The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood
Open accessAbstract
As the tissue that contains the largest representation of the human proteome, blood is the most important fluid for clinical diagnostics. However, although changes of plasma protein profiles reflect physiological or pathological conditions associated with many human diseases, only a handful of plasma proteins are routinely used in clinical tests. Reasons for this include the intrinsic complexity of the plasma proteome, the heterogeneity of human diseases and the rapid degradation of proteins in sampled blood. We report an integrated microfluidic system, the integrated blood barcode chip that can sensitively sample a large panel of protein biomarkers over broad concentration ranges and within 10 min of sample collection. It enables on-chip blood separation and rapid measurement of a panel of plasma proteins from quantities of whole blood as small as those obtained by a finger prick. Our device holds potential for inexpensive, noninvasive and informative clinical diagnoses, particularly in point-of-care settings.
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Cites
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“3a ), the prostate cancer marker PSA and eleven proteins secreted by various white blood cells, have been associated with tumor microenvironment formation, tumor progression and tumor metastasi”
Background
Cited by
Rissin, D. M., Kan, C. W., Campbell, T. G., Howes, S. C., Fournier, D. R., Song, L., Piech, T., Patel, P. P., Chang, L., Rivnak, A. J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1641 · Cited by 2,119
Plasmonic ELISA for the ultrasensitive detection of disease biomarkers with the naked eye
de la Rica, R., & Stevens, M. M. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.186 · Cited by 873
Ma, C., Fan, R., Ahmad, H., Shi, Q., Comin-Anduix, B., Chodon, T., Koya, R. C., Liu, C.-C., Kwong, G. A., Radu, C. G., et al. (2011) · Nature Medicine · doi:10.1038/nm.2375 · Cited by 441
Self-citationDu, W., Li, L., Nichols, K. P., & Ismagilov, R. F. (2009) · Lab on a Chip · doi:10.1039/b908978k · Cited by 351
Lab-on-chip technology for chronic disease diagnosis
Wu, J., Dong, M., Rigatto, C., Liu, Y., & Lin, F. (2018) · npj Digital Medicine · doi:10.1038/s41746-017-0014-0 · Cited by 170
Metadata
- Authors
- Fan, R., Vermesh, O., Srivastava, A., Yen, B. K. H., Qin, L., Ahmad, H., Kwong, G. A., Liu, C.-C., Gould, J., Hood, L., & Heath, J. R.
- Venue
- Nature Biotechnology
- Published
- 2008-11-16
- Volume
- 26
- Issue
- 12
- Pages
- 1373-1378
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2088298294
- Cited by
- 539
- References
- 4
- FWCI
- 25.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Fan, R., Vermesh, O., Srivastava, A., Yen, B. K. H., Qin, L., Ahmad, H., Kwong, G. A., Liu, C.-C., Gould, J., Hood, L., & Heath, J. R. (2008). Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood. Nature Biotechnology. https://doi.org/10.1038/nbt.1507
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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