Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease
Abstract
Recent studies have demonstrated that, in addition to their central role in cellular catabolic reactions, lysosomes are implicated in many cellular processes, including metabolism, membrane repair, and cell death. Lysosomal membrane permeabilization (LMP) has emerged as a pathway by which cell demise is regulated under physiological conditions and contributes to cell death in many pathological situations. Here, we review the latest evidence on LMP‐mediated cell death, the upstream and downstream signals involved, and the role of LMP in the normal physiology of organisms. We also discuss the contributions of lysosomal damage and LMP to the pathogenic features of several disease states, such as lysosomal storage disorders and other neurodegenerative conditions.
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In other experimental settings, lysosomes are permeabilized before mitochondria via a mechanism that optionally involves BAX recruitment to the lysosomal membrane followed by activation of its pore-forming activity.
“In other experimental settings, however, lysosomes are permeabilized before mitochondria [752, 760, 761], via a mechanism that optionally involves BAX recruitment to the lysosomal membrane followed by the activation of its pore-forming activity [762–765].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [752]
Lysosome-dependent cell death is relevant for several pathophysiological conditions, including inflammation, tissue remodeling, aging, neurodegeneration, cardiovascular disorders, and intracellular pathogen response.
“Lysosome-dependent cell death is relevant for several pathophysiological conditions, including inflammation, tissue remodeling (e.g., mammary gland involution after lactation), aging, neurodegeneration, cardiovascular disorders, and intracellular pathogen response [750–752].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [752]
Inhibiting LMP or blocking cathepsin activity pharmacologically or genetically retards lysosome-dependent cell death in vitro and in vivo.
“Lysosome-dependent cell death can be retarded in vitro and in vivo by inhibiting LMP or blocking cathepsin activity via pharmacological or genetic means [750, 752].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [752]
RCD is a primary etiological determinant in diseases with irreversible loss of post-mitotic tissues such as myocardial infarction and neurodegeneration.
“On the one hand, RCD constitutes a primary etiological determinant in diseases associated with the irreversible loss of post-mitotic tissues (e.g., myocardial infarction, neurodegeneration) [687, 752, 851, 869, 1035, 1036].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [752]
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Pshezhetsky, A. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1046671 · Cited by 48 · see citing works
Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress
Eno, C. O., Zhao, G., Venkatanarayan, A., Wang, B., Flores, E. R., & Li, C. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.051 · Cited by 44 · see citing works
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Pacheco, F. J., Almaguel, F. G., Evans, W., Ríos-Colón, L., Filippov, V. A., Leoh, L. S., Rook-Arena, E., Mediavilla-Varela, M., León, M. A. D., & Casiano, C. A. (2014) · Inflammation Research · doi:10.1007/s00011-014-0760-2 · Cited by 41 · see citing works
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Krenn, M. A., Schürz, M., Teufl, B., Uchida, K., Eckl, P., & Bresgen, N. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.12.007 · Cited by 32 · see citing works
Lipton, P. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0301-2 · Cited by 30 · see citing works
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Impairment of homeostasis in lysosomal storage disorders
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Necrotic cell death in Caenorhabditis elegans.
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Flagged first, then by citations
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Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationAutophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Menzies, F. M., Fleming, A., Caricasole, A., Bento, C. F., Andrews, S. P., Ashkenazi, A., Füllgrabe, J., Jackson, A., Jimenez Sanchez, M., Karabiyik, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.022 · Cited by 1,134 · see citing works
Lysosomal cell death mechanisms in aging
Gómez-Sintes, R., Ledesma, M. D., & Boya, P. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.009 · Cited by 216 · see citing works
Self-citationCabrera-Reyes, F., Parra-Ruiz, C., Yuseff, M. I., & Zanlungo, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.790568 · Cited by 24 · see citing works
- Authors
- Serrano‐Puebla, A., & Boya, P.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Boya, Patricia
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2015-11-24
- Volume
- 1371
- Issue
- 1
- Pages
- 30-44
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2180008421
- Cited by
- 204
- References
- 96
- Citations by year
- 2026: 23 · 2025: 16 · 2024: 22 · 2023: 20 · 2022: 18 · 2021: 21 · 2020: 27 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 8 · 2015: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MINECO (SAF2012-36079)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomal membrane permeabilization, cell death, lysosomes, lysosomal storage disease, neurodegenerative diseases, membrane repair, cellular metabolism, pathogenesis
- MeSH terms
- Animals, Disease, Health, Humans, Intracellular Membranes, Lysosomes, Permeability, Cell Death
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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