The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600

Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy

Rawlinson, C., Jenkins, S. I., Thei, L., Dallas, M. L., & Chen, R. (2020) · Brain Sciences · doi:10.3390/brainsci10030159 · Cited by 99

Compounds from Natural Sources as Protein Kinase Inhibitors

Baier, A., & Szyszka, R. (2020) · Biomolecules · doi:10.3390/biom10111546 · Cited by 96

Metabolic reprogramming by class I and II histone deacetylases

Mihaylova, M. M., & Shaw, R. J. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.09.003 · Cited by 100

Metformin prevents against oxidative stress-induced senescence in human periodontal ligament cells

Kuang, Y., Hu, B., Ge, F., Xiang, M., Deng, Y., Tan, M., Li, J., & Song, J. (2019) · Biogerontology · doi:10.1007/s10522-019-09838-x · Cited by 94

BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis

Chen, Q., Lei, J. H., Bao, J., Wang, H., Hao, W., Li, L., Peng, C., Masuda, T., Miao, K., Xu, J., et al. (2020) · Advanced Science · doi:10.1002/advs.201903616 · Cited by 96

A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels

Lanning, N. J., Looyenga, B. D., Kauffman, A. L., Niemi, N. M., Sudderth, J., DeBerardinis, R. J., & MacKeigan, J. P. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.065 · Cited by 94

Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells

Rodrigues-Moreira, S., Moreno, S. G., Ghinatti, G., Lewandowski, D., Hoffschir, F., Ferri, F., Gallouët, A.-S., Gay, D. L., Motohashi, H., Yamamoto, M. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.013 · Cited by 99

Mitochondrial Dysfunction as an Underlying Cause of Skeletal Muscle Disorders

Chen, T., Koh, K.-Y., Lin, K. M.-C., & Chou, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112926 · Cited by 95

AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells

Agarwal, S., Bell, C. M., Rothbart, S. B., & Moran, R. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.665133 · Cited by 97

Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells

Galdieri, L. C., Gatla, H. R., Vancurova, I., & Vančura, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.742247 · Cited by 96

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation

Choi, B. K., Lee, D. Y., Lee, D. G., Kim, Y. H., Kim, S.-H., Oh, H. S., Han, C., & Kwon, B. S. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.02 · Cited by 93

Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

Grogan, P. T., Sleder, K. D., Samadi, A. K., Zhang, H., Timmermann, B. N., & Cohen, M. S. (2012) · Investigational New Drugs · doi:10.1007/s10637-012-9888-5 · Cited by 90

Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer

Xiong, Y., Zhao, Y. D., Miao, L., Lin, C. M., & Huang, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.005 · Cited by 90

Quiescence Entry, Maintenance, and Exit in Adult Stem Cells

Mohammad, K., Dakik, P., Medkour, Y., Mitrofanova, D., & Titorenko, V. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092158 · Cited by 94

Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies

Mossenta, M., Busato, D., Bo, M. D., & Toffoli, G. (2020) · Cancers · doi:10.3390/cancers12061668 · Cited by 93

Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases

Cai, H., Liu, Y., Men, H., & Zheng, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.683151 · Cited by 91

Metformin Repurposing for Parkinson Disease Therapy: Opportunities and Challenges

Agostini, F., Masato, A., Bubacco, L., & Bisaglia, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010398 · Cited by 90

The role of hydrogen sulfide in aging and age-related pathologies

Perridon, B. W., Leuvenink, H. G. D., Hillebrands, J., van Goor, H., & Bos, E. M. (2016) · Aging · doi:10.18632/aging.101026 · Cited by 90

Molecular interplay between mutant p53 proteins and autophagy in cancer cells

Cordani, M., Butera, G., Pacchiana, R., & Donadelli, M. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.11.003 · Cited by 90

Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

Meng, Y., Pan, M., Zheng, B., Chen, Y., Li, W., Yang, Q., Zheng, Z., Sun, N., Zhang, Y., & Li, X. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7261 · Cited by 89

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival

Zhao, B., Qiang, L., Joseph, J., Kalyanaraman, B., Viollet, B., & He, Y. (2016) · Genes & Diseases · doi:10.1016/j.gendis.2015.12.002 · Cited by 94

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

Zhu, Q., Ghoshal, S., Rodrigues, A. P. C., Gao, S., Asterian, A., Kamenecka, T. M., Barrow, J. C., & Chakraborty, A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85510 · Cited by 89

Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy

Ramirez, J. A. Z., Romagnoli, G. G., & Kaneno, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118745 · Cited by 91

Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity

Cao, Y., Li, Y., Wang, X., Liu, S., Zhang, Y., Liu, G., Ye, S., Zheng, Y., Zhao, J., Zhu, X., et al. (2023) · Immunity · doi:10.1016/j.immuni.2022.12.017 · Cited by 88

Sirtuins: from metabolic regulation to brain aging

Duan, W. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00036 · Cited by 89

Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK

Yao, L., Wan, J., Li, H., Ding, J. H., Wang, Y., Wang, X., & Li, M. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0114-0 · Cited by 88

Paternal low protein diet programs preimplantation embryo gene expression, fetal growth and skeletal development in mice

Watkins, A. J., Sirovica, S., Stokes, B., Isaacs, M. A., Addison, O., & Martin, R. A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.02.009 · Cited by 91

Ovotoxicity of cigarette smoke: A systematic review of the literature

Budani, M. C., & Tiboni, G. M. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.06.184 · Cited by 90

Molecular Connections Between Circadian Clocks and Aging

Welz, P.-S., & Benitah, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.036 · Cited by 90

Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1α signaling pathway

Yang, Q., Han, B., Xue, J., Lv, Y., Li, S., Liu, Y., Wu, P., Wang, X., & Zhang, Z. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114855 · Cited by 89

Cell death as a result of calcium signaling modulation: A cancer-centric prospective

Danese, A., Leo, S., Rimessi, A., Wieckowski, M. R., Fiorica, F., Giorgi, C., & Pinton, P. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119061 · Cited by 91

Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies

Grumati, P., & Bonaldo, P. (2012) · Cells · doi:10.3390/cells1030325 · Cited by 96

AMP-activated protein kinase stimulates osteoblast differentiation and mineralization through autophagy induction

Li, Y., Su, J., Sun, W., Cai, L., & Deng, Z. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3498 · Cited by 87

The mitochondrial H+-ATP synthase and the lipogenic switch

Vázquez‐Martín, A., Corominas-Faja, B., Cufí, S., Vellón, L., Oliveras‐Ferraros, C., Menendez, O. J., Joven, J., Lupu, R., & Menéndez, J. A. (2013) · Cell Cycle · doi:10.4161/cc.23352 · Cited by 89

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

Thewes, V., Simon, R., Hlevnjak, M., Schlotter, M., Schroeter, P., Schmidt, K. V., Wu, Y., Anzeneder, T., Wang, W., Windisch, P. Y., et al. (2017) · Oncogene · doi:10.1038/onc.2017.32 · Cited by 90

Interaction of central and peripheral clocks in physiological regulation

Barclay, J. L., Tsang, A. H. K., & Oster, H. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00030-7 · Cited by 91

Differential Contribution of Insulin and Amino Acids to the mTORC1-Autophagy Pathway in the Liver and Muscle

Naito, T., Kuma, A., & Mizushima, N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.456228 · Cited by 88

The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword

Chai, P., Ni, H., Zhang, H., & Fan, X. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.16245 · Cited by 87

Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes

Abelin, J. G., Patel, J., Lu, X., Feeney, C. M., Fagbami, L., Creech, A. L., Hu, R., Lam, D., Davison, D., Pino, L. K., et al. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.058354 · Cited by 87

CCCP‐induced mitochondrial dysfunction – characterization and analysis of integrated stress response to cellular signaling and homeostasis

Koncha, R. R., Ramachandran, G., Sepuri, N. B. V., & Ramaiah, K. V. A. (2021) · FEBS Journal · doi:10.1111/febs.15868 · Cited by 85

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review)

Li, N., Huang, D., Lü, N., & Luo, L. (2015) · Oncology Reports · doi:10.3892/or.2015.4288 · Cited by 85

Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate–activated protein kinase-autophagy for the balance between T helper 17 and Tregs

Park, M.-J., Lee, S.-Y., Moon, S., Son, H., Lee, S., Kim, E., Byun, J. K., Shin, D. Y., Park, S., Yang, C. W., et al. (2016) · Translational research · doi:10.1016/j.trsl.2016.03.006 · Cited by 85

Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis

Nepal, S., & Park, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.013 · Cited by 84

AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer

Cao, W., Li, J., Hao, Q., Vadgama, J. V., & Wu, Y. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1107-2 · Cited by 86

Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes

Brunkard, J. O. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.022 · Cited by 89

Protein-Based Nanomedicine for Therapeutic Benefits of Cancer

Zhang, Q., Zhang, J., Song, J., Liu, Y., Ren, X., & Zhao, Y. (2021) · ACS Nano · doi:10.1021/acsnano.1c00476 · Cited by 84

Metabolically Healthy Obesity—Does it Exist?

Boonchaya‐anant, P., & Apovian, C. M. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0441-1 · Cited by 87

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis

Tanwar, P. S., Kaneko-Tarui, T., Zhang, L., & Teixeira, J. M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds272 · Cited by 91

Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

Liu, J., Wu, J., Sun, A., Sun, Y., Yu, X., Liu, N., Dong, S., Yang, F., Zhang, L., Zhong, X., et al. (2016) · Cell & Bioscience · doi:10.1186/s13578-016-0099-1 · Cited by 86

AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema

Cheng, X.-Y., Li, Y., Huang, C., Li, J., & Yao, H. (2017) · Oncotarget · doi:10.18632/oncotarget.15116 · Cited by 84

Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers

Law, B. Y. K., Mok, S. W. F., Chan, W. K., Xu, S., Wu, A., Yao, X., Wang, J. R., Liu, L., & Wong, V. K. W. (2016) · Oncotarget · doi:10.18632/oncotarget.6980 · Cited by 83

The Arabidopsis KINβγ Subunit of the SnRK1 Complex Regulates Pollen Hydration on the Stigma by Mediating the Level of Reactive Oxygen Species in Pollen

Gao, X., Liu, C., Li, D. D., Zhao, T., Li, F., Jia, X. N., Zhao, X., & Zhang, X. S. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006228 · Cited by 83

New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway

Hsu, S., Cheng, K., Mgbeahuruike, M. O., Lin, Y., Wu, C., Wang, H., Yen, C., Chiu, C., & Sheu, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179453 · Cited by 83

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK

Hsu, C.-C., Zhang, X., Wang, G., Zhang, W., Cai, Z., Pan, B., Gu, H., Xu, C. S., Jin, G., Xu, X. S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.025 · Cited by 83

The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1–MFN2 pathway and Parkin mitophagy

Cai, J., Huang, J., Yang, J., Chen, X., Zhang, H., Zhu, Y., Liu, Q., & Zhang, Z. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04385-0 · Cited by 83

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

Osborn, L. J., Schultz, K. B., Massey, W. J., DeLucia, B., Choucair, I., Varadharajan, V., Banerjee, R., Fung, K., Horak, A. J., Orabi, D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202934119 · Cited by 85

AMPK: The energy sensor at the crossroads of aging and cancer

Penugurti, V., Manne, R., Bai, L., Kant, R., & Lin, H. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.08.002 · Cited by 86

Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathways

Jang, Y. J., Koo, H. J., Sohn, E., Kang, S. C., Rhee, D., & Pyo, S. (2015) · Food & Function · doi:10.1039/c5fo00397k · Cited by 82

The Role of AMP-Activated Protein Kinase as a Potential Target of Treatment of Hepatocellular Carcinoma

Jiang, X., Tan, H., Teng, S., Chan, Y.-T., Wang, D., & Wang, N. (2019) · Cancers · doi:10.3390/cancers11050647 · Cited by 85

PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration

You, W., Knoops, K., Berendschot, T. T. J. M., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M., & Gorgels, T. G. M. F. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01953-0 · Cited by 84

Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation

Yerra, V. G., & Kumar, A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9824-3 · Cited by 82

An evolutionary perspective of AMPK–TOR signaling in the three domains of life

Roustan, V., Jain, A., Teige, M., Ebersberger, I., & Weckwerth, W. (2016) · Journal of Experimental Botany · doi:10.1093/jxb/erw211 · Cited by 82

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Bilanges, B., Alliouachene, S., Pearce, W. P., Morelli, D., Szabadkai, G., Chung, Y.-L., Chicanne, G., Valet, C., Hill, J. M., Voshol, P. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01969-4 · Cited by 86

Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways

Tan, X., Xu, A., Zhao, T., Zhao, Q., Zhang, J., Fan, C., Deng, Y., Freywald, A., Genth, H., & Xiang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-20459-1 · Cited by 87

Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway

Li, S., Li, C. R., Pang, X., Zhang, J., Yu, G., Yeo, A. J., Lavin, M. F., Shao, H., Jia, Q., & Peng, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.719589 · Cited by 81

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Yap, K. M., Sekar, M., Seow, L.-J., Gan, S. H., Bonam, S. R., Rani, N. N. I. M., Lum, P. T., Subramaniyan, V., Wu, Y. S., Fuloria, N. K., et al. (2021) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s316667 · Cited by 81

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

Yadav, E., Yadav, P. S., Khan, M. M. U., Singh, H., & Verma, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.922232 · Cited by 81

Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy

Mir, S. U., Schwarze, S. R., Jin, L., Zhang, J., Friend, W., Miriyala, S., St Clair, D., & Craven, R. J. (2013) · Autophagy · doi:10.4161/auto.25889 · Cited by 69

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop

Wang, Y., Zhang, J., Huang, Z., Huang, X., Zheng, W.-B., Yin, X., Li, Y.-L., Li, B., & He, Q. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.265 · Cited by 81

The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming

Tang, H.-W., Hu, Y., Chen, C., Xia, B., Zirin, J. D., Yuan, M., Asara, J. M., Rabinow, L., & Perrimon, N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.023 · Cited by 81

A Metabolism Toolbox for CAR T Therapy

Xu, X., Gnanaprakasam, J. R., Sherman, J. W., & Wang, R. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00322 · Cited by 82

1,8-Cineole promotes G0/G1 cell cycle arrest and oxidative stress-induced senescence in HepG2 cells and sensitizes cells to anti-senescence drugs

Rodenak‐Kladniew, B., Castro, A., Stärkel, P., Galle, M., & Crespo, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117271 · Cited by 82

Life or death: disease-tolerant coral species activate autophagy following immune challenge

Fuess, L. E., Pinzón, J. H., Weil, E. F., Grinshpon, R. D., & Mydlarz, L. D. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.0771 · Cited by 83

Fetal liver mesenchymal stem cells restore ovarian function in premature ovarian insufficiency by targeting MT1

Huang, B., Qian, C., Ding, C., Meng, Q., Zou, Q., & Li, H. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1490-8 · Cited by 80

Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells

Tsai, S.-C., Yang, J., Peng, S., Lu, C., Chiang, J., Chung, J., Lin, M.-W., Lin, J.-K., Amagaya, S., CHUNG, C. W.-S., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1579 · Cited by 80

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

Wu, T., Liang, X., Wang, M., Li, J., Liu, Z., Guo, H., Liu, Y., Bai, Y., Cheng, Y.-Z., & Nan, K. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s95606 · Cited by 82

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy

Salatto, C. T., Miller, R., Cameron, K. O., Cokorinos, E., Reyes, A. R., Ward, J., Calabrese, M. F., Kurumbail, R. G., Rajamohan, F., Kalgutkar, A. S. S., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237925 · Cited by 85

Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy

Yerra, V. G., Kalvala, A. K., Sherkhane, B., Areti, A., & Kumar, A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.029 · Cited by 82

Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway

Fu, S.-C., Liu, J., Lee, K.-I., Tang, F., Fang, K., Yang, C., Su, C., Chen, H., Hsu, R., & Chen, Y. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104795 · Cited by 82

Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma

Hong, H., Chen, X., Wang, H., Gu, X., Yuan, Y., & Zhang, Z. (2023) · PROTEOMICS · doi:10.1002/pmic.202200432 · Cited by 79

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Park, M. S., & Sweeney, G. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9337-8 · Cited by 79

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Barbieri, E., Agostini, D., Polidori, E., Potenza, L., Guescini, M., Lucertini, F., Annibalini, G., Stocchi, L., Santi, M. D., & Stocchi, V. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/917085 · Cited by 82

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Sumita, K., Lo, Y., Takeuchi, K., Senda, M., Kofuji, S., Ikeda, Y., Terakawa, J., Sasaki, M., Yoshino, H., Majd, N., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.011 · Cited by 80

Autophagy Paradox of Cancer: Role, Regulation, and Duality

Verma, A. K., Bharti, P. S., Rafat, S., Bhatt, D., Goyal, Y., Pandey, K. K., Ranjan, S. K., Almatroodi, S. A., Alsahli, M. A., Rahmani, A. H., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8832541 · Cited by 78

GSK3B induces autophagy by phosphorylating ULK1

Ryu, H. Y., Kim, L. E., Jeong, H., Yeo, B. K., Lee, J., Nam, H., Ha, S., An, H., Park, H., Jung, S., et al. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00570-6 · Cited by 80

Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition

Tian, J., Geiss, C., Zarse, K., Madreiter‐Sokolowski, C. T., & Ristow, M. (2021) · Aging · doi:10.18632/aging.203597 · Cited by 81

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Stone, J. D., Narine, A., Shaver, P. R., Fox, J. C., Vuncannon, J. R., & Tulis, D. A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00446.2012 · Cited by 78

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Gao, A. W., Chatzispyrou, I. A., Kamble, R., Liu, Y. J., Herzog, K., Smith, R. L., van Lenthe, H., Vervaart, M. A. T., van Cruchten, A., Luyf, A. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02539-w · Cited by 77

Minireview: Obesity and Breast Cancer: A Tale of Inflammation and Dysregulated Metabolism

Simpson, E. R., & Brown, K. A. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1011 · Cited by 78

Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways

Snaebjornsson, M. T., & Schulze, A. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0065-6 · Cited by 79

Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway

Xia, Y., Zhang, H., Wu, X., Xu, Y., & Tan, Q. (2024) · Biogerontology · doi:10.1007/s10522-024-10099-6 · Cited by 78

Aldehyde dehydrogenase‐2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP‐activated protein kinase signaling in mice

Hou, G., Chen, L., Liu, G., Li, L., Yang, Y., Yan, H., Zhang, H., Tang, J. P., Yang, Y., Lin, X., et al. (2016) · Hepatology · doi:10.1002/hep.29006 · Cited by 81

CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies

Castro-Sánchez, S., García-Yagüe, Á. J., Kügler, S., & Lastres-Becker, I. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101118 · Cited by 76

The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis

Lv, H., An, B., Yu, Q., Cao, Y., Liu, Y., & Li, S. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.075 · Cited by 76

Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation

Yi, Y., Chen, D., Ao, J., Zhang, W., Yi, J., Ren, X., Fei, J., Li, F., Niu, M., Chen, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914786117 · Cited by 77

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Rahman, F. A., & Quadrilatero, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03807-9 · Cited by 77

SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer

Yang, Y., He, J., Zhang, B., Zhang, Z., Jia, G., Liu, S., Wu, T., He, X., & Wang, N. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04411-2 · Cited by 76

Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development

Caturano, A., Vetrano, E., Galiero, R., Salvatore, T., Docimo, G., Epifani, R., Alfano, M., Sardu, C., Marfella, R., Rinaldi, L., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2305165 · Cited by 77

The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells

Zhang, S., You, X.-H., Zheng, Y., Shen, Y., Xiong, X., & Sun, Y. (2022) · Journal of Clinical Investigation · doi:10.1172/jci162434 · Cited by 76

AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics

Paz, M. V., Cotán, D., Garrido‐Maraver, J., Oropesa-Ávila, M., de la Mata, M., Pavón, A. D., de Lavera, I., Alcocer‐Gómez, E., Álvarez-Córdoba, M., & Sánchez-Alcázar, J. A. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_3 · Cited by 116

AMPK Control of Metabolic Signaling

Shaw, R. J. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.231.3

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

Tamargo‐Gómez, I., & Mariño, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123812 · Cited by 258

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638

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Sharma, A., Anand, S. K., Singh, N., Dwivedi, U. N., & Kakkar, P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113614 · Cited by 207