The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
SDPR induces membrane curvature and functions in the formation of caveolae
Open accessAbstract
Caveolae are plasma membrane invaginations with a characteristic flask-shaped morphology. They function in diverse cellular processes, including endocytosis. The mechanism by which caveolae are generated is not fully understood, but both caveolin proteins and PTRF (polymerase I and transcript release factor, also known as cavin) are important. Here we show that loss of SDPR (serum deprivation protein response) causes loss of caveolae. SDPR binds directly to PTRF and recruits PTRF to caveolar membranes. Overexpression of SDPR, unlike PTRF, induces deformation of caveolae and extensive tubulation of the plasma membrane. The B-subunit of Shiga toxin (STB) also induces membrane tubulation and these membrane tubes also originate from caveolae. STB colocalizes extensively with both SDPR and caveolin 1. Loss of caveolae reduces the propensity of STB to induce membrane tubulation. We conclude that SDPR is a membrane-curvature-inducing component of caveolae, and that STB-induced membrane tubulation is facilitated by caveolae.
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Cites
Caveolin, a protein component of caveolae membrane coats
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Pathways of clathrin-independent endocytosis
Mayor, S., & Pagano, R. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2216 · Cited by 1,556
How proteins produce cellular membrane curvature
Zimmerberg, J., & Kozlov, M. M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1784 · Cited by 1,278
Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
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PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function
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Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits
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Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms
Parton, R. G., & Richards, A. A. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00128.x · Cited by 603
Shiga toxin induces tubular membrane invaginations for its uptake into cells
Römer, W., Berland, L., Chambon, V., Gaus, K., Windschiegl, B., Tenza, D., Aly, M. R. E., Fraisier, V., Florent, J.-C., Perrais, D., et al. (2007) · Nature · doi:10.1038/nature05996 · Cited by 583
Cited by
Endocytosis unplugged: Multiple ways to enter the cell
Kumari, S., MG, S., & Mayor, S. (2010) · Cell Research · doi:10.1038/cr.2010.19 · Cited by 599
Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan
Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338
Membrane curvature in cell biology: An integration of molecular mechanisms
Jarsch, I. K., Daste, F., & Gallop, J. L. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201604003 · Cited by 328
Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation
Chidlow, J. H., & Sessa, W. C. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq075 · Cited by 310
Exploring the caves: cavins, caveolins and caveolae
Hansen, C. G., & Nichols, B. J. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.005 · Cited by 295
Self-citation
Metadata
- Authors
- Hansen, C. G., Bright, N. A., Howard, G., & Nichols, B. J.
- Venue
- Nature Cell Biology
- Published
- 2009-06-14
- Volume
- 11
- Issue
- 7
- Pages
- 807-814
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2132854782
- Cited by
- 257
- References
- 38
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
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