High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

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Items 301–400 of 1,023

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3. Whole genome sequencing reveals rare off‐target mutations and considerable inherent genetic or/and somaclonal variations in CRISPR /Cas9‐edited cotton plants
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5. High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
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7. Efficiency and Inheritance of Targeted Mutagenesis in Maize Using CRISPR-Cas9
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8. A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action
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9. Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells
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10. Web-based design and analysis tools for CRISPR base editing
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11. A chemical-inducible CRISPR–Cas9 system for rapid control of genome editing
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12. Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway
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14. Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design
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15. Enhanced Cytosolic Delivery and Release of CRISPR/Cas9 by Black Phosphorus Nanosheets for Genome Editing
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16. Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease
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17. CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruzi
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18. Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
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20. Accelerated homologous recombination and subsequent genome modification in Drosophila
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21. Lentivirus pre-packed with Cas9 protein for safer gene editing
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23. A CRISPR toolbox to study virus–host interactions
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24. Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool
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25. CRISPR–Cas system enables fast and simple genome editing of industrial Saccharomyces cerevisiae strains
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26. Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
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27. TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity
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28. Genome Editing in Plants: Exploration of Technological Advancements and Challenges
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30. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9
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31. Knockout of two Bna MAX 1 homologs by CRISPR /Cas9‐targeted mutagenesis improves plant architecture and increases yield in rapeseed ( Brassica napus L.)
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32. CRISPR transcriptional repression devices and layered circuits in mammalian cells
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33. CRISPR-Cas3 induces broad and unidirectional genome editing in human cells
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34. CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
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35. Expanding the CRISPR imaging toolset withStaphylococcus aureusCas9 for simultaneous imaging of multiple genomic loci
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36. Potential high-frequency off-target mutagenesis induced by CRISPR/Cas9 in Arabidopsis and its prevention
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37. The CRISPR/Cas9 system and its applications in crop genome editing
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38. Synthetic CRISPR RNA-Cas9–guided genome editing in human cells
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39. CRISPR/Cas9 genome editing technology in filamentous fungi: progress and perspective
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40. Off-target predictions in CRISPR-Cas9 gene editing using deep learning
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41. Precise insertion and guided editing of higher plant genomes using Cpf1 CRISPR nucleases
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42. Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice
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43. Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing
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44. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
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45. Biallelic genome modification in F 0 Xenopus tropicalis embryos using the CRISPR/Cas system
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46. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis
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47. Therapeutic strategies for sickle cell disease: towards a multi-agent approach
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48. Development of CRISPR-Cas systems for genome editing and beyond
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49. Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9
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50. Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy
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51. CRISPR–Cas: a tool for cancer research and therapeutics
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52. Reversion of FMR1 methylation and silencing by editing the triplet repeats in Fragile X iPSC-derived neurons
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57. CRISPR/Cas9 in locusts: Successful establishment of an olfactory deficiency line by targeting the mutagenesis of an odorant receptor co-receptor (Orco)
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64. Functional validation of cadherin as a receptor of Bt toxin Cry1Ac in Helicoverpa armigera utilizing the CRISPR/Cas9 system
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73. CRISPR ‐LbCas12a‐mediated modification of citrus
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74. Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing
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77. Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells
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78. Efficient CRISPR/Cas9-Mediated Gene Editing in Arabidopsis thaliana and Inheritance of Modified Genes in the T2 and T3 Generations
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79. Effective gene targeting in rabbits using RNA-guided Cas9 nucleases
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80. Stable RNA interference rules for silencing
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81. The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells
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82. AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines
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83. Genome engineering using the CRISPR/Cas system
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84. Patterns of CRISPR/Cas9 activity in plants, animals and microbes
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85. CRISPR ribonucleoprotein-mediated genetic engineering in plants
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86. Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease
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87. CRISPR/Cas9-mediated genome editing and gene replacement in plants: Transitioning from lab to field
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88. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma
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89. Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system
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90. Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
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91. A general strategy to construct small molecule biosensors in eukaryotes
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92. A high-efficiency CRISPR/Cas9 system for targeted mutagenesis in Cotton (Gossypium hirsutum L.)
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93. CRISPR/Cas9-mediated mutagenesis of the dihydroflavonol-4-reductase-B (DFR-B) locus in the Japanese morning glory Ipomoea (Pharbitis) nil
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94. CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection
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95. Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
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96. Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity
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97. Efficient Targeted Genome Modification in Maize Using CRISPR/Cas9 System
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98. Cas9-mediated genome editing in the methanogenic archaeon Methanosarcina acetivorans
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99. Targeted Mutagenesis of the Tomato PROCERA Gene Using Transcription Activator-Like Effector Nucleases
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100. Precise Gene Deletion and Replacement Using the CRISPR/Cas9 System in Human Cells
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