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Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
Open accessAbstract
Guanine-rich DNA sequences that can adopt non-Watson-Crick structures in vitro are prevalent in the human genome. Whether such structures normally exist in mammalian cells has, however, been the subject of active research for decades. Here we show that the G-quadruplex-interacting drug pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. A chromatin immunoprecipitation sequencing analysis of the DNA damage marker γH2AX provided the genome-wide distribution of pyridostatin-induced sites of damage and revealed that pyridostatin targets gene bodies containing clusters of sequences with a propensity for G-quadruplex formation. As a result, pyridostatin modulated the expression of these genes, including the proto-oncogene SRC. We observed that pyridostatin reduced SRC protein abundance and SRC-dependent cellular motility in human breast cancer cells, validating SRC as a target of this drug. Our unbiased approach to define genomic sites of action for a drug establishes a framework for discovering functional DNA-drug interactions.
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“there is strong evidence that deregulated G4-formation is a major driver of genomic instability”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [26]
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“Error-prone polymerases might be engaged at slowed or stalled replication forks to ensure complete G4 replication, as specialized polymerases like eta, kappa, and Rev1 are essential for G4 stability – further increasing the density of localized genomic damages (26,78–80).”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [26]
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Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
Self-citationThe DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
Genome-Wide Mapping of in Vivo Protein-DNA Interactions
Johnson, D. S., Mortazavi, A., Myers, R. M., & Wold, B. (2007) · Science · doi:10.1126/science.1141319 · Cited by 2,927
Siddiqui-Jain, A., Grand, C. L., Bearss, D. J., & Hurley, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182256799 · Cited by 2,274
Prevalence of quadruplexes in the human genome
Huppert, J. L., & Balasubramanian, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki609 · Cited by 1,795
Self-citationHickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220
Self-citationYeatman, T. J. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1366 · Cited by 1,113
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Quantitative visualization of DNA G-quadruplex structures in human cells
Biffi, G., Tannahill, D., McCafferty, J., & Balasubramanian, S. (2013) · Nature Chemistry · doi:10.1038/nchem.1548 · Cited by 2,173
Self-citationG-quadruplexes and their regulatory roles in biology
Rhodes, D., & Lipps, H. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv862 · Cited by 1,526
DNA secondary structures: stability and function of G-quadruplex structures
Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,485
The regulation and functions of DNA and RNA G-quadruplexes
Varshney, D., Spiegel, J., Zyner, K. G., Tannahill, D., & Balasubramanian, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0236-x · Cited by 1,292
Self-citationHigh-throughput sequencing of DNA G-quadruplex structures in the human genome
Chambers, V. S., Marsico, G., Boutell, J. M., Antonio, M. D., Smith, G. P., & Balasubramanian, S. (2015) · Nature Biotechnology · doi:10.1038/nbt.3295 · Cited by 1,261
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Aguilera, A., & García‐Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,029
G-quadruplex structures mark human regulatory chromatin
Hänsel-Hertsch, R., Beraldi, D., Lensing, S. V., Marsico, G., Zyner, K., Parry, A., Di Antonio, M., Pike, J., Kimura, H., Narita, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3662 · Cited by 964
Self-citationThe Structure and Function of DNA G-Quadruplexes
Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920
“lated protein that marks stand break sites, and is found to occur predominantly at predicted G4 regions of the cellular genome (Figure 3D) [47].”
Self-citationDNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Hänsel‐Hertsch, R., Antonio, M. D., & Balasubramanian, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.3 · Cited by 882
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Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P.-C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.032 · Cited by 700
Re-evaluation of G-quadruplex propensity with G4Hunter
Bedrat, A., Lacroix, L., & Mergny, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw006 · Cited by 693
Salinomycin kills cancer stem cells by sequestering iron in lysosomes
Mai, T. T., Hamaï, A., Hienzsch, A., Cañeque, T., Müller, S., Wicinski, J., Cabaud, O., Leroy, C., David, A., Acevedo, V., et al. (2017) · Nature Chemistry · doi:10.1038/nchem.2778 · Cited by 621
Self-citationBiffi, G., Antonio, M. D., Tannahill, D., & Balasubramanian, S. (2013) · Nature Chemistry · doi:10.1038/nchem.1805 · Cited by 615
Self-citationCX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Xu, H., Antonio, M. D., McKinney, S. E., Mathew, V., Ho, B., O’Neil, N. J., Santos, N. D., Silvester, J., Wei, V., Garcia, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14432 · Cited by 574
Self-citationQuadruplex Nucleic Acids as Novel Therapeutic Targets
Neidle, S. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01835 · Cited by 587
A Genetic Map of the Response to DNA Damage in Human Cells
Olivieri, M., Cho, T., Álvarez-Quilón, A., Li, K., Schellenberg, M. J., Zimmermann, M., Hustedt, N., Rossi, S. E., Adam, S., Melo, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.040 · Cited by 551
G-quadruplexes: a promising target for cancer therapy
Kosiol, N., Juranek, S., Brossart, P., Heine, A., & Paeschke, K. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01328-4 · Cited by 561
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 520
Maizels, N., & Graybuck, L. T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003468 · Cited by 510
Mendoza, Ó., Bourdoncle, A., Boulé, J.-B., Brosh, R. M., & Mergny, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw079 · Cited by 452
Quadruplex nucleic acids as targets for anticancer therapeutics
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G-quadruplex structures are stable and detectable in human genomic DNA
Lam, E. Y. N., Beraldi, D., Tannahill, D., & Balasubramanian, S. (2013) · Nature Communications · doi:10.1038/ncomms2792 · Cited by 462
Self-citationWhole genome experimental maps of DNA G-quadruplexes in multiple species
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Larrieu, D., Britton, S., Demir, M., Rodriguez, R., & Jackson, S. P. (2014) · Science · doi:10.1126/science.1252651 · Cited by 431
Self-citationTranscription–replication conflicts: how they occur and how they are resolved
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G-Quadruplexes: Prediction, Characterization, and Biological Application
Kwok, C. K., & Merrick, C. J. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.06.012 · Cited by 393
i-Motif DNA: Structure, stability and targeting with ligands
Day, H. A., Pavlou, P., & Waller, Z. A. E. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.05.047 · Cited by 384
Single-molecule visualization of DNA G-quadruplex formation in live cells
Antonio, M. D., Ponjavic, A., Radzevičius, A., Ranasinghe, R. T., Catalano, M., Zhang, X., Shen, J., Needham, L.-M., Lee, S. F., Klenerman, D., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-0506-4 · Cited by 374
Self-citationDNA helicases involved in DNA repair and their roles in cancer
Brosh, R. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3560 · Cited by 361
Existence and consequences of G-quadruplex structures in DNA
Murat, P., & Balasubramanian, S. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.10.012 · Cited by 346
Self-citationHänsel‐Hertsch, R., Spiegel, J., Marsico, G., Tannahill, D., & Balasubramanian, S. (2018) · Nature Protocols · doi:10.1038/nprot.2017.150 · Cited by 334
Self-citationDe Magis, A., Manzo, S. G., Russo, M., Marinello, J., Morigi, R., Sordet, O., & Capranico, G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810409116 · Cited by 332
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Maizels, N. (2015) · EMBO Reports · doi:10.15252/embr.201540607 · Cited by 312
Clynes, D., Jelinska, C., Xella, B., Ayyub, H., Scott, C., Mitson, M., Taylor, S., Higgs, D. R., & Gibbons, R. J. (2015) · Nature Communications · doi:10.1038/ncomms8538 · Cited by 303
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Murat, P., Zhong, J., Lekieffre, L., Cowieson, N. P., Clancy, J. L., Preiß, T., Balasubramanian, S., Khanna, R., & Tellam, J. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1479 · Cited by 281
Self-citationLago, S., Nadai, M., Cernilogar, F. M., Kazerani, M., Domíniguez Moreno, H., Schotta, G., & Richter, S. N. (2021) · Nature Communications · doi:10.1038/s41467-021-24198-2 · Cited by 269
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
Zimmer, J., Tacconi, E. M. C., Folio, C., Badie, S., Porru, M., Klare, K., Tumiati, M., Markkanen, E., Halder, S., Ryan, A., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.004 · Cited by 261
“G4 structures have been subsequently detected with several other structure-specific antibodies (Biffi et al., 2013; Henderson et al., 2014; Schaffitzel et al., 2001) and interacting small molecules (Lam et al., 2013; Müller et al., 2010; Rodriguez et al., 2012).”
InfluentialSelf-citationG-quadruplexes in viruses: function and potential therapeutic applications
Métifiot, M., Amrane, S., Litvak, S., & Andréola, M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku999 · Cited by 259
Visualization of RNA-Quadruplexes in Live Cells
Laguerre, A., Hukezalie, K. R., Winckler, P., Katranji, F., Chanteloup, G., Pirrotta, M., Perrier‐Cornet, J., Wong, J. M. Y., & Monchaud, D. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b03413 · Cited by 249
Fluorescent Probes for G‐Quadruplex Structures
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Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Gendre, P. L., Warmerdam, E., de Jager, M. H., Groothuis, G. M. M., et al. (2014) · Inorganic Chemistry · doi:10.1021/ic403011h · Cited by 245
Shivalingam, A., Izquierdo, M. A., Marois, A. L., Vyšniauskas, A., Suhling, K., Kuimova, M. K., & Vilar, R. (2015) · Nature Communications · doi:10.1038/ncomms9178 · Cited by 234
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Valton, A.-L., Hassan‐Zadeh, V., Lema, I., Boggetto, N., Alberti, P., Saintomé, C., Riou, J., & Prioleau, M. (2014) · The EMBO Journal · doi:10.1002/embj.201387506 · Cited by 226
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Lyu, J., Shao, R., Yung, P. Y. K., & Elsässer, S. J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1073 · Cited by 220
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Micco, M., Collie, G. W., Dale, A. G., Ohnmacht, S. A., Pazitna, I., Gunaratnam, M., Reszka, A. P., & Neidle, S. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301899y · Cited by 189
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Xu, S., Li, Q., Xiang, J., Yang, Q., Sun, H., Guan, A., Wang, L., Liu, Y., Yu, L., Shi, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep24793 · Cited by 183
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Self-citationAgarwala, P., Pandey, S., & Maiti, S. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob02681k · Cited by 175
Marchetti, C., Zyner, K. G., Ohnmacht, S. A., Robson, M. P., Haider, S. M., Morton, J. P., Marsico, G., Vo, T. D., Laughlin, S., Ahmed, A. A., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01781 · Cited by 168
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Self-citationZhang, S., Sun, H., Wang, L., Liu, Y., Chen, H., Li, Q., Guan, A., Liu, M., & Tang, Y. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky665 · Cited by 158
RetractedAmrane, S., Kerkour, A., Bedrat, A., Vialet, B., Andréola, M., & Mergny, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja501500c · Cited by 157
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Metadata
- Authors
- Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Balasubramanian, Shankar
- Jackson, Stephen P
- ORCID
- Venue
- Nature Chemical Biology
- Published
- 2012-02-05
- Volume
- 8
- Issue
- 3
- Pages
- 301-310
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- PMC
- PMC3433707
- OpenAlex
- W2042374693
- Cited by
- 741
- References
- 50
- Citations by year
- 2026: 35 · 2025: 55 · 2024: 66 · 2023: 53 · 2022: 41 · 2021: 60 · 2020: 58 · 2019: 56 · 2018: 52 · 2017: 52 · 2016: 39 · 2015: 54 · 2014: 49 · 2013: 44 · 2012: 27
- FWCI
- 22.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Wellcome Trust (092096/Z/10/Z, 086861/Z/08/Z, 086861, 092096)
- Cancer Research UK (11961, C6/A11224, 11224, A11224, C9681/A11961)
- Biotechnology and Biological Sciences Research Council (BB/G008337/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- pyridostatin, G-quadruplex, alternative DNA structures, DNA damage, γH2AX, cell cycle arrest, breast cancer, guanine-rich DNA, gene expression regulation, drug-DNA interaction, ChIP-seq
- MeSH terms
- Proto-Oncogene Mas, Aminoquinolines, Antineoplastic Agents, Breast Neoplasms, Cell Cycle, DNA, DNA Damage, Drug Screening Assays, Antitumor, Humans, Molecular Weight, Picolinic Acids, Structure-Activity Relationship, Tumor Cells, Cultured, Cell Proliferation, G-Quadruplexes
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