T. P. O., Davis, J., Prigge, A. D., & Ridge, K. M. (2020) · The FASEB Journal · doi:10.1096/fj.202001607r · Cited by 138
Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease
Welch, G., & Tsai, L. (2022) · The EMBO Reports · doi:10.15252/embr.202154217 · Cited by 129
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
Sun, X., Liu, T., Zhao, J., Xia, H., Xie, J., Guo, Y., Zhong, L., Li, M., Yang, Q., Peng, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19941-0 · Cited by 129
ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
Carozza, J. A., Cordova, A. F., Brown, J. A., AlSaif, Y., Böhnert, V., Cao, X., Mardjuki, R. E., Skariah, G. M., Fernández, D., & Li, L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119189119 · Cited by 131
Jiang, G.-L., Yang, X., Zhou, H., Long, J., Liu, B., Zhang, L.-M., & Lü, D. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.03.010 · Cited by 132
Meng, F., Yu, Z., Zhang, D., Chen, S., Guan, H., Zhou, R., Wu, Q., Zhang, Q. Y., Liu, S., Ramani, M. K. V., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.07.040 · Cited by 130
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
Yang, L., Jia, R., Ge, T., Ge, S., Zhuang, A., Chai, P., & Fan, X. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01176-8 · Cited by 136
Tijhuis, A. E., Johnson, S. C., & McClelland, S. E. (2019) · Molecular Cytogenetics · doi:10.1186/s13039-019-0429-1 · Cited by 131
Radiotherapy induced immunogenic cell death by remodeling tumor immune microenvironment
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Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation
Chen, J., Cao, Y., Markelc, B., Kaeppler, J., Vermeer, J. A. F., & Muschel, R. J. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127458 · Cited by 134
Structural basis for nucleosome-mediated inhibition of cGAS activity
Cao, D., Han, X., Fan, X., Xu, R.-M., & Zhang, X. (2020) · Cell Research · doi:10.1038/s41422-020-00422-4 · Cited by 130
Cadmium activates the innate immune system through the AIM2 inflammasome
Zhao, L., Liao, M., Li, L., Chen, L., Zhang, T., & Li, R. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111122 · Cited by 130
Guo, X., Ni, J., Liang, Z., Xue, J., Fenech, M. F., & Wang, X. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.11.001 · Cited by 127
Challenges for immunotherapy for the treatment of platinum resistant ovarian cancer
Saux, O. L., Ray-Coquard, I. L., & Labidi‐Galy, S. I. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.08.017 · Cited by 127
Kreienkamp, R., Graziano, S., Coll-Bonfill, N., Bedia‐Diaz, G., Cybulla, E., Vindigni, A., Dorsett, D., Kubben, N., Batista, L. F. Z., & Gonzalo, S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.090 · Cited by 125
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Zhen, Y., Radulovic, M., Vietri, M., & Stenmark, H. (2021) · The EMBO Journal · doi:10.15252/embj.2020106922 · Cited by 126
Epigenetic dysregulation from chromosomal transit in micronuclei
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Cytosolic sensing of immuno-stimulatory DNA, the enemy within
Dhanwani, R., Takahashi, M., & Sharma, S. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.11.004 · Cited by 123
Micronuclei and Genome Chaos: Changing the System Inheritance
Ye, C. J., Sharpe, Z. J., Alemara, S., Mackenzie, S., Liu, G., Abdallah, B. Y., Horne, S. D., Regan, S. M., & Heng, H. H. (2019) · Genes · doi:10.3390/genes10050366 · Cited by 133
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Ragu, S., Matos-Rodrigues, G. E., & López, B. S. (2020) · Genes · doi:10.3390/genes11040409 · Cited by 131
Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS–cGAMP–STING Pathway
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Basit, A., Cho, M.-G., Kim, E.-Y., Kwon, D., Kang, S., & Lee, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0416-y · Cited by 124
Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease
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Sen, T., Corte, C. M. D., Milutinovic, S., Cardnell, R. J., Diao, L., Ramkumar, K., Gay, C. M., Stewart, C. A., Fan, Y.-H., Shen, L., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.08.009 · Cited by 122
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection
Zhou, Z. L., Zhang, X., Lei, X., Xiao, X., Jiao, T., Ma, R., Dong, X., Jiang, Q., Wang, W., Shi, Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00800-3 · Cited by 120
Negative regulation of type I IFN signaling
Arimoto, K.-I., Miyauchi, S., Stoner, S. A., Fan, J.-B., & Zhang, D.-E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mir0817-342r · Cited by 117
Marill, J., Anesary, N. M., & Paris, S. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.07.029 · Cited by 121
Carozza, J. A., Brown, J. A., Böhnert, V., Fernández, D., AlSaif, Y., Mardjuki, R. E., Smith, M. A., & Li, L. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.07.007 · Cited by 116
Ghosh, A., Shao, L., Sampath, P., Zhao, B., Patel, N. V., Zhu, J., Behl, B., Parise, R. A., Beumer, J. H., O’Sullivan, R. J., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.013 · Cited by 118
Lohard, S., Bourgeois, N., Maillet, L., Gautier, F., Fétiveau, A., Lasla, H., Nguyen, F., Vuillier, C., Dumont, A., Moreau‐Aubry, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13689-y · Cited by 120
Krisnawan, V. E., Stanley, J. A., Schwarz, J. K., & DeNardo, D. G. (2020) · Cancers · doi:10.3390/cancers12102916 · Cited by 115
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Smith, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.611347 · Cited by 116
Targeting ATR in patients with cancer
Ngoi, N. Y. L., Pilie, P. G., McGrail, D. J., Zimmermann, M., Schlacher, K., & Yap, T. A. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00863-5 · Cited by 119
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
Shen, J. Z., Qiu, Z., Wu, Q., Finlay, D., Garcia, G., Sun, D., Rantala, J., Barshop, W., Hope, J. L., Gimple, R. C., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.042 · Cited by 113
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway
Takahashi, M., Lio, C. J., Campeau, A., Steger, M., Ay, F., Mann, M., Gonzalez, D. J., Jain, M., & Sharma, S. (2021) · Nature Immunology · doi:10.1038/s41590-021-00896-3 · Cited by 118
Chen, J., Harding, S. M., Natesan, R., Tian, L., Benci, J. L., Li, W., Minn, A. J., Asangani, I. A., & Greenberg, R. A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108080 · Cited by 111
Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells
Flynn, P. J., Koch, P. D., & Mitchison, T. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2103585118 · Cited by 118
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Hu, M.-M., & Shu, H.-B. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062903 · Cited by 110
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING
Tian, J., Zhang, D., Kurbatov, V., Wang, Q., Wang, Y., Fang, D., Wu, L., Bosenberg, M., Muzumdar, M. D., Khan, S. A., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020106065 · Cited by 114
The DNA Damage Response and Inflammation in Cancer
Klapp, V., Álvarez-Abril, B., Leuzzi, G., Kroemer, G., Ciccia, A., & Galluzzi, L. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1220 · Cited by 115
Wang, G., Xu, D., Zhang, Z., Li, X., Sun, J., Sun, J., Li, X., Li, X., Zhou, M., & Zheng, T. (2021) · npj Precision Oncology · doi:10.1038/s41698-021-00200-4 · Cited by 118
Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and Immunotherapy
Yum, S., Li, M., Frankel, A. E., & Chen, Z. J. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055636 · Cited by 109
Leuzzi, G., Vasciaveo, A., Taglialatela, A., Chen, X., Firestone, T. M., Hickman, A. R., Mao, W., Thakar, T., Vaitsiankova, A., Huang, J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.008 · Cited by 113
MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
Kitajima, S., Tani, T., Springer, B. F., Campisi, M., Osaki, T., Haratani, K., Chen, M., Knelson, E. H., Mahadevan, N. R., Ritter, J., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.08.015 · Cited by 107
Monjazeb, A. M., Giobbie‐Hurder, A., Lako, A., Thrash, E. M., Brennick, R. C., Kao, K. Z., Manuszak, C., Gentzler, R. D., Tesfaye, A. A., Jabbour, S. K., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4632 · Cited by 112
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Sun, H., Huang, Y., Mei, S., Xu, F., Liu, X., Zhao, F., Yin, L., Zhang, D., Wei, L., Wu, C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108586 · Cited by 105
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Calcagno, D. M., Ng, R. P., Toomu, A., Zhang, C., Huang, K., Aguirre, A. D., Weissleder, R., Daniels, L. B., Fu, Z., & King, K. R. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz1974 · Cited by 107
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Wang, L., Yang, L., Wang, C., Wei, Z., Ju, Z., Zhang, W., Shen, J., Peng, Y., An, C., Luu, Y. T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci130445 · Cited by 106
Li, C., Liu, W., Wang, F., Hayashi, T., Mizuno, K., Hattori, S., Fujisaki, H., & Ikejima, T. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.037 · Cited by 106
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Falcomatà, C., Bärthel, S., Widholz, S. A., Schneeweis, C., Montero, J. J., Toska, A., Mir, J., Kaltenbacher, T., Heetmeyer, J., Swietlik, J. J., et al. (2022) · Nature Cancer · doi:10.1038/s43018-021-00326-1 · Cited by 103
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Liu, C., Wang, X., Qin, W., Tu, J., Li, C., Zhao, W., Ma, L., Liu, B., Qiu, H., & Yuan, X. (2023) · 癌症：英文版 · doi:10.1002/cac2.12412 · Cited by 99
Takaki, T., Millar, R., Hiley, C. T., & Boulton, S. J. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.04.017 · Cited by 101
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Zhao, X. R., Zhang, K., Wang, Y., Jiang, W., Cheng, H., Wang, Q., Xiang, T., Zhang, Z., Liu, J., & Shi, J. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202108883 · Cited by 94
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Andrade, B., Jara‐Gutiérrez, C., Paz-Araos, M., Vázquez, M. C., Díaz, P., & Murgas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315182 · Cited by 96
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Cristini, A., Tellier, M., Constantinescu, F., Accalai, C., Albulescu, L.-O., Heiringhoff, R. S., Béry, N., Sordet, O., Murphy, S., & Gromak, N. (2022) · Nature Communications · doi:10.1038/s41467-022-30604-0 · Cited by 98
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Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response
Jena, K. K., Mehto, S., Nath, P., Chauhan, N. R., Sahu, R., Dhar, K., Das, S. K., Kolapalli, S. P., Murmu, K. C., Jain, A., et al. (2020) · EMBO Reports · doi:10.15252/embr.202050051 · Cited by 90
Paffenholz, S. V., Salvagno, C., Ho, Y.-J., Limjoco, M., Baslan, T., Tian, S., Kulick, A. R., de Stanchina, E., Wilkinson, J. E., Barriga, F. M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117754119 · Cited by 93
Heritable transcriptional defects from aberrations of nuclear architecture
Papathanasiou, S., Mynhier, N. A., Liu, S., Brunette, G. J., Stokasimov, E., Jacob, E., Li, L., Comenho, C., van Steensel, B., Buenrostro, J. D., et al. (2023) · Nature · doi:10.1038/s41586-023-06157-7 · Cited by 90
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Haschka, M. D., Karbon, G., Fava, L. L., & Villunger, A. (2018) · EMBO Reports · doi:10.15252/embr.201745440 · Cited by 95
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DNA damage-induced immune response: Micronuclei provide key platform
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Metadata
- Authors
- Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., Osborn, R. T., Wheeler, A. P., Nowotny, M., Gilbert, N., Chandra, T., Reijns, M. A. M., & Jackson, A. P.
- Affiliations
- Institute of Genetics and Cancer (GB)
- International Institute of Molecular and Cell Biology (PL)
- Corresponding author
- Reijns, Martin A. M.
- Jackson, Andrew P.
- ORCID
- Venue
- Nature
- Published
- 2017-07-24
- Volume
- 548
- Issue
- 7668
- Pages
- 461-465
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5870830
- OpenAlex
- W2738136165
- Cited by
- 1,752
- References
- 56
- Citations by year
- 2026: 208 · 2025: 196 · 2024: 225 · 2023: 233 · 2022: 216 · 2021: 231 · 2020: 193 · 2019: 125 · 2018: 99 · 2017: 26
- FWCI
- 54.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Howard Hughes Medical Institute
- Wellcome Trust
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (158709)
- Medical Research Council (1805075, MR/K01563X/1, MC_PC_15075)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- cGAS, micronuclei, genomic instability, innate immunity, cytosolic DNA sensing, autoinflammation, chromothripsis, DNA damage, interferon-stimulated genes, cancer, mitosis, lagging chromosomes, immunostimulatory DNA
- MeSH terms
- Chromothripsis, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Animals, Cell Cycle, Chromatin, Cytoplasm, DNA, DNA Damage, Female, Humans, Immunity, Innate, Inflammation, Lasers, Male, Mitosis, Nuclear Envelope, Nucleotidyltransferases, Microdissection, Genomic Instability, Cell Line, Tumor, Micronuclei, Chromosome-Defective, Mice, Single-Cell Analysis, Transcriptome
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