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Mediation effect of plasma metabolites on the relationship between immune cells and the risk of prostatitis: A study by bidirectional 2-sample and Bayesian-weighted Mendelian randomization

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Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotypePreprint

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Targeting glutamine metabolism in CD4+ T‐cell‐mediated autoimmune diseases

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Narrowband Ultraviolet B Induces Peripheral Regulatory T Cells to Exert Antigen‐Specific Immune Suppression

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Cancer metabolism rewiring and chromatin methylation: a vulnerable epi-metabolic link

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Oligopeptide-loaded metal-organic framework nanocomposites promote regulatory T cell differentiation against periodontitis

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Gut microbial dysbiosis: The hidden culprit behind Aplastic anaemia?

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Modulating Anti-Inflammatory Macrophage Polarization and Regulatory T Cell Differentiation via Aminooxyacetic Acid-Loaded Hydrogel for Promoting Allogeneic Skin Transplantation

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Multi-omics insights into Shenling Baizhu Powder’s amelioration of murine asthma through gut microbiota and Glutamine-GLS1 pathway

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A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance

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Phospho-enol pyruvate carboxykinase inhibition limits effector function in inflammatory T cells

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Metabolites in the tumor microenvironment: Key drivers of immune cell fate and function as therapeutic targets in cancer

Zhao, X.-P., Mai, C.-T., Zhao, Y., Zhou, X.-Y., Lai, N.-H., Zhang, X.-J., & Fan, X. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189590 · Cited by 1

Th17/Treg imbalance: a key driver of neutrophilic inflammation in severe asthma

Yao, B., Song, C., Li, S., Ran, Z., Wang, C., Wu, M., & Yuan, Q. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116920 · Cited by 1

The role of Th17 cells in the pathogenesis of Parkinson's disease: From immune dysregulation to neurodegeneration

Zhao, J., Liang, H., & Bi, Y. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111990 · Cited by 1

Peripheral blood DNA methylation partially reports on immune cell type composition in the frontal brain

Meijer, M., Fu, M. P., Navarro‐Delgado, E. I., Engelbrecht, H.-R., Turecki, G., Chan, M. H.-M., & Kobor, M. S. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101316 · Cited by 1

Metabolic Bottlenecks and Opportunities: Reshaping the Tumor Microenvironment for Cancer Immunotherapy

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Metabolic reprogramming-driven neuroimmunoregulation: Key mechanisms and therapeutic opportunities and challenges in central nervous system disorders

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The Potential Utility of (2S,4R)-4-[18F]fluoroglutamine as a Novel Metabolic Imaging Marker for Inflammation Explored by Rat Models of Arthritis and Paw Edema

Kim, M.-J., Akula, H. K., Marden, J. A., Li, K., Hu, B. X., Vaska, P., & Qü, W. (2024) · Molecular Imaging and Biology · doi:10.1007/s11307-024-01967-1 · Cited by 1

Regulation of cytokine secretion by immunometabolites

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Epigenetics of T cell-mediated immunological responses

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αKG inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolismPreprint

Matias, M. I., Yong, C. S. M., Foroushani, A. B. K., Sezgin, E., Levental, K. R., Talebi, A., Mongellaz, C., Dehair, J., Wong, M., Kinet, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.24.256560 · Cited by 1

LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3Preprint

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IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activationPreprint

Brune, Z., Lu, A., Moss, M. A., Brune, L., Huang, A., Matta, B., & Barnes, B. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.26.609422 · Cited by 1

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Decitabine may effectively treat CMML/MDS-associated inflammatory bowel disease by regulating the Th17/Treg balancePreprint

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La reprogramación metabólica inducida por patrones moleculares de la pared fúngica regula la expresión de citoquinas

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Fas gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

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Anthocyanin attenuates disturbance of intestinal barrier in high fat-high cholesterol diet-challenged mice through regulating the response of T helper 17 cells

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T cell differentiation from mice spleen tissue v1Preprint

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Additional file 6 of Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Ahmed, S., Mahony, C. B., Torres, A., Murillo‐Saich, J., Kemble, S., Cedeño, M., John, P. C. L., Bhatti, A., Croft, A. P., & Gumá, M. (2023) · Figshare · doi:10.6084/m9.figshare.24172054

Additional file 5 of Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Ahmed, S., Mahony, C. B., Torres, A., Murillo‐Saich, J., Kemble, S., Cedeño, M., John, P. C. L., Bhatti, A., Croft, A. P., & Gumá, M. (2023) · Figshare · doi:10.6084/m9.figshare.24172051

Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis)

Dar, S. A., Das, S., Jawed, A., Nasreen, N., & Rai, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13947-5.00010-5

T cell metabolism and cancer immunotherapy

Li, Q., & Zhang, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13827-0.00006-8

Methyl-CpG-Binding Domain Protein 2 is Involved in Th17 Cell Differentiation by Positively Regulating Leptin Expression

Xia, Y., Zhang, X., & Wu, D. (2025) · Current Molecular Medicine · doi:10.2174/0115665240341834250121080510

Immunometabolism Governs T Cell Immunity

Raynor, J. L., Shi, H., & Chi, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00275-1

Inhibitory effects of wogonin on hepatocellular carcinoma through modulation of lactate metabolism and suppression of regulatory T-cell differentiation

Meng, F., Zhang, Y., Gu, X., Ma, T., Chen, Z., Fang, H., Wu, L., Xu, H., & Huang, Y. (2025) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2025.102545

Ammonium metabolism rewiring in the prostate cancer microenvironment: Mechanisms and clinical prospects

Ye, Z., Wu, H., Li, Z., Ye, R., Rao, Y., Liu, B., & Gao, B. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1673513

Multi-omics revealed GOT1/ALDH3A1 pathway attenuated head and neck squamous cell carcinoma and increased cisplatin sensitivity through ROS induced by mitochondrial dysfunction

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Recent Progress of Epigenetic Reprogramming Biomedicine to Activate Immunotherapeutic Antitumor Effects

Huang, C., Yu, B., Qiu, W., Cheng, H. B., & Li, S. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500270

Metabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2-deficient murine astrocytesPreprint

Blakeley, N., Naz, S., Liu, Z., Renner, T. M., Leclerc, S., Comin, C. H., da Silva, M. V., Vergette, C., Porter, C. J., Perkins, T. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.16.694710

Additional file 4 of A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis

Fan, W., Zeng, S., Wang, X., Wang, G., Liao, D., Li, R., He, S., Li, W., Huang, J., Li, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26738811

Additional file 4 of Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Ahmed, S., Mahony, C. B., Torres, A., Murillo‐Saich, J., Kemble, S., Cedeño, M., John, P., Bhatti, A., Croft, A. P., & Gumá, M. (2023) · Figshare · doi:10.6084/m9.figshare.24172048

Additional file 3 of Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Ahmed, S., Mahony, C. B., Torres, A., Murillo‐Saich, J., Kemble, S., Cedeño, M., John, P., Bhatti, A., Croft, A. P., & Gumá, M. (2023) · Figshare · doi:10.6084/m9.figshare.24172045

Additional file 2 of Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Ahmed, S., Mahony, C. B., Torres, A., Murillo‐Saich, J., Kemble, S., Cedeño, M., John, P., Bhatti, A., Croft, A. P., & Gumá, M. (2023) · Figshare · doi:10.6084/m9.figshare.24172042

Additional file 1 of A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis

Fan, W., Zeng, S., Wang, X., Wang, G., Liao, D., Li, R., He, S., Li, W., Huang, J., Li, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26103815

Additional file 1 of Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Ahmed, S., Mahony, C. B., Torres, A., Murillo‐Saich, J., Kemble, S., Cedeño, M., John, P., Bhatti, A., Croft, A. P., & Gumá, M. (2023) · Figshare · doi:10.6084/m9.figshare.24172039

Additional file 3 of A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis

Fan, W., Zeng, S., Wang, X., Wang, G., Liao, D., Li, R., He, S., Li, W., Huang, J., Li, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26738808

Additional file 2 of A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis

Fan, W., Zeng, S., Wang, X., Wang, G., Liao, D., Li, R., He, S., Li, W., Huang, J., Li, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26103969

Glutaminase-mediated glutamate metabolism is critical for maintaining Th17/Treg balance

Jin, X., & Tao, J. (2025) · Central European Journal of Immunology · doi:10.5114/ceji.2025.155429

Regulatory mechanisms of the trade off between Th17 cells and Treg cells

Huang, L., Chen, Z., & Jiao, F. (2026) · Journal of Biological Physics · doi:10.1007/s10867-026-09701-4

Natural and Artificial Hematopoietic Cell Reprogramming

Yu, D. H., Liu, W., Liu, F., & Cheng, L. (2026) · Cellular Reprogramming · doi:10.1177/21524971261424117

Tumor microenvironment-induced epigenetic reprogramming of Tregs and its impact on immunotherapy

Li, W., & Tong, J. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1787421

IDH1 Mutant Glioma Favors Group 3 Innate Lymphoid Cells and Is Resistant to Immune Checkpoint Expression

Erdem, Ş., Haliloğlu, Y., Uslu, İ. N., Houran, M. A., Ulutabanca, H., Vural, A., Erturhan, M. B., Canatan, H., & Eken, A. (2026) · Inflammation Research · doi:10.1007/s00011-026-02223-8

Natural Killer Cells and Pre-B Acute Lymphoblastic Leukemia : Evidence for an Unconventional Cytotoxicity Pathway

Nicoletti, S. (2017) · theses.fr (ABES) · doi:10.70675/89efde8dzf329z4c08zad57z08ffd23d7992

Etude du métabolisme des lymphocytes T CD4+ Foxp3+ régulateurs à l’homéostasie et dans un contexte inflammatoire

Divoux, J. (2019) · theses.fr (ABES) · doi:10.70675/d126d218zea04z4801zb226z2aa67dc82945

Targeting the metabolic environment to modulate T cell effector function

Matias, M. I. (2019) · theses.fr (ABES) · doi:10.70675/0582ddaaze61dz4707z9cb1zdb8fe1d82653

Étude de l’influence de la glutaminolyse des macrophages dans les maladies cardio-métaboliques

Merlin, J. (2020) · theses.fr (ABES) · doi:10.70675/68e10f28zf840z48bfz9bacz5511a3a2b208

Régulation métabolique de la plasticité des ILC2 au cours de l'infection par Mycobacterium tuberculosis

Corral, D. (2020) · theses.fr (ABES) · doi:10.70675/5891ec8az223cz458dzb5cezd92ba38e80aa

IGF1 Receptor Inhibition Amplifies the Effects of Cancer Drugs by Autophagy and Immune-Dependent Mechanisms

Tian, A.-L. (2022) · theses.fr (ABES) · doi:10.70675/bf82f2b6zc957z4d06z9332zd8b7d5ba24a4

Network pharmacology combined with pharmacology to explore the mechanism of Zengye Runzao Decoction in treating Sjögren's Syndrome

Liu, R., Zhou, Q., Zhang, J., & Li, J. (2026) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2026.100390

TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling

Yu, X., An, D., Ren, D., He, P., Yang, Y., Chen, N., Wang, R., Wu, S., Feng, J., & Feng, M. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48040403

Multi-omics integration identifies PFOS-associated immune signatures in Kawasaki disease

Quan, J., Tu, J., Li, D., Zhang, Z., Xue, L., Li, T., & Xi, S. (2026) · Environment International · doi:10.1016/j.envint.2026.110279

MechAInistic: A Reviewer-Supervised Multi-Agent LLM System for Auditable Mechanistic Drug-Hypothesis GenerationPreprint

Loecker, J., Pujara, N., Bryant, W., Puniya, B. L., Packrisamy, P., Hamed, A. A., & Helikar, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.11.723319

Sulfur mustard exposure induces inflammatory injury by Dnmt3b-mediated DNA methylation via oleic acid accumulation in Treg cells

Sun, Y., Jiang, X., Cen, J., Shi, Q., He, L., Du, X., Xu, Q., Xu, H., Xiao, K., & Li, S. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112177

T-cell subset biomarkers across the rheumatoid arthritis disease continuum: from clinical utility to adoption in daily practice

Anioke, I. C., Taştekin, F., Alp, G., Ng, H., Ravi, P., Parker, I., Lou, M., Gul, H. L., Duquenne, L. M., Villeneuve, É., et al. (2026) · Rheumatology · doi:10.1093/rheumatology/keag286

Ammonia metabolic reprogramming in the tumor microenvironment: emergence of an immunosuppressive niche

Ye, Z., Wu, H., Li, Z., Ye, R., 饶应良, Liu, B., & Gao, B. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1826809

TET Enzymes as Epigenetic Integrators in Intestinal Immunity, Inflammation, and Disease

Singh, D. K., Yamaguchi, Y., Huang, L., Saito, C., Cassidy, O. G., & Nishiyama, K. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16070375

Targeting regulatory T cell plasticity in gastric cancer: a unified bimodal model and precision immunotherapy paradigm: a hypothesis-generating review

Zhou, P., Wang, D., Zhang, H., Zhang, F., Li, Z., & Xi, H. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1882680

d‐Sorbose Promotes Regulatory T‐Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition

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