The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells
Open accessAbstract
The vasculature is a prominent component of the subventricular zone neural stem cell niche. Although quiescent neural stem cells physically contact blood vessels at specialized endfeet, the significance of this interaction is not understood. In contrast, it is well established that vasculature-secreted soluble factors promote lineage progression of committed progenitors. Here we specifically investigated the role of cell–cell contact-dependent signalling in the vascular niche. Unexpectedly, we find that direct cell–cell interactions with endothelial cells enforce quiescence and promote stem cell identity. Mechanistically, endothelial ephrinB2 and Jagged1 mediate these effects by suppressing cell-cycle entry downstream of mitogens and inducing stemness genes to jointly inhibit differentiation. In vivo, endothelial-specific ablation of either of the genes which encode these proteins, Efnb2 and Jag1 respectively, aberrantly activates quiescent stem cells, resulting in depletion. Thus, we identify the vasculature as a critical niche compartment for stem cell maintenance, furthering our understanding of how anchorage to the niche maintains stem cells within a pro-differentiative microenvironment.
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Cites
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Self-citationEph-Ephrin Bidirectional Signaling in Physiology and Disease
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A specialized vascular niche for adult neural stem cells
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Cited by
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
“In the SVZ, endothelial cell expression of ephrinB2 and Jagged1 promotes NSC quiescence by suppressing cell-cycle entry and inhibiting differentiation, and loss of either gene results in NSC activation and depletion (Ottone et al., 2014).”
BackgroundNeural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
Zhang, J., Muri, J., Fitzgerald, G., Gorski, T., Gianni-Barrera, R., Masschelein, E., D’Hulst, G., Gilardoni, P., Turiel, G., Fan, Z., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.004 · Cited by 533
Neurogenesis in the embryonic and adult brain: same regulators, different roles
Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493
Metadata
- Authors
- Ottone, C., Krusche, B., Whitby, A., Clements, M., Quadrato, G., Pitulescu, M. E., Adams, R. H., & Parrinello, S.
- Venue
- Nature Cell Biology
- Published
- 2014-10-05
- Volume
- 16
- Issue
- 11
- Pages
- 1045-1056
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2009953822
- Cited by
- 282
- References
- 53
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- green
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