The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A tough biodegradable elastomer
Abstract
Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility with cells and tissues. A strong, biodegradable, and biocompatible elastomer could be useful for fields such as tissue engineering, drug delivery, and in vivo sensing. We designed, synthesized, and characterized a tough biodegradable elastomer from biocompatible monomers. This elastomer forms a covalently crosslinked, three-dimensional network of random coils with hydroxyl groups attached to its backbone. Both crosslinking and the hydrogen-bonding interactions between the hydroxyl groups likely contribute to the unique properties of the elastomer. In vitro and in vivo studies show that the polymer has good biocompatibility. Polymer implants under animal skin are absorbed completely within 60 days with restoration of the implantation sites to their normal architecture.
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“Many medical devices are implanted in the dynamic mechanical environment of the human body. They need to adapt to states of continuous relaxation and contraction to maintain their own performance without mechanical stimulation of the surrounding tissues [14,15].”
From Synthesis of Poly(l-lactide-co-ε-caprolactone) Copolymer: Structure, Toughness, and Elasticity (2021) · cites this paper as [14]
In the citing paper
“For example, while PCLA copolymers attained UTS levels above 30 MPa, poly(glycerol sebacate) (PGS) exhibited a tensile strength slightly above 0.5 MPa [15].”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
In the citing paper
“As reported [15], PGS has a Young's modulus of around 0.3 MPa, an ultimate tensile strength above 0.5 MPa and attains elongation at break values slightly below 350%.”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
In the citing paper
“Furthermore, as reported [15], PGS is fully amorphous at body temperature, with no glass transition temperatures being observed above 80 1 C.”
From Designing biodegradable multiblock PCL/PLA thermoplastic elastomers (2005) · cites this paper as [15]
Citations
Cites
Hansen, M., Nielsen, S. E., & Berg, K. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90397-9 · Cited by 3,488
Introduction to Physical Polymer Science
Sperling, L. H. (2005) · doi:10.1002/0471757128 · Cited by 2,917
Boyd, D. R. (1993) · Endeavour · doi:10.1016/0160-9327(93)90217-q · Cited by 1,928
New Challenges in Biomaterials
Peppas, N. A., & Langer, R. (1994) · Science · doi:10.1126/science.8134835 · Cited by 1,163
Self-citationScience and technology of rubber
(1995) · Choice Reviews Online · doi:10.5860/choice.32-2771 · Cited by 954
Handbook of Biodegradable Polymers
(1998) · CRC Press eBooks · doi:10.1201/9780367802219 · Cited by 712
Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00051-5 · Cited by 709
Fibrillar Structure and Mechanical Properties of Collagen
Fratzl, P., Misof, K., Žižak, I., Rapp, G., Amenitsch, H. W., & Bernstorff, S. (1998) · Journal of Structural Biology · doi:10.1006/jsbi.1998.3966 · Cited by 667
Introduction to physical polymer science
Sherrington, D. C. (1993) · Reactive Polymers · doi:10.1016/0923-1137(93)90096-x · Cited by 665
Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration
West, J. L., & Hubbell, J. A. (1998) · Macromolecules · doi:10.1021/ma981296k · Cited by 635
Research works printed but not linked: 3
- Voet, D. & Voet, J.G. Biochemistry (John Wiley & Sons, New York, 1995).
- Stryer, L. Biochemistry (W.H. Freeman and Company, New York; 1995).
- Northup, S.J. & Cammack, J.N. Handbook of biomaterials evaluation (ed. von Recum, A.F.) 325–339 (Taylor & Francis, Philadelphia; 1999).
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Items 401–500 of 1,000
Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters
Zhu, C., Kustra, S., & Bettinger, C. J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.03.041 · Cited by 54
“This family of synthetic polymers includes polyester-based materials such as poly(glycerol-co-sebacate) (PGS) [3], poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) (APS) [4], and poly(1,8-octanediol-co-citric acid) (POC) [5].”
BackgroundMethodRezk, A. I., Kim, K., & Kim, C. S. (2020) · Polymers · doi:10.3390/polym12112667 · Cited by 54
“The addition of PCL increased the viscosity of the polymer blend, making PGS suitable for electrospinning [16,18].”
MethodBiodegradable sensors: A comprehensive review
Sreejith, S., Joseph, L. M. I. L., Kollem, S., VIJUMON, V. T., & Ajayan, J. (2023) · Measurement · doi:10.1016/j.measurement.2023.113261 · Cited by 53
Scaffold Sheet Design Strategy for Soft Tissue Engineering
Tran, R. T., Thevenot, P., Zhang, Y., Gyawali, D., Tang, L., & Yang, J. Y. (2010) · Materials · doi:10.3390/ma3021375 · Cited by 53
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BackgroundLi, Y., Huang, W., Cook, W. D., et al. (2013) · Biomedical Materials · doi:10.1088/1748-6041/8/3/035006 · Cited by 53
“Since the publication of a seminal work on poly(glycerol sebacate) (PGS) in 2002 [4], there have been an increasing number of research studies on the development of biodegradable elastomeric biomaterials for soft-tissue engineering applications [3, 5, 6].”
BackgroundLin, D., Yang, K. C., Tang, W. D., Liu, Y., Yuan, Y., & Liu, C. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.04.031 · Cited by 53
Dippold, D., Tallawi, M., Tansaz, S., Roether, J. A., & Boccaccini, A. R. (2016) · European Polymer Journal · doi:10.1016/j.eurpolymj.2015.12.030 · Cited by 53
Developing a Clinically Relevant Tissue Engineered Heart Valve—A Review of Current Approaches
Nachlas, A. L. Y., Li, S., & Davis, M. E. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700918 · Cited by 54
Current Strategies for Engineered Vascular Grafts and Vascularized Tissue Engineering
Chen, J., Zhang, D., Wu, L., & Zhao, M. (2023) · Polymers · doi:10.3390/polym15092015 · Cited by 46
Poly(Glycerol Sebacate) Elastomer: A Novel Material for Mechanically Loaded Bone Regeneration
Zaky, S. H., Lee, K., Gao, J., et al. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0172 · Cited by 52
“3,8 PGS also has clear advantages over collagen-based materials.”
Self-citationMitsak, A. G., Dunn, A. M., & Hollister, S. J. (2011) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2011.11.003 · Cited by 52
Tobias, I. S., Lee, H., Engelmayr, G. C., et al. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.05.036 · Cited by 52
“This surface-eroding behavior concurs with previously reported studies of PGS cured to a lower crosslink density via a lower applied pressure and temperature (30 mTorr, 120°C for 48 hours) which was shown to swell negligibly in water and degrade via surface erosion [22,23].”
Kim, J., Dadsetan, M., Ameenuddin, S., Windebank, A. J., Yaszemski, M. J., & Lu, L. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32810 · Cited by 53
Bat, E., van Kooten, T. G., Feijén, J., & Grijpma, D. W. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.01.010 · Cited by 52
Biomaterials-based microfluidics for engineered tissue constructs
Bettinger, C. J., & Borenstein, J. T. (2010) · Soft Matter · doi:10.1039/c0sm00247j · Cited by 52
Elastase-Sensitive Elastomeric Scaffolds with Variable Anisotropy for Soft Tissue Engineering
Guan, J., Fujimoto, K. L., & Wagner, W. R. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9628-x · Cited by 52
Liverani, L., Piegat, A., Niemczyk, A., et al. (2016) · European Polymer Journal · doi:10.1016/j.eurpolymj.2016.06.009 · Cited by 52
Zhang, X., Jia, C., Qiao, X., Liu, T., & Sun, K. (2017) · Polymer Testing · doi:10.1016/j.polymertesting.2017.06.012 · Cited by 52
Construction of a nanofiber network within 3D printed scaffolds for vascularized bone regeneration
Geng, M., Zhang, Q., Gu, J., et al. (2021) · Biomaterials Science · doi:10.1039/d0bm02058c · Cited by 51
Microwave Synthesis and Melt Blending of Glycerol Based Toughening Agent with Poly(lactic acid)
Coativy, G., Misra, M., & Mohanty, A. K. (2016) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.5b01596 · Cited by 51
Tunable Temperature Memory Effect of Photo-Cross-Linked Star PCL–PEG Networks
Wang, L., Di, S., Wang, W., Chen, H., Yang, X., Gong, T., & Zhou, S. (2014) · Macromolecules · doi:10.1021/ma4023229 · Cited by 51
Yan, Y. W., Potts, M., Jiang, Z., & Sencadas, V. (2018) · Composites Science and Technology · doi:10.1016/j.compscitech.2018.04.010 · Cited by 51
“Materials and processing Poly(glycerol sebacate) (PGS) was prepared according to the method explained elsewhere [20, 22].”
MethodWang, P., Berry, D. B., Song, Z., Kiratitanaporn, W., Schimelman, J. B., Moran, A., He, F., Xi, B., Cai, S., & Chen, S. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910391 · Cited by 52
Crapo, P. M., Gao, J., & Wang, Y. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31598 · Cited by 51
Self-citationLiu, Q., Tian, M., Shi, R., et al. (2007) · Journal of Applied Polymer Science · doi:10.1002/app.25606 · Cited by 51
Polyelectrolyte Gels: Fundamentals, Fabrication and Applications
Wanasingha, N., Dorishetty, P., Dutta, N. K., & Choudhury, N. R. (2021) · Gels · doi:10.3390/gels7030148 · Cited by 53
From Molecules to Machines: A Multiscale Roadmap to Intelligent, Multifunctional Soft Robotics
Li, Y., Schreiber, S., Yang, H., Liu, M., Little, J. M., Cao, W., Luo, Y., Bao, Y., Shih, C., Bai, H., et al. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00972 · Cited by 53
Yan, Y. W., Sencadas, V., Jin, T., et al. (2017) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2017.08.033 · Cited by 50
“3 Poly(glycerol sebacate) (PGS), is a ductile and biodegradable elastomer usually obtained by poly-condensation of glycerol and sebacic acid [4, 5].”
BackgroundValerio, O., Misra, M., & Mohanty, A. K. (2017) · Polymer Testing · doi:10.1016/j.polymertesting.2017.12.018 · Cited by 50
Sun, L., Wang, M., Chen, S., Sun, B., Guo, Y., He, C., Mo, X., Zhu, B., & You, Z. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.040 · Cited by 50
Mostafavi, A., Daemi, H., Rajabi, S., & Baharvand, H. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117632 · Cited by 52
Ryu, H., Wang, X., Xie, Z., Kim, J., Liu, Y., Bai, W., Song, Z. F., Song, J. W., Zhao, Z., Kim, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202303429 · Cited by 51
Self-citationHu, X., Kang, H., Li, Y., Li, M., Wang, R., Xu, R., Qiao, H., & Zhang, L. (2015) · Polymer Chemistry · doi:10.1039/c5py01332a · Cited by 51
McMullin, E., Rebar, H. T., & Mather, P. T. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b00470 · Cited by 49
Sha, D., Wu, Z., Zhang, J., Ma, Y., Yang, Z., & Yuan, Y. (2021) · European Polymer Journal · doi:10.1016/j.eurpolymj.2021.110830 · Cited by 49
Zhang, D., Giese, M. L., Prukop, S. L., & Grunlan, M. A. (2010) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.24488 · Cited by 48
Timbart, L., Tse, M. Y., Pang, S. C.-N., et al. (2009) · Macromolecular Bioscience · doi:10.1002/mabi.200800318 · Cited by 49
Sonseca, Á., Camarero‐Espinosa, S., Peponi, L., Weder, C., Foster, E. J., Kenny, J. M., & Giménez, E. (2014) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.27367 · Cited by 48
Dey, J., Xu, H., Nguyen, K. T., et al. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32846 · Cited by 48
Self-healing of pores in PLGAs
Huang, J., Mazzara, J. M., Schwendeman, S. P., & Thouless, M. D. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.02.025 · Cited by 48
“Since their first patented use in the 1960s, they now form key components of many products that have been approved by the US Food and Drug Administration, such as sutures [1], cardiovascular stents [2–4], skin implants [5,6], and a plethora of drug-delivery devices such as microparticles [7–9], patches [10], and in-si…”
BackgroundKeirouz, A., Fortunato, G., Zhang, M., Callanan, A., & Radacsi, N. (2019) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2019.06.009 · Cited by 48
“PGS is synthesized via the polycondensation of glycerol and sebacic acid to form a pre-polymer, which can be further covalently crosslinked [10,11].”
MethodQi, J., Chen, S., Lan, C., et al. (2020) · Advanced Energy Materials · doi:10.1002/aenm.202001185 · Cited by 48
Kim, K., Yoo, J., Shim, J., Ryu, Y., Choi, S.-Y., Lee, J., Lee, H. M., Koo, J., & Kang, S. (2021) · Advanced Materials Technologies · doi:10.1002/admt.202001297 · Cited by 53
Improving fluorescence imaging of biological cells on biomedical polymers
Jaafar, I. H., LeBlon, C. E., Wei, M., Ou-Yang, D., Coulter, J. P., & Jedlicka, S. S. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.12.007 · Cited by 47
Designing Bioactive Delivery Systems for Tissue Regeneration
Davis, H. E., & Leach, J. K. (2010) · Annals of Biomedical Engineering · doi:10.1007/s10439-010-0135-y · Cited by 47
Bertram, J. P., Jay, S. M., Hynes, S. R., Robinson, R., Criscione, J. M., & Lavik, E. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.04.012 · Cited by 47
“When implanted in vivo, PLGA elicits an inflammatory response resulting in fibrous capsule formation around the implant [42].”
BackgroundResultYan, Y. W., Sencadas, V., Zhang, J., Zu, G., Wei, D., & Jiang, Z. (2017) · Composites Science and Technology · doi:10.1016/j.compscitech.2017.02.007 · Cited by 47
Recent advances on electrospun scaffolds as matrices for tissue-engineered heart valves
Ibrahim, D. M., Kakarougkas, A., & Allam, N. K. (2017) · Materials Today Chemistry · doi:10.1016/j.mtchem.2017.05.001 · Cited by 47
Gerges, I., Tamplenizza, M., Martello, F., Recordati, C., Martelli, C., Ottobrini, L., Tamplenizza, M., Guelcher, S. A., Tocchio, A., & Lenardi, C. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.011 · Cited by 46
Huyer, L. D., Bannerman, D., Wang, Y., Savoji, H., Knee‐Walden, E. J., Brissenden, A. J., Yee, B., Shoaib, M., Bobicki, E. R., Amsden, B. G., et al. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900245 · Cited by 48
Self-citationFinite element analysis of an accordion-like honeycomb scaffold for cardiac tissue engineering
Jean, A., & Engelmayr, G. C. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2010.06.032 · Cited by 47
“(2008) PGS polymer was synthesized by reacting glycerol and sebacic acid (1:1 molar ratio, Sigma) under heat (120 1C) and vacuum ðC15 mTorrÞ for 72 h (Wang et al., 2002), cast into 250mm thick sheets by curing (7.”
InfluentialPolymeric triglyceride analogs prepared by enzyme-catalyzed condensation polymerization
Zhang, Y., Spinella, S., Xie, W., Cai, J., Yang, Y., Wang, Y., & Gross, R. A. (2012) · European Polymer Journal · doi:10.1016/j.eurpolymj.2012.11.011 · Cited by 47
“glycerol and sorbitol) were prepared using chemical catalysts such as those based on titanium and tin alkoxides [23–27].”
MethodSelf-citationGautrot, J. E., & Zhu, X. X. (2008) · Chemical Communications · doi:10.1039/b719021b · Cited by 46
Kafouris, D., Kossivas, F., Constantinides, C., Nguyen, N. Q., Wesdemiotis, C., & Patrickios, C. S. (2013) · Macromolecules · doi:10.1021/ma3016882 · Cited by 49
Gadomska‐Gajadhur, A., Wrzecionek, M., Matyszczak, G., Piętowski, P., Więcław, M. M., & Ruśkowski, P. (2018) · Organic Process Research & Development · doi:10.1021/acs.oprd.8b00306 · Cited by 46
Shape memory polymers with silicon-containing segments
Schoener, C. A., Weyand, C. B., Murthy, R., & Grunlan, M. A. (2010) · Journal of Materials Chemistry · doi:10.1039/b924032b · Cited by 46
Design and Development of Transient Sensing Devices for Healthcare Applications
Janićijević, Ž., Huang, T., Bojórquez, D. I. S., Tonmoy, T. H., Pané, S., Makarov, D., & Baraban, L. (2024) · Advanced Science · doi:10.1002/advs.202307232 · Cited by 46
pH-responsive scaffolds generate a pro-healing response
You, J., Rafat, M., Almeda, D., Maldonado, N., Guo, P., Nabzdyk, C. S., Chun, M., LoGerfo, F. W., Hutchinson, J. W., Pradhan‐Nabzdyk, L., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.011 · Cited by 47
“In contrast, the synthetic scaffold PLG is observed to have an inflammatory response resulting in the formation of a thick fibrous capsule by day 14 [43].”
BackgroundMulti‐Material Tissue Engineering Scaffold with Hierarchical Pore Architecture
Morgan, K. Y., Sklaviadis, D., Tochka, Z. L., Fischer, K. M., Hearon, K., Morgan, T. D., Langer, R., & Freed, L. E. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201601146 · Cited by 45
Self-citationYoon, S., & Chen, B. (2018) · Polymer Chemistry · doi:10.1039/c8py00544c · Cited by 46
Wu, Y., D’Amato, A. R., Yan, A. M., Wang, R. Q., Ding, X., & Wang, Y. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00804 · Cited by 45
Self-citationRastegar, S., Mehdikhani, M., Bigham, A., et al. (2021) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2021.124543 · Cited by 45
A neuroinductive biomaterial based on dopamine
Gao, J., Kim, Y. M., Coe, H., Zern, B. J., Sheppard, B. J., & Wang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606237103 · Cited by 45
Self-citationLei, L., Li, L., Zhang, L., et al. (2009) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2009.04.034 · Cited by 45
Toughening Self‐Healing Elastomers with Chain Mobility
Tan, M., Thornton, P. M., Thangavel, G., et al. (2024) · Advanced Science · doi:10.1002/advs.202308154 · Cited by 44
Chandorkar, Y., Bhaskar, N., Madras, G., & Basu, B. (2015) · Biomacromolecules · doi:10.1021/bm5017282 · Cited by 44
Frydrych, M., Román, S., Green, N. H., MacNeil, S., & Chen, B. (2015) · Polymer Chemistry · doi:10.1039/c5py01136a · Cited by 44
Huang, P., Bi, X., Gao, J., Sun, L., Wang, S., Chen, S., Fan, X., You, Z., & Wang, Y. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02542g · Cited by 44
Self-citationBioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration
Souza, M. T., Tansaz, S., Zanotto, E. D., & Boccaccini, A. R. (2017) · Materials · doi:10.3390/ma10010083 · Cited by 44
“PGS is a synthetic polymer, firstly reported in the context of tissue engineering in 2002 [4].”
BackgroundThe Application of microRNAs in Biomaterial Scaffold‐Based Therapies for Bone Tissue Engineering
Arriaga, M. A., Ding, M., Gutierrez, A. S., & Chew, S. A. (2019) · Biotechnology Journal · doi:10.1002/biot.201900084 · Cited by 44
Preparation of poly(glycerol sebacate) fibers for tissue engineering applications
Gültekinoğlu, M., Öztürk, Ş., Chen, B., et al. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.109297 · Cited by 44
Biodegradable elastomer for soft tissue engineering
Lee, L. Y., Wu, S. C., Fu, S., Zeng, S. Y., Leong, W. S., & Tan, L. P. (2009) · European Polymer Journal · doi:10.1016/j.eurpolymj.2009.07.016 · Cited by 44
Liu, Q., Tian, M., Ding, T., et al. (2005) · Journal of Applied Polymer Science · doi:10.1002/app.22397 · Cited by 44
Xu, B. S., Li, Y., Zhu, C., et al. (2014) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.12.008 · Cited by 43
Zou, F., Sun, X., & Wang, X. (2019) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2019.05.024 · Cited by 43
Different methods of synthesizing poly(glycerol sebacate) (PGS): A review
Godinho, B., Gama, N., & Ferreira, A. R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1033827 · Cited by 43
Scaffold design considerations for peripheral nerve regeneration
Yu, L., Bennett, C. J., Lin, C.-H., Su, Y., & Yang, J. Y. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad628d · Cited by 43
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A Novel Family of Biodegradable Poly(ester amide) Elastomers
Cheng, H., Hill, P. S., Siegwart, D. J., Vacanti, N. M., Lytton‐Jean, A. K. R., Cho, S., Ye, A., Langer, R., & Anderson, D. G. (2011) · Advanced Materials · doi:10.1002/adma.201003482 · Cited by 42
Self-citationMukherjee, S., Gualandi, C., Focarete, M. L., Ravichandran, R., Venugopal, J. R., Raghunath, M., & Ramakrishna, S. (2011) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-011-4351-2 · Cited by 42
“synthetic polymers, where the natural component is responsible of enhancing cell attachment while the synthetic one acts as the supporting phase with proper mechanical properties [29–31]; (ii) the synthesis of new polymers specifically developed to possess mechanical performances suitable for MTE [3, 32–37].”
BackgroundOzcelik, B., Blencowe, A., Palmer, J. A., Ladewig, K., Stevens, G. W., Abberton, K. M., Morrison, W. A., & Qiao, G. G. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.019 · Cited by 42
Dopant‐Free Hydrogels with Intrinsic Photoluminescence and Biodegradable Properties
Tsou, Y., Zhang, X., Bai, X., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201802607 · Cited by 42
Biomimetic poly(glycerol sebacate)/polycaprolactone blend scaffolds for cartilage tissue engineering
Liu, Y., Tian, K., Hao, J., Yang, T., Geng, X., & Zhang, W. (2019) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-019-6257-3 · Cited by 42
Denis, P., Wrzecionek, M., Gadomska‐Gajadhur, A., & Sajkiewicz, P. (2019) · Polymers · doi:10.3390/polym11122113 · Cited by 42
“For the research group who first synthesized PGS polymer, there were two fundamental hypotheses and several criteria [1].”
BackgroundInfluentialInterplay of biomaterials and micro-scale technologies for advancing biomedical applications
Khademhosseini, A., Bettinger, C. J., Karp, J. M., Yeh, J., Ling, Y., Borenstein, J. T., Fukuda, J., & Langer, R. (2006) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856206778667488 · Cited by 42
Self-citationThe influence of lactic on the properties of Poly (glycerol–sebacate–lactic acid)
Sun, Z., Wu, L., Huang, W., et al. (2008) · Materials Science and Engineering C · doi:10.1016/j.msec.2008.06.010 · Cited by 41
Polyester derived from recycled poly(ethylene terephthalate) waste for regenerative medicine
Sarkar, K., Meka, S. R. K., Bagchi, A., Krishna, N. S., Ramachandra, S. G., Madras, G., & Chatterjee, K. (2014) · RSC Advances · doi:10.1039/c4ra09560j · Cited by 40
Combinatorial Approach to Develop Tailored Biodegradable Poly(xylitol dicarboxylate) Polyesters
Dasgupta, Q., Chatterjee, K., & Madras, G. (2014) · Biomacromolecules · doi:10.1021/bm5013025 · Cited by 41
Microfibrous silver-coated polymeric scaffolds with tunable mechanical properties
Kalakonda, P., Aldhahri, M. M., Abdel-wahab, M. S., Tamayol, A., Mollazadeh‐Moghaddam, K., Rached, F. B., Pain, A., Khademhosseini, A., Memić, A., & Chaı̈eb, S. (2017) · RSC Advances · doi:10.1039/c6ra25151j · Cited by 41
A growth-accommodating implant for paediatric applications
Feins, E. N., Lee, Y., O’Cearbhaill, E. D., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0142-5 · Cited by 41
Rahmani, M., Khani, M., Rabbani, S., Mashaghi, A., Noorizadeh, F., Majidi, R. F., & Ghanbari, H. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110626 · Cited by 41
Biomaterials in skin tissue engineering
Wei, C., Feng, Y., Che, D., Zhang, J., Zhou, X., Shi, Y., & Wang, L. (2021) · International Journal of Polymeric Materials · doi:10.1080/00914037.2021.1933977 · Cited by 42
“of glycerol and sebacic acid, and it is a biodegradable elastomer with biocompatibility([78]).”
BackgroundDjordjevic, I., Choudhury, N. R., Dutta, N. K., & Kumar, S. (2011) · Polymer International · doi:10.1002/pi.2996 · Cited by 41
Wang, D., Tang, Z., Wang, Z., Zhang, L., & Guo, B. (2021) · Polymer Chemistry · doi:10.1039/d1py01287h · Cited by 39
Park, H., Larson, B. L., Kolewe, M. E., Vunjak‐Novakovic, G., & Freed, L. E. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.11.005 · Cited by 43
“However, in contrast to previously used collagen sponge scaffolds, we selected PGS, a mechanically robust synthetic elastomer [4, 5] that can be reproducibly microengineered into scaffolds with precise, cardiomimetic microarchitectures [10, 13, 14].”
MethodTissue engineering for treatment of vocal fold scar
Long, J. L. (2010) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0b013e32833febf2 · Cited by 40
Phosphoester cross-linked vegetable oil to construct a biodegradable and biocompatible elastomer
Liu, Z., Xu, Y., Cao, L., Bao, C., Sun, H., Wang, L., Dai, K., & Zhu, L. (2012) · Soft Matter · doi:10.1039/c2sm25115a · Cited by 39
Synthesis and degradation of sorbitol‐based polymers
Pasupuleti, S., & Madras, G. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.33840 · Cited by 40
Tevlek, A., Hosseinian, P., Cansel, O., et al. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.11.082 · Cited by 40
Sonseca, Á., & Fray, M. E. (2017) · RSC Advances · doi:10.1039/c7ra02509b · Cited by 42
Biodegradable and Bioactive PCL–PGS Core–Shell Fibers for Tissue Engineering
Hou, L., Zhang, X., Mikael, P. E., Lei, L., Dong, W., Zheng, Y., Simmons, T. J., Zhang, F., & Linhardt, R. J. (2017) · ACS Omega · doi:10.1021/acsomega.7b00460 · Cited by 40
Metadata
- Authors
- Wang, Y., Ameer, G. A., Sheppard, B. J., & Langer, R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Northwestern University (US)
- Venue
- Nature Biotechnology
- Published
- 2002-06
- Volume
- 20
- Issue
- 6
- Pages
- 602-606
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W1994054444
- Cited by
- 1,314
- References
- 45
- Citations by year
- 2026: 27 · 2025: 56 · 2024: 59 · 2023: 60 · 2022: 65 · 2021: 78 · 2020: 77 · 2019: 76 · 2018: 73 · 2017: 65 · 2016: 66 · 2015: 66 · 2014: 79 · 2013: 66 · 2012: 67
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (5-R01-HL60435, R01HL060435)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- biodegradable elastomers, tough polymers, biocompatibility, covalent cross-linking, hydrogen bonding, hydroxyl groups, tissue engineering, drug delivery, in vivo sensing, polymer implants, biodegradation
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Biocompatible Materials, Decanoates, Decanoic Acids, Dicarboxylic Acids, Elasticity, Female, Glycerol, Materials Testing, Models, Molecular, Polyglycolic Acid, Polymers, Skin, Stress, Mechanical, Tensile Strength, 3T3 Cells, Lactic Acid, Absorbable Implants, Elastomers, Mice, Rats
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