Protein-protein interaction networks and biology—what's the connection?
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Network edges are susceptible to ascertainment biases and confounding factors that can induce spurious relationships.
“Notably, edges are susceptible to ascertainment biases52,214,215 and confounding factors that can induce spurious relationships178 (FIG. 2b).”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [52]
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Network medicine: an approach to complex kidney disease phenotypes
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Systems biology and gene networks in Alzheimer’s disease
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Simulated Evolution of Protein-Protein Interaction Networks with Realistic Topology
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GRAPE: graph-regularized protein language modeling unlocks TCR-epitope binding specificity
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Accurate multiple network alignment through context-sensitive random walk
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Rigid-Docking Approaches to Explore Protein–Protein Interaction Space
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- Authors
- Hakes, L., Pinney, J. W., Robertson, D. L., & Lovell, S. C.
- Affiliations
- University of Manchester (GB)
- Venue
- Nature Biotechnology
- Published
- 2008-01
- Volume
- 26
- Issue
- 1
- Pages
- 69-72
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2165160727
- Cited by
- 200
- References
- 37
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 7 · 2023: 12 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 9 · 2017: 15 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 17 · 2012: 16
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (BB/F007620/1, BB/C515412/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- protein-protein interaction network, network analysis
- MeSH terms
- Algorithms, Binding Sites, Biology, Protein Binding, Sensitivity and Specificity, Signal Transduction, Information Storage and Retrieval, Artifacts, Proteome, Protein Interaction Mapping
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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