Cited by 288Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsHeat shock proteins research

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Targeting proteins for degradation.

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Schrader, Erin K, Harstad, Kristine G, Matouschek, Andreas·2009·Nature Chemical Biology

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Abstract

Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response. In eukaryotic cells, an ATP-dependent protease called the proteasome is responsible for much of this proteolysis. Proteins are targeted for proteasomal degradation by a two-part degron, which consists of a proteasome binding signal and a degradation initiation site. Here we describe how both components contribute to the specificity of degradation.

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Authors: Schrader, E. K., Harstad, K. G., & Matouschek, A.
Affiliations: Northwestern University (US)
Corresponding author: Matouschek, Andreas
ORCID: Matouschek, Andreas
Venue: Nature Chemical Biology
Publisher: Springer Science and Business Media LLC
Published: 2009-10-19
Volume: 5
Issue: 11
Pages: 815-822
ISSN: 1552-4450 (ISSN-L)
1552-4469
DOI: 10.1038/nchembio.250
PMC: PMC4228941
OpenAlex: W4211006098
Cited by: 287
References: 127
Citations by year: 2026: 9 · 2025: 6 · 2024: 14 · 2023: 17 · 2022: 20 · 2021: 15 · 2020: 17 · 2019: 18 · 2018: 14 · 2017: 19 · 2016: 9 · 2015: 10 · 2014: 20 · 2013: 9 · 2012: 25
FWCI: 2.27
Type: journal article
Language: en
Update notices: erratum (2009-12-01)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Chemical Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (U54CA143869, T32CA080621)
National Institute of General Medical Sciences (R01GM64003, R01GM063004, T32GM008061)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords: protein degradation, proteasome, proteasomal degradation, degron, ubiquitin ligase, protein targeting, misfolded proteins, adaptive immune response, proteolysis
MeSH terms: Valosin Containing Protein, Adenosine Triphosphatases, Adenosine Triphosphate, Bacterial Proteins, Binding Sites, Cell Physiological Phenomena, Ornithine Decarboxylase, Peptide Chain Initiation, Translational, Peptide Hydrolases, Peptides, Proteins, Protein Folding, Cell Cycle Proteins, Ubiquitin, Proteasome Endopeptidase Complex

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