Cited by 7473D Printing in Biomedical ResearchTissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications

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Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells

Anderson, Daniel G, Levenberg, Shulamit, Langer, Robert·2004·Nature Biotechnology

DOI 10.1038/nbt981

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Abstract

Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell-material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.

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Authors: Anderson, D. G., Levenberg, S., & Langer, R.
Affiliations: Massachusetts Institute of Technology (US)
ORCID: Anderson, Daniel G
Levenberg, Shulamit
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2004-06-13
Volume: 22
Issue: 7
Pages: 863-866
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt981
OpenAlex: W2052098523
Cited by: 747
References: 21
Citations by year: 2026: 1 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 19 · 2020: 26 · 2019: 17 · 2018: 28 · 2017: 26 · 2016: 38 · 2015: 37 · 2014: 48 · 2013: 53 · 2012: 59
FWCI: 33.04
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 60435, R01HL060435)
Topics: Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: human embryonic stem cells, cell-material interactions, biomaterials, tissue engineering, cell therapy, cell attachment, cell proliferation, gene expression
MeSH terms: Biocompatible Materials, Embryo, Mammalian, Humans, Polymers, Stem Cells, Combinatorial Chemistry Techniques, Microarray Analysis

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Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells

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