The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Winter, Georg E, Radic, Branka, Mayor-Ruiz, Cristina, Blomen, Vincent A, Trefzer, Claudia, Kandasamy, Richard K, Huber, Kilian V M, Gridling, Manuela, Chen, Doris, Klampfl, Thorsten, Kralovics, Robert, Kubicek, Stefan, Fernandez-Capetillo, Oscar, Brummelkamp, Thijn R, Superti-Furga, Giulio·2014·Nature Chemical Biology

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  42. βTrCP1 promotes SLC35F2 protein ubiquitination and inhibits cancer progression in HeLa cells
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  62. Metabolic Control Analysis
    2003 · CRC Press eBooks
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