Cited by 1,314biodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applicationsPolymer Surface Interaction Studies

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A tough biodegradable elastomer

Wang, Yadong, Ameer, Guillermo A., Sheppard, Barbara J., Langer, Robert·2002·Nature Biotechnology

DOI 10.1038/nbt0602-602

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Abstract

Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility with cells and tissues. A strong, biodegradable, and biocompatible elastomer could be useful for fields such as tissue engineering, drug delivery, and in vivo sensing. We designed, synthesized, and characterized a tough biodegradable elastomer from biocompatible monomers. This elastomer forms a covalently crosslinked, three-dimensional network of random coils with hydroxyl groups attached to its backbone. Both crosslinking and the hydrogen-bonding interactions between the hydroxyl groups likely contribute to the unique properties of the elastomer. In vitro and in vivo studies show that the polymer has good biocompatibility. Polymer implants under animal skin are absorbed completely within 60 days with restoration of the implantation sites to their normal architecture.

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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
Hansen, M., Nielsen, S. E., & Berg, K. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90397-9 · Cited by 3,488
Introduction to Physical Polymer Science
Sperling, L. H. (2005) · doi:10.1002/0471757128 · Cited by 2,917
Advanced organic chemistry
Boyd, D. R. (1993) · Endeavour · doi:10.1016/0160-9327(93)90217-q · Cited by 1,928
New Challenges in Biomaterials
Peppas, N. A., & Langer, R. (1994) · Science · doi:10.1126/science.8134835 · Cited by 1,163
Self-citation
Science and technology of rubber
(1995) · Choice Reviews Online · doi:10.5860/choice.32-2771 · Cited by 954
Handbook of Biodegradable Polymers
(1998) · CRC Press eBooks · doi:10.1201/9780367802219 · Cited by 712
Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering
Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00051-5 · Cited by 709
Fibrillar Structure and Mechanical Properties of Collagen
Fratzl, P., Misof, K., Žižak, I., Rapp, G., Amenitsch, H. W., & Bernstorff, S. (1998) · Journal of Structural Biology · doi:10.1006/jsbi.1998.3966 · Cited by 667
Introduction to physical polymer science
Sherrington, D. C. (1993) · Reactive Polymers · doi:10.1016/0923-1137(93)90096-x · Cited by 665
Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration
West, J. L., & Hubbell, J. A. (1998) · Macromolecules · doi:10.1021/ma981296k · Cited by 635

Show all 45 references

Research works printed but not linked: 3

Voet, D. & Voet, J.G. Biochemistry (John Wiley & Sons, New York, 1995).
Stryer, L. Biochemistry (W.H. Freeman and Company, New York; 1995).
Northup, S.J. & Cammack, J.N. Handbook of biomaterials evaluation (ed. von Recum, A.F.) 325–339 (Taylor & Francis, Philadelphia; 1999).

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“Sebacic acid is an intermediate in fatty acid oxidation [52].”
Background
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Park, H., Cannizzaro, C., Vunjak‐Novakovic, G., Langer, R., Vacanti, C. A., & Farokhzad, O. C. (2007) · Tissue Engineering · doi:10.1089/ten.2007.13.ft-353 · Cited by 8
Self-citation
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Krupke, H., Zoratto, N., Rabut, L., Gao, D., Paunović, N., Cerrejon, D. K., Dehapiot, B., & Leroux, J. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113947 · Cited by 7
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Piszko, P. J., Kryszak, B., Gazińska, M. A., Słota, D., Sobczak‐Kupiec, A., Włodarczyk, M., Szwed, A., Rudnicka, K., & Szustakiewicz, K. (2023) · Ceramics International · doi:10.1016/j.ceramint.2023.05.071 · Cited by 7
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“Sebacic acid can also be found naturally in some plants, such as castor oil [ 42, 43 ].”
Poly(glycerol sebacate)-based soft-tissue-mimicked active layers for triboelectric nanogenerators
Timusk, M., Nirwan, V. P., Lapčinskis, L., et al. (2024) · Journal of Materials Science · doi:10.1007/s10853-024-09588-3 · Cited by 7
“PGS can exhibit a range of Young’s modulus values of 0.04–2.3 MPa, depending on the degree of crosslinking [11, 15, 16].”
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Optimizing the conditions of PGSu synthesis with simplex method
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“Initially, PGS was obtained in the form of an elastomer, but subsequent modiﬁcations of the synthesis parameters (temperature, time, pressure) allowed to obtain also waxes and resin (Loh et al., 2015; Wang et al., 2002a; Wang et al., 2002b).”
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Ruther, F., Zimmermann, A., Engel, F. B., et al. (2019) · Advanced Engineering Materials · doi:10.1002/adem.201900986 · Cited by 7
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Strandman, S., & Zhu, X. X. (2015) · Elsevier eBooks · doi:10.1016/b978-0-85709-698-2.00011-8 · Cited by 7
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Scaffolds and Fluid Flow in Cardiac Tissue Engineering
Radisic, M., Cannizzaro, C., & Vunjak‐Novakovic, G. (2006) · FDMP: Fluid Dynamics & Materials Processing · doi:10.3970/fdmp.2006.002.001 · Cited by 7
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Matloubi, M., Sarem, M., Heck, B., Reiter, G., & Shastri, V. P. (2023) · Matter · doi:10.1016/j.matt.2023.05.021 · Cited by 7
Poly(glycerol sebacate): A Comparative Study of Various Synthesis Methods
Andrä-Żmuda, S., Chaber, P., Maksymiak, M. M., et al. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c01548 · Cited by 6
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Chen, Y. G., Dombaxe, C. P., D’Amato, A. R., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122598 · Cited by 6
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Authors: Wang, Y., Ameer, G. A., Sheppard, B. J., & Langer, R.
Affiliations: Massachusetts Institute of Technology (US)
Northwestern University (US)
ORCID: Wang, Yadong
Ameer, Guillermo A.
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2002-06
Volume: 20
Issue: 6
Pages: 602-606
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt0602-602
OpenAlex: W1994054444
Cited by: 1,314
References: 45
Citations by year: 2026: 27 · 2025: 56 · 2024: 59 · 2023: 60 · 2022: 65 · 2021: 78 · 2020: 77 · 2019: 76 · 2018: 73 · 2017: 65 · 2016: 66 · 2015: 66 · 2014: 79 · 2013: 66 · 2012: 67
FWCI: 8.56
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (5-R01-HL60435, R01HL060435)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords: biodegradable elastomers, tough polymers, biocompatibility, covalent cross-linking, hydrogen bonding, hydroxyl groups, tissue engineering, drug delivery, in vivo sensing, polymer implants, biodegradation
MeSH terms: Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Biocompatible Materials, Decanoates, Decanoic Acids, Dicarboxylic Acids, Elasticity, Female, Glycerol, Materials Testing, Models, Molecular, Polyglycolic Acid, Polymers, Skin, Stress, Mechanical, Tensile Strength, 3T3 Cells, Lactic Acid, Absorbable Implants, Elastomers, Mice, Rats

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A tough biodegradable elastomer

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