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A tough biodegradable elastomer
Abstract
Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility with cells and tissues. A strong, biodegradable, and biocompatible elastomer could be useful for fields such as tissue engineering, drug delivery, and in vivo sensing. We designed, synthesized, and characterized a tough biodegradable elastomer from biocompatible monomers. This elastomer forms a covalently crosslinked, three-dimensional network of random coils with hydroxyl groups attached to its backbone. Both crosslinking and the hydrogen-bonding interactions between the hydroxyl groups likely contribute to the unique properties of the elastomer. In vitro and in vivo studies show that the polymer has good biocompatibility. Polymer implants under animal skin are absorbed completely within 60 days with restoration of the implantation sites to their normal architecture.
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“Many medical devices are implanted in the dynamic mechanical environment of the human body. They need to adapt to states of continuous relaxation and contraction to maintain their own performance without mechanical stimulation of the surrounding tissues [14,15].”
From Synthesis of Poly(l-lactide-co-ε-caprolactone) Copolymer: Structure, Toughness, and Elasticity (2021) · cites this paper as [14]
In the citing paper
“For example, while PCLA copolymers attained UTS levels above 30 MPa, poly(glycerol sebacate) (PGS) exhibited a tensile strength slightly above 0.5 MPa [15].”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
In the citing paper
“As reported [15], PGS has a Young's modulus of around 0.3 MPa, an ultimate tensile strength above 0.5 MPa and attains elongation at break values slightly below 350%.”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
In the citing paper
“Furthermore, as reported [15], PGS is fully amorphous at body temperature, with no glass transition temperatures being observed above 80 1 C.”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
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“On the other hand, degradable elastomers have been introduced recently by the Langer group’s first report on poly(glycerol-sebacate) (PGS) (Wang et al., 2002).”
BackgroundHudson, J. E., Frith, J. E., Donose, B. C., Rondeau, E., Mills, R. J., Wolvetang, E. J., Brooke, G. P., & Cooper-White, J. J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.007 · Cited by 17
“The elastic modulus of a material is related to the density of cross-links through the following formula [31]:”
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Microscale Technologies for Engineering Complex Tissue Structures
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Biodegradable Polyester Thermogelling System as Emerging Materials for Therapeutic Applications
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Polyglycerol sebacate‐based elastomeric materials for arterial regeneration
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“Scaffolds with tailored mechanical properties were obtained, with Young moduli ranging from 0.03 to 1.4 MPa, elongation at break from 125% to 265% and ultimate tensile strength higher than 0.2 MPa [13,37,38].”
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“Polycondensation with a reduced pressure is the earliest reported and most promising method for synthesizing pre-PGS, which involves esterification at high temperatures under an inert gas atmosphere [32–35].”
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“…optimize this TEVG, we also evaluated the impact of coating the graft with poly(glycerol sebacate) (PGS), a well-studied rapidly degrading polymer, 20,21 which has been shown to have a lower level of lymphocytic in-filtrate, compared to poly(lactide-co-glycolide), at 1 and 2 month time points…”
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Metadata
- Authors
- Wang, Y., Ameer, G. A., Sheppard, B. J., & Langer, R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Northwestern University (US)
- Venue
- Nature Biotechnology
- Published
- 2002-06
- Volume
- 20
- Issue
- 6
- Pages
- 602-606
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W1994054444
- Cited by
- 1,314
- References
- 45
- Citations by year
- 2026: 27 · 2025: 56 · 2024: 59 · 2023: 60 · 2022: 65 · 2021: 78 · 2020: 77 · 2019: 76 · 2018: 73 · 2017: 65 · 2016: 66 · 2015: 66 · 2014: 79 · 2013: 66 · 2012: 67
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (5-R01-HL60435, R01HL060435)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- biodegradable elastomers, tough polymers, biocompatibility, covalent cross-linking, hydrogen bonding, hydroxyl groups, tissue engineering, drug delivery, in vivo sensing, polymer implants, biodegradation
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Biocompatible Materials, Decanoates, Decanoic Acids, Dicarboxylic Acids, Elasticity, Female, Glycerol, Materials Testing, Models, Molecular, Polyglycolic Acid, Polymers, Skin, Stress, Mechanical, Tensile Strength, 3T3 Cells, Lactic Acid, Absorbable Implants, Elastomers, Mice, Rats
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