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High-Resolution Profiling of Histone Methylations in the Human Genome

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The DNA Damage Response: Making It Safe to Play with Knives

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription

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Prevalence of quadruplexes in the human genome

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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Promising G-Quadruplex-Targeted Dibenzoquinoxaline Type-1 Photosensitizer Triggers DNA Damage in Triple-Negative Breast Cancer Cells

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G-quadruplexes: A possible epigenetic target for nutrition

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Proximity Ligation Assay Detection of Protein–DNA Interactions—Is There a Link between Heme Oxygenase-1 and G-quadruplexes?

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G-quadruplex in animal development: Contribution to gene expression and genomic heterogeneity

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Evolutionary dynamics of predicted G-quadruplexes in human and other great apes

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Combination of dl922-947 Oncolytic Adenovirus and G-Quadruplex Binders Uncovers Improved Antitumor Activity in Breast Cancer

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Coordinating Replication with Transcription

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Pyrazine-based G-quadruplex fluorescent probes: Transformation between aggregation-induced emission and disaggregation-induced emission via slight variations in structures

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Genome-Wide Transcriptional Response of Mycobacterium smegmatis MC2155 to G-Quadruplex Ligands BRACO-19 and TMPyP4

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Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability

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Illuminating the G-Quadruplex: A Review on Fluorescent Probes for Detecting Polymorphic G-Quartet DNA Structures

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DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells

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Small molecule chaperones facilitate the folding of RNA G-quadruplexes

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Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems

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Study of the synthesis, antiproliferative properties, and interaction with DNA and polynucleotides of cisplatin-like Pt(II) complexes containing carcinogenic polyaromatic amines

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Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins

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Anti-HIV activity of new higher order G-quadruplex aptamers obtained from tetra-end-linked oligonucleotides

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Quadruplex detection in human cells

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Selective recognition of human telomeric G-quadruplex with designed peptide via hydrogen bonding followed by base stacking interactions

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Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands

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Lesion Recognition and Cleavage of Damage-Containing Quadruplexes and Bulged Structures by DNA Glycosylases

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Guanosine and isoguanosine derivatives for supramolecular devices

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Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with an ability to induce distinct G-quadruplex topologies in telomeric DNA

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Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors

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Alternative paths to telomere elongation

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Single-Molecule Analysis of Thymine Dimer-Containing G-Quadruplexes Formed from the Human Telomere Sequence

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Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin

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Diphenylaminothiophen-derived fluorescent ligands targeting mitochondrial DNA G-quadruplexes potentially for triple-negative breast cancer therapy

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Ligand‐Mediated G‐Quadruplex Induction in a Double‐Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide

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Biased and unbiased strategies to identify biologically active small molecules

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Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal

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RNA G-quadruplex formation in defined sequence in living cells detected by bimolecular fluorescence complementation

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Influence of the SPR Experimental Conditions on the G-Quadruplex DNA Recognition by Porphyrin Derivatives

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DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy

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Designing a New Class of Bases for Nucleic Acid Quadruplexes and Quadruplex‐Active Ligands

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Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

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Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres

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A Personal History of Quadruplex–Small Molecule Targeting

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Chemical biology on the genome

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CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres

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Resolving Roadblocks to Telomere Replication

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A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells

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A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes

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Molecular engineering of a wash-free, clover-like G-quadruplex fluorescent probe that exploits a new mechanism of disaggregation-and-binding-induced emission

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Assessing Roles of Cations in G-Quadruplex-Based Nanowires by NMR

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Guanine-quadruplexes are increased in mild cognitive impairment and correlate with cognitive function and chromosomal DNA damage

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Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells

Bartosik, A. R., Hou, P., Tang, S., Vaughn, J. P., Smaldino, P. J., Ratan, A., Mayo, M. W., & Wang, Y. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf621 · Cited by 13

The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations

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α-2′-Deoxyguanosine can switch DNA G-quadruplex topologies from antiparallel to parallel

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Dual role of G-quadruplex in translocation renal cell carcinoma: Exploring plausible Cancer therapeutic innovation

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Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

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Molecular rec§ognition of telomere DNA sequence by 2, 6 anthraquinone derivatives leads to thermal stabilization and induces apoptosis in cancer cells

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Folate deficiency and DNA-methyltransferase inhibition modulate G-quadruplex frequency

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DNA G-quadruplexes: Structural and functional insights

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The 3′ terminal region of Zika virus RNA contains a conserved G-quadruplex and is unfolded by human DDX17

Gemmill, D. L., Nelson, C. R., Badmalia, M. D., Pereira, H. S., Kerr, L., Wolfinger, M. T., & Patel, T. R. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2023-0036 · Cited by 12

Analysis of Nucleotide Variations in Human G-Quadruplex Forming Regions Associated with Disease States

Neupane, A., Chariker, J. H., & Rouchka, E. C. (2023) · Genes · doi:10.3390/genes14122125 · Cited by 11

Stabilizing DNAzymes through Encapsulation in a Metal–Organic Framework

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ATR activity controls stem cell quiescence via the cyclin F–SCF complex

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Subcellular Duplex DNA and G‐Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

Domarco, O., Kieler, C., Pirker, C., Dinhof, C., Englinger, B., Reisecker, J. M., Timelthaler, G., García, M. D., Peinador, C., Keppler, B. K., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201900934 · Cited by 12

Small-Molecule-Based Self-Assembled Ligands for G-Quadruplex DNA Surface Recognition

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Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligandsPreprint

Pipier, A., Bossaert, M., Riou, J., Noirot, C., Nguyễn, L.-T., Serre, R.-F., Bouchez, O., Defrancq, É., Calsou, P., Britton, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.18.953851 · Cited by 12

Triazolyl Dibenzo[a,c]phenazines Stabilize Telomeric G‐quadruplex and Inhibit Telomerase

Pal, S., Fatma, K., Ravichandiran, V., & Dash, J. (2021) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.202100468 · Cited by 11

DHX36 maintains genomic integrity by unwinding G‐quadruplexes

Mizumoto, A., Yokoyama, Y., Miyoshi, T., Takikawa, M., Ishikawa, F., & Sadaie, M. (2023) · Genes to Cells · doi:10.1111/gtc.13061 · Cited by 11

Systematic Evaluation of Benchmark G4 Probes and G4 Clinical Drugs using three Biophysical Methods: A Guideline to Evaluate Rapidly G4‐Binding Affinity

Laigre, E., Bonnet, H., Beauvineau, C., Lavergne, T., Verga, D., Defrancq, É., Dejeu, J., & Teulade‐Fichou, M. (2024) · ChemBioChem · doi:10.1002/cbic.202400210 · Cited by 11

Expanding the Functions of KHSRP Protein: Insights into DNA G‐Quadruplex Binding

Russomanno, P., Zizza, P., Cerofolini, L., D’Aria, F., Iachettini, S., Vito, S. D., Biroccio, A., Amato, J., Fragai, M., & Pagano, B. (2025) · Advanced Science · doi:10.1002/advs.202410086 · Cited by 11

Recent Progress and Potential of G4 Ligands in Cancer Immunotherapy

Lin, J., Gong, Z., Lu, Y., Cai, J., Zhang, J., Tan, J., Huang, Z., & Chen, S. (2025) · Molecules · doi:10.3390/molecules30081805 · Cited by 12

Cationic porphyrins as destabilizer of a G-quadruplex located at the promoter of humanMYH7 βgene

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Detection of G-quadruplex structures with a minimalistic crescent-shaped carbazole-indolium ligand

Lin, J.-H., Chen, X., & Hu, M.-H. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.131498 · Cited by 11

Effects of messenger RNA structure and other translational control mechanisms on major histocompatibility complex‐I mediated antigen presentation

Murat, P., & Tellam, J. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1262 · Cited by 11

Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells

Sidibe, A., Hamon, F., Largy, E., Gómez, D., Teulade‐Fichou, M., Trentesaux, C., & Riou, J. (2012) · Biochimie · doi:10.1016/j.biochi.2012.07.003 · Cited by 12

Molecular Recognition of Human Telomeric DNA by Phenanthroline-Based G-Quadruplex Ligands

Artese, A., Parrotta, L., Alcaro, S., Ortuso, F., Costa, G., & Sissi, C. (2013) · Open Journal of Medicinal Chemistry · doi:10.4236/ojmc.2013.32006 · Cited by 11

A DNA Polymerase Stop Assay for Characterization of G-Quadruplex Formation and Identification of G-Quadruplex-Interactive Compounds

Wu, G., & Han, H. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9666-7_12 · Cited by 11

The DHX36-specific-motif (DSM) enhances specificity by accelerating recruitment of DNA G-quadruplex structures

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Pyridine-bis(benzimidazole) induces DNA damage at G-quadruplex loci and promotes synthetic lethality with DNA repair inhibition

Yan, J., Bu, L., Wang, Y., Yao, H., Li, G., Zheng, K., & Huang, J. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf543 · Cited by 10

G4-DNA formation and chromatin remodelling are interdependent in human cells

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Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA gene

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Fluorescence reporting of G-quadruplex structures and modulating their DNAzyme activity using polyethylenimine–pyrene conjugate

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Precise Cross-Dimensional Regulation of the Structure of a Photoreversible DNA Nanoswitch

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Structural modification of nonspecific thiazole orange for ligand-DNA interaction study: Understanding the ligand recognition selectivity towards G4-DNA over duplex-DNA

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Promoter G-quadruplex favours epigenetic reprogramming-induced atypical expression of ZEB1 in cancer cells

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Whole-genome mapping of small-molecule targets for cancer medicine

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Interaction analysis of anti-cancer drug Methotrexate with bcl-2 promoter stabilization and its transcription regulation

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