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SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment

Traer, Colin J., Rutherford, Anna C., Palmer, Krysten J., Wassmer, Thomas, Oakley, Jacqueline, Attar, Naomi, Carlton, Jez G., Kremerskothen, Joachim, Stephens, David J., Cullen, Peter J.·2007·Nature Cell Biology
DOI 10.1038/ncb1656
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Abstract

SNX-BAR proteins are a sub-family of sorting nexins implicated in endosomal sorting. Here, we establish that through its phox homology (PX) and Bin-Amphiphysin-Rvs (BAR) domains, sorting nexin-4 (SNX4) is associated with tubular and vesicular elements of a compartment that overlaps with peripheral early endosomes and the juxtanuclear endocytic recycling compartment (ERC). Suppression of SNX4 perturbs transport between these compartments and causes lysosomal degradation of the transferrin receptor (TfnR). Through an interaction with KIBRA, a protein previously shown to bind dynein light chain 1, we establish that SNX4 associates with the minus end-directed microtubule motor dynein. Although suppression of KIBRA and dynein perturbs early endosome-to-ERC transport, TfnR sorting is maintained. We propose that by driving membrane tubulation, SNX4 coordinates iterative, geometric-based sorting of the TfnR with the long-range transport of carriers from early endosomes to the ERC. Finally, these data suggest that by associating with molecular motors, SNX-BAR proteins may coordinate sorting with carrier transport between donor and recipient membranes.

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  • Retromer associates with accessory proteins and cargo adaptors including sorting nexins, the WASH complex, RAB GTPase regulators including TBC1D5 and ANKRD27/VARP, and RME8.

    “To function, Retromer associates with accessory proteins and cargo adaptors including sorting nexins (SNXs) [24][25][26][27][28][29][30][31][32][33][34], the WASH complex [35][36][37][38][39], RAB GTPase regulators including TBC1D5 and ANKRD27/VARP [40][41][42][43][44][45][46], and RME8 [47].”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [32]

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Research works printed but not linked: 40

  1. Maxfield, F. R. & McGraw, T. E. Endocytic recycling. Nature Rev. Mol. Cell Biol. 5, 121–132 (2004). · DOI · Paper page
  2. Gruenberg J. & Stenmark, H. The biogenesis of multivesicular endosomes. Nature Rev. Mol. Cell Biol. 5, 317–323 (2004). · DOI
  3. Bonifacino, J. S. & Rojas, R. Retrograde transport from endosomes to the trans-Golgi network. Nature Rev. Mol. Cell Biol. 7, 568–579 (2006). · DOI
  4. van der Goot, G. & Gruenberg, J. Intra-endosomal membrane traffic. Trends Cell Biol. 16, 514–521 (2006). · DOI
  5. Caviston, J. P. & Holzbaur, E. L. F. Microtubules motors at the intersection of trafficking and transport. Trends Cell Biol. 16, 530–537 (2006). · DOI
  6. Soldati, T. & Schliwa, M. Powering membrane traffic in endocytosis and recycling. Nature Rev. Mol. Cell Biol. 7, 897–908 (2006). · DOI
  7. Aniento, F., Emans, N., Griffths, G. & Gruenberg, J. Cytoplasmic dynein-dependent vesicular transport from early to late endosomes. J. Cell Biol. 123, 1373–1387 (1993). · DOI
  8. Burkhardt, J. K., Echeverri, C. J., Nilsson, T. & Vallee, R. B. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J. Cell Biol. 139, 469–484 (1997). · DOI
  9. Driskell, O. J., Mironov, A., Allan, V. J. & Woodman, P. G. Dynein is required for receptor sorting and the morphogenesis of early endosomes. Nature Cell Biol. 9, 113–120 (2007). · DOI
  10. Hoepfner, S. et al. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell 121, 437–450 (2005). · DOI
  11. Carlton, J. G., Bujny, M. V., Rutherford, A. & Cullen, P. J. Sorting nexins — unifying trends and new perspectives. Traffic 6, 75–82 (2005). · DOI
  12. Pelham, H. R. B. Insights from yeast endosomes. Curr. Opin. Cell Biol. 14, 454–462 (2002). · DOI
  13. Seaman, M. N. J. Recycling your receptors with retromer. Trends Cell Biol. 15, 68–75 (2005). · DOI · Paper page
  14. Arighi, C. N., Hartnell, L. M., Aguilar, R. C., Haft, C. R. & Bonifacino, J. S. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J. Cell Biol. 165, 123–133 (2004). · DOI · Paper page
  15. Carlton, J. G. et al. Sorting nexin-1 mediates tubular endosome-to-TGN transport through co-incidence sensing of high curvature membranes and 3-phosphoinositides. Curr. Biol. 14, 1791–1800 (2004). · DOI · Paper page
  16. Seaman, M. N. J. Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J. Cell Biol. 165, 111–122 (2004). · DOI · Paper page
  17. Chang, A. & Fink, G. R. Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole. J. Cell Biol. 128, 39–49 (1995). · DOI
  18. Ekena, K. & Stevens, T. H. The Saccharomyces cerevisiae MVP1 gene interacts with VPS1 and is required for vacuolar protein sorting. Mol. Cell. Biol. 15, 1671–1678 (1995). · DOI
  19. Hettema, E. H., Lewis, M. J., Black, M. W. & Pelham, H. R. B. Retromer and the sorting nexins Snx4/41/42 mediate distinct retrieval pathways from yeast endosomes. EMBO J. 22, 548–557 (2003). · DOI
  20. Krsmanovic, T., Pawelec, A., Sydor, T. & Kolling, R. Control of Ste6 recycling by ubiquitination in the early endocytic pathway in yeast. Mol. Biol. Cell 16, 2809–2821 (2005). · DOI
  21. Teasdale, R. D., Loci, D., Houghton, F., Karlsson, L. & Glesson, P. A. A large family of endosome-localised proteins related to sorting nexin-1. Biochem. J. 358, 7–16 (2001). · DOI
  22. Leprince, C. et al. Sorting nexin-4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J. Cell Sci. 116, 1937–1948 (2003). · DOI
  23. Kremerskothen, J. et al. Characterisation of KIBRA, a novel WW domain-containing protein. Biochem. Biophys. Res. Commun. 300, 862–867 (2003). · DOI
  24. Rayala, S. K. et al. Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. J. Biol. Chem. 281, 19092–19099 (2006). · DOI
  25. Papassotiropoulos, A. et al. Common Kibra alleles are associated with human memory performance. Science 314, 475–478 (2006). · DOI
  26. Carlton, J. G. & Cullen, P. J. Co-incidence detection in phosphoinositide signalling. Trends Cell Biol. 15, 540–547 (2005). · DOI
  27. Peter, B. J. et al. BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science 303, 495–499 (2004). · DOI · Paper page
  28. Ikonomov, O. C. et al. Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. J. Biol. Chem. 278, 50863–50871 (2003). · DOI
  29. Dove, S. K. et al. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J. 23, 1922–1933 (2004). · DOI
  30. Jeffries, T. R., Dove, S. K., Michell, R. H. & Parker, P. J. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol. Biol. Cell 15, 2652–2663 (2004). · DOI
  31. Rutherford, A. C. et al. The mammalian phosphatidylinositol 3 monophosphate 5-kinase PIKfyve regulates endosome-to-TGN retrograde transport. J. Cell Sci. 119, 3944–3957 (2006). · DOI
  32. Lundmark, R. & Carlsson, S. R. Regulated membrane recruitment of dynamin-2 mediated by sorting nexin-9. J. Biol. Chem. 279, 42694–42702 (2004). · DOI
  33. Soulet, F., Yarar, D., Leonard, M. & Schmid, S. L. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol. Biol. Cell 16, 2058–2067 (2005). · DOI
  34. Roux, A., Cappello, G., Cartaud, J., Prost, J., Goud, B. & Bassereau, P. A minimal system allowing tubulation with molecular motors pulling on giant liposomes. Proc. Natl Acad. Sci. USA. 99, 5394–5399 (2002). · DOI
  35. Dia, J. et al. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. Dev. Cell 7, 771–776 (2004). · DOI
  36. Jing, S. Q., Spencer, T., Miller, K., Hopkins, C. R. & Trowbridge, I. S. Role of the human transferrin receptor cytoplasmic domain in endocytosis: localisation of a specific signal sequence for internalization. J. Cell Biol. 110, 283–294 (1990). · DOI
  37. Johnson, L. S., Dunn, K. W., Pytowski, B. & McGraw, T. E. Endosome acidification and receptor trafficking: bafilomycin A1 shows receptor externalization by a mechanism involving the receptor's internalization motif. Mol. Biol. Cell 4, 1251–1266 (1993). · DOI
  38. Dunn, K. W., McGraw, T. E. & Maxfield, F. R. Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome. J. Cell Biol. 109, 3303–3314 (1989). · DOI · Paper page
  39. Lane, J. D. et al. Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis. J. Cell Biol. 156, 495–509 (2002). · DOI
  40. Watson, P. & Stephens, D. J. Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells. J. Cell Sci. 119, 2758–2767 (2006). · DOI

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Metadata

Authors
Traer, C. J., Rutherford, A. C., Palmer, K. J., Wassmer, T., Oakley, J., Attar, N., Carlton, J. G., Kremerskothen, J., Stephens, D. J., & Cullen, P. J.
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2007-11-11
Volume
9
Issue
12
Pages
1370-1380
ISSN
  • 1465-7392
  • 1476-4679
DOI
10.1038/ncb1656
Cited by
244
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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