ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

Chk1 and Chk2 kinases in checkpoint control and cancer

Bartek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00110-7 · Cited by 1,513

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,304

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

Rothkamm, K., Krüger, I., Thompson, L. H., & Lübrich, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5706-5715.2003 · Cited by 1,187

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091

Ubiquitination and deubiquitination involved in cell cycle progression

van Leuken, R. J. (2008) · Utrecht University Repository (Utrecht University)

TOLERANCE OF THYMINE GLYCOL AT THE BLUNT DNA DOUBLE STRAND BREAK FOR NONHOMOLOGUS END JOINING REPAIR AND INTERFERENCE BY BASE EXCISION REPAIR

Chalasani, S. L. (2015) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/mkf5-my97

Disruption of DNA Repair by Cell Cycle and Transcriptional CDK Inhibition

Cornell, L., Johnson, N., & Shapiro, G. I. (2015) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-14151-0_17

Identification and Functional Characterizations of Novel Post-Translational Modifications of DNA Repair Proteins

Cai, Q. (2014) · eScholarship (California Digital Library)

Chromatin Responses to DNA Damage

Falbo, K. B., & Shen, X. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8044-1_4

Estudo da integridade genômica durante o processo de diferenciação de células-tronco adultas em células com características neurais

Lambert, A. P. F., & Bonatto, D. (2009) · Americanae (AECID Library) · doi:10.13140/rg.2.2.10637.15841

Proapoptotic Bid Association with Mre11-Rad50-Nbs1 Complex is Indispensable for Checkpoint Activation after DNA DamagePreprint

Ta, V. B. T., Bezstarosti, K., Demmers, J., Maculins, T., Schellekens, K., van Gent, D. C., & Persengiev, S. P. (2007) · Nature Precedings · doi:10.1038/npre.2007.1203.1

Cyclin A/CDK2 regulates multiple G2 phase pathways

Oakes, V. (2012)

CHK2 is Negatively Regulated by Protein Phosphatase 2A

Freeman, A. K. (2010) · Digital Commons - University of South Florida (University of South Florida)

The Role of BRCA1 Domains and Motifs in Tumor Suppression

Velkova, A. (2009) · Defense Technical Information Center (DTIC) · doi:10.21236/ada511277

Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells

Granotier-Beckers, C., & Francois, D. (2011) · InTech eBooks · doi:10.5772/24130 · Cited by 1

Cell Cycle Control

Matthews, D. J., & Gerritsen, M. E. (2010) · Wiley eBooks · doi:10.1002/9780470555293.ch6

PARP inhibition tested in a mammary epithelial cell line model

Halldorsdottir, A. M. (2010)

Roles for Histones H4 Serine 1 Phosphorylation in DNA Double Strand Break Repair and Chromatin Compaction: A Dissertation

Foley, M. A. (2008) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/shgk-q661

Replication fork stability in mammalian cells

Elvers, I. (2011) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Synergy Between DNA Replication and Repair Mechanisms

Zannis‐Hadjopoulos, M., & Rampakakis, E. (2011) · InTech eBooks · doi:10.5772/24164

Role of ATM (ataxia telangiectasia mutated) and Artemis proteins for the repair of DNA double-strand breaks by homologous recombination in mammalian cells

Köcher, S. (2011)

Telomere Structure in Telomerase Regulation

Vodenicharov, M. D., & Wellinger, R. J. (2012) · Wiley eBooks · doi:10.1002/9781118268667.ch7

Mitotic Response to DNA Damage in Early Drosophila Embroyos: a Dissertation

Kwak, S. (2008) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/mn1v-vr34

Tissue Biology of Proliferation and Cell Death Among Retinal Progenitor Cells

Linden, R., Martins, R. A. P., Silveira, M. S., Borges, H. L., Sholl‐Franco, A., Madeira, L. F., & Carneiro, A. C. D. (2009) · Springer eBooks · doi:10.1007/978-90-481-3375-8_13

Regulation of cellular signalling pathways by Adenovirus

Forrester, N. A. (2012) · University of Birmingham Institutional Research Archive (University of Birmingham)

Regulation of DNA Double Strand Break Response

Chen, C. (2014) · DukeSpace (Duke University)

Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae

Hashash, N. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Inhibitors of DNA Repair and Response to Ionising Radiation

Vischioni, B., Nicolay, N. H., Sharma, R. A., & Helleday, T. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8044-1_7

Investigation of mechanisms that suppress non-allelic homologous recombination

George, C. M. (2013) · eCommons (Cornell University)

Characterization and functional studies of PPM1D in breast cancer

Pärssinen, J. (2007) · Tampere University Institutional Repository (Tampere University)

Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence

Jalili, E. (2013)

Linking Human RecQ Helicases to DNA Damage Response and Aging

Cheng, W., Ahn, B., & Bohr, V. A. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_15

Role of checkpoint kinase 1 in malignant melanoma

Smith, J. (2013) · Enlighten: Theses (The University of Glasgow)

Analysis of p53 and c-MYC, two key transcription factors involved in tumorigenesis

Jung, P. (2008) · doi:10.5282/edoc.10559

The mechanism of DNA double-strand break (DSB) resection in human cells

Yang, S.-H. (2013) · Texas ScholarWorks (Texas Digital Library)

c-Myc Attenuates The Ability of Doxorubicin to Reduce The Colony Formation Partially Through Regulating Nbs1 in U2OS Cells*

Han-Qing, S. H. I., Huang, H., Zhang, X., Zhang, J., Xiu-Tan, L. U. O., Xiu-E, P. E. N. G., Huang, B., & Lu, J. (2010) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2010.00048

SEARCHING FOR RADIOSENSITIZERS: DEVELOPMENT OF A NOVEL ASSAY AND HIGH-THROUGHPUT SCREENING

Katz, D. R. (2008) · TSpace (University of Toronto)

Contributions of NHEJ and HRR in the processing of DNA double strand breaks and chromosome breaks throughout the cell cycle

Siemann, M. (2014) · DuEPublico (University of Duisburg-Essen)

Defects in the ATR-dependent DNA damage response pathway and human syndromes

O’Driscoll, M. (2009) · Institutional Repositories DataBase (IRDB) · doi:10.11343/amn.53.s23

Recombinational Repair of a Chromosomal DNA Double Strand Break: A Dissertation

Sinha, M. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/1gjt-k669

Interplay between ATM and ATR for the regulation of cellular responses to DNA damage

Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)

Cell Cycle: Regulation

McAndrew, C. W., Gastwirt, R. F., & Donoghue, D. J. (2008) · Wiley eBooks · doi:10.1002/9780470048672.wecb057

Human Genome & Diseases: Review Aneuploidy in the normal and diseased brain

Kingsbury, M. A., Yung, Y. C., Peterson, S. E., Westra, J. W., Chun, J. J. M., & Dorris, H. L. (2006)

The Role of CDK2 and CDK9 in the Radiation Response of human HNSCC Cancer Cells

Soffar, A. A. (2013) · Qucosa (Saxon State and University Library Dresden)

The Role of the Nonhomologous

Říha, K., Heacock, M. L., & Shippen, D. E. (2006)

Bedeutung der c-Abl-Aktivität für die Reaktion auf DNA-Schädigung und für die genetische Stabilität Bcr-Abl-negativer Zellen Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften (Dr. rer. nat.)

Naturwissenschaften, F., & Fischer-Bosch-Institut, M. (2011)

Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling

Zielinska-Chomej, K. (2015) · Figshare

DOCTEUR DE L'UNIVERSITÉ DE GRENOBLE

Vu, H. L. (2011)

Review Article The ups and downs of DNA repair biomarkers for PARP inhibitor therapies

Wang, X., & Weaver, D. T. (2011)

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

Jazayeri, A. R., Balestrini, A., Garner, E., Haber, J. E., & Costanzo, V. (2008)

Effect of holliday junction binding peptides on the prostate cancer cell lines

Dey, M. (2013) · CSUN ScholarWorks (California State University, Northridge)

Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)

Reini, K. (2006)

Cellular response pathways to formaldehyde

Graaf, D. C. (2009) · doi:10.6083/m41n7z38

The control of centrosome duplication after genotoxic stress

Inanç, B. (2011) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/18014

The response of mouse mesenchymal stromal cells to radiation-induced DNA double-strand breaks

Sugrue, T. (2013) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/17260

The DNA damage and the DNA synthesis checkpoints converge at the MBF transcription factor

Ivanova, T. G. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Combining gemcitabine with checkpoint kinase inhibitors to sensitize pancreatic tumors

Saini, P. (2015) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5028

Maintenance of genome integrity in gametes: coping with accidental and programmed DNA double-strand breaks during meiosis

Manfrini, N. (2011) · BOA (University of Milano-Bicocca)

Molecular dissection of telomere dysfunction and analysis of G-overhangs in Arabidopsis thaliana

Heacock, M. L. (2009) · OakTrust (Texas A&M University Libraries)

14-3-3 proteins in cancer

Gardino, A. K., & Yaffe, M. B. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139046947.025

Coping with DNA Damage and Replication Stress

Ulrich, H. D. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559852-00178

Topoisomerase-II Inhibitor

National Cancer Institute (2020) · Definitions · doi:10.32388/pofhux

Factors affecting the formation, stability, and expression of unintegrated lentiviral vector genomes

Bayer, M. (2010) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/j9mp-1c47

Bedeutung der Expression von RAD51 für die Reparatur von DNA-Schäden mittels Homologer Rekombination in humanen Tumorzelllinien

Seelbach, J. I. (2014)

Replication fork dynamics and the DNA damage

Petermann, E. (2016)

Signaling of DNA Replication Stress Through the ATR Checkpoint

Shiotani, B., & Zou, L. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_16 · Cited by 1

Cell Cycle Responses to Hyperthermia

Furusawa, Y. (2016) · Springer eBooks · doi:10.1007/978-981-10-0719-4_6

Effects of HSV-1 infection on disparate cell signaling pathways

Gregory, D. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/frbp-wa82

Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis

Enriquez-Rios, V. D. (2015) · doi:10.21007/etd.cghs.2015.0085

Mitotic catastrophie: the role of chromosome-binding proteins and DNA damage

Ho, C. Y. (2010) · doi:10.32657/10356/47452

Understanding the Molecular Dynamics of YPEL3 and FHIT Gene Expression

Kelley, K. D. (2010) · OhioLink ETD Center (Ohio Library and Information Network)

Role of VHL in DNA double-strand break repair and genomic instability in renal cell carcinoma

Metcalf, J. L. (2013) · TSpace (University of Toronto)

Molecular mechanisms of anti-proliferative effects of the Traditional Chinese Medicinal compound Rocaglamide A on cancers

Neumann, J. (2012) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00013237

Estudio de las fosfatasas hCdc14 en el ciclo de división celular y en la respuesta al daño en el DNA

de la Roca, P. A. (2015) · Gredos (University of Salamanca) · doi:10.14201/gredos.127302

The effect of UVA irradiation on the DNA damage response in a human keratinocyte cell line

Eastham, M. (2016) · Lancaster EPrints (Lancaster University)

Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors

Lanser, B. B. (2012) · Open ULeth Scholarship (OPUS) (University of Lethbridge)

Testing the relationship between checkpoint adaptation and micronuclei in human fibroblastic glioma and normal lung cells

Lewis, C. W. (2014) · Open ULeth Scholarship (OPUS) (University of Lethbridge)

High-Throughput Screening for Novel Anti-cancer Radiosensitizers for Head and Neck Cancer

Ito, E. (2010) · TSpace (University of Toronto)

New Insights into the Regulation of Hematopoietic Stem Cell Self-Renewal.

Jones, M. (2015) · Deep Blue (University of Michigan)

A Genome-scale RNA Interference Screen Identifies Novel Regulators of DNA Double-strand Break Repair

Young, J. T. F. (2016) · TSpace (University of Toronto)

Simulation Analysis of the Homologous Recombination Repair Distribution over the Cell Cycle

Kurpas, M. K., & Puszyński, K. (2017) · Advances in intelligent systems and computing · doi:10.1007/978-3-319-66905-2_19

Determining the link between genome integrity and seed quality

Gillett, R. M. (2017) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis

Li, L. (2015) · TSpace (University of Toronto)

A deficiência das proteínas de checkpoint HUS1 e RAD9 promove a variação do número de cópias no genoma de Leishmania major

Gomez, R. O. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-25042018-163036

The Molecular Physiology of Ageing: New Targets for Regenerative Medicine

Macip, S., & Althubiti, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-15458-5_3

Improving Outcomes in Prostate Cancer

Gilson, C. (2019) · UCL Discovery (University College London)

ATR Inhibitors as Potent Modulators of DNA End Resection CapacityPreprint

Dibitetto, D., Sims, J. R., Ascenção, C. F. R., Feng, K., Freire, R., & Smolka, M. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.13.905059

Regulation of the ATR Pathway in the Replication Stress Response

Luzwick, J. W. (2016)

MiRNA-106a is a Novel Regulator of Radiation Resistance through Targeting LITAF and ATM in Prostate Cancer

Hoey, C. (2018) · TSpace (University of Toronto)

REX1 DNA exonuclease deficiency, accumulation of single tranded DNA and complex human genetic disorders

O’Driscoll, A. (2008)

Investigating molecular targets of the DNA damage response in triple negative breast cancer

Ward, A. (2021) · The University of Queensland · doi:10.14264/662cbf8

Regulation of Follicular Atresia by WIP1-Mediated Apoptosis and AutophagyPreprint

Zhou, S., Xi, Y., Chen, Y., Yan, W., Wu, M., Li, M., Wu, T., Zhang, J., Shen, W. D., Luo, A., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-826867/v1

Investigation of environmental virus-host interactions: chlorpyrifos effects on Epstein-Barr virus and B-lymphocyte replication

Miller, K. (2019) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)

Noncoding RNA Mediated Regulation of Gene Expression in Disease and Development

Mueller, A. C. (2013) · doi:10.18130/v3022r

Characterization of homologous recombination proteins in telomere processing and t-circle formation

Stockton, P. D. Q. (2009) · eScholarship (California Digital Library)

X-ray repair cross-complementing protein 1 associated multiprotein complexes in base excision repair

Hanssen‐Bauer, A. (2012) · NORA - Norwegian Open Research Archives

Overview of the DNA Damage Checkpoint

Dupré, A., & Gautier, J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-221-2_11

Faculty Opinions recommendation of A role for the MRN complex in ATR activation via TOPBP1 recruitment.

Maiorano, D. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718000275.793477407

Faculty Opinions recommendation of The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

Dutta, A. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1163880.625956

Faculty Opinions recommendation of Human CtIP promotes DNA end resection.

Comai, L. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1093988.548939

APOBEC3B Improves Response to PD-1 Blockade Through DSBs–ATR–CHK1 PathwayPreprint

Yang, H., Chen, S., Ma, Y., Wang, R., Wang, Y., Zeng, Q., Guo, W., Xie, B., Zhou, X., Liu, T., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1606737/v1

Faculty Opinions recommendation of MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.

Riedel, R. F. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735180166.793580994

Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses

(2021) · Frontiers research topics · doi:10.3389/978-2-88966-580-8

In Brief

(2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1862

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

Cuadrado, M., Martínez-Pastor, B., Murga, M., Toledo, L. I., Gutierrez‐Martinez, P., Lopez, E., & Fernández-Capetillo, Ó. (2006) · The Journal of Cell Biology · doi:10.1083/jcb1725oia9 · Cited by 12

Distinct roles of ATR and DNA‐PKcs in triggering DNA damage responses in ATM‐deficient cells

Tomimatsu, N., Mukherjee, B., & Burma, S. (2009) · EMBO Reports · doi:10.1038/embor.2009.60 · Cited by 135

Distinct modes of ATR activation after replication stress and DNA double‐strand breaks in Caenorhabditis elegans

García‐Muse, T., & Boulton, S. J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600896 · Cited by 163

The Journal of Experimental Medicine CORRESPONDENCE Oscar Fernandez-Capetillo:

Cuadrado, M., Martínez-Pastor, B., Murga, M., & Toledo, L. I. (2013)

P (2011) Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol Cell Biol 31: 573–583

Limbo, O., Porter-Goff, M. E., Rhind, N., & Russell, P. R. (2016)