The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600

Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases

Shah, S. Z. A., Zhao, D., Hussain, T., & Yang, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.004 · Cited by 55

CCCP induces autophagy in an AMPK-independent manner

Kwon, K.-Y., Viollet, B., & Yoo, O. J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.038 · Cited by 55

Archaeal Histone Contributions to the Origin of Eukaryotes

Brunk, C. F., & Martin, W. F. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.04.002 · Cited by 55

ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

Yang, J., Hsu, J., Park, S., Lee, S. Y., Li, J., Bai, M., Alves, C. M. M. M., Tseng, W., Michelet, X., Ho, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11932-0 · Cited by 56

Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes

Sukumaran, A., Choi, K., & Dasgupta, B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00671 · Cited by 62

Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer

Cozzo, A. J., Coleman, M. F., Pearce, J. B., Pfeil, A. J., Etigunta, S. K., & Hursting, S. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590192 · Cited by 55

Activated AMPK by metformin protects against fibroblast proliferation during pulmonary fibrosis by suppressing FOXM1

Gu, X., Han, Y., Yang, C., Ji, H.-M., Lan, Y., Bi, Y., Zheng, C., Qu, J., Cheng, M.-H., & Gao, J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105844 · Cited by 55

Leptin signaling and leptin resistance

Liu, J., Lai, F., Hou, Y., & Zheng, R. (2022) · Medical Review · doi:10.1515/mr-2022-0017 · Cited by 61

The interplay between autophagy and cGAS-STING signaling and its implications for cancer

Schmid, M., Fischer, P., Engl, M., Widder, J., Gruber, S., & Slade, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1356369 · Cited by 61

Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction

Rudokas, M. W., McKay, M., Toksoy, Z., Eisen, J. N., Bögner, M., Young, L. H., & Akar, F. G. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02357-1 · Cited by 55

Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids

Cai, H., Tian, C., Chen, L., Yang, Y., Sun, A. X., McCracken, K. W., Tchieu, J. H., Gu, M., Mackie, K., & Guo, F. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.02.010 · Cited by 58

AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators

Moreno-Arriola, E., Hafidi, M. E., Ortega-Cuéllar, D., & Carvajal, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148089 · Cited by 57

Potential Therapeutic Benefits of Maintaining Mitochondrial Health in Peripheral Neuropathies

Areti, A., Yerra, V. G., Komirishetty, P., & Kumar, A. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151126215358 · Cited by 55

Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells

Ibáñez-Cabellos, J. S., Aguado, C., Pérez‐Cremades, D., García‐Giménez, J. L., Bueno‐Betí, C., García-López, E., Mateo, C. R., Novella, S., Hermenegildo, C., & Pallardó, F. V. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.010 · Cited by 55

STIM2 interacts with AMPK and regulates calcium‐induced AMPK activation

Chauhan, A. S., Liu, X., Ji, J., Lee, H., Yadav, R. K., Liu, J., Zhou, Y., & Gan, B. (2018) · The FASEB Journal · doi:10.1096/fj.201801225r · Cited by 56

Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway

Cai, C.-C., Zhu, J., Ye, L.-X., Dai, Y., Fang, M., Hu, Y., Pan, S., Chen, S., Li, P., Fu, X., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4248529 · Cited by 55

Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation

Lee, J., Lee, H., Lee, S., Kang, J. H., Lee, S.-H., Kim, S., Cho, E. S., Kim, N. H., Yook, J. I., & Kim, S. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.036 · Cited by 55

Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway

Yu, H. J., Xie, Y., Zhou, Z., Zhou, W., Dai, X., & Xu, B. (2019) · Technology in Cancer Research & Treatment · doi:10.1177/1533033819870781 · Cited by 55

Study on the inhibitive effect of Catalpol on diabetic nephropathy

Chen, J., Yang, Y., Lv, Z., Shu, A., Du, Q., Wang, W., Chen, Y., & Xu, H. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118120 · Cited by 55

Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms

Haddadi, R., Shahidi, Z., & Brooshghalan, S. E. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153320 · Cited by 57

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

Benvenuto, M., Albonici, L., Focaccetti, C., Ciuffa, S., Fazi, S., Cifaldi, L., Miele, M. T., Maio, F. D., Tresoldi, I., Manzari, V., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186635 · Cited by 55

Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target

Karakas, D., & Ozpolat, B. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01917-8 · Cited by 54

The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health

Hevener, A. L., Ribas, V., Moore, T. M., & Zhou, Z. (2020) · Endocrinology · doi:10.1210/endocr/bqz017 · Cited by 54

miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone

Fan, J., Ruan, J., Liu, W., Zhu, L., Zhu, X., Yi, H., Cui, S., Zhao, J., & Cui, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.12138 · Cited by 54

Mitochondria–actin cytoskeleton crosstalk in cell migration

Yadav, T., Gau, D. M., & Roy, P. S. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30729 · Cited by 54

Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy

Xu, B., Zhou, Z., Fang, J., Wang, J., Tao, K., Liu, J., & Liu, S.-H. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.026 · Cited by 54

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming

Marignac, V. L. M., Smith, S. E., Toban, N., Bazile, M., & Aloyz, R. S. (2013) · Oncotarget · doi:10.18632/oncotarget.1508 · Cited by 54

Metabolic regulation of T cell differentiation and function

Park, B. V., & Pan, F. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.027 · Cited by 58

Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis

Wang, B., Wang, X., Chen, L., Huang, L., & Dong, R.-Z. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.090 · Cited by 54

AMPK beta subunits: more than just a scaffold in the formation of AMPK complex

Sanz, P., Rubio, T., & García-Gimeno, M. A. (2013) · FEBS Journal · doi:10.1111/febs.12364 · Cited by 57

AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension

Teng, R., Du, J., Afolayan, A. J., Eis, A., Shi, Y., & Konduri, G. G. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00200.2012 · Cited by 54

GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells

Yang, Y., Wang, H., Wang, S., Xu, M., Liu, M., Liao, M., Frank, J. A., Adhikari, S., Bower, K. A., Shi, X., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1620 · Cited by 54

Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions

Jahrling, J. B., & Laberge, R.-M. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150610125856 · Cited by 55

Metformin Attenuates Radiation-Induced Pulmonary Fibrosis in a Murine Model

Wang, J., Wang, Y., Han, J., Mei, H., Yu, D., Ding, Q., Zhang, T., Wu, G., Peng, G., & Lin, Z. (2017) · Radiation Research · doi:10.1667/rr14708.1 · Cited by 54

Metformin, an Anti-diabetic Drug to Target Leukemia

Biondani, G., & Peyron, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00446 · Cited by 56

Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells

Parousis, A., Carter, H. N., Tran, C., Erlich, A. T., Moosavi, Z. S. M., Pauly, M., & Hood, D. A. (2018) · Autophagy · doi:10.1080/15548627.2018.1491488 · Cited by 57

LINC00857 Interacting with YBX1 to Regulate Apoptosis and Autophagy via MET and Phosphor-AMPKa Signaling

Su, W., Wang, L., Zhao, H., Hu, S., Zhou, Y., Guo, C., Wu, B., Li, L., Yang, Z., Beer, D. G., et al. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.10.025 · Cited by 54

Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways

Pashootan, P., Saadati, F., Fahimi, H., Rahmati, M., Strippoli, R., Zarrabi, A., Cordani, M., & Moosavi, M. A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123622 · Cited by 53

Understanding Metabolic Regulation at a Systems Level: Metabolite Sensing, Mathematical Predictions, and Model Organisms

Watson, E. V., Yilmaz, L. S., & Walhout, A. J. M. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-112414-055257 · Cited by 55

Understanding the mTOR signaling pathway via mathematical modeling

Sulaimanov, N., Klose, M., Busch, H. S., & Boerries, M. (2017) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1379 · Cited by 54

The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway

Huang, X., Wu, H., Jiang, R., Sun, G., Shen, J., Ma, M., Ma, C., Zhang, S., Huang, Z., Wu, Q., et al. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.05.020 · Cited by 53

Cordycepin Augments the Chemosensitivity of Human Glioma Cells to Temozolomide by Activating AMPK and Inhibiting the AKT Signaling Pathway

Bi, Y., Han, L., Yi, D., Sun, Y., Bai, Y., Zhong, S., Song, Y., Zhao, G., & Chen, Y. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00551 · Cited by 53

Heat-Killed Bifidobacterium breve B-3 Enhances Muscle Functions: Possible Involvement of Increases in Muscle Mass and Mitochondrial Biogenesis

Toda, K., Yamauchi, Y., Tanaka, A., Kuhara, T., Odamaki, T., Yoshimoto, S., & Xiao, J. (2020) · Nutrients · doi:10.3390/nu12010219 · Cited by 54

AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury

Kong, G., Zhou, L., Serger, E., Palmisano, I., Virgiliis, F. D., Hutson, T. H., McLachlan, E., Freiwald, A., Montanara, P. L., Shkura, K., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0252-3 · Cited by 54

Metabolic Reprogramming and Renal Fibrosis

Zhu, X., Jiang, L., Long, M., Wei, X. S., Hou, Y., & Du, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.746920 · Cited by 53

Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/β-Catenin Signaling

Hu, L., Ding, M., & He, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.830340 · Cited by 53

C6 ceramide dramatically increases vincristine sensitivity bothin vivoandin vitro, involving AMP-activated protein kinase–p53 signaling

Chen, M., Jiang, Q. L., Liu, Y.-Y., Zhang, Y., He, B., Wei, M.-X., Lu, J., Ji, Y. I., & Lu, P. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv094 · Cited by 52

Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)

Olekšák, P., Nepovimová, E., Chrienová, Ž., Musílek, K., Patočka, J., & Kuča, K. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114498 · Cited by 53

Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus

Zhao, L., Hu, X., Xiao, F., Zhang, X., Zhao, L., & Wang, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929520 · Cited by 54

B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity

Oļeiņika, K., Šlisere, B., Catalán, D., & Rosser, E. C. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac079 · Cited by 54

Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors

Gupta, A., Das, D., & Taneja, R. (2024) · Cancers · doi:10.3390/cancers16071313 · Cited by 52

Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR signaling pathways

Zamanian, M. Y., Golmohammadi, M., Yumashev, A., Hjazi, A. M., Toama, M. A., AbdRabou, M. A., Gehlot, A., Alwaily, E. R., Shirsalimi, N., Yadav, P. K., et al. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4071 · Cited by 53

Exercise-specific adaptations in human skeletal muscle: Molecular mechanisms of making muscles fit and mighty

Thomas, A. C. Q., Stead, C. A., Burniston, J. G., & Phillips, S. M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.010 · Cited by 57

The Microtubule-associated Protein EB1 Links AIM2 Inflammasomes with Autophagy-dependent Secretion

Wang, L., Huang, H., Huang, M.-P., Liou, W., Chang, Y., Wu, C., Ojcius, D. M., & Chang, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559153 · Cited by 54

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre‐conditioning

Stetler, R. A., Leak, R. K., Yin, W., Zhang, L., Wang, S., Gao, Y., & Chen, J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07951.x · Cited by 52

Hypoxia promotes liver stage malaria infection in primary human hepatocytes in vitro

Ng, S., March, S., Galstian, A., Hanson, K. K., Carvalho, T., Mota, M. M., & Bhatia, S. N. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.013490 · Cited by 52

GPR119: a promising target for nonalcoholic fatty liver disease

Yang, J. W., Kim, H. S., Im, J. H., Kim, J. W., Jun, D. W., Lim, S., Lee, K., Choi, J. M., Kim, S. K., & Kang, K. W. (2015) · The FASEB Journal · doi:10.1096/fj.15-273771 · Cited by 53

Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice

Liu, G.-Y., Liu, J., Wang, Y., Liu, Y., Shao, Y., Han, Y., Qin, Y.-R., Xiao, F., Li, P., Zhao, L., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0239 · Cited by 52

MYC-induced metabolic stress and tumorigenesis

Wolpaw, A. J., & Dang, C. V. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.05.003 · Cited by 52

Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation

Xu, C., Wang, Y., Tu, Q., Zhang, Z., Chen, M., Mwangi, J., Li, Y., Jin, Y., Zhao, X., & Lai, R. (2018) · Oncogene · doi:10.1038/s41388-018-0556-x · Cited by 53

Overcoming platinum-acquired resistance in ovarian cancer patient-derived xenografts

Ricci, F., Brunelli, L., Affatato, R., Chilà, R., Verza, M., Indraccolo, S., Falcetta, F., Fratelli, M., Fruscio, R., Pastorelli, R., et al. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919839543 · Cited by 52

Catalpol induces autophagy and attenuates liver steatosis in ob/ob and high-fat diet-induced obese mice

Ren, H., Wang, D., Zhang, L., Kang, X., Li, Y., Zhou, X., & Yuan, G. (2019) · Aging · doi:10.18632/aging.102396 · Cited by 52

Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study

Balusamy, S. R., Perumalsamy, H., Veerappan, K., Huq, M. A., Rajeshkumar, S., Thangavelu, L. P., & Kim, Y. J. (2020) · BioMed Research International · doi:10.1155/2020/6040727 · Cited by 54

Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth

Deng, Z., Li, X., Ramírez, M. B., Purtell, K., Choi, I., Lu, J., Yu, Q., & Yue, Z. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020215118 · Cited by 52

Foetal-neonatal exposure of Di (2-ethylhexyl) phthalate disrupts ovarian development in mice by inducing autophagy

Zhang, Y., Mu, X., Gao, R., Geng, Y., Liu, X., Chen, X., Wang, Y., Ding, Y., Wang, Y., & He, J. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.06.042 · Cited by 51

Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development

Song, Y., Xie, L., Lee, Y., Brede, D. A., Lyne, F. M., Kassaye, Y. A., Thaulow, J., Caldwell, G. S., Salbu, B., & Tollefsen, K. E. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135912 · Cited by 52

Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway

Wang, X., Zhang, J., Xiu, C., Yang, J., Fang, J., & Lei, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7151946 · Cited by 51

Therapeutic strategies targeting AMPK-dependent autophagy in cancer cells

Yuan, W., Fang, W., Zhang, R., Lyu, H., Xiao, S., Guo, D. S., Ali, D. W., Michalak, M., Chen, X., Zhou, C., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119537 · Cited by 53

The burgeoning importance of PIWI-interacting RNAs in cancer progression

Deng, X., Liao, T., Xie, J., Kang, D., He, Y., Sun, Y., Wang, Z., Jiang, Y., Miao, X., Yan, Y., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2491-7 · Cited by 52

New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells

Li, X., Kover, K. L., Heruth, D. P., Watkins, D. J., Moore, W. V., Jackson, K., Zang, M., Clements, M. A., & Yan, Y. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1090 · Cited by 54

Se-Allylselenocysteine induces autophagy by modulating the AMPK/mTOR signaling pathway and epigenetic regulation of PCDH17 in human colorectal adenocarcinoma cells

Wu, J.-C., Wang, F.-Z., Tsai, M.-L., Lo, C., Badmaev, V., Ho, C., Wang, Y., & Pan, M. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500373 · Cited by 51

Mammalian target of rapamycin and tuberous sclerosis complex

Wataya‐Kaneda, M. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.04.005 · Cited by 54

Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells

An, H., Kim, K.-S., Lee, J., Mi-Hyun, P., Moon, H., Park, S.-J., Baik, J.-S., Kim, C., & Lee, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114607 · Cited by 51

The Combination of RAD001 and MK-2206 Exerts Synergistic Cytotoxic Effects against PTEN Mutant Gastric Cancer Cells: Involvement of MAPK-Dependent Autophagic, but Not Apoptotic Cell Death Pathway

Ji, D., Zhang, Z., Cheng, L., Chang, J., Wang, S., Zheng, B., Zheng, R., Sun, Z., Wang, C., Zhang, Z.-Q., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085116 · Cited by 51

LKB 1 and AMP ‐activated protein kinase: regulators of cell polarity

Nakano, A., & Takashima, S. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2012.01629.x · Cited by 63

Downregulation of autophagy gene expression in endometria from women with polycystic ovary syndrome

Šumarac-Dumanović, M., Apostolović, M., Janjetović, K., Jeremić, D., Popadic, D. M., Ljubić, A., Micić, J., Stamenković, J., Tubic, A., Stevanović, D., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.009 · Cited by 52

Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway

Hu, J., Cui, W., Ding, W., Gu, Y., Wang, Z., & Fan, W. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480416 · Cited by 51

RAS signalling in energy metabolism and rare human diseases

Dard, L., Bellancé, N., Lacombe, D., & Rossignol, R. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.05.003 · Cited by 56

Suppression of AMPK/aak‐2 by NRF2/SKN‐1 down‐regulates autophagy during prolonged oxidative stress

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Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status

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PARP10 (ARTD10) modulates mitochondrial function

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