High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

Cited by (1,023)

Items 201–300 of 1,023

  1. Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
    Josh Tycko, Vic E. Myer, Patrick D. Hsu · 2016 · Molecular Cell
  2. Isolation of single-base genome-edited human iPS cells without antibiotic selection
    Yuichiro Miyaoka, Amanda H. Chan, Luke M. Judge, Jennie C. Yoo, Miller Huang, Trieu Nguyen, Paweena P. Lizarraga, Po-Lin So, Bruce R. Conklin · 2014 · Nature Methods
  3. CRISPR/Cas9-mediated efficient targeted mutagenesis in Chardonnay (Vitis vinifera L.)
    Chong Ren, Xianju Liu, Zhan Zhang, Yi Wang, Wei Duan, Shaohua Li, Zhenchang Liang · 2016 · Scientific Reports
  4. Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9
    Chul‐Yong Park, Duk Hyoung Kim, Jin Jea Sung, Jin Jea Sung, Jaehun Lee, Sangsu Bae, Dong‐Wook Kim, Dong‐Wook Kim, Jin‐Soo Kim · 2015 · Cell stem cell
  5. Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
    Zuckermann, Marc, Hovestadt, Volker, Knobbe-Thomsen, Christiane B., Zapatka, Marc, Northcott, Paul A., Schramm, Kathrin, Belic, Jelena, Jones, David T. W., Tschida, Barbara, Moriarity, Branden et al. · 2015 · Nature Communications
  6. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice
    Tomomi Aida, Keiho Chiyo, Takako Usami, Harumi Ishikubo, Risa Imahashi, Yusaku Wada, Kenji F. Tanaka, Tetsushi Sakuma, Takashi Yamamoto, Kohichi Tanaka · 2015 · Genome biology
  7. Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas
    Andrew A. Horwitz, Jessica M. Walter, Max G. Schubert, Stephanie H. Kung, Kristy M. Hawkins, Darren Platt, Aaron D. Hernday, Tina Mahatdejkul-Meadows, Wayne Szeto, Sunil S. Chandran et al. · 2015 · Cell Systems
  8. Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
    Maurice Labuhn, Felix F. Adams, Michelle Shu Wen Ng, Sabine Knoess, Axel Schambach, Emmanuelle Charpentier, Adrian Schwarzer, Juan Luis Mateo, Jan‐Henning Klusmann, Dirk Heckl · 2017 · Nucleic Acids Research
  9. Evolution of Resistance Against CRISPR/Cas9 Gene Drive
    Robert L. Unckless, Andrew G. Clark, Philipp W. Messer · 2016 · Genetics
  10. Targeting Hepatitis B Virus With CRISPR/Cas9
    Seeger, Christoph, Sohn, Ji A · 2014 · Molecular Therapy - Nucleic Acids
  11. CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections
    Ferdy R. van Diemen, Elisabeth M. Kruse, Marjolein J. G. Hooykaas, Carlijn E. Bruggeling, Anita C. Schürch, Petra M. van Ham, Saskia Marijke Imhof, Monique Nijhuis, Emmanuel J. H. J. Wiertz, Robert Jan Lebbink · 2016 · PLoS Pathogens
  12. One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
    He Huang, Guosong Zheng, Weihong Jiang, Haifeng Hu, Yinhua Lü · 2015 · Acta Biochimica et Biophysica Sinica
  13. High efficient multisites genome editing in allotetraploid cotton (Gossypium hirsutum) using CRISPR/Cas9 system
    Pengcheng Wang, Jun Zhang, Lin Sun, Yizan Ma, Jiao Xu, Sijia Liang, Jinwu Deng, Jiafu Tan, Qinghua Zhang, Lili Tu et al. · 2017 · Plant Biotechnology Journal
  14. Improving CRISPR-Cas specificity with chemical modifications in single-guide RNAs
    Ryan, Daniel E, Taussig, David, Steinfeld, Israel, Phadnis, Smruti M, Lunstad, Benjamin D, Singh, Madhurima, Vuong, Xuan, Okochi, Kenji D, McCaffrey, Ryan, Olesiak, Magdalena et al. · 2018 · Nucleic Acids Research
  15. orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants
    Waring Trible, Leonora Olivos-Cisneros, Sean K. McKenzie, Jonathan Saragosti, Ni‐Chen Chang, Benjamin John Matthews, Peter R. Oxley, Daniel J. C. Kronauer · 2017 · Cell
  16. A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9
    Lun Cui, A. Vigouroux, François Rousset, Hugo Varet, Varun Khanna, David Bikard · 2018 · Nature Communications
  17. CRISPR-Cas9: A Preclinical and Clinical Perspective for the Treatment of Human Diseases
    Garima Sharma, Ashish Ranjan Sharma, Manojit Bhattacharya, Sang‐Soo Lee, Chiranjib Chakraborty · 2020 · Molecular Therapy
  18. CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity
    Cícera Regina Lazzarotto, Nikolay L. Malinin, Yichao Li, Ruochi Zhang, Yang Yang, GaHyun Lee, Eleanor Cowley, Yanghua He, Xin Lan, Kasey Jividen et al. · 2020 · Nature Biotechnology
  19. Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases
    Young Hoon Sung, Jong Min Kim, Hyun-Taek Kim, Jaehoon Lee, Jisun Jeon, Young Jin, Jung-Hwa Choi, Young Ho Ban, Sang‐Jun Ha, Cheol‐Hee Kim et al. · 2013 · Genome Research
  20. CRISPR Crops: Plant Genome Editing Toward Disease Resistance
    Thorsten Langner, Sophien Kamoun, Khaoula Belhaj · 2018 · Annual Review of Phytopathology
  21. TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery
    Artem A. Nemudryi, Kamila R. Valetdinova, Sergey P. Medvedev, Suren M. Zakian · 2014 · Acta Naturae
  22. Synthetic biology in mammalian cells: next generation research tools and therapeutics
    Florian Lienert, Jason J. Lohmueller, Abhishek Dinkarnath Garg, Pamela A. Silver · 2014 · Nature Reviews Molecular Cell Biology
  23. Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line
    Patrick Essletzbichler, Tomasz Konopka, Federica Santoro, Doris Chen, Bianca V. Gapp, Róbert Královics, Thijn R. Brummelkamp, Sebastian M. B. Nijman, Tilmann Bürckstümmer · 2014 · Genome Research
  24. Next-generation stem cells — ushering in a new era of cell-based therapies
    Erin A. Kimbrel, Robert Lanza · 2020 · Nature Reviews Drug Discovery
  25. Novel CRISPR–Cas Systems: An Updated Review of the Current Achievements, Applications, and Future Research Perspectives
    Sweta Nidhi, Uttpal Anand, Patrik Olekšák, Pooja Tripathi, Jonathan A. Lal, George Thomas, Kamil Kuča, Vijay Shankar Tripathi · 2021 · International Journal of Molecular Sciences
  26. Brains, Genes, and Primates
    Juan Carlos Izpisúa Belmonte, Edward M. Callaway, Sarah J. Caddick, Patricia Smith Churchland, Guoping Feng, Gregg E. Homanics, Kuo‐Fen Lee, David A. Leopold, Cory Thomas Miller, Jude F. Mitchell et al. · 2015 · Neuron
  27. Structural basis for mismatch surveillance by CRISPR–Cas9
    Jack P. K. Bravo, Mu‐Sen Liu, Grace N. Hibshman, Tyler L. Dangerfield, Kyungseok Jung, Ryan S. McCool, Kenneth Allen Johnson, David Ward Taylor · 2022 · Nature
  28. CRISPR-Cas9 for cancer therapy: Opportunities and challenges
    Chen, Minjiang, Mao, Aiwu, Xu, Min, Weng, Qiaoyou, Mao, Jianting, Ji, Jiansong · 2019 · Cancer Letters
  29. Optical Control of CRISPR/Cas9 Gene Editing
    James Hemphill, Erin K. Borchardt, Kalyn A. Brown, Aravind Asokan, Alexander Deiters · 2015 · Journal of the American Chemical Society
  30. Genome modification by CRISPR /Cas9
    Yuanwu Ma, Lianfeng Zhang, Xingxu Huang · 2014 · FEBS Journal
  31. Efficient and Heritable Gene Targeting in Tilapia by CRISPR/Cas9
    Minghui Li, Hui‐Hui Yang, Jiue Zhao, Lingling Fang, Hongjuan Shi, Mengru Li, Yun-Lv Sun, Xianbo Zhang, Dongneng Jiang, Linyan Zhou et al. · 2014 · Genetics
  32. Streptococcus thermophilus CRISPR-cas9 systems enable specific editing of the human genome
    Müller, Maximilian, Lee, Ciaran M, Gasiunas, Giedrius, Davis, Timothy H, Cradick, Thomas J, Siksnys, Virginijus, Bao, Gang, Cathomen, Toni, Mussolino, Claudio · 2016 · Molecular Therapy
  33. Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
    Yuichiro Miyaoka, Jennifer R. Berman, Samantha Cooper, Steven J. Mayerl, Amanda H. Chan, Bin Zhang, George A. Karlin-Neumann, Bruce R. Conklin · 2016 · Scientific Reports
  34. Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
    Digvijay Singh, Samuel H. Sternberg, Jingyi Fei, Jennifer A. Doudna, Taekjip Ha · 2016 · Nature Communications
  35. Synthetic nucleases for genome engineering in plants: prospects for a bright future
    Holger Puchta, Friedrich Fauser · 2013 · The Plant Journal
  36. CRISPR technologies for genome, epigenome and transcriptome editing
    Lukas Villiger, Julia Joung, Luke W. Koblan, Jonathan S. Weissman, Omar O. Abudayyeh, Jonathan S. Gootenberg · 2024 · Nature Reviews Molecular Cell Biology
  37. An Efficient Genotyping Method for Genome-modified Animals and Human Cells Generated with CRISPR/Cas9 System
    Xiaoxiao Zhu, Yajie Xu, Shanshan Yu, Lu Lu, Mingqin Ding, Jing Cheng, Guoxu Song, Xing Gao, Liangming Yao, Dongdong Fan et al. · 2014 · Scientific Reports
  38. Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges
    Taha, Eman A., Lee, Joseph, Hotta, Akitsu · 2022 · Journal of Controlled Release
  39. Advances in therapeutic CRISPR/Cas9 genome editing
    Savić, Nataša, Schwank, Gerald · 2016 · Translational Research
  40. Promoterless gene targeting without nucleases ameliorates haemophilia B in mice
    Adi Barzel, Nicole K. Paulk, Yubin Shi, Y. Huang, Kirk C. Chu, Feijie Zhang, Paul N. Valdmanis, Laura P. Spector, Matthew Hebden Porteus, Karin M. L. Gaensler et al. · 2014 · Nature
  41. Multi‐input CRISPR/Cas genetic circuits that interface host regulatory networks
    Alec A. K. Nielsen, Christopher A. Voigt · 2014 · Molecular Systems Biology
  42. Human Germline Genome Editing
    Ormond, Kelly E., Mortlock, Douglas P., Scholes, Derek T., Bombard, Yvonne, Brody, Lawrence C., Faucett, W. Andrew, Garrison, Nanibaa’ A., Hercher, Laura, Isasi, Rosario, Middleton, Anna et al. · 2017 · The American Journal of Human Genetics
  43. Investigating human disease using stem cell models
    Jared L. Sterneckert, Peter Reinhardt, Hans Robert Schöler · 2014 · Nature Reviews Genetics
  44. Application of CRISPRi for prokaryotic metabolic engineering involving multiple genes, a case study: Controllable P(3HB-co-4HB) biosynthesis
    Li Lv, Yilin Ren, Jinchun Chen, Qiong Wu, Guo‐Qiang Chen · 2015 · Metabolic Engineering
  45. Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
    Yin, Hao, Song, Chun-Qing, Suresh, Sneha, Kwan, Suet-Yan, Wu, Qiongqiong, Walsh, Stephen, Ding, Junmei, Bogorad, Roman L, Zhu, Lihua Julie, Wolfe, Scot A et al. · 2018 · Nature Chemical Biology
  46. In vivo base editing of post-mitotic sensory cells
    Yeh, Wei-Hsi, Chiang, Hao, Rees, Holly A., Edge, Albert S. B., Liu, David R. · 2018 · Nature Communications
  47. Genome Editing with Engineered Nucleases in Plants
    Yuriko Osakabe, Keishi Osakabe · 2014 · Plant and Cell Physiology
  48. Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer
    Xiaoqing Zhou, Jige Xin, Nana Fan, Qingjian Zou, Jiao Huang, Zhen Ouyang, Yu Zhao, Bentian Zhao, Zhaoming Liu, Sisi Lai et al. · 2014 · Cellular and Molecular Life Sciences
  49. Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells
    Wu, Yuxuan, Zhou, Hai, Fan, Xiaoying, Zhang, Ying, Zhang, Man, Wang, Yinghua, Xie, Zhenfei, Bai, Meizhu, Yin, Qi, Liang, Dan et al. · 2015 · Cell Research
  50. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
    Chen, Yongchang, Zheng, Yinghui, Kang, Yu, Yang, Weili, Niu, Yuyu, Guo, Xiangyu, Tu, Zhuchi, Si, Chenyang, Wang, Hong, Xing, Ruxiao et al. · 2015 · Human Molecular Genetics
  51. Cas9 versus Cas12a/Cpf1: Structure–function comparisons and implications for genome editing
    Swarts, Daan C., Jinek, Martin · 2018 · WIREs RNA
  52. Potential pitfalls of CRISPR/Cas9‐mediated genome editing
    Peng, Rongxue, Lin, Guigao, Li, Jinming · 2016 · The FEBS Journal
  53. The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells
    Ciaran M. Lee, Thomas James Cradick, Gang Bao · 2016 · Molecular Therapy
  54. Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
    Kwon, Deborah Y., Zhao, Ying-Tao, Lamonica, Janine M., Zhou, Zhaolan · 2017 · Nature Communications
  55. Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
    Michelle L. Luo, Adam S. Mullis, Ryan T. Leenay, Chase L. Beisel · 2014 · Nucleic Acids Research
  56. Review of CRISPR/Cas9 sgRNA Design Tools
    Yingbo Cui, Jiaming Xu, Minxia Cheng, Xiangke Liao, Shaoliang Peng · 2018 · Interdisciplinary Sciences Computational Life Sciences
  57. High-throughput mapping of regulatory DNA
    Rajagopal, Nisha, Srinivasan, Sharanya, Kooshesh, Kameron, Guo, Yuchun, Edwards, Matthew D, Banerjee, Budhaditya, Syed, Tahin, Emons, Bart J M, Gifford, David K, Sherwood, Richard I · 2016 · Nature Biotechnology
  58. Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice
    Li, Ling, Song, Linjiang, Liu, Xiaowei, Yang, Xi, Li, Xia, He, Tao, Wang, Ning, Yang, Suleixin, Yu, Chuan, Yin, Tao et al. · 2017 · ACS Nano
  59. In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges
    Rubul Mout, Moumita Ray, Yi-Wei Lee, Federica Scaletti, Vincent M. Rotello · 2017 · Bioconjugate Chemistry
  60. Development of Commercial Thermo-sensitive Genic Male Sterile Rice Accelerates Hybrid Rice Breeding Using the CRISPR/Cas9-mediated TMS5 Editing System
    Hai L. Zhou, Ming He, Jing Li, Liang Chen, Zhihao Huang, Shaoyan Zheng, Liya Zhu, Erdong Ni, Dagang Jiang, Bingran Zhao et al. · 2016 · Scientific Reports
  61. CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo
    Hong Chang, Bin Yi, Ruixia Ma, Xiaoguo Zhang, Hongyou Zhao, Yaguang Xi · 2016 · Scientific Reports
  62. Targeted mutagenesis in chicken using CRISPR/Cas9 system
    Isao Oishi, Kyoko Yoshii, Daichi Miyahara, Hiroshi KAGAMI, Takahiro Tagami · 2016 · Scientific Reports
  63. Genome editing with the CRISPR‐Cas system: an art, ethics and global regulatory perspective
    Debin Zhang, Amjad Hussain, Hakim Manghwar, Kabin Xie, Shengsong Xie, Shuhong Zhao, Robert M. Larkin, Ping Qing, Shuangxia Jin, Fang Ding · 2020 · Plant Biotechnology Journal
  64. iPS cell technologies: significance and applications to CNS regeneration and disease
    Hideyuki Okano, Shinya Yamanaka · 2014 · Molecular Brain
  65. New applications of synthetic biology tools for cyanobacterial metabolic engineering
    Santos-Merino, María, Singh, Amit K., Ducat, Daniel C. · 2019 · Frontiers in Bioengineering and Biotechnology
  66. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects
    Yuanpeng Gao, Haibo Wu, Yongsheng Wang, Xin Liu, Linlin Chen, Qian Li, Chenchen Cui, Xu Liu, Jingcheng Zhang, Yong Zhang · 2017 · Genome biology
  67. Selection of highly efficient sgRNAs for CRISPR/Cas9-based plant genome editing
    Gang Liang, Huimin Zhang, Dengji Lou, Diqiu Yu · 2016 · Scientific Reports
  68. CRISPR-Cas9 and CRISPR-Cpf1 mediated targeting of a stomatal developmental gene EPFL9 in rice
    Xiaojia Yin, Akshaya Kumar Biswal, Jacqueline Dionora, Kristel M. Perdigon, Christian Paolo Balahadia, Shamik Mazumdar, Caspar Chater, Hsiang‐Chun Lin, Robert A. Coe, Tobias Kretzschmar et al. · 2017 · Plant Cell Reports
  69. Generation of inheritable and “transgene clean” targeted genome-modified rice in later generations using the CRISPR/Cas9 system
    Rongfang Xu, Hao Li, Ruiying Qin, Juan Li, Chun-Hong Qiu, Ya-Chun Yang, Hui Ma, Li Li, Pengcheng Wei, Jian-Bo Yang · 2015 · Scientific Reports
  70. Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
    Singh, Ritambhara, Kuscu, Cem, Quinlan, Aaron, Qi, Yanjun, Adli, Mazhar · 2015 · Nucleic Acids Research
  71. A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
    O'Geen, Henriette, Henry, Isabelle M., Bhakta, Mital S., Meckler, Joshua F., Segal, David J. · 2015 · Nucleic Acids Research
  72. Chromatin accessibility and guide sequence secondary structure affect CRISPR ‐Cas9 gene editing efficiency
    Jensen, Kristopher Torp, Fløe, Lasse, Petersen, Trine Skov, Huang, Jinrong, Xu, Fengping, Bolund, Lars, Luo, Yonglun, Lin, Lin · 2017 · FEBS Letters
  73. Targeted mutagenesis using CRISPR/Cas system in medaka
    Satoshi Ansai, Masato Kinoshita · 2014 · Biology Open
  74. Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum
    Jeffrey C. Wagner, Randall J. Platt, Stephen J. Goldfless, Feng Zhang, Jacquin C. Niles · 2014 · Nature Methods
  75. CRISPR‐Cas9 Genome Editing in Drosophila
    Scott J. Gratz, Clifford Dustin Rubinstein, Melissa M. Harrison, Jill Wildonger, Kate M. O’Connor-Giles · 2015 · Current Protocols in Molecular Biology
  76. mRNA transcript therapy
    Weissman, Drew · 2015 · Expert Review of Vaccines
  77. Retinal stem cell transplantation: Balancing safety and potential
    Mandeep S. Singh, Susanna S. Park, Thomas Arno Albini, M. Valeria Canto-Soler, Henry J. Klassen, Robert Edward MacLaren, Masayo Takahashi, Aaron Nagiel, Steven D. Schwartz, Kapil Bharti · 2019 · Progress in Retinal and Eye Research
  78. Efficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase
    Tao Xu, Yongchao Li, Zhou Jason Shi, Christopher L. Hemme, Yuan Li, Yonghua Zhu, Joy D. Van Nostrand, Zhili He, Jizhong Z. Zhou · 2015 · Applied and Environmental Microbiology
  79. CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells
    Hoban, Megan D, Lumaquin, Dianne, Kuo, Caroline Y, Romero, Zulema, Long, Joseph, Ho, Michelle, Young, Courtney S, Mojadidi, Michelle, Fitz-Gibbon, Sorel, Cooper, Aaron R et al. · 2016 · Molecular Therapy
  80. Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease
    Wataru Fujii, Kurenai Kawasaki, Koji Sugiura, Kunihiko Naito · 2013 · Nucleic Acids Research
  81. The Impact of Plant-Parasitic Nematodes on Agriculture and Methods of Control
    Gregory C. Bernard, Marceline Egnin, C.K. Bonsi · 2017 · InTech eBooks
  82. CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank
    Geurts, Maarten H., de Poel, Eyleen, Amatngalim, Gimano D., Oka, Rurika, Meijers, Fleur M., Kruisselbrink, Evelien, van Mourik, Peter, Berkers, Gitte, de Winter-de Groot, Karin M., Michel, Sabine et al. · 2020 · Cell Stem Cell
  83. Biological plasticity rescues target activity in CRISPR knock outs
    Smits, Arne H., Ziebell, Frederik, Joberty, Gerard, Zinn, Nico, Mueller, William F., Clauder-Münster, Sandra, Eberhard, Dirk, Fälth Savitski, Maria, Grandi, Paola, Jakob, Petra et al. · 2019 · Nature Methods
  84. Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system
    Masafumi Inui, Mami Miyado, Maki Igarashi, Moe Tamano, Atsushi Kubo, Satoshi Yamashita, Hiroshi Asahara, Maki Fukami, Shuji Takada · 2014 · Scientific Reports
  85. CRISPR/Cas9 advances engineering of microbial cell factories
    Tadas Jakočiūnas, Michael Krogh Jensen, Jay D. Keasling · 2015 · Metabolic Engineering
  86. An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
    Jian Ping Cao, Lizhen Wu, Shang‐Min Zhang, Min Lu, William K.C. Cheung, Wesley L. Cai, Molly Gale, Qi Xu, Qin Yan · 2016 · Nucleic Acids Research
  87. Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
    Weixin Tang, Johnny H. Hu, David R. Liu · 2017 · Nature Communications
  88. Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases
    Bloom, Kristie, Ely, Abdullah, Mussolino, Claudio, Cathomen, Toni, Arbuthnot, Patrick · 2013 · Molecular Therapy
  89. Enabling plant synthetic biology through genome engineering
    Nicholas J. Baltes, Daniel F. Voytas · 2014 · Trends in biotechnology
  90. Transgenic Mouse Models in Cancer Research
    Urša Lampreht Tratar, Simon Horvat, Maja Čemažar · 2018 · Frontiers in Oncology
  91. Application of CRISPR/Cas9 in Crop Quality Improvement
    Qier Liu, Fan Yang, Jingjuan Zhang, Hang Liu, Shanjida Rahman, Shahidul Islam, Wujun Ma, Maoyun She · 2021 · International Journal of Molecular Sciences
  92. Multigene Knockout Utilizing Off-Target Mutations of the CRISPR/Cas9 System in Rice
    M. Endo, Masafumi Mikami, Seiichi Toki · 2014 · Plant and Cell Physiology
  93. The Functions and Unique Features of LncRNAs in Cancer Development and Tumorigenesis
    Kenzui Taniue, Nobuyoshi Akimitsu · 2021 · International Journal of Molecular Sciences
  94. CRISPR/Cas9 and Genome Editing in Drosophila
    Andrew Roger Bassett, Ji‐Long Liu · 2013 · Journal of genetics and genomics/Journal of Genetics and Genomics
  95. Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer Cells
    Zheng Hu, Lan Yu, Da Zhu, Wencheng Ding, Xiaoli Wang, Changlin Zhang, Liming Wang, Xiaohui Jiang, Hui Shen, Dan He et al. · 2014 · BioMed Research International
  96. Breaking-Cas—interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes
    Juan Carlos Oliveros, Mònica Franch, Daniel Tabas‐Madrid, David San León, Lluı́s Montoliu, Pilar Cubas, Florencio Pazos · 2016 · Nucleic Acids Research
  97. Spontaneous immortalization of chicken fibroblasts generates stable, high-yield cell lines for serum-free production of cultured meat
    Laura Pasitka, Merav Cohen, Avner Ehrlich, Boaz Gildor, E. Reuveni, Muneef Ayyash, G. Wissotsky, A. Herscovici, R. Kaminker, A. Niv et al. · 2022 · Nature Food
  98. Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system
    Xiaolong Wang, Honghao Yu, Anmin Lei, Jiankui Zhou, Wenxian Zeng, Haijing Zhu, Zhiming Dong, Yiyuan Niu, Bingbo Shi, Bei Cai et al. · 2015 · Scientific Reports
  99. Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq
    Kim, Daesik, Kim, Sojung, Kim, Sunghyun, Park, Jeongbin, Kim, Jin-Soo · 2016 · Genome Research
  100. CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
    Wenyan Jiang, Luciano A. Marraffini · 2015 · Annual Review of Microbiology