High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

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6. Genome-wide CRISPR off-target prediction and optimization using RNA-DNA interaction fingerprints
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12. Genome Editing in Patient iPSCs Corrects the Most Prevalent USH2A Mutations and Reveals Intriguing Mutant mRNA Expression Profiles
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13. A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types
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19. CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line
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23. Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks
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25. Genome editing approaches to augment livestock breeding programs
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26. Newer Gene Editing Technologies toward HIV Gene Therapy
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27. CRISPR/Cas9-Mediated Deletion of CTG Expansions Recovers Normal Phenotype in Myogenic Cells Derived from Myotonic Dystrophy 1 Patients
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28. Concise Review: Assessing the Genome Integrity of Human Induced Pluripotent Stem Cells: What Quality Control Metrics?
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29. Hemophilia A ameliorated in mice by CRISPR-based in vivo genome editing of human Factor VIII
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30. Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System
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31. Broadening the GMO risk assessment in the EU for genome editing technologies in agriculture
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32. Coassembly of nucleus-targeting gold nanoclusters with CRISPR/Cas9 for simultaneous bioimaging and therapeutic genome editing
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33. CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective
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34. Programmable DNA looping using engineered bivalent dCas9 complexes
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35. The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex
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36. High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs
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37. Applications of CRISPR Genome Engineering in Cell Biology
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38. Highly efficient heritable targeted deletions of gene clusters and non-coding regulatory regions in Arabidopsis using CRISPR/Cas9
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39. Conferring DNA virus resistance with high specificity in plants using virus-inducible genome-editing system
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40. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
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41. Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application
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42. A fast and reliable strategy to generate TALEN-mediated gene knockouts in the diatom Phaeodactylum tricornutum
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43. Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
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44. CRISPR–Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics
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45. Evaluation of sgRNA Target Sites for CRISPR-Mediated Repression of TP53
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46. The new CRISPR–Cas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals
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47. A reversible haploid mouse embryonic stem cell biobank resource for functional genomics
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48. Development and Application of CRISPR/Cas in Microbial Biotechnology
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49. Plant synthetic biology for producing potent phyto-antimicrobials to combat antimicrobial resistance
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50. Precise Genome Editing of Drosophila with CRISPR RNA-Guided Cas9
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51. CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo
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52. Biosensing: CRISPR-powered diagnostics
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53. Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR–Cas9-mediated mutagenesis
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57. Reverse Transcriptase: From Transcriptomics to Genome Editing
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58. CRISPRoff enables spatio-temporal control of CRISPR editing
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59. Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy
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64. Mechanism of duplex DNA destabilization by RNA-guided Cas9 nuclease during target interrogation
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65. Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors
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68. Applications of CRISPR-Cas9 as an Advanced Genome Editing System in Life Sciences
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69. Direct Injection of CRISPR/Cas9-Related mRNA into Cytoplasm of Parthenogenetically Activated Porcine Oocytes Causes Frequent Mosaicism for Indel Mutations
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70. A Guide RNA Sequence Design Platform for the CRISPR/Cas9 System for Model Organism Genomes
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72. CRISPR-Cas9 technology: applications and human disease modelling
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75. Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona
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76. Non-GMO genetically edited crop plants
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77. Comparing Zinc Finger Nucleases and Transcription Activator-Like Effector Nucleases for Gene Targeting in Drosophila
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80. Targeted gene insertion into Z chromosome of chicken primordial germ cells for avian sexing model development
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81. Targeted Gene Manipulation in Plants Using the CRISPR/Cas Technology
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82. May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells
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84. Cattle with a precise, zygote-mediated deletion safely eliminate the major milk allergen beta-lactoglobulin
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85. Current strategies for Site-Directed RNA Editing using ADARs
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86. Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment
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87. Production of hypoallergenic milk from DNA-free beta-lactoglobulin (BLG) gene knockout cow using zinc-finger nucleases mRNA
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88. Stem cell-derived kidney organoids: engineering the vasculature
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89. Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System
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90. POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status
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92. Current Bioinformatics Tools to Optimize CRISPR/Cas9 Experiments to Reduce Off-Target Effects
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94. Determining the Specificities of TALENs, Cas9, and Other Genome-Editing Enzymes
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95. Anti‐HIV‐1 potency of the CRISPR/Cas9 system insufficient to fully inhibit viral replication
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96. New breeding technique “genome editing” for crop improvement: applications, potentials and challenges
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97. The applications of CRISPR /Cas system in molecular detection
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98. The impact of CRISPR–Cas9 on target identification and validation
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99. CRISPR/Cas9 gene-editing strategies in cardiovascular cells
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100. Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells
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