The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Open accessAbstract
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.
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“To increase ATP availability, the cells increase the catabolism of energy stores, such as fatty acids, and the biosynthesis of”
From Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways (2015) · cites this paper as [71]
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RetractedAMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Metadata
- Authors
- Mihaylova, M. M., & Shaw, R. J.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Shaw, Reuben J.
- Venue
- Nature Cell Biology
- Published
- 2011-09
- Volume
- 13
- Issue
- 9
- Pages
- 1016-1023
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC3249400
- OpenAlex
- W2079580613
- Cited by
- 2,923
- References
- 134
- Citations by year
- 2026: 142 · 2025: 202 · 2024: 220 · 2023: 208 · 2022: 254 · 2021: 224 · 2020: 258 · 2019: 240 · 2018: 237 · 2017: 223 · 2016: 178 · 2015: 175 · 2014: 126 · 2013: 129 · 2012: 98
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- American Diabetes Association
- American Cancer Society
- Leona M. and Harry B. Helmsley Charitable Trust
- National Institutes of Health
- National Cancer Institute (P01CA120964)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080425)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- AMPK, AMPK signaling, autophagy, cell growth, cellular metabolism, metabolic reprogramming, cell polarity, downstream effectors, ATP depletion
- MeSH terms
- Animals, Autophagy, Humans, Models, Biological, Signal Transduction, Cell Polarity, Protein Subunits, Cell Proliferation, AMP-Activated Protein Kinases, Eukaryota
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