Cited by 404Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity

Open access

Jeffery, Elise, Church, Christopher D., Holtrup, Brandon, Colman, Laura, Rodeheffer, Matthew S.·2015·Nature Cell Biology

DOI 10.1038/ncb3122PMC PMC4380653

Open this paper in CoChat — free account

Abstract

Excessive accumulation of white adipose tissue (WAT) is the defining characteristic of obesity. WAT mass is composed primarily of mature adipocytes, which are generated through the proliferation and differentiation of adipocyte precursors (APs). Although the production of new adipocytes contributes to WAT growth in obesity, little is known about the cellular and molecular mechanisms underlying adipogenesis in vivo. Here, we show that high-fat diet feeding in mice rapidly and transiently induces proliferation of APs within WAT to produce new adipocytes. Importantly, the activation of adipogenesis is specific to the perigonadal visceral depot in male mice, consistent with the patterns of obesogenic WAT growth observed in humans. Furthermore, we find that in multiple models of obesity, the activation of APs is dependent on the phosphoinositide 3-kinase (PI3K)-AKT2 pathway; however, the development of WAT does not require AKT2. These data indicate that developmental and obesogenic adipogenesis are regulated through distinct molecular mechanisms.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ncb3122

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
Global burden of obesity in 2005 and projections to 2030
Kelly, T., Yang, W., Chen, C.-S., Reynolds, K., & He, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.102 · Cited by 3,319
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357
Fat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860
Forming functional fat: a growing understanding of adipocyte differentiation
Cristancho, A. G., & Lazar, M. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3198 · Cited by 1,382
The nuts and bolts of AGC protein kinases
Pearce, L. R., Komander, D., & Alessi, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2822 · Cited by 1,294

Show all 53 references

Sorted by citations

Items 201–300 of 399

Proliferation of nutrition sensing preadipocytes upon short term HFD feeding
Kulenkampff, E., & Wolfrum, C. (2018) · Adipocyte · doi:10.1080/21623945.2018.1521229 · Cited by 22
Activating PIK3CA mutation promotes adipogenesis of adipose-derived stem cells in macrodactyly via up-regulation of E2F1
Sun, B., Jiang, Y., Cui, H., Xia, F., Han, G., Dai, X., Zhou, S., Mao, H., & Wang, B. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02806-1 · Cited by 20
Extracellular Vesicles from Adipose Tissue Stem Cells in Diabetes and Associated Cardiovascular Disease; Pathobiological Impact and Therapeutic Potential
Constantin, A. L., Filippi, A., Alexandru, N., Nemecz, M., & Georgescu, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249598 · Cited by 20
A Single Bout of Fasting (24 h) Reduces Basal Cytokine Expression and Minimally Impacts the Sterile Inflammatory Response in the White Adipose Tissue of Normal Weight F344 Rats
Speaker, K. J., Paton, M. M., Cox, S. S., & Fleshner, M. (2016) · Mediators of Inflammation · doi:10.1155/2016/1698071 · Cited by 20
M2 macrophages infusion ameliorates obesity and insulin resistance by remodeling inflammatory/macrophages' homeostasis in obese mice
Zhang, Q., Hao, H., Xie, Z., Cheng, Y., Yin, Y., Xie, M., Huang, H., Gao, J., Liu, H., Tong, C., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.005 · Cited by 20
Identification of SCARA3 with potential roles in metabolic disorders
Peng, H., Guo, Q., Su, T., Xiao, Y., Li, C., Huang, Y., & Luo, X. (2020) · Aging · doi:10.18632/aging.202228 · Cited by 19
Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin
Quattrocelli, M., Wintzinger, M., Miz, K., Panta, M., Prabakaran, A. D., Barish, G. D., Chandel, N. S., & McNally, E. M. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211906 · Cited by 19
Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors
Varshney, R., Das, S., Trahan, G. D., Farriester, J. W., Mullen, G. P., Kyere-Davies, G., Presby, D. M., Houck, J. A., Webb, P. G., Dzieciątkowska, M., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105750 · Cited by 19
Self-citation
Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia
Minic, M., Rocha, N., Harris, J. R., Groeneveld, M. P., Leiter, S. M., Wareham, N. J., Sleigh, A., de Lonlay, P., Hussain, K., O’Rahilly, S., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00768 · Cited by 19
Preparation of Stepwise Adipogenesis-Mimicking ECM-Deposited PLGA–Collagen Hybrid Meshes and Their Influence on Adipogenic Differentiation of hMSCs
Chen, Y., Lee, K., Chen, Y. G., Yang, Y., Kawazoe, N., & Chen, G. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00866 · Cited by 19
Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis
Gourronc, F. A., Markan, K. R., Kulhánková, K., Zhu, Z., Sheehy, R. M., Quelle, D. E., Zingman, L. V., Kurago, Z., Ankrum, J. A., & Klingelhutz, A. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236741 · Cited by 19
The role of Wnt pathway in obesity induced inflammation and diabetes: a review
Das, B., Das, M. K., Kalita, A., & Baro, M. R. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00862-8 · Cited by 20
Ciliary control of adipocyte progenitor cell fate regulates energy storage
Scamfer, S. R., Lee, M. D., & Hilgendorf, K. I. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1083372 · Cited by 19
Adipose cell hypertrophy precedes the appearance of small adipocytes by 3 days in C57BL/6 mouse upon changing to a high fat diet
Li, Y., Periwal, V., Cushman, S. W., & Stenkula, K. G. (2015) · Adipocyte · doi:10.1080/21623945.2015.1128588 · Cited by 18
From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling
Vo, N., Zhang, Q., & Sung, H. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.13062 · Cited by 17
ADAMTS5 promotes murine adipogenesis and visceral adipose tissue expansion
Bauters, D., Scroyen, I., Deprez-Poulain, R. F., & LIJNEN, H. R. (2016) · Thrombosis and Haemostasis · doi:10.1160/th16-01-0015 · Cited by 17
Reduced Number of Adipose Lineage and Endothelial Cells in Epididymal fat in Response to Omega-3 PUFA in Mice Fed High-Fat Diet
Adamcová, K., Horakova, O., Bardová, K., Janovská, P., Březinová, M., Kuda, O., Rossmeisl, M., & Kopecký, J. (2018) · Marine Drugs · doi:10.3390/md16120515 · Cited by 17
Response to the photoperiod in the white and brown adipose tissues of Fischer 344 rats fed a standard or cafeteria diet
Gibert‐Ramos, A., Ibars, M., Salvadó, M. J., & Crescenti, A. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.04.005 · Cited by 22
Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
Buffolo, M., Pires, K. M. P., Ferhat, M., Ilkun, O. L., Makaju, A., Achenbach, A., Bowman, F. M., Atkinson, D. L., Holland, W. L., Amri, E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.092 · Cited by 17
Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
Lee, Y. M., Jin, B., Lee, S. Y., Song, M., Bae, H., Min, B., Park, J., Lee, D., & Kim, H. (2016) · Molecules · doi:10.3390/molecules21111424 · Cited by 17
Identification of the ectoenzyme CD38 as a marker of committed preadipocytes
Carrière, A., Jeanson, Y., Côté, J.-A., Dromard, C., Galinier, A., Menzel, S., Barreau, C., Dupuis-Coronas, S., Arnaud, E., Girousse, A., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.140 · Cited by 17
Capturing the multifaceted function of adipose tissue macrophages
Matz, A. J., Qu, L., Karlinsey, K., Vella, A. T., & Zhou, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148188 · Cited by 16
Obesity under the moonlight of c-MYC
Nevzorova, Y. A., & Cubero, F. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1293218 · Cited by 16
Pantothenic Acid Alleviates Fat Deposition and Inflammation by Suppressing the JNK/P38 MAPK Signaling Pathway
Zhao, C., Wen, Z., Gao, Y., Xiao, F., Yan, J., Wang, X., & Meng, T. (2024) · Journal of Medicinal Food · doi:10.1089/jmf.2023.k.0292 · Cited by 16
LMO3 reprograms visceral adipocyte metabolism during obesity
Wagner, G., Fenzl, A., Lindroos‐Christensen, J., Einwallner, E., Husa, J., Witzeneder, N., Rauscher, S., Gröger, M., Derdak, S. V., Mohr, T. T., et al. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02089-9 · Cited by 16
Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging
Luca, M. D., Mandalà, M., & Rose, G. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111522 · Cited by 16
A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG
Barrueco, R. R., Latorre, J., Devis, L., Lluch, A., Bonifaci, N., Llobet, F. J., Oliván, M., Coll‐Iglesias, L., Gassner, K., Davis, M. L., et al. (2021) · Advanced Science · doi:10.1002/advs.202104759 · Cited by 16
Metformin Inhibits Lipid Droplets Fusion and Growth via Reduction in Cidec and Its Regulatory Factors in Rat Adipose-Derived Stem Cells
Yang, L., Jia, X., Fang, D., Cheng, Y., Zhai, Z., Deng, W., Du, B., Lu, T., Wang, L., Yang, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115986 · Cited by 16
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes
Mattar, P., Bravo, R., Tobar, N., Fuentes, C., Troncoso, R., Breitwieser, G. E., Lavandero, S., & Cifuentes, M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.020 · Cited by 16
Developmental and functional heterogeneity of thermogenic adipose tissue
Ruan, H. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa029 · Cited by 16
How obesity affects adipocyte turnover
Han, S. M., Nahmgoong, H., Yim, K. M., & Kim, J. B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.004 · Cited by 17
Lipodystrophy as a Late Effect after Stem Cell Transplantation
Tews, D., Schulz, A., Denzer, C., von Schnurbein, J., Ceccarini, G., Debatin, K., & Wabitsch, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081559 · Cited by 15
Unraveling White Adipose Tissue Heterogeneity and Obesity by Adipose Stem/Stromal Cell Biology and 3D Culture Models
Baptista, L. S., Silva, K. R., Jobeili, L., Guillot, L., & Sigaudo‐Roussel, D. (2023) · Cells · doi:10.3390/cells12121583 · Cited by 16
The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function
Carli, J. F. M., LeDuc, C. A., Zhang, Y., Stratigopoulos, G., & Leibel, R. L. (2018) · The FASEB Journal · doi:10.1096/fj.201701216r · Cited by 15
Association of intracellular lipid accumulation in subcutaneous adipocyte precursors and plasma adipokines in bariatric surgery candidates
Hristov, I., Mocanu, V., Zugun‐Eloae, F., Labusca, L. S., Cretu-Silivestru, I. S., Oboroceanu, T., Tiron, C. E., Tiron, A., Burlacu, A., Pînzariu, A. C., et al. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1081-9 · Cited by 14
The impact of dietary fatty acids on human adipose tissue
Petrus, P., & Arner, P. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000624 · Cited by 14
Molecular insights into therapeutic promise of targeting of Wnt/β-catenin signaling pathway in obesity
Nijhawan, P., Behl, T., BUNGAU, S. G., Uddin, M. S., Zengin, G., & Arora, S. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05784-x · Cited by 15
Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
Kang, H., Min, B.-K., Choi, W., Jeon, J., Kim, D. W., Park, S., Lee, Y.-K., Kim, H.-J., Byeon, J.-E., Go, Y., et al. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00672-1 · Cited by 14
The composition, function, and regulation of adipose stem and progenitor cells
Liao, X., Zhou, H., & Deng, T. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.02.014 · Cited by 14
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity
He, T., Wang, S., Li, S., Shen, H., Hou, L., Liu, Y., Wei, Y., Xie, F., Zhang, Z., Zhao, Z., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106289 · Cited by 14
White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease
Rabadán-Chávez, G. M., de la Garza, R. I. D., & Jacobo‐Velázquez, D. A. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166853 · Cited by 15
Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells
Zeve, D., Millay, D. P., Seo, J. H., & Graff, J. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152129 · Cited by 14
Disabled-2 Determines Commitment of a Pre-adipocyte Population in Juvenile Mice
Tao, W., Moore, R., Meng, Y., Yeasky, T. M., Smith, E. R., & Xu, X.-X. (2016) · Scientific Reports · doi:10.1038/srep35947 · Cited by 13
The contribution of bone marrow-derived cells to the human adipocyte pool
Arner, P., & Rydén, M. (2017) · Adipocyte · doi:10.1080/21623945.2017.1306158 · Cited by 14
Potentiation of Adipogenesis by Reactive Oxygen Species Is a Unifying Mechanism in the Proadipogenic Properties of Bisphenol A and Its New Structural Analogues
Singh, R. D., Wager, J. L., Scheidl, T. B., Connors, L. T., Easson, S., Callaghan, M. A., Alatorre-Hinojosa, S., Swift, L. H., Colarusso, P., Jadli, A. S., et al. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0150 · Cited by 13
Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing, A., Jeffery, E. C., CHURCH, C. D., Goodell, J., Saavedra-Peña, R. D. M., Saha, M., Holtrup, B., Voisin, M., Alavi, N. S., Floody, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115527 · Cited by 15
Self-citation
Inhibition of high-fat diet-induced inflammatory responses in adipose tissue by SF1-expressing neurons of the ventromedial hypothalamus
Rashid, M., Kondoh, K., Pálfalvi, G., Nakajima, K., & Minokoshi, Y. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112627 · Cited by 13
Prep1 prevents premature adipogenesis of mesenchymal progenitors
Maroni, G., Va, T., Egorov, A. D., Morelli, M. J., Luongo, R., Levantini, E., Blasi, F., Magli, M. C., & Penkov, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-15828-1 · Cited by 13
The Impact of Maternal Obesity on Adipose Progenitor Cells
Lecoutre, S., Maqdasy, S., Lambert, M., & Breton, C. (2023) · Biomedicines · doi:10.3390/biomedicines11123252 · Cited by 14
Low‐Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation
Wang, Y., Mak, J., Lee, M. Y. K., Xu, A., & Ip, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4501757 · Cited by 13
Expansion and inflammation of white adipose tissue - focusing on adipocyte progenitors
Liu, W., Li, D., Cao, H., Li, H., & Wang, Y. (2020) · Biological Chemistry · doi:10.1515/hsz-2019-0451 · Cited by 12
Innervation of adipocytes is limited in mouse perivascular adipose tissue
Hanscom, M., Morales‐Soto, W., Watts, S. W., Jackson, W. F., & Gulbransen, B. D. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00041.2024 · Cited by 11
Sex differences in the lipid profiles of visceral adipose tissue with obesity and gonadectomy
Varghese, M., Rajendiran, T. M., Soni, T., Zhang, J., Maddipati, K. R., & Singer, K. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100803 · Cited by 12
Insights of the role of estrogen in obesity from two models of ERα deletion
Saavedra-Peña, R. D. M., Taylor, N., & Rodeheffer, M. S. (2022) · Journal of Molecular Endocrinology · doi:10.1530/jme-21-0260 · Cited by 11
Self-citation
Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
Matz, A., Qu, L., Karlinsey, K. S., & Zhou, B. (2022) · Cells · doi:10.3390/cells11081336 · Cited by 11
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene
Jia-yao, C., Jiaoling, W., Chengyu, H., Guixiang, W., & Zang, L. (2023) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2023.10.004 · Cited by 11
Adipo‐specific chemerin knockout alters the metabolomic profile of adipose tissue under normal and high‐fat diet conditions: Application of an untargeted liquid chromatography–tandem mass spectrometry metabolomics method
Yanan, Y., Jia, Y., Lin, X., Jing, Q., & Xiao-hui, W. (2021) · Biomedical Chromatography · doi:10.1002/bmc.5220 · Cited by 11
GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity
English, J., Orofino, J., Cederquist, C., Paul, I., Li, H., Auwerx, J. H., Emili, A., Belkina, A. C., Cardamone, M. D., & Perissi, V. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101682 · Cited by 11
Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development
Liu, Q., Li, C., Deng, B., Gao, P., Wang, L., Li, Y., Shiri, M., Alkaifi, F., Zhao, J., Stephens, J. M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112166 · Cited by 11
Indispensable role of lipoprotein bound-ApoE in adipogenesis and endocytosis induced by postprandial TRL
Zhang, M., Li, Y., Wei, X.-H., Tian, F., Ouyang, F., Zhao, S., & Liu, L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.027 · Cited by 10
A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation
Das, R., Giri, J., Paul, P. K., Froelich, N. E., Chinnadurai, R., McCoy, S. S., BUSHMAN, W. A., & Galipeau, J. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00244-5 · Cited by 10
Autologous adipose-derived stromal vascular fraction and platelet concentrates for the treatment of complex perianal fistulas
Tutino, R., Franco, S. D., Massani, M., Bonventre, S., Mazzola, G. C., Re, G. L., Gulotta, E., Mambou, L. J. K., Stassi, G., Cocorullo, G., et al. (2022) · Techniques in Coloproctology · doi:10.1007/s10151-022-02675-0 · Cited by 10
Inflammatory markers and androstenedione modify the effect of serum testosterone on obesity among men: Findings from a Chinese population
Huan, C., Wang, M., Song, Y., Jia, Z., Wei, D., Wang, L., Xu, Q., Wang, J., Zhao, M., Geng, J., et al. (2023) · Andrology · doi:10.1111/andr.13544 · Cited by 10
Fat Decisions: Leptin Regulates Bone versus Fat in the Marrow
Rodeheffer, M. S., & Horowitz, M. C. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.05.006 · Cited by 10
Self-citation
Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat
Rivera-Gonzalez, G. C., Butka, E. G., Gonzalez, C. E., Mintz, R. L., Kleb, S. S., Josephson, V., Kong, W., Jindal, K., Kamimoto, K., Shook, B. A., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.07.004 · Cited by 9
Self-citation
Two paths to fat
Rosen, E. D. (2015) · Nature Cell Biology · doi:10.1038/ncb3133 · Cited by 9
Endogenous Omega‐3 Polyunsaturated Fatty Acids Reduce the Number and Differentiation of White Adipocyte Progenitors in Mice
Chen, C., Su, C., & Kang, J. X. (2019) · Obesity · doi:10.1002/oby.22626 · Cited by 9
Characterization of adipose depot-specific stromal cell populations by single-cell mass cytometry
Lee, J. H., Ealey, K. N., Patel, Y., Verma, N., Thakkar, N., Park, S., Kim, J., & Sung, H. (2022) · iScience · doi:10.1016/j.isci.2022.104166 · Cited by 10
Panax notoginseng extract and total saponin suppress diet-induced obesity and endoplasmic reticulum stress in epididymal white adipose tissue in mice
Tan, Y., Zhang, X., Zhou, Y., Miao, L., Xu, B., Khan, H. Z., Wang, Y., Yu, H., & Cheang, W. S. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00629-0 · Cited by 9
Navigating the Adipocyte Precursor Niche: Cell-Cell Interactions, Regulatory Mechanisms and Implications for Adipose Tissue Homeostasis
Kesharwani, D., & Brown, A. C. (2024) · Journal of Cellular Signaling · doi:10.33696/signaling.5.114 · Cited by 9
Molecular Mechanisms Involved in Insulin Resistance: Recent Updates and Future Challenges
Singh, A., Ghai, N., & Bedi, P. M. S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104806 · Cited by 9
Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice
Ghosh, A., Chénier, I., Leung, Y. H., Oppong, A. K., Peyot, M., Madiraju, S. R. M., Al‐Khairi, I., Abubaker, J. A., Al‐Mulla, F., Prentki, M., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111292 · Cited by 9
Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity
Kong, W., Peng, Y., Ji, C., Liu, Z., Liu, Z., Gao, S., 张跃新, 陳嘉文, Li, X., Bao, M., et al. (2023) · Clinical Science · doi:10.1042/cs20230433 · Cited by 8
Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
Peics, J., Vishvanath, L., Zhang, Q., Shan, B., Pedersen, T. Å., & Gupta, R. K. (2020) · Journal of Visualized Experiments · doi:10.3791/61610 · Cited by 8
Multi-Omics Analysis to Examine Gene Expression and Metabolites From Multisite Adipose-Derived Mesenchymal Stem Cells
Yang, C., Zhang, J., Wu, T., Zhao, K., Wu, X., Shi, J., Sun, W. Y., & Kong, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.627347 · Cited by 8
BCAA catabolism drives adipogenesis via an intermediate metabolite and promotes subcutaneous adipose tissue expansion during obesityPreprint
Shao, J., Liu, Y., Zhang, X., Shu, L., Yu, J., Yang, S., Gao, C., Wang, C.-M., Cao, N., Zhou, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.18.504380 · Cited by 9
Contributions of white adipose tissue to energy requirements for female reproduction
Anaya, E. S., de Groot, E. L., Lydon, J. P., Pangas, S. A., & Hartig, S. M. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.012 · Cited by 7
Distinct precursor landscape of subcutaneous and visceral fat in development and aging
Lin, F., & Sul, H. S. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116706 · Cited by 7
Differential roles of insulin receptor in adipocyte progenitor cells in mice
Yuan, Y., Shi, Z., Xiong, S., Hu, R., Song, Q., Song, Z., Ong, S., & Jiang, Y. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111968 · Cited by 7
Positive Impacts of Aphanizomenon Flos Aquae Extract on Obesity-Related Dysmetabolism in Mice with Diet-Induced Obesity
Terzo, S., Calvi, P., Giardina, M., Gallizzi, G., Carlo, M. D., Nuzzo, D., Picone, P., Puleio, R., Mulè, F., Scoglio, S., et al. (2023) · Cells · doi:10.3390/cells12232706 · Cited by 7
Adipose Tissue Stromal Cells: Rheostats for Adipose Tissue Function and Metabolic Disease Risk
Scheidl, T. B., Wager, J. L., & Thompson, J. A. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.02.025 · Cited by 8
High‐fat diet decreases H3K27ac in mice adipose‐derived stromal cells
da Silva, V. S., Simão, J. D. J., Plata, V. T. G., Bispo, A. F. S., de Sá, R. D. C. D. C., Machado, C. F., Stumpp, T., Alonso‐Vale, M. I. C., & Armelin‐Correa, L. (2022) · Obesity · doi:10.1002/oby.23537 · Cited by 7
Programming Mechanism of Adipose Tissue Expansion in the Rat Offspring of Obese Mothers Occurs in a Sex-Specific Manner
Ibáñez, C. A., Lira-León, G., Reyes‐Castro, L. A., Rodríguez-González, G. L., Lomas‐Soria, C., Hernández-Rojas, A., Bravo-Flores, E., Solis‐Paredes, J. M., Estrada‐Gutiérrez, G., & Zambrano, E. (2023) · Nutrients · doi:10.3390/nu15102245 · Cited by 7
Adipocyte gene expression in obesity — insights gained and challenges ahead
Markussen, L. K., & Mandrup, S. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102060 · Cited by 7
Prepubertal androgen signaling is required to establish male fat distribution
Sebo, Z. L., & Rodeheffer, M. S. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.04.001 · Cited by 7
Self-citation
EH Domain-Containing 2 Deficiency Restricts Adipose Tissue Expansion and Impairs Lipolysis in Primary Inguinal Adipocytes
Fryklund, C., Morén, B., Shah, S., Grossi, M., Degerman, E., Matthaeus, C., & Stenkula, K. G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.740666 · Cited by 7
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy
Chen, L., You, Q., Liu, M., Li, S., Wu, Z., Hu, J., Ma, Y., Xia, L.-Y., Zhou, Y., Xu, N., et al. (2022) · eLife · doi:10.7554/elife.72443 · Cited by 6
Adiponectin expressing skeletal stem/progenitor cells in the bone and bone marrow homeostasis
Palmisano, B., Corsi, A., & Riminucci, M. (2024) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2024.100524 · Cited by 6
Inter-organ Crosstalk and the Effect on the Aging Process in Obesity
Armutçu, F., & Özen, O. A. (2023) · Current Aging Science · doi:10.2174/1874609816666230223110458 · Cited by 6
RXRα cooperates with KLF8 to promote the differentiation of intramuscular preadipocytes in goat
Xu, Q., Wang, Y., Zhang, Y., Zhu, J., & Lin, Y. (2020) · Animal Biotechnology · doi:10.1080/10495398.2020.1732397 · Cited by 6
A Short S-Equol Exposure Has a Long-Term Inhibitory Effect on Adipogenesis in Mouse 3T3-L1 Cells
Mandujano-Lázaro, G., Galavíz-Hernández, C., Reyes-López, C. A. S., Almanza-Pérez, J. C., Giacoman‐Martínez, A., López‐Camarillo, C., Huang, F., & Marchat, L. A. (2021) · Applied Sciences · doi:10.3390/app11209657 · Cited by 6
Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity
Imrie, H., Viswambharan, H., Haywood, N. J., Bridge, K., Yuldasheva, N. Y., Galloway, S. L., Simmons, K. J., Cubbon, R. M., Sukumar, P., Watt, N. T., et al. (2022) · Adipocyte · doi:10.1080/21623945.2022.2089394 · Cited by 6
Targeted Proteomic Analysis of Small GTPases in Murine Adipogenesis
Yang, Y., Huang, M., & Wang, Y. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00974 · Cited by 6
The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue
Campbell, J. E., Beaudry, J. L., Svendsen, B., Baggio, L. L., Gordon, A. N., Ussher, J. R., Wong, C. K., Gribble, F. M., D’Alessio, D. A., Reimann, F. M., et al. (2022) · doi:10.2337/figshare.19184462 · Cited by 6
A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity
Mund, C., Sinha, A. N., Aderhold, A., Mateska, I., Hagag, E., Traikov, S., Gercken, B., Soto, A., Pollock, J., Arndt, L., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156358 · Cited by 5
PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
Chen, H., Sun, B., Gao, W., Qiu, Y., Wei, W., Li, Y., Ye, W., Song, H., Hua, C., & Lin, X. (2024) · iScience · doi:10.1016/j.isci.2024.110467 · Cited by 5
Visceral fat distribution: Interracial studies
Banerjee, S., Lv, J., He, C., Qi, B., Ding, W., Long, K., Chen, J., Wen, J., & Chen, P. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.10.001 · Cited by 5
White Adipocyte Stem Cell Expansion Through Infant Formula Feeding: New Insights into Epigenetic Programming Explaining the Early Protein Hypothesis of Obesity
Melnik, B. C., Weiskirchen, R., John, S. M., Stremmel, W., Leitzmann, C., Weiskirchen, S., & Schmitz, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104493 · Cited by 6
Sex- and depot-specific differences in cellular insulin responsiveness during adipose expansion
Neuhaus, M., & Stenkula, K. G. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123743 · Cited by 5
Physical Expansion Preconditioning Promotes Host-Derived Adipocyte Dedifferentiation and Migration into Fat Grafts in a Murine Model
He, Y., Liang, Z., Tang, H., Li, J., Ma, J., Shi, J., Cai, J., & Liao, Y. (2023) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000011069 · Cited by 5

Authors: Jeffery, E., Church, C. D., Holtrup, B., Colman, L., & Rodeheffer, M. S.
Affiliations: Yale University (US)
Corresponding author: Rodeheffer, Matthew S.
ORCID: Holtrup, Brandon
Rodeheffer, Matthew S.
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2015-03-02
Volume: 17
Issue: 4
Pages: 376-385
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb3122
PMC: PMC4380653
OpenAlex: W2000524154
Cited by: 404
References: 53
Citations by year: 2026: 14 · 2025: 26 · 2024: 29 · 2023: 44 · 2022: 42 · 2021: 39 · 2020: 39 · 2019: 42 · 2018: 37 · 2017: 40 · 2016: 35 · 2015: 16
FWCI: 33.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000142)
National Institute of General Medical Sciences (T32GM007223)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090489, R56DK090489, DK-045735, DK090489, P30DK045735)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: adipocyte precursors, adipogenesis, obesity, white adipose tissue, high-fat diet, adipocyte proliferation
MeSH terms: Wortmannin, Phosphoinositide-3 Kinase Inhibitors, Androstadienes, Animals, Eating, Male, Mice, Inbred C57BL, Obesity, Random Allocation, Tamoxifen, Mice, Knockout, Phosphatidylinositol 3-Kinases, Cell Proliferation, Adipogenesis, Proto-Oncogene Proteins c-akt, Mice, Adipose Tissue, White, Adipocytes, White, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks