Cited by 7473D Printing in Biomedical ResearchTissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications

The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.

Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells

Anderson, Daniel G, Levenberg, Shulamit, Langer, Robert·2004·Nature Biotechnology

DOI 10.1038/nbt981

Open this paper in CoChat — free account

Abstract

Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell-material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.

Integrity signals

Registry

Crossref · 10.1038/nbt981

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947
Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609
The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
Moll, R., Franke, W. W., Schiller, D. L., Geiger, B., & Krepler, R. (1982) · Cell · doi:10.1016/0092-8674(82)90400-7 · Cited by 5,239
Printing Proteins as Microarrays for High-Throughput Function Determination
MacBeath, G., & Schreiber, S. L. (2000) · Science · doi:10.1126/science.289.5485.1760 · Cited by 2,767
Role of cell shape in growth control
Folkman, J., & Moscona, A. (1978) · Nature · doi:10.1038/273345a0 · Cited by 2,422
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
Yaffe, D., & Saxel, O. (1977) · Nature · doi:10.1038/270725a0 · Cited by 2,153
Principles of Tissue Engineering
(2014) · Elsevier eBooks · doi:10.1016/c2011-0-07193-4 · Cited by 1,912
Stem cells find their niche
Spradling, A. C., Drummond‐Barbosa, D., & Kai, T. (2001) · Nature · doi:10.1038/35102160 · Cited by 1,465
Endothelial cells derived from human embryonic stem cells
Levenberg, S., Golub, J. S., Amit, M., Itskovitz‐Eldor, J., & Langer, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032074999 · Cited by 818
Self-citation
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds
Levenberg, S., Huang, N. F., Lavik, E., Rogers, A. B., Itskovitz‐Eldor, J., & Langer, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735463100 · Cited by 691
Self-citation

Flagged first, then by citations

Show all 21 references

1 of the 21 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 743

Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides – A model for biofunctional scaffolds
Chau, Y., Luo, Y., Cheung, A. C. Y., Nagai, Y., Zhang, S., Kobler, J. B., Zeitels, S. M., & Langer, R. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.11.046 · Cited by 168
Self-citation
Overlooked? Underestimated? Effects of Substrate Curvature on Cell Behavior
Baptista, D., Teixeira, L. M., van Blitterswijk, C., Giselbrecht, S., & Truckenmüller, R. K. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.01.006 · Cited by 165
Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation
Bratt‐Leal, A. M., Carpenedo, R. L., Ungrin, M., Zandstra, P. W., & McDevitt, T. C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.113 · Cited by 168
Guidance of stem cell fate on 2D patterned surfaces
Kolind, K., Leong, K. W., Besenbacher, F., & Foss, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.070 · Cited by 163
Tissue matrix arrays for high-throughput screening and systems analysis of cell function
Beachley, V. Z., Wolf, M. T., Sadtler, K., Manda, S. S., Jacobs, H. N., Blatchley, M. R., Bader, J. S., Pandey, A., Pardoll, D. M., & Elisseeff, J. H. (2015) · Nature Methods · doi:10.1038/nmeth.3619 · Cited by 165
Particle-localized AC and DC manipulation and electrokinetics
Velev, O. D., Gangwal, S., & Petsev, D. N. (2009) · Annual Reports Section C (Physical Chemistry) · doi:10.1039/b803015b · Cited by 160
Cell patterning chip for controlling the stem cell microenvironment
Rosenthal, A. D., MacDonald, A., & Joel Voldman, B. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.03.023 · Cited by 158
Rapid Fabrication of Micro‐ and Nanoscale Patterns by Replica Molding from Diatom Biosilica
Lošić, D., Mitchell, J. G., Lal, R., & Voelcker, N. H. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200600872 · Cited by 155
Materials for stem cell factories of the future
Celiz, A. D., Smith, J. G. W., Langer, R., Anderson, D. G., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L. E., Denning, C. N., & Alexander, M. R. (2014) · Nature Materials · doi:10.1038/nmat3972 · Cited by 158
Self-citation
A Combinatorial Library of Photocrosslinkable and Degradable Materials
Anderson, D. G., Tweedie, C. A., Hossain, N., Navarro, S. M., Brey, D. M., Vliet, K. J. V., Langer, R., & Burdick, J. A. (2006) · Advanced Materials · doi:10.1002/adma.200600529 · Cited by 155
Self-citation
Combinatorial Low‐Volume Synthesis of Well‐Defined Polymers by Enzyme Degassing
Chapman, R., Gormley, A. J., Stenzel, M. H., & Stevens, M. M. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201600112 · Cited by 153
Effect of citric acid crosslinking cellulose‐based hydrogels on osteogenic differentiation
Raucci, M. G., Alvarez‐Perez, M. A., Demitri, C., Giugliano, D., Benedictis, V. M. D., Sannino, A., & Ambrosio, L. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35343 · Cited by 150
Biomaterials for Personalized Cell Therapy
Facklam, A. L., Volpatti, L. R., & Anderson, D. G. (2019) · Advanced Materials · doi:10.1002/adma.201902005 · Cited by 152
Self-citation
Nanotechnology Solutions for Alzheimer's Disease: Advances in Research Tools, Diagnostic Methods and Therapeutic Agents
Nazem, A., & Mansoori, G. A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13210 · Cited by 150
Integrated Micro/Nanoengineered Functional Biomaterials for Cell Mechanics and Mechanobiology: A Materials Perspective
Shao, Y., & Fu, J. (2013) · Advanced Materials · doi:10.1002/adma.201304431 · Cited by 151
Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
Vassey, M., Figueredo, G. P., Scurr, D. J., Vasilevich, A. S., Vermeulen, S., Carlier, A., Luckett, J., Beijer, N. R. M., Williams, P. M., Winkler, D. A., et al. (2020) · Advanced Science · doi:10.1002/advs.201903392 · Cited by 149
High-Throughput Discovery of Synthetic Surfaces That Support Proliferation of Pluripotent Cells
Derda, R., Musah, S., Orner, B. P., Klim, J. R., Li, L., & Kiessling, L. L. (2010) · Journal of the American Chemical Society · doi:10.1021/ja906089g · Cited by 144
A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells
Dolatshahi‐Pirouz, A., Nikkhah, M., Gaharwar, A. K., Hashmi, B., Guermani, E., Aliabadi, H., Camci‐Unal, G., Ferrante, T. C., Foss, M., Ingber, D. E., et al. (2014) · Scientific Reports · doi:10.1038/srep03896 · Cited by 143
Lab-on-a-chip devices as an emerging platform for stem cell biology
Gupta, K., Kim, D., Ellison, D. D., Smith, C. L., Kundu, A., Tuan, J., Suh, K. Y., & Levchenko, A. (2010) · Lab on a Chip · doi:10.1039/c004689b · Cited by 143
Defined Substrates for Human Embryonic Stem Cell Growth Identified from Surface Arrays
Derda, R., Li, L., Orner, B. P., Lewis, R. L., Thomson, J. A., & Kiessling, L. L. (2007) · ACS Chemical Biology · doi:10.1021/cb700032u · Cited by 139
Designing stem cell niches for differentiation and self-renewal
Donnelly, H., Salmerón‐Sánchez, M., & Dalby, M. J. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0388 · Cited by 142
Polysaccharides for tissue engineering: Current landscape and future prospects
Tchobanian, A., Oosterwyck, H. V., & Fardim, P. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.10.039 · Cited by 145
Bioengineering approaches to guide stem cell-based organogenesis
Gjorevski, N., Ranga, A., & Lutolf, M. P. (2014) · Development · doi:10.1242/dev.101048 · Cited by 137
Microfluidic static droplet arrays with tuneable gradients in material composition
Sun, M. Z., Bithi, S. S., & Vanapalli, S. A. (2011) · Lab on a Chip · doi:10.1039/c1lc20709a · Cited by 141
Engineering strategies to mimic the glioblastoma microenvironment
Rape, A. D., Ananthanarayanan, B., & Kumar, S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.08.012 · Cited by 138
Engineering the Stem Cell Microenvironment
Metallo, C. M., Mohr, J. C., Detzel, C. J., de Pablo, J. J., Wie, B. V., & Palecek, S. P. (2007) · Biotechnology Progress · doi:10.1021/bp060350a · Cited by 133
Bio-Inspired Extreme Wetting Surfaces for Biomedical Applications
Shin, S., Seo, J., Han, H., Kang, S., Kim, H., & Lee, T. (2016) · Materials · doi:10.3390/ma9020116 · Cited by 137
Generation of static and dynamic patterned co-cultures using microfabricated parylene-C stencils
Wright, D., Rajalingam, B., Selvarasah, S., Dokmeci, M. R., & Khademhosseini, A. (2007) · Lab on a Chip · doi:10.1039/b706081e · Cited by 132
Using Nanotopography and Metabolomics to Identify Biochemical Effectors of Multipotency
Tsimbouri, P. M., McMurray, R. J., Burgess, K., Alakpa, E. V., Reynolds, P. M., Murawski, K., Kingham, E., Oreffo, R. O. C., Gadegaard, N., & Dalby, M. J. (2012) · ACS Nano · doi:10.1021/nn304046m · Cited by 128
Engineering tissues for in vitro applications
Khetani, S. R., & Bhatia, S. N. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.08.009 · Cited by 127
Biomaterials for stem cell engineering and biomanufacturing
Xu, Y., Chen, C., Hellwarth, P. B., & Bao, X. (2019) · Bioactive Materials · doi:10.1016/j.bioactmat.2019.11.002 · Cited by 127
Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo
Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J., Figueredo, G. P., Mbadugha, C., Teo, A. C. K., Latif, A., Kämmerling, L., et al. (2020) · Matter · doi:10.1016/j.matt.2020.03.018 · Cited by 130
Pushing the Limits of High Throughput PET-RAFT Polymerization
Ng, G., Yeow, J., Chapman, R., Isahak, N., Wolvetang, E. J., Cooper-White, J. J., & Boyer, C. A. (2018) · Macromolecules · doi:10.1021/acs.macromol.8b01600 · Cited by 127
Development and therapeutic applications of advanced biomaterials
Karp, J. M., & Langer, R. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.09.008 · Cited by 126
Self-citation
New approaches to biomaterials design
Kohn, J. (2004) · Nature Materials · doi:10.1038/nmat1249 · Cited by 126
Materiomics: An ‐omics Approach to Biomaterials Research
Cranford, S. W., de Boer, J., van Blitterswijk, C., & Buehler, M. J. (2013) · Advanced Materials · doi:10.1002/adma.201202553 · Cited by 128
Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine
Markert, C. D., Guo, X., Skardal, A., Wang, Z., Bharadwaj, S., Zhang, Y., Bonin, K., & Guthold, M. (2013) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2013.07.008 · Cited by 123
Nanofabrication and Microfabrication of Functional Materials for Tissue Engineering
Park, H., Cannizzaro, C., Vunjak‐Novakovic, G., Langer, R., Vacanti, C. A., & Farokhzad, O. C. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0198 · Cited by 123
Self-citation
A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells
Zhang, R., Mjoseng, H. K., Hoeve, M. A., Bauer, N. G., Pells, S., Besseling, R., Velugotla, S., Tourniaire, G., Kishen, R. E. B., Tsenkina, Y., et al. (2013) · Nature Communications · doi:10.1038/ncomms2341 · Cited by 122
Fabrication methods of an engineered microenvironment for analysis of cell–biomaterial interactions
Shin, H. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.007 · Cited by 123
Micro- and nanofabrication of chitosan structures for regenerative engineering
Jiang, T., Deng, M., James, R., Nair, L. S., & Laurencin, C. T. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.07.003 · Cited by 121
Novel materials for bone and cartilage regeneration
Bonzani, I. C., George, J. H., & Stevens, M. M. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.09.009 · Cited by 122
Small molecule microarrays: recent advances and applications
Uttamchandani, M., Walsh, D. P., Yao, S. Q., & Chang, Y. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2004.12.005 · Cited by 121
Chiral Design for Polymeric Biointerface: The Influence of Surface Chirality on Protein Adsorption
Wang, X., Gan, H. K., & Sun, T. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201101032 · Cited by 116
Systems approaches and algorithms for discovery of combinatorial therapies
Feala, J. D., Cortes, J., Duxbury, P. M., Piermarocchi, C., McCulloch, A. D., & Paternostro, G. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.51 · Cited by 116
A new approach to the rationale discovery of polymeric biomaterials
Kohn, J., Welsh, W. J., & KNIGHT, D. D. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.022 · Cited by 114
Protein and small molecule microarrays: powerful tools for high-throughput proteomics
Uttamchandani, M., Wang, J., & Yao, S. Q. (2005) · Molecular BioSystems · doi:10.1039/b513935j · Cited by 114
An adaptable hydrogel array format for 3-dimensional cell culture and analysis
Jongpaiboonkit, L., King, W. J., Lyons, G. E., Paguirigan, A. L., Warrick, J. W., Beebe, D. J., & Murphy, W. L. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.040 · Cited by 112
Endothelialization of implanted cardiovascular biomaterial surfaces: The development from in vitro to in vivo
Liu, T., Liu, S., Zhang, K., Chen, J., & Huang, N. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35025 · Cited by 111
Precision Assembly of Complex Cellular Microenvironments using Holographic Optical Tweezers
Kirkham, G. R., Britchford, E. R., Upton, T., Ware, J. S., Gibson, G. M., Devaud, Y. R., Ehrbar, M., Padgett, M. J., Allen, S., Buttery, L. D. K., et al. (2015) · Scientific Reports · doi:10.1038/srep08577 · Cited by 111
Three‐dimensional cell culture microarray for high‐throughput studies of stem cell fate
Fernandes, T. G., Kwon, S., Bale, S. S., Lee, M., Diogo, M. M., Clark, D. S., Cabral, J. M. S., & Dordick, J. S. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22661 · Cited by 108
Rapid Assembly of Heterogeneous 3D Cell Microenvironments in a Microgel Array
Li, Y., Chen, P., Wang, Y., Yan, S., Feng, X., Du, W., Koehler, S. A., Demirci, U., & Liu, B. (2016) · Advanced Materials · doi:10.1002/adma.201600247 · Cited by 108
Combinatorial screening of cell proliferation on poly(l-lactic acid)/poly(d,l-lactic acid) blends
Simon, C. G., Eidelman, N., Kennedy, S. B., Sehgal, A., Khatri, C. A., & Washburn, N. R. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.04.050 · Cited by 107
Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application
Zhu, H., Yang, H., Ma, Y., Lu, T. J., Xu, F., Genin, G. M., & Lin, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000639 · Cited by 107
Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays
Hook, A. L., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., Davies, M. C., Williams, P. M., & Alexander, M. R. (2013) · Advanced Materials · doi:10.1002/adma.201204936 · Cited by 105
Self-citation
A High‐Throughput Assay of Cell‐Surface Interactions using Topographical and Chemical Gradients
Yang, J., Rose, F. R. A. J., Gadegaard, N., & Alexander, M. R. (2008) · Advanced Materials · doi:10.1002/adma.200801942 · Cited by 104
A User’s Guide to Machine Learning for Polymeric Biomaterials
Meyer, T. A., Ramirez, C., Tamasi, M., & Gormley, A. J. (2022) · ACS Polymers Au · doi:10.1021/acspolymersau.2c00037 · Cited by 106
Cell trapping in microfluidic chips
Johann, R. M. (2006) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-0369-6 · Cited by 103
Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays
Yang, J., Mei, Y., Hook, A. L., Taylor, M., Urquhart, A. J., Bogatyrev, S. R., Langer, R., Anderson, D. G., Davies, M. C., & Alexander, M. R. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.028 · Cited by 102
Self-citation
Combinatorial Material Mechanics: High‐Throughput Polymer Synthesis and Nanomechanical Screening
Tweedie, C. A., Anderson, D. G., Langer, R., & Vliet, K. J. V. (2005) · Advanced Materials · doi:10.1002/adma.200501142 · Cited by 102
Self-citation
Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?
Schneeberger, K., Spee, B., Costa, P., Sachs, N., Clevers, H., & Malda, J. (2017) · Biofabrication · doi:10.1088/1758-5090/aa6121 · Cited by 100
Functionalization of biomaterials with small osteoinductive moieties
Maia, F. R., Bidarra, S. J., Granja, P. L., & Barrias, C. C. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.08.004 · Cited by 102
Microengineering methods for cell-based microarrays and high-throughput drug-screening applications
Xu, F., Wu, J., Wang, S., Durmus, N. G., Gurkan, U. A., & Demirci, U. (2011) · Biofabrication · doi:10.1088/1758-5082/3/3/034101 · Cited by 98
Microscale Strategies for Generating Cell-Encapsulating Hydrogels
Selimović, Š., Oh, J., Bae, H., Dokmeci, M. R., & Khademhosseini, A. (2012) · Polymers · doi:10.3390/polym4031554 · Cited by 99
Culture conditions for human embryonic stem cells
Skottman, H., & Hovatta, O. (2006) · Reproduction · doi:10.1530/rep.1.01079 · Cited by 97
Cell microarrays in drug discovery
Castel, D., Pitaval, A., Debily, M.-A., & Gidrol, X. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.05.015 · Cited by 96
Stem cells in microfluidics
Wu, H.-W., Lin, C.-C., & Lee, G. (2011) · Biomicrofluidics · doi:10.1063/1.3528299 · Cited by 96
High-throughput analysis of signals regulating stem cell fate and function
Underhill, G. H., & Bhatia, S. N. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.05.036 · Cited by 93
Patterned and switchable surfaces for biomolecular manipulation
Hook, A. L., Voelcker, N. H., & Thissen, H. W. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.03.040 · Cited by 93
3D Biomaterial Microarrays for Regenerative Medicine: Current State‐of‐the‐Art, Emerging Directions and Future Trends
Gaharwar, A. K., Arpanaei, A., Andresen, T. L., & Dolatshahi‐Pirouz, A. (2015) · Advanced Materials · doi:10.1002/adma.201503918 · Cited by 93
Polymer microarrays for cellular adhesion
Tourniaire, G., Collins, J. E., Campbell, S., Mizomoto, H., Ogawa, S., Thaburet, J.-F. O., & Bradley, M. (2006) · Chemical Communications · doi:10.1039/b602009g · Cited by 95
Application of biomaterials to advance induced pluripotent stem cell research and therapy
Tong, Z., Solanki, A., Hamilos, A. E., Levy, O., Wen, K., Yin, X., & Karp, J. M. (2015) · The EMBO Journal · doi:10.15252/embj.201490756 · Cited by 90
Micro- and nanoscale technologies for tissue engineering and drug discovery applications
Chung, B. G., Kang, L., & Khademhosseini, A. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2.12.1653 · Cited by 90
Comparison of Biomaterials and Extracellular Matrices as a Culture Platform for Multiple, Independently Derived Human Embryonic Stem Cell Lines
Hongisto, H., Rajala, K. M., Ojala, M., Panula, S., Areva, S., Kellomäki, M., Suuronen, R., & Skottman, H. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0316 · Cited by 88
High throughput miniature drug-screening platform using bioprinting technology
Rodríguez-Dévora, J. I., Zhang, B., Reyna, D., Shi, Z., & Xu, T. (2012) · Biofabrication · doi:10.1088/1758-5082/4/3/035001 · Cited by 86
Using biomaterials to study stem cell mechanotransduction, growth and differentiation
McMurray, R. J., Dalby, M. J., & Tsimbouri, P. M. (2014) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1957 · Cited by 86
Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity
Sanni, O., Chang, C., Anderson, D. G., Langer, R., Davies, M. C., Williams, P. M., Williams, P. M., Alexander, M. R., & Hook, A. L. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400648 · Cited by 84
Self-citation
High-throughput approaches for screening and analysis of cell behaviors
Seo, J., Shin, J.-Y., Leijten, J., Jeon, O., Camci‐Unal, G., Dikina, A. D., Brinegar, K. N., Ghaemmaghami, A. M., Alsberg, E., & Khademhosseini, A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.022 · Cited by 86
Materials control of the epigenetics underlying cell plasticity
Nemec, S. R., & Kilian, K. A. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-00238-z · Cited by 84
Chemical and physical properties of regenerative medicine materials controlling stem cell fate
Kaivosoja, E., Barreto, G., Levón, K., Virtanen, S., Ainola, M., & Konttinen, Y. T. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.573805 · Cited by 83
Micro- and nanoengineering for stem cell biology: the promise with a caution
Gupta, K., Kim, D., Beebe, D. J., & Levchenko, A. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.03.006 · Cited by 82
Chemical patterning in biointerface science
Ogaki, R., Alexander, M. R., & Kingshott, P. (2010) · Materials Today · doi:10.1016/s1369-7021(10)70057-2 · Cited by 85
Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
Celiz, A. D., Smith, J. G. W., Patel, A. K., Hook, A. L., Rajamohan, D., George, V. T., Flatt, L., Patel, M. J., Epa, V. C., Singh, T., et al. (2015) · Advanced Materials · doi:10.1002/adma.201501351 · Cited by 81
Self-citation
Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth
Buck, M. E., Breitbach, A. S., Belgrade, S. K., Blackwell, H. E., & Lynn, D. M. (2009) · Biomacromolecules · doi:10.1021/bm9001552 · Cited by 83
Strategies for cell manipulation and skeletal tissue engineering using high-throughput polymer blend formulation and microarray techniques
Khan, F., Tare, R. S., Kanczler, J. M., Oreffo, R. O. C., & Bradley, M. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.101 · Cited by 81
Cell Adhesion Profiling Using Extracellular Matrix Protein Microarrays
Kuschel, C., Steuer, H., Maurer, A., Kanzok, B., Stoop, R., & Angres, B. (2006) · BioTechniques · doi:10.2144/000112134 · Cited by 81
Neural tissue engineering: Bioresponsive nanoscaffolds using engineered self-assembling peptides
Koss, K. M., & Unsworth, L. D. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.08.026 · Cited by 80
TOF-SIMS Analysis of a 576 Micropatterned Copolymer Array To Reveal Surface Moieties That Control Wettability
Urquhart, A. J., Taylor, M., Anderson, D. G., Langer, R., Davies, M. C., & Alexander, M. R. (2007) · Analytical Chemistry · doi:10.1021/ac071560k · Cited by 80
Self-citation
Molecular and functional analysis using live cell microarrays
Chen, D. S., & Davis, M. M. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.01.001 · Cited by 79
Culture development for human embryonic stem cell propagation: molecular aspects and challenges
Rao, B. M., & Zandstra, P. W. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.08.001 · Cited by 79
Fourier Transform Infrared Imaging for High-Throughput Analysis of Pharmaceutical Formulations
Chan, K. L. A., & Kazarian, S. G. (2005) · Journal of Combinatorial Chemistry · doi:10.1021/cc049840q · Cited by 78
Density Control of Poly(ethylene glycol) Layer To Regulate Cellular Attachment
Satomi, T., Nagasaki, Y., Kobayashi, H., Otsuka, H., & Kataoka, K. (2007) · Langmuir · doi:10.1021/la0624384 · Cited by 77
Polyisocyanopeptide hydrogels: A novel thermo-responsive hydrogel supporting pre-vascularization and the development of organotypic structures
Zimoch, J., Padial, J. S., Klar, A. S., Vallmajó-Martín, Q., Meuli, M., Biedermann, T., Wilson, C., Rowan, A. E., & Ernst Reichmann, A. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.01.042 · Cited by 80
Defining Long-Term Maintenance Conditions of Human Embryonic Stem Cells With Arrayed Cellular Microenvironment Technology
Brafman, D. A., Shah, K. D., Fellner, T., Chien, S., & Willert, K. (2009) · Stem Cells and Development · doi:10.1089/scd.2008.0410 · Cited by 76
Designed Multifunctional Nanocomposites for Biomedical Applications
Yiu, H. H. P., Niu, H., Biermans, E., TENDELOO, G. V., & Rosseinsky, M. J. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200902117 · Cited by 76
Microarray platforms for enzymatic and cell-based assays
Díaz‐Mochon, J. J., Tourniaire, G., & Bradley, M. (2006) · Chemical Society Reviews · doi:10.1039/b511848b · Cited by 76
Superwettable nanodendritic gold substrates for direct miRNA SERS detection
Song, Y., Xu, T., Xu, L., & Zhang, X. (2018) · Nanoscale · doi:10.1039/c8nr07348a · Cited by 75
Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials
Nitti, P., Narayanan, A., Pellegrino, R., Villani, S., Madaghiele, M., & Demitri, C. (2023) · Bioengineering · doi:10.3390/bioengineering10101122 · Cited by 77
High Throughput Surface Characterisation of a Combinatorial Material Library
Urquhart, A. J., Anderson, D. G., Taylor, M., Alexander, M. R., Langer, R., & Davies, M. C. (2007) · Advanced Materials · doi:10.1002/adma.200700949 · Cited by 75
Self-citation
The effects of interactive mechanical and biochemical niche signaling on osteogenic differentiation of adipose-derived stem cells using combinatorial hydrogels
Nii, M., Lai, J. H., Keeney, M., Han, L., Behn, A. W., Imanbayev, G., & Yang, F. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.11.002 · Cited by 74

Authors: Anderson, D. G., Levenberg, S., & Langer, R.
Affiliations: Massachusetts Institute of Technology (US)
ORCID: Anderson, Daniel G
Levenberg, Shulamit
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2004-06-13
Volume: 22
Issue: 7
Pages: 863-866
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt981
OpenAlex: W2052098523
Cited by: 747
References: 21
Citations by year: 2026: 1 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 19 · 2020: 26 · 2019: 17 · 2018: 28 · 2017: 26 · 2016: 38 · 2015: 37 · 2014: 48 · 2013: 53 · 2012: 59
FWCI: 33.04
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 60435, R01HL060435)
Topics: Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: human embryonic stem cells, cell-material interactions, biomaterials, tissue engineering, cell therapy, cell attachment, cell proliferation, gene expression
MeSH terms: Biocompatible Materials, Embryo, Mammalian, Humans, Polymers, Stem Cells, Combinatorial Chemistry Techniques, Microarray Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks