The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,600

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Hardie, D. G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2249 · Cited by 2,261

Eaten alive: a history of macroautophagy

Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,155

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943

Circadian integration of metabolism and energetics

Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, É., Shyy, J. Y.-J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.009 · Cited by 1,840

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., & Hardie, D. G. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-28 · Cited by 1,694

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589

Autophagy in mammalian development and differentiation

Mizushima, N., & Levine, B. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-823 · Cited by 1,555

Network organization of the human autophagy system

Behrends, C., Sowa, M. E., Gygi, S. P., & Harper, J. W. (2010) · Nature · doi:10.1038/nature09204 · Cited by 1,554

A central integrator of transcription networks in plant stress and energy signalling

Gonzalez, E. B., Rolland, F., Thevelein, J. M., & Sheen, J. (2007) · Nature · doi:10.1038/nature06069 · Cited by 1,526

Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

Woods, A., Dickerson, K., Heath, R. B., Hong, S. P., Momcilovic, M., Johnstone, S. R., Carlson, M., & Carling, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.005 · Cited by 1,418

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Lizcano, J. M., Göransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Mäkelä, T. P., Hardie, D. G., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600110 · Cited by 1,381

AMPK and PPARδ Agonists Are Exercise Mimetics

Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145

The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

Altarejos, J. Y., & Montminy, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3072 · Cited by 1,061

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2063 · Cited by 1,052 · cited 1×

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

Zhang, B. B., Zhou, G., & Li, C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.012 · Cited by 1,042

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

Hurley, R. L., Anderson, K. A., Franzone, J. M., Kemp, B. E., Means, A. R., & Witters, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503824200 · Cited by 1,004

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science · doi:10.1126/science.1172156 · Cited by 958

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Cool, B. L., Zinker, B. A., Chiou, W. J. H., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A. L., Gagné, G. D., Iyengar, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.005 · Cited by 939

Structure of mammalian AMPK and its regulation by ADP

Xiao, B., Sanders, M. J., Underwood, E., Heath, R., Mayer, F. V., Carmena, D., Jing, C., Walker, P. A., Eccleston, J. F., Haire, L. F., et al. (2011) · Nature · doi:10.1038/nature09932 · Cited by 926

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., Zierath, J. R., & Auwerx, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.006 · Cited by 921

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

Pacholec, M., Bleasdale, J. E., Chrunyk, B., Cunningham, D., Flynn, D., Garofalo, R. S., Griffith, D., Griffor, M., Loulakis, P., Pabst, B., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.088682 · Cited by 915

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Liang, J., Shao, S. H., Xu, Z.-X., Hennessy, B. T., Ding, Z., Larrea, M. D., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1537 · Cited by 886

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E.-M., & Mandelkow, E. (1997) · Cell · doi:10.1016/s0092-8674(00)80208-1 · Cited by 878

The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor

Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 852

LKB1-Dependent Signaling Pathways

Alessi, D. R., Sakamoto, K., & Bayascas, J. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142702 · Cited by 805

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773

Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice

Zang, M., Xu, S., Maitland, K. A., Zuccollo, A., Hou, X., Jiang, B., Wierzbicki, M., Verbeuren, T. J., & Cohen, R. A. (2006) · Diabetes · doi:10.2337/db05-1188 · Cited by 672

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

Um, J.-H., Park, S.-J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., Kim, M. K., Viollet, B., & Chung, J. H. (2010) · Diabetes · doi:10.2337/db09-0482 · Cited by 647

AMPK is a direct adenylate charge-regulated protein kinase

Oakhill, J. S., Steel, R., Chen, Z.-P., Scott, J. W., Ling, N., Tam, S., & Kemp, B. E. (2011) · Science · doi:10.1126/science.1200094 · Cited by 612

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

Carling, D., Zammit, V. A., & Hardie, D. G. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80292-2 · Cited by 599

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

Das, S. K., Eder, S., Schauer, S., Diwoky, C., Temmel, H., Guertl, B., Gorkiewicz, G., Tamilarasan, K. P., Kumari, P., Trauner, M., et al. (2011) · Science · doi:10.1126/science.1198973 · Cited by 594

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

Baas, A., Kuipers, J., van der Wel, N. N., Batlle, E., Koerten, H., Peters, P., & Clevers, H. (2004) · Cell · doi:10.1016/s0092-8674(04)00114-x · Cited by 562

SNF1/AMPK pathways in yeast

Hedbacker, K. (2008) · Frontiers in Bioscience · doi:10.2741/2854 · Cited by 554

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

Ahmadian, M., Abbott, M. J., Tang, T., Hudak, C. S. S., Kim, Y., Bruss, M. D., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.002 · Cited by 536

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

Mihaylova, M. M., Vasquez, D. S., Ravnskjaer, K., Denechaud, P.-D., Yu, R. T., Alvarez, J. G., Downes, M., Evans, R. M., Montminy, M., & Shaw, R. J. (2011) · Cell · doi:10.1016/j.cell.2011.03.043 · Cited by 533

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Nakada, D., Saunders, T. L., & Morrison, S. J. (2010) · Nature · doi:10.1038/nature09571 · Cited by 524

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

Shang, L., Chen, S., Du, F., Li, S., Zhao, L., & Wang, X. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100844108 · Cited by 517

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

Kamada, Y., Yoshino, K., Kondo, C., Kawamata, T., Oshiro, N., Yonezawa, K., & Ohsumi, Y. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01344-09 · Cited by 505

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stressPreprint

Zaugg, K., Yao, Y., Reilly, P. T., Kannan, K., Kiarash, R., Mason, J. M., Huang, P., Sawyer, S. K., Fuerth, B. J., Faubert, B., et al. (2011) · Genes & Development · doi:10.1101/gad.1987211 · Cited by 504

The Association of AMPK with ULK1 Regulates Autophagy

Lee, J. W., Park, S., Takahashi, Y., & Wang, H.-G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015394 · Cited by 482

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

Sakamoto, K., & Holman, G. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90331.2008 · Cited by 481

AMP-activated Protein Kinase Is Required for the Lipid-lowering Effect of Metformin in Insulin-resistant Human HepG2 Cells

Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K. X., Herscovitz, H., Brecher, P. I., Ruderman, N. B., & Cohen, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408149200 · Cited by 455

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

McGee, S. L., van Denderen, B. J. W., Howlett, K. F., Mollica, J., Schertzer, J. D., Kemp, B. E., & Hargreaves, M. (2008) · Diabetes · doi:10.2337/db07-0843 · Cited by 455

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I. P., Celler, J. W., Hawley, S. A., Prescott, A. R., Woods, A., Carling, D., & Hardie, D. G. (1998) · Biochemical Journal · doi:10.1042/bj3340177 · Cited by 437

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Lee, J. H., Koh, H., Kim, M.-J., Kim, Y., Lee, S. Y., Karess, R. E., Lee, S. H., Shong, M., Kim, J., Kim, J., et al. (2007) · Nature · doi:10.1038/nature05828 · Cited by 431

Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription

Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., & Uyeda, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107895200 · Cited by 424

AMP-activated protein kinase and its downstream transcriptional pathways

Cantó, C., & Auwerx, J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0454-z · Cited by 421

Primary cilia regulate mTORC1 activity and cell size through Lkb1

Boehlke, C. S., Kotsis, F., Patel, V., Braeg, S., Voelker, H., Bredt, S., Beyer, T., Janusch, H., Hamann, C., Gödel, M., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2117 · Cited by 412

AMP-Activated Protein Kinase as a Drug Target

Hardie, D. G. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105304 · Cited by 411

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Foretz, M., Ancellin, N., Andréelli, F., Saintillan, Y., Grondin, P., Kahn, A., Thorens, B., Vaulont, S., & Viollet, B. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1331 · Cited by 406

TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells

Herrero‐Martín, G., Høyer‐Hansen, M., García‐García, C., Fumarola, C., Farkas, T., López‐Rivas, A., & Jäättelä, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.8 · Cited by 400

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., & Dillin, A. (2011) · Nature · doi:10.1038/nature09706 · Cited by 393

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

Anderson, K. A., Ribar, T. J., Lin, F., Noeldner, P. K., Green, M. F., Muehlbauer, M. J., Witters, L. A., Kemp, B. E., & Means, A. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.011 · Cited by 385

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

Bungard, D., Fuerth, B. J., Zeng, P.-Y., Faubert, B., Maas, N. L., Viollet, B., Carling, D., Thompson, C. B., Jones, R. G., & Berger, S. L. (2010) · Science · doi:10.1126/science.1191241 · Cited by 381

A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

Xie, M., Zhang, D., Dyck, J. R. B., Li, Y., Zhang, H., Morishima, M., Mann, D. L., Taffet, G. E., Baldini, A., Khoury, D. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604708103 · Cited by 358

Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver

Dentin, R., Girard, J. R., & Postic, C. (2004) · Biochimie · doi:10.1016/j.biochi.2004.11.008 · Cited by 346

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

Oakhill, J. S., Chen, Z., Scott, J. W., Steel, R., Castelli, L. A., Ling, N. X. Y., Macaulay, S. L., & Kemp, B. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009705107 · Cited by 337

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

Tamás, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G., & Cantrell, D. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052469 · Cited by 328

PAR-1 Kinase Plays an Initiator Role in a Temporally Ordered Phosphorylation Process that Confers Tau Toxicity in Drosophila

Nishimura, I., Yang, Y., & Lu, B. (2004) · Cell · doi:10.1016/s0092-8674(04)00170-9 · Cited by 324

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

Narbonne, P., & Roy, R. (2008) · Nature · doi:10.1038/nature07536 · Cited by 324

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

Bricambert, J., Miranda, J., Benhamed, F., Girard, J. R., Postic, C., & Dentin, R. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41624 · Cited by 318

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

Stephan, J. S., Yeh, Y.-Y., Ramachandran, V., Deminoff, S. J., & Herman, P. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903316106 · Cited by 316

Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p

Wang, Z., Wilson, W. A., Fujino, M., & Roach, P. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5742-5752.2001 · Cited by 300

A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity

Martin, S. G., & Johnston, D. S. (2003) · Nature · doi:10.1038/nature01296 · Cited by 293

AMP-activated protein kinase regulates the assembly of epithelial tight junctions

Zhang, L., Li, J., Young, L., & Caplan, M. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0608531103 · Cited by 282

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

Zheng, B., & Cantley, L. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610157104 · Cited by 275

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

Berdeaux, R., Goebel, N., Banaszynski, L. A., Takemori, H., Wandless, T. J., Shelton, G. D., & Montminy, M. (2007) · Nature Medicine · doi:10.1038/nm1573 · Cited by 270

Activation of 5′-AMP-activated Kinase with Diabetes Drug Metformin Induces Casein Kinase Iɛ (CKIɛ)-dependent Degradation of Clock Protein mPer2

Um, J. H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., & Chung, J. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700070200 · Cited by 244

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry

Watts, J. L., Morton, D. G., Bestman, J. E., & Kemphues, K. J. (2000) · Development · doi:10.1242/dev.127.7.1467 · Cited by 242

A Hormone-Dependent Module Regulating Energy Balance

Wang, B., Moya, N., Niessen, S., Hoover, H. S., Mihaylova, M. M., Shaw, R. J., Yates, J. R., Fischer, W. H., Thomas, J. B., & Montminy, M. (2011) · Cell · doi:10.1016/j.cell.2011.04.013 · Cited by 242

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue

Watt, M. J., Holmes, A. G., Pinnamaneni, S. K., GARNHAM, A. P., Steinberg, G. R., Kemp, B. E., & Febbraio, M. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2005 · Cited by 241

LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism

Jansen, M., ten Klooster, J. P., Offerhaus, G. J. A., & Clevers, H. C. (2009) · Physiological Reviews · doi:10.1152/physrev.00026.2008 · Cited by 233

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

Dykens, J. A., Jamieson, J., Marroquin, L., Nadanaciva, S., Billis, P. A., & Will, Y. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.08.013 · Cited by 220 · cited 1×

AMP-activated Protein Kinase Regulates HNF4α Transcriptional Activity by Inhibiting Dimer Formation and Decreasing Protein Stability

Hong, Y. H., Varanasi, U. S., Yang, W., & Leff, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304112200 · Cited by 220

Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase

Suzuki, A., Okamoto, S., Lee, S. P., Saito, K., Shiuchi, T., & Minokoshi, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02222-06 · Cited by 213

AMPK and autophagy get connected

Hardie, D. G. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.12 · Cited by 209

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation

Nakano, A., Kato, H., Watanabe, T., Min, K.-D., Yamazaki, S., Asano, Y., Seguchi, O., Higo, S., Shintani, Y., Asanuma, H., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2060 · Cited by 195

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

Zagórska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R., & Alessi, D. R. (2010) · Science Signaling · doi:10.1126/scisignal.2000616 · Cited by 193

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Thornton, C., Bright, N. J., Sastre, M., Muckett, P. J., & Carling, D. (2011) · Biochemical Journal · doi:10.1042/bj20101485 · Cited by 193

AMP-activated protein kinase: Also regulated by ADP?

Hardie, D. G., Carling, D., & Gamblin, S. J. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.06.004 · Cited by 187

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

Tong, X., Zhao, F., Mancuso, A., Gruber, J. J., & Thompson, C. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911316106 · Cited by 165

Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.

Sato, R., Goldstein, J. L., & Brown, M. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9261 · Cited by 164

Snf1‐related protein kinase 1 is needed for growth in a normal day–night light cycle

Thelander, M., Olsson, T., & Ronne, H. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600182 · Cited by 155

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J., & Hardie, D. G. (2009) · Biochemical Journal · doi:10.1042/bj20091372 · Cited by 146

AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner

Um, J.-H., Pendergast, J. S., Springer, D., Foretz, M., Viollet, B., Brown, A. L., Kim, M. K., Yamazaki, S., & Chung, J. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018450 · Cited by 146

Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK→ERK1/2 pathway

Kodiha, M., Rassi, J. G., Brown, C. M., & Stochaj, U. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00176.2007 · Cited by 138

AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

Amato, S., Liu, X., Zheng, B., Cantley, L. C., RAKIC, P. T., & Man, H. (2011) · Science · doi:10.1126/science.1201678 · Cited by 129

AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

Williams, T., Courchet, J., Viollet, B., Brenman, J. E., & Polleux, F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013660108 · Cited by 123

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

Kazgan, N., Williams, T., Forsberg, L. J., & Brenman, J. E. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-04-0347 · Cited by 123

STRADα Regulates LKB1 Localization by Blocking Access to Importin-α, and by Association with Crm1 and Exportin-7

Dorfman, J., & Macara, I. G. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0454 · Cited by 116

Neither LKB1 Nor AMPK Are the Direct Targets of Metformin

Hardie, D. G. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.032 · Cited by 113

An expression screen reveals modulators of class II histone deacetylase phosphorylation

Chang, S., Bezprozvannaya, S., Li, S., & Olson, E. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503275102 · Cited by 108

Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila

Johnson, E. C., Kazgan, N., Bretz, C. A., Forsberg, L. J., Hector, C. E., Worthen, R. J., Onyenwoke, R. U., & Brenman, J. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012799 · Cited by 105

The FKBP12‐rapamycin‐associated protein (FRAP) is a CLIP‐170 kinase

Choi, J. H., Bertram, P. G., Drenan, R. M., Carvalho, J. J., Zhou, H. H., & Zheng, X.-F. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf197 · Cited by 98

Regulation of LKB1/STRAD Localization and Function by E-Cadherin

Sebbagh, M., Santoni, M.-J., Hall, B., Borg, J., & Schwartz, M. A. (2008) · Current Biology · doi:10.1016/j.cub.2008.11.033 · Cited by 93

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas

Rothbart, S. B., Racanelli, A. C., & Moran, R. G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1873 · Cited by 90

Metformin Inhibits Nuclear Receptor TR4–Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity

Kim, E., Liu, N.-C., Yu, I.-C. I., Lin, H., Lee, Y., Sparks, J. D., Chen, L., & Chang, C. (2011) · Diabetes · doi:10.2337/db10-0393 · Cited by 87

KIN‐29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC

van der Linden, A. M., Nolan, K. M., & Sengupta, P. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601479 · Cited by 87

New Role for hPar-1 Kinases EMK and C-TAK1 in Regulating Localization and Activity of Class IIa Histone Deacetylases

Dequiedt, F., Martin, M., von Blume, J., Vertommen, D., Lecomte, E., Mari, N., Heinen, M.-F., Bachmann, M., Twizere, J., Huang, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00231-06 · Cited by 81

Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations

Halseth, A. E., Ensor, N. J., White, T., Ross, S. A., & Gulve, E. A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00557-0 · Cited by 68

The LKB1/AMPK polarity pathway

Mirouse, V., & Billaud, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.12.025 · Cited by 67

Diverse Cytopathologies in Mitochondrial Disease Are Caused by AMP-activated Protein Kinase Signaling

Bokko, P. B., Francione, L. M., Bandala‐Sanchez, E., Ahmed, A. U., Annesley, S. J., Huang, X., Khurana, T., Kimmel, A. R., & Fisher, P. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0881 · Cited by 67

Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice

Yang, J., Maika, S. D., Craddock, L., KING, J. A. C., & Liu, Z. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.094 · Cited by 64

AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor

Inoue, E., & Yamauchi, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.124 · Cited by 63

AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane

Zhang, L., Jouret, F., Rinehart, J., Sfakianos, J., Mellman, I., Lifton, R. P., Young, L. H., & Caplan, M. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.186932 · Cited by 55

AMP-activated Protein Kinase Phosphorylates Golgi-specific Brefeldin A Resistance Factor 1 at Thr1337 to Induce Disassembly of Golgi Apparatus

Miyamoto, T., Oshiro, N., Yoshino, K., Nakashima, A., Eguchi, S., Takahashi, M., Ono, Y., Kikkawa, U., & Yonezawa, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708296200 · Cited by 49

GSK/Sirtris compounds dogged by assay artifacts

Schmidt, C. (2010) · Nature Biotechnology · doi:10.1038/nbt0310-185 · Cited by 36

ADaPting to Energetic Stress

Bland, M. L., & Birnbaum, M. J. (2011) · Science · doi:10.1126/science.1208444 · Cited by 23

Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

McDonald, A., Fogarty, S., Leclerc, I., Hill, E. V., Hardie, D. G., & Rutter, G. A. (2009) · Islets · doi:10.4161/isl.1.3.9608 · Cited by 22

Non-CDK-bound p27 (p27NCDK) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways

Björklund, M., Vaahtomeri, K., Peltonen, K., Viollet, B., Mäkelä, T. P., Band, A. M., & Laiho, M. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.12.014 · Cited by 13

Targeting the Core of Transcription

Hardie, D. G. (2010) · Science · doi:10.1126/science.1195447 · Cited by 8

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

AKT/PKB Signaling: Navigating the Network

Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772

Mitochondria: In Sickness and in Health

Nunnari, J., & Suomalainen, A. (2012) · Cell · doi:10.1016/j.cell.2012.02.035 · Cited by 3,479

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081

Ageing as a Risk Factor for Disease

Niccoli, T., & Partridge, L. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.024 · Cited by 1,831

AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics

Paz, M. V., Cotán, D., Garrido‐Maraver, J., Oropesa-Ávila, M., de la Mata, M., Pavón, A. D., de Lavera, I., Alcocer‐Gómez, E., Álvarez-Córdoba, M., & Sánchez-Alcázar, J. A. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_3 · Cited by 116

AMPK Control of Metabolic Signaling

Shaw, R. J. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.231.3

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

Tamargo‐Gómez, I., & Mariño, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123812 · Cited by 258

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638

AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

Sharma, A., Anand, S. K., Singh, N., Dwivedi, U. N., & Kakkar, P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113614 · Cited by 207