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Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells
Abstract
Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell-material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.
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“Synthetic polymer-based culture allows organoid formation conditions to be evaluated using high-throughput methods143–145.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [145]
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Metadata
- Authors
- Anderson, D. G., Levenberg, S., & Langer, R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Nature Biotechnology
- Published
- 2004-06-13
- Volume
- 22
- Issue
- 7
- Pages
- 863-866
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2052098523
- Cited by
- 747
- References
- 21
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 19 · 2020: 26 · 2019: 17 · 2018: 28 · 2017: 26 · 2016: 38 · 2015: 37 · 2014: 48 · 2013: 53 · 2012: 59
- FWCI
- 33.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 60435, R01HL060435)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- human embryonic stem cells, cell-material interactions, biomaterials, tissue engineering, cell therapy, cell attachment, cell proliferation, gene expression
- MeSH terms
- Biocompatible Materials, Embryo, Mammalian, Humans, Polymers, Stem Cells, Combinatorial Chemistry Techniques, Microarray Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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