The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A tough biodegradable elastomer
Abstract
Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility with cells and tissues. A strong, biodegradable, and biocompatible elastomer could be useful for fields such as tissue engineering, drug delivery, and in vivo sensing. We designed, synthesized, and characterized a tough biodegradable elastomer from biocompatible monomers. This elastomer forms a covalently crosslinked, three-dimensional network of random coils with hydroxyl groups attached to its backbone. Both crosslinking and the hydrogen-bonding interactions between the hydroxyl groups likely contribute to the unique properties of the elastomer. In vitro and in vivo studies show that the polymer has good biocompatibility. Polymer implants under animal skin are absorbed completely within 60 days with restoration of the implantation sites to their normal architecture.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many medical devices are implanted in the dynamic mechanical environment of the human body. They need to adapt to states of continuous relaxation and contraction to maintain their own performance without mechanical stimulation of the surrounding tissues [14,15].”
From Synthesis of Poly(l-lactide-co-ε-caprolactone) Copolymer: Structure, Toughness, and Elasticity (2021) · cites this paper as [14]
In the citing paper
“For example, while PCLA copolymers attained UTS levels above 30 MPa, poly(glycerol sebacate) (PGS) exhibited a tensile strength slightly above 0.5 MPa [15].”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
In the citing paper
“As reported [15], PGS has a Young's modulus of around 0.3 MPa, an ultimate tensile strength above 0.5 MPa and attains elongation at break values slightly below 350%.”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
In the citing paper
“Furthermore, as reported [15], PGS is fully amorphous at body temperature, with no glass transition temperatures being observed above 80 1 C.”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
Citations
Cites
Hansen, M., Nielsen, S. E., & Berg, K. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90397-9 · Cited by 3,488
Introduction to Physical Polymer Science
Sperling, L. H. (2005) · doi:10.1002/0471757128 · Cited by 2,917
Boyd, D. R. (1993) · Endeavour · doi:10.1016/0160-9327(93)90217-q · Cited by 1,928
New Challenges in Biomaterials
Peppas, N. A., & Langer, R. (1994) · Science · doi:10.1126/science.8134835 · Cited by 1,163
Self-citationScience and technology of rubber
(1995) · Choice Reviews Online · doi:10.5860/choice.32-2771 · Cited by 954
Handbook of Biodegradable Polymers
(1998) · CRC Press eBooks · doi:10.1201/9780367802219 · Cited by 712
Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00051-5 · Cited by 709
Fibrillar Structure and Mechanical Properties of Collagen
Fratzl, P., Misof, K., Žižak, I., Rapp, G., Amenitsch, H. W., & Bernstorff, S. (1998) · Journal of Structural Biology · doi:10.1006/jsbi.1998.3966 · Cited by 667
Introduction to physical polymer science
Sherrington, D. C. (1993) · Reactive Polymers · doi:10.1016/0923-1137(93)90096-x · Cited by 665
Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration
West, J. L., & Hubbell, J. A. (1998) · Macromolecules · doi:10.1021/ma981296k · Cited by 635
Research works printed but not linked: 3
- Voet, D. & Voet, J.G. Biochemistry (John Wiley & Sons, New York, 1995).
- Stryer, L. Biochemistry (W.H. Freeman and Company, New York; 1995).
- Northup, S.J. & Cammack, J.N. Handbook of biomaterials evaluation (ed. von Recum, A.F.) 325–339 (Taylor & Francis, Philadelphia; 1999).
Cited by
Sorted by citations
Items 801–900 of 1,000
Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies
Chhaya, M. P., Melchels, F. P. W., Wiggenhauser, P. S., Schantz, J. T., & Hutmacher, D. W. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2852-7.00010-x · Cited by 16
Poly (glycerol sebacate) elastomer supports osteogenic phenotype for bone engineering applications
Zaky, S. H., Hangadora, C. K., Tudares, M. A., et al. (2014) · Biomedical Materials · doi:10.1088/1748-6041/9/2/025003 · Cited by 16
“Unlike the widely applied synthetic polymers such as poly(lactic acid) (PLA)- and poly(glycolic acid) (PGA)-based materials, a PGS-based scaffold induces a less inflammatory response with minimal fibrous infiltration and no tissue toxicity underlining its biocompatibility [5, 14].”
BackgroundSelf-citationSynthesis of Shape Memory Poly(glycerol sebacate)-Stearate Polymer
Coativy, G., Misra, M., & Mohanty, A. K. (2016) · Macromolecular Materials and Engineering · doi:10.1002/mame.201600294 · Cited by 16
Choi, S. M., Lee, Y., Son, J. Y., et al. (2017) · Macromolecular Research · doi:10.1007/s13233-017-5007-y · Cited by 16
Microwave-assisted facile fabrication of porous poly (glycerol sebacate) scaffolds
Lee, S. H., Lee, K., Gade, P. S., et al. (2017) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2017.1335076 · Cited by 16
“Hydroxyl groups of glycerol react with the carboxylic acid groups of sebacic acid while releasing water molecules [1,17,18].”
BackgroundMethodSelf-citationChan, H., Cho, C., Hsu, K., He, C., Kuo, C., Chu, C., Chen, Y., Chen, C., & Rwei, S. (2019) · Macromolecular Materials and Engineering · doi:10.1002/mame.201900103 · Cited by 16
Micro- and Nanofabricated Scaffolds
Bettinger, C. J., Borenstein, J. T., & Langer, R. (2007) · Elsevier eBooks · doi:10.1016/b978-012370615-7/50028-7 · Cited by 16
Self-citationBiodegradable Elastomers Enabling Thermoprocessing Below 100 °C
Panja, S., Siehr, A., Sahoo, A., Siegel, R. A., & Shen, W. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c01197 · Cited by 16
Golbaten‐Mofrad, H., Salehi, M. H., Jafari, S. H., et al. (2022) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35073 · Cited by 15
Guler, S., Eichholz, K. F., Chariyev‐Prinz, F., et al. (2022) · Bioengineering · doi:10.3390/bioengineering10010030 · Cited by 15
“The DSC results show that the synthesized polymeric PGS-deB blends are amorphous at 37 °C [56].”
BackgroundEffect of curing time on the mechanical properties of poly(glycerol sebacate)
Wu, Z., Jin, K., Wang, L., & Fan, Y. (2023) · Journal of Applied Polymer Science · doi:10.1002/app.53700 · Cited by 15
Bag, J., Mukherjee, S., & Karati, D. (2023) · Polymer Bulletin · doi:10.1007/s00289-023-04983-3 · Cited by 16
“Conversely, synthetic materials with enhanced biocompatibility, controlled degradation, and controllable mechanical properties can be made [33, 34].”
Liu, Y.-Y., Intini, C., Dobricic, M., O’Brien, F. J., LLorca, J., & Echeverry‐Rendón, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135827 · Cited by 15
Yen, C., He, H., Fei, Z., Zhang, X., Lee, L. J., & Ho, W. S. W. (2010) · International Journal of Polymeric Materials · doi:10.1080/00914037.2010.504162 · Cited by 15
Ji, Y., Wang, X., & Liang, K. (2014) · RSC Advances · doi:10.1039/c4ra08033e · Cited by 15
Efficient synthesis of hydroxyl functioned polyesters from natural polyols and sebacic acid
Ning, Z. Y., Zhang, Q. S., Wu, Q., et al. (2011) · Chinese Chemical Letters · doi:10.1016/j.cclet.2010.12.033 · Cited by 15
Rahmani, M., Majidi, R. F., Khani, M., Mashaghi, A., Noorizadeh, F., & Ghanbari, H. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.109633 · Cited by 15
Agarwal, S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-444-53349-4.00145-x · Cited by 15
Mohamed, M. A., Shahini, A., Rajabian, N., Caserto, J. S., El-Sokkary, A. M. A., Akl, M. A., Andreadis, S. T., & Cheng, C. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.022 · Cited by 15
Wang, B., Ji, P., Ma, Y., Song, J., You, Z., & Chen, S. (2021) · Cellulose · doi:10.1007/s10570-021-04053-9 · Cited by 15
“PGS was synthesized according to previous paper (Wang et al. 2002).”
MethodWater soluble flexible and wearable electronic devices: a review
Bokka, N., Selamneni, V., Adepu, V., Jajjara, S., & Sahatiya, P. (2021) · Flexible and Printed Electronics · doi:10.1088/2058-8585/ac3c35 · Cited by 15
Zulkifli, Z., Tan, J. J., Ishak, K. M. K., Rusli, A., Abdullah, M. K., Shuib, R. K., Shafiq, M. D., & Hamid, Z. A. A. (2022) · Journal of Applied Polymer Science · doi:10.1002/app.52272 · Cited by 16
Biodegradable poly(glycerin citrate) and its application to controlled release of theophylline
Liu, S., Jiang, M., Ye, S., et al. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.34886 · Cited by 15
Parthiban, A., Likhitsup, A., Choo, F. M., et al. (2010) · Polymer Chemistry · doi:10.1039/b9py00310j · Cited by 15
Timbart, L., Tse, M. Y., Pang, S. C.-N., et al. (2010) · Materials · doi:10.3390/ma3021156 · Cited by 15
Tissue engineering applications of injectable biomaterials
Kona, S., Wadajkar, A. S., & Nguyen, K. T. (2011) · Elsevier eBooks · doi:10.1533/9780857091376.2.142 · Cited by 15
Surface Treatments for Microfluidic Biocompatibility
Shirtcliffe, N. J., Toon, R., & Roach, P. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-134-9_17 · Cited by 15
Application Prospect and Preliminary Exploration of GelMA in Corneal Stroma Regeneration
Su, G., Li, G., Wang, W., & Xu, L. (2022) · Polymers · doi:10.3390/polym14194227 · Cited by 14
“For the first time, Wang reported the synthesis of PGS as a robust biodegradable polyester [48].”
BackgroundGodinho, B., Nogueira, R., Gama, N., & Ferreira, A. R. (2024) · Journal of Polymers and the Environment · doi:10.1007/s10924-024-03212-w · Cited by 14
Crapo, P. M., & Wang, Y. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33019 · Cited by 14
“We have previously shown that PGS mass loss is not significant after 10 days of agitation at 37 C in culture medium(10) and reaches only 17% 6 6% after 60 days of agitation at 37 C in PBS.(18) PGS degrades linearly in vivo, losing 25% of compressive modulus and 50% of mass after 21 days of subcutaneous implantation.”
BackgroundSelf-citationSailakshmi, G., Mitra, T., Chatterjee, S., & Gnanamani, A. (2013) · International Journal of Life Science and Medical Research · doi:10.5963/lsmr0302004 · Cited by 14
“2%, a decrease in mechanical strength was observed and this could be reasoned to high degree of cross-linking of GA with the biopolymers which is clearly proved from the results of TNBS assay [25] .”
ResultDie Entwicklung von Substrattopographien im Mikro‐ und Nanobereich zur Steuerung von Zellfunktionen
Bettinger, C. J., Langer, R., & Borenstein, J. T. (2009) · Angewandte Chemie · doi:10.1002/ange.200805179 · Cited by 14
Self-citationBiodegradable and temperature‐responsive thermoset polyesters with renewable monomers
Lee, X. Y., Wahit, M. U., & Adrus, N. (2016) · Journal of Applied Polymer Science · doi:10.1002/app.44007 · Cited by 14
Xiao, Y., Lang, S., Zhou, M., Qin, J. Y., Yin, R., Gao, J., Heise, A., & Lang, M. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb02507b · Cited by 14
Kaya, M., Ahi, Z. B., Ergene, E., et al. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3000 · Cited by 14
“PGS was shown to enhance cellular response and hemocompatibility in vitro and in vivo (Motlagh, Yang, Lui, Webb, & Ameer, 2006; Y. Wang et al., 2002; Y. D. Wang et al., 2003).”
BackgroundFarr, N. T. H., Pashneh‐Tala, S., Stehling, N., Claeyssens, F., Green, N. H., & Rodenburg, C. (2019) · Macromolecular Rapid Communications · doi:10.1002/marc.201900484 · Cited by 14
In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model
Latorre, M., Szafron, J. M., Ramachandra, A. B., et al. (2022) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-022-01562-9 · Cited by 14
“In addition to the need for more data, there is clearly a need for a fully coupled 3D FSG model, one coupling a full constrained mixture model with full unsteady Navier-Stokes solutions to characterize graft behavior during the cardiac cycle, such as in exercise, as well as to capture transient remodeling behavior for…”
MethodOdedra, D., Chiu, L. L. Y., Reis, L. A., Rask, F., Chiang, K., & Radisic, M. (2010) · Springer eBooks · doi:10.1007/978-3-7091-0385-2_15 · Cited by 14
Li, Y., Thouas, G. A., & Chen, Q. (2014) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2014.08.027 · Cited by 14
Ni’mah, H., Rochmadi, R., Woo, E. M., Widiasih, D. A., & Mayangsari, S. (2019) · International Journal of Technology · doi:10.14716/ijtech.v10i3.2936 · Cited by 14
“PGS is a biodegradable and biocompatible synthetic elastomer, which shows mechanical behavior resembling the properties of soft tissue (Wang et al., 2002; Rai et al., 2012).”
BackgroundCracks outrun erosion in degradable polymers
Shi, M., Steck, J. G., Yang, X., et al. (2020) · Extreme Mechanics Letters · doi:10.1016/j.eml.2020.100978 · Cited by 14
“In the absence of mechanical load, PGS degrades through urface erosion [29].”
BackgroundSun, Z., Wu, L., Lu, X., Meng, Z., Zheng, Y., & Dong, D. (2008) · Applied Surface Science · doi:10.1016/j.apsusc.2008.06.157 · Cited by 14
A Comprehensive Review on Biodegradable Materials and Technologies for Transient Electronics
Ding, Z., Qiao, J., Gao, W., Wang, C., & Guan, Y. (2025) · Advanced Materials Technologies · doi:10.1002/admt.202501928 · Cited by 13
Biodegradable Polymeric Membranes for Organic Solvent/Water Pervaporation Applications
Chang, P.-Y., Wang, J., Li, S., et al. (2021) · Membranes · doi:10.3390/membranes11120970 · Cited by 13
“These two biodegradable polyester membranes exhibited the characteristic CH and C=O peaks around 2960 cm−1 and 1740 cm−1 [50], while the APS membrane (amino alcohol-based poly(ester amide) [51]) displayed an additional NH peak at 1650 cm−1.”
BackgroundGelatin-modified 3D printed PGS elastic hierarchical porous scaffold for cartilage regeneration
Wang, S., Chen, H., Huang, J., et al. (2023) · APL Bioengineering · doi:10.1063/5.0152151 · Cited by 13
An overview of the production of tissue extracellular matrix and decellularization process
Dehghani, S., Aghaee, Z., Soleymani, S., Tafazoli, M., Ghabool, Y., & Tavassoli, A. (2023) · Cell and Tissue Banking · doi:10.1007/s10561-023-10112-1 · Cited by 14
“Conversely, direct scaffold seeding could be applied through autologous stem cells; mature mesenchymal stromal cells are an exceptional candidate for this purpose (Lutolf and Hubbell 2005; Wang et al. 2002).”
Chen, H., Hou, T., Zhang, M., Du, J., Hua, L., Chen, X., Zhang, A., Jin, Y. Q., Zhou, L., & Li, G. (2024) · Energy & environment materials · doi:10.1002/eem2.12706 · Cited by 13
Novel branched poly(l-lactide) with poly(glycerol-co-sebacate) core
Cheng, S., Li-jing, Y., & Gong, F. (2010) · Polymer Bulletin · doi:10.1007/s00289-009-0237-6 · Cited by 13
Tevlek, A., Agacik, D. T., & Aydın, H. M. (2019) · Journal of Applied Polymer Science · doi:10.1002/app.48689 · Cited by 13
Polyhydroxyalkanoates-based bionanocomposites
Anjum, M. N., Malik, S. A., Bilal, C. H., et al. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816751-9.00013-1 · Cited by 13
Extruded poly (glycerol sebacate) and polyglycolic acid vascular graft forms a neoartery
Fukunishi, T., Lui, C., Ong, C. S., et al. (2022) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3282 · Cited by 13
“novel biodegradable polymer (Wang et al., 2002) and has since become increasingly utilized in a variety of biomedical applications (Newman et al.”
BackgroundLow methacrylated poly(glycerol sebacate) for soft tissue engineering
Becerril-Rodriguez, I. C., & Claeyssens, F. (2022) · Polymer Chemistry · doi:10.1039/d2py00212d · Cited by 14
Jen, M. C., Baler, K., Hood, A. R., Shin, S., Shea, L. D., & Ameer, G. A. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34449 · Cited by 13
“In this regard, POC and PGS are promising biodegradable elastomers that have desirable mechanical properties that are comparable to native tissue.(32,33) Although therapeutic proteins or drugs can be delivered from biomaterials, there are significant challenges in maintaining long-term therapeutic levels due to short…”
BackgroundSelf-citationNatarajan, J., Madras, G., & Chatterjee, K. (2016) · RSC Advances · doi:10.1039/c6ra11476h · Cited by 13
Gade, P. S., Lee, K., Pfaff, B. N., et al. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0102 · Cited by 13
Self-citationMerle, B., Kraus, X., Tallawi, M., et al. (2018) · Materials Letters · doi:10.1016/j.matlet.2018.03.051 · Cited by 13
Poly(glycerol citrate)‐polylactide nonwovens toward tissue engineering applications
Wrzecionek, M., Bandzerewicz, A., Dutkowska, E., et al. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5407 · Cited by 13
Safranski, D. L., Crabtree, J. C., Huq, Y., et al. (2011) · Polymer · doi:10.1016/j.polymer.2011.08.033 · Cited by 13
Strain stiffening of peripheral nerves subjected to longitudinal extensions in vitro
Giannessi, E., Stornelli, M. R., & Sergi, P. N. (2019) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2019.10.012 · Cited by 15
Biodegradable Thermoplastic Elastomers Achieved by Unchaining Intrinsic Entropic Elasticity
Chen, C., Wang, L., Liu, F., Hu, Q., Wang, J., Hu, B., & Zhu, J. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202515241 · Cited by 12
Advances in polymer-based scaffolding for enhanced wound healing: a comprehensive review
Tamnna, Sharma, T., Mittal, R., & Kaushik, P. (2024) · International Journal of Polymeric Materials · doi:10.1080/00914037.2024.2367208 · Cited by 12
“Glycerol is FDA-approved as a food fuel and a natural metabolic intermediate for the oxidation of medium-and long-chain fatty acids [107,108] .”
An oligomeric switch that rapidly decreases the peel strength of a pressure-sensitive adhesive
Robertson, F. J., Wang, Y., & Rosing, H. (2014) · International Journal of Adhesion and Adhesives · doi:10.1016/j.ijadhadh.2014.07.016 · Cited by 12
Self-citationFabrication and characterization of biodegradable polymeric films as a corneal stroma substitute
Javanmard, S. H., Salehi, S., Fathi, M., et al. (2014) · Advanced Biomedical Research · doi:10.4103/2277-9175.148291 · Cited by 12
“Poly (glycerol sebacate) (PGS), a novel biodegradable tough elastomer developed recently, is a material with properties well suited to soft tissue requirements.[4] It is a covalently cross‐linked, three‐dimensional network of random coils with hydroxyl groups attached to its backbone; both the cross‐linking and the hy…”
BackgroundCorder, R. D., Tilly, J. C., Ingram, W. F., et al. (2019) · ACS Applied Polymer Materials · doi:10.1021/acsapm.9b00855 · Cited by 12
Jiang, W., Hsu, W.-Y., Ao-Ieong, W.-S., Wang, C.-Y., Wang, J., & Yet, S. (2021) · Biofabrication · doi:10.1088/1758-5090/ac1259 · Cited by 12
“PGSA is a photocurable polyester from PGS after acrylation while conserving the biocompatibility and elastomeric properties of PGS [17, 43].”
BackgroundRekabgardan, M., Parandakh, A., Shahriari, S., et al. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103383 · Cited by 12
Parameswaranpillai, J., D., M. D. C., Rangappa, S. M., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85832-8.00002-x · Cited by 12
Heiny, M., & Shastri, V. P. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.5b01681 · Cited by 12
Ni, N., Ji, J., Chen, S., et al. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600058 · Cited by 12
Kakde, D. D., Powell, L. G., Bansal, K. K., Howdle, S. M., Irvine, D. J., Mantovani, G., Millar, G., Dailey, L. A., Stone, V., Johnston, H. J., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.08.003 · Cited by 12
“Accordingly, polyester materials are regarded as a material of choice for biomedical applications including drug delivery [5-9], as diagnostic agents [10, 11] and for tissue engineering [12-16].”
BackgroundFracture‐Resistant and Bioresorbable Drug‐Eluting Poly(glycerol Sebacate) Coils
Mollazadeh‐Moghaddam, K., Nejad, H. R., Chen, A., Ju, J., Tamayol, A., Liu, X., Zhang, Y. S., Öklü, R., & Khademhosseini, A. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800109 · Cited by 12
Advances in Bioresorbable Electronics and Uses in Biomedical Sensing
Kuzma, M., Gerhard, E. M., Shan, D., & Yang, J. Y. (2020) · Springer eBooks · doi:10.1007/978-3-030-34467-2_2 · Cited by 12
A universal scaling law of mammalian touch
Andrews, J. W., Adams, M. J., & Montenegro‐Johnson, T. D. (2020) · Science Advances · doi:10.1126/sciadv.abb6912 · Cited by 13
Wrzecionek, M., Ruśkowski, P., & Gadomska‐Gajadhur, A. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5233 · Cited by 12
Reconstruction of Vascular and Urologic Tubular Grafts by Tissue Engineering
Caneparo, C., Chabaud, S., & Bolduc, S. (2021) · Processes · doi:10.3390/pr9030513 · Cited by 12
“PGS is an elastomeric polymer with a 1‐ to 2‐month degradation period in subcutaneous studies [32].”
BackgroundRekabgardan, M., Rahmani, M., Soleimani, M., et al. (2021) · ASAIO Journal · doi:10.1097/mat.0000000000001423 · Cited by 12
Microfluidic Systems for Engineering Vascularized Tissue Constructs
Tian, W.-C., & Finehout, E. J. (2008) · Springer eBooks · doi:10.1007/978-0-387-09480-9_7 · Cited by 12
Poly(glycerol sebacate) combined with chondroitinase ABC promotes spinal cord repair in rats
Qi, P., Guo, Y., & Kong, F. (2017) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33984 · Cited by 12
Tough Ordered Mesoporous Elastomeric Biomaterials Formed at Ambient Conditions
Rajasekharan, A. K., Gyllensten, C., Blomstrand, E., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01924 · Cited by 12
Bioelastomers in Tissue Engineering
You, Z., & Wang, Y. (2010) · Springer eBooks · doi:10.1007/978-3-7091-0385-2_4 · Cited by 12
Self-citationMartín‐Cabezuelo, R., Hernández, J. C. R., Vilariño‐Feltrer, G., et al. (2021) · Polymers · doi:10.3390/polym13030382 · Cited by 11
“Indeed, PGS has been reported in the literature to be biocompatible [4,8], although spin-coated samples are being used in this case, which could trigger a disadvantageous performance.”
BackgroundHu, J. J., Liu, C., Lin, C., et al. (2021) · Polymers · doi:10.3390/polym13091527 · Cited by 11
“Crosslinked polyesters such as poly(glycerol sebacate) [7] and poly(1,8-octanediol citrate) [8] have several attractive features for use as scaffold materials.”
BackgroundAxioti, E., Dixon, E. G., Reynolds‐Green, M., Alexander, E. C. H., Brugnoli, B., Keddie, D. J., Couturaud, B., Suksiriworapong, J., Swainson, S. M. E., Francolini, I., et al. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113828 · Cited by 11
Development and characterization of elastic nanocomposites for craniofacial contraction osteogenesis
Levi‐Polyachenko, N. H., Rosenbalm, T. N., Kuthirummal, N., Shelton, J. E., Hardin, W., Teruel, M., Hobley, E., Wang, R., Day, C. S., Narayanan, V., et al. (2014) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33220 · Cited by 11
Masoumi, N., Howell, M. C., Johnson, K. L., et al. (2014) · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine · doi:10.1177/0954411914534837 · Cited by 11
“Effects of cyclic stretch on solid PGS membranes PGS was introduced by Wang et al.21 and its biomedical applications have recently been reviewed by Rai et al.35 Initial tests of the bioreactor, in which the effects of cyclic stretch on solid PGS membrane mechanical properties were evaluated, offered confirmation of an…”
MethodInfluentialYan, Y. W., Sencadas, V., Zhang, J., et al. (2017) · Advanced Materials Interfaces · doi:10.1002/admi.201700484 · Cited by 11
Yapor, J. P., Neufeld, B. H., Tapia, J. B., & Reynolds, M. M. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00566d · Cited by 11
Flaig, F., Bellani, C. F., Uyumaz, Ö., et al. (2021) · Materials Advances · doi:10.1039/d0ma00673d · Cited by 11
Dual-functional antibiofilm polymer composite for biodegradable medical devices
Chang, C.-T., Chen, Y., Hsieh, Y., et al. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.111985 · Cited by 11
Chang, C., & Yeh, Y. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100248 · Cited by 12
Materials for implantable systems
Neves, H. P. (2013) · Elsevier eBooks · doi:10.1533/9780857096289.1.3 · Cited by 15
El-Laboudy, H., Shaker, M. A., & Younes, H. M. (2011) · Soft Materials · doi:10.1080/1539445x.2010.528726 · Cited by 11
Kim, J., Yaszemski, M. J., & Lu, L. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32166 · Cited by 11
“Both macromers are completely amorphous at the operation temperature (378C) and appeared to be elastomer-like material at the temperature similar to a vulcanized rubber.(23,26)”
BackgroundPholpabu, P., Yerneni, S. S., Zhu, C., Campbell, P. G., & Bettinger, C. J. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00192 · Cited by 11
Prévôt, M. E., & Hegmann, E. (2017) · ACS symposium series · doi:10.1021/bk-2017-1253.ch001 · Cited by 11
Hsieh, Y., Chang, C.-T., Jen, I.-H., Pu, F.-C., Shen, S.-H., Wan, D., & Wang, J. (2018) · ACS Applied Nano Materials · doi:10.1021/acsanm.8b00723 · Cited by 11
Poly(Glycerol-Sebacate) Elastomer: A Mini Review
Murat, A. H. (2017) · Orthoplastic Surgery & Orthopedic Care International Journal · doi:10.31031/ooij.2017.01.000507 · Cited by 11
“For instance, if crosslink density increases in proportion with curing time or heat, the degradation kinetics decreases [1,4].”
BackgroundMethodInfluentialLi, C., Hu, M.-H., & Hu, J. J. (2019) · Polymers · doi:10.3390/polym11091492 · Cited by 12
Biomimetic Approach to Cardiac Tissue Engineering: Oxygen Carriers and Channeled Scaffolds
Radisic, M., Park, H., Chen, F., Salazar-Lazzaro, J. E., Wang, Y., Dennis, R. G., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.ft-170 · Cited by 11
Self-citationPerin, G. B., Moreno, S., Zhou, Y., Günther, M., Boye, S., Voit, B. I., Felisberti, M. I., & Appelhans, D. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.3c00828 · Cited by 11
Metadata
- Authors
- Wang, Y., Ameer, G. A., Sheppard, B. J., & Langer, R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Northwestern University (US)
- Venue
- Nature Biotechnology
- Published
- 2002-06
- Volume
- 20
- Issue
- 6
- Pages
- 602-606
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W1994054444
- Cited by
- 1,314
- References
- 45
- Citations by year
- 2026: 27 · 2025: 56 · 2024: 59 · 2023: 60 · 2022: 65 · 2021: 78 · 2020: 77 · 2019: 76 · 2018: 73 · 2017: 65 · 2016: 66 · 2015: 66 · 2014: 79 · 2013: 66 · 2012: 67
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (5-R01-HL60435, R01HL060435)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- biodegradable elastomers, tough polymers, biocompatibility, covalent cross-linking, hydrogen bonding, hydroxyl groups, tissue engineering, drug delivery, in vivo sensing, polymer implants, biodegradation
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Biocompatible Materials, Decanoates, Decanoic Acids, Dicarboxylic Acids, Elasticity, Female, Glycerol, Materials Testing, Models, Molecular, Polyglycolic Acid, Polymers, Skin, Stress, Mechanical, Tensile Strength, 3T3 Cells, Lactic Acid, Absorbable Implants, Elastomers, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
