Cited by 279CRISPR and Genetic EngineeringGenetically Modified Organisms ResearchTransgenic Plants and Applications

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With a free pass, CRISPR-edited plants reach market in record time

Waltz, Emily·2018·Nature Biotechnology

DOI 10.1038/nbt0118-6b

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BackgroundInfluential
A status-quo review on CRISPR-Cas9 gene editing applications in tomato
Chandrasekaran, M., Boopathi, T., & Manivannan, P. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.169 · Cited by 45
CRISPR technology towards genome editing of the perennial and semi-perennial crops citrus, coffee and sugarcane
Prado, G. S., Rocha, D. C., dos Santos, L. N., Contiliani, D. F., Nóbile, P. M., Martinati, J. C., Padilha, L., Maluf, M. P., Lubini, G., Pereira, T. C., et al. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1331258 · Cited by 47
“…is worth remarking that, despite the groundbreaking application of CRISPR in molecular plant breeding, only a few CRISPR-based crops have been approved for commercialization, such as soybean (Waltz, 2018), canola (Waltz, 2018), maize (Waltz, 2016), tomato (Waltz, 2022), and camelina (Waltz, 2018).”
Background
Delivery of CRISPR/Cas Components into Higher Plant Cells for Genome Editing
Кулуев, Б. Р., Гумерова, Г. Р., Mikhaylova, E. V., Геращенков, Г. А., Rozhnova, N. A., Vershinina, Z. R., Khyazev, A. V., Matniyazov, R. T., Baymiev, A. K., Baymiev, A. K., et al. (2019) · Russian Journal of Plant Physiology · doi:10.1134/s102144371905011x · Cited by 41
CRISPR-Cas-Led Revolution in Diagnosis and Management of Emerging Plant Viruses: New Avenues Toward Food and Nutritional Security
Sharma, S. K., Gupta, O. P., Pathaw, N., Sharma, D., Maibam, A., Sharma, P., Sanasam, J., Karkute, S. G., Kumar, S., & Bhattacharjee, B. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.751512 · Cited by 43
How do consumers respond to labels for crispr (gene-editing)?
Hu, Y., House, L., & Gao, Z. (2022) · Food Policy · doi:10.1016/j.foodpol.2022.102366 · Cited by 38
Multi-faceted CRISPR-Cas9 strategy to reduce plant based food loss and waste for sustainable bio-economy – A review
Palanivel, H., Abda, E. M., Shah, S., Prabhu, S. V., Jayakumar, M., Karmegam, N., Kim, W., & Govarthanan, M. (2023) · Journal of Environmental Management · doi:10.1016/j.jenvman.2023.117382 · Cited by 42
Genome-editing technologies: the gap between application and policy
Li, G., Liu, Y., & Chen, Y. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-1566-1 · Cited by 38
“The USA and Japan have adopted registration and recording systems that allow transgene-free GECs to be commercially cultivated and sold free from regulation (Waltz, 2018; https://r.nikkei.com/article/ DGXMZO49807430T10C19A9000000?s=4).”
Background
Epigenetic Footprints of CRISPR/Cas9-Mediated Genome Editing in Plants
Lee, J. H., Mazarei, M., Pfotenhauer, A. C., Dorrough, A. B., Poindexter, M. R., Hewezi, T., Lenaghan, S. C., Graham, D. E., & Stewart, C. N. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01720 · Cited by 39
“Frontiers in Plant Science | www.frontiersin Edited by: Nicola Joan Patron, Earlham Institute, United Kingdom Reviewed by: Holger Puchta, Karlsruhe Institute of Technology (KIT), Germany Kan Wang, Iowa State University, United States *Correspondence: C. Neal Stewart Jr. nealstewart@utk.edu Specialty section: This arti…”
BackgroundInfluential
Gene Editing Technologies for Sugarcane Improvement: Opportunities and Limitations
Mohan, C., Easterling, M., & Yau, Y. (2021) · Sugar Tech · doi:10.1007/s12355-021-01045-8 · Cited by 36
CRISPR/Cas9‐Based Genome Editing and its Applications for Functional Genomic Analyses in Plants
Li, J., Li, Y., & Ma, L. (2019) · Small Methods · doi:10.1002/smtd.201800473 · Cited by 36
Principles of Nanoparticle Design for Genome Editing in Plants
Sharma, P., & Lew, T. T. S. (2022) · Frontiers in Genome Editing · doi:10.3389/fgeed.2022.846624 · Cited by 35
“, 2019), the rulings by United States and Japan to relax the regulations for genome-edited crops signaled a positive atmosphere which could lead to less restrictive regulatory purviews worldwide (Waltz, 2018).”
Background
A rice gene encoding glycosyl hydrolase plays contrasting roles in immunity depending on the type of pathogens
Kim, C., Park, J. Y., Choi, G., Kim, S., Vo, K. T. X., Jeon, J., Kang, S., & Lee, Y. (2021) · Molecular Plant Pathology · doi:10.1111/mpp.13167 · Cited by 33
“…against diverse pathogens and pests but also expedite targeted modifications of specific genes to enhance resistance against a wide range of pathogens without triggering the regulatory processes associated with releasing genetically modified crops (Kanchiswamy et al., 2015; Waltz, 2016, 2018).”
Background
Show me the benefits! Determinants of behavioral intentions towards CRISPR in the United States
Baum, C., Kamrath, C., Bröring, S., & de Steur, H. (2023) · Food Quality and Preference · doi:10.1016/j.foodqual.2023.104842 · Cited by 28
Latest biotechnology tools and targets for improving abiotic stress tolerance in protein legumes
Détain, A., Bhowmik, P., Leborgne‐Castel, N., & Ochatt, S. (2022) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2022.104824 · Cited by 33
CRISPR-Cas9 mediated understanding of plants’ abiotic stress-responsive genes to combat changing climatic patterns
Choudry, M. W., Riaz, R., Nawaz, P., Ashraf, M., Ijaz, B., & Bakhsh, A. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01405-z · Cited by 31
“Though, some of the promising genome-edited crop lines using the CRISPR toolset are in the commercialization process such as drought and salt-tolerant soybeans developed by disrupting the Drb2a and Drb2b genes using CRISPR have been approved by USDA (Waltz 2018).”
Resolving Neurodevelopmental and Vision Disorders Using Organoid Single-Cell Multi-omics
Brancati, G., Treutlein, B., & Camp, J. G. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.001 · Cited by 32
CRISPR/Cas-mediated germplasm improvement and new strategies for crop protection
Dong, G., & Fan, Z. (2024) · Crop Health · doi:10.1007/s44297-023-00020-x · Cited by 28
“This encompasses edited variants like bristlegrass, mushroom, canola oil from herbicide-tolerant Canola plant, starch from waxy maize, and high oleic acid soybean oil from Calyno soybean [133, 134].”
Strategies for Engineering Reproductive Sterility in Plantation Forests
Fritsche, S., Klocko, A. L., Boron, A. K., Brunner, A. M., & Thorlby, G. J. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01671 · Cited by 28
ROLE OF CRISPR TO IMPROVE ABIOTIC STRESS TOLERANCE IN CROP PLANTS
Farooq, M., Bashir, M., Khan, M., Iqbal, B., & Ali, Q. (2021) · Biological and Clinical Sciences Research Journal · doi:10.54112/bcsrj.v2021i1.69 · Cited by 26
“When opposed to traditional genetically modified plants, such improved plants can also be used in development programs, as well as the resulting plants can be used immediately with fewer acceptability or consumption problems and fewer regulatory procedures (Waltz, 2018).”
Background
CRISPR-Cas9 in agriculture: Approaches, applications, future perspectives, and associated challenges
Adhikari, P., & Poudel, M. (2020) · Malaysian Journal of Halal Research · doi:10.2478/mjhr-2020-0002 · Cited by 23
“These improved crops can be used in breeding programs and resulting varieties can be used directly with relatively lesser consumption issues and lesser regulatory procedures as compared to transgenic crops/ conventional genetically modified (GM) crops[12].”
Background
Genome Editing: Revolutionizing the Crop Improvement
Saurabh, S. (2021) · Plant Molecular Biology Reporter · doi:10.1007/s11105-021-01286-7 · Cited by 29
“…oleic soybean variety, and the CRISPR-edited anti-browning button mushroom, waxy corn, green bristlegrass with delayed flowering, false flax with increased omega-3 oil content, and drought- and salt-tolerant soybean has reach market will also not be subject to regulatory evaluation (Waltz 2018).”
Background
CRISPR/Cas9-Edited Rice: A New Frontier for Sustainable Agriculture
Mehta, S., Lal, S. K., Sahu, K. P., Venkatapuram, A. K., Kumar, M., Sheri, V., Panditi, V., Vishwakarma, C., Yadav, R., Jameel, M. R., et al. (2020) · Springer eBooks · doi:10.1007/978-981-15-1322-0_23 · Cited by 27
Pathway Editing Targets for Thiamine Biofortification in Rice Grains
Minhas, A. P., Tuli, R., & Puri, S. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00975 · Cited by 26
“Two CRISPR-Cas9 edited plants (white button mushroom resistant to browning and Camelina sativa with enhanced omega-3 oil content) have been de-regulated in the US market (Waltz, 2016, 2018).”
Background
CRISPR activation: identifying and using novel genes for plant disease resistance breeding
McLaughlin, J. E., Foka, I. C. K., Lawton, M. A., & Di, R. (2025) · Frontiers in Genome Editing · doi:10.3389/fgeed.2025.1596600 · Cited by 28
A contingent valuation analysis for assessing the market for genetically modified planting materials among banana producing households in Uganda
Kikulwe, E., & Asindu, M. (2020) · GM crops & food · doi:10.1080/21645698.2020.1720498 · Cited by 25
Shotguns vs Lasers: Identifying barriers and facilitators to scaling-up plant molecular farming for high-value health products
Menary, J., Hobbs, M., de Albuquerque, S. M., Pacho, A., Drake, P. M. W., Prendiville, A., K‐C., J., & Fuller, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229952 · Cited by 24
“In the United States and other countries in the Americas, crops bred with NPBTs have found relatively quick routes to market where regulation is no stricter than for conventionally-bred crops [43].”
Functional Analysis of the teosinte branched 1 Gene in the Tetraploid Switchgrass (Panicum virgatum L.) by CRISPR/Cas9-Directed Mutagenesis
Liu, Y., Wang, W., Yang, B., Currey, C. J., & Fei, S. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.572193 · Cited by 23
“Germplasm generated through CRISPR/Cas9-based genome editing method without foreign DNAs may bypass or simplify the regulatory process required for crops created with traditional transgenic approaches (Waltz, 2018).”
Background
Global role of plant breeding in tackling climate change
Begna, T. C. (2017) · International Journal of Agricultural Science and Food Technology · doi:10.17352/2455-815x.000111 · Cited by 23

Authors: Waltz, E.
Corresponding author: Waltz, Emily
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2018-01
Volume: 36
Issue: 1
Pages: 6-7
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt0118-6b
OpenAlex: W2783502825
Cited by: 279
References: 5
Citations by year: 2026: 18 · 2025: 21 · 2024: 34 · 2023: 28 · 2022: 35 · 2021: 40 · 2020: 43 · 2019: 38 · 2018: 21
Type: other
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
Keywords: CRISPR gene editing, regulatory approval, commercialization, medicinal plants, plant biotechnology regulation
MeSH terms: Gene Editing, Genome, Plant, Camellia, Plants, Genetically Modified, CRISPR-Cas Systems

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