Cited by 747DNA and Nucleic Acid ChemistryMetal complexes synthesis and propertiesEpigenetics and DNA Methylation

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

Open access

Rodriguez, Raphaël, Miller, Kyle M, Forment, Josep V, Bradshaw, Charles R, Nikan, Mehran, Britton, Sébastien, Oelschlaegel, Tobias, Xhemalce, Blerta, Balasubramanian, Shankar, Jackson, Stephen P·2012·Nature Chemical Biology

DOI 10.1038/nchembio.780PMC PMC3433707

Open this paper in CoChat — free account

Abstract

Guanine-rich DNA sequences that can adopt non-Watson-Crick structures in vitro are prevalent in the human genome. Whether such structures normally exist in mammalian cells has, however, been the subject of active research for decades. Here we show that the G-quadruplex-interacting drug pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. A chromatin immunoprecipitation sequencing analysis of the DNA damage marker γH2AX provided the genome-wide distribution of pyridostatin-induced sites of damage and revealed that pyridostatin targets gene bodies containing clusters of sequences with a propensity for G-quadruplex formation. As a result, pyridostatin modulated the expression of these genes, including the proto-oncogene SRC. We observed that pyridostatin reduced SRC protein abundance and SRC-dependent cellular motility in human breast cancer cells, validating SRC as a target of this drug. Our unbiased approach to define genomic sites of action for a drug establishes a framework for discovering functional DNA-drug interactions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nchembio.780

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
Self-citation
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
Genome-Wide Mapping of in Vivo Protein-DNA Interactions
Johnson, D. S., Mortazavi, A., Myers, R. M., & Wold, B. (2007) · Science · doi:10.1126/science.1141319 · Cited by 2,927
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription
Siddiqui-Jain, A., Grand, C. L., Bearss, D. J., & Hurley, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182256799 · Cited by 2,274
Prevalence of quadruplexes in the human genome
Huppert, J. L., & Balasubramanian, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki609 · Cited by 1,795
Self-citation
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220
Self-citation
A renaissance for SRC
Yeatman, T. J. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1366 · Cited by 1,113

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 601–700 of 747

Metal–stabilized G–quadruplexes: biological insights and sensing applications
Kim, S.-M., Kim, D., & Kim, Y. (2025) · BMB Reports · doi:10.5483/bmbrep.2025-0048 · Cited by 2
The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes
Harrod, A., Feng, H., Ghaddar, N., Schiavoni, F., Lane, K. A., Wu, L., Zuazua‐Villar, P., Kozik, Z., Dobbs, F. M., van Eijk, P., et al. (2026) · Genome biology · doi:10.1186/s13059-026-04080-4 · Cited by 2
Discovery of “folded DNA” structures in human cells: Potential drug targets
Raffa, R. B., Pergolizzi, J. V., Taylor, R., & Ossipov, M. H. (2018) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12758 · Cited by 2
A Novel G-Quadruplex Structure within Apolipoprotein E Promoter: A New Promising Target in Cancer and Dementia Fight?
Pirota, V., Stritto, A. D., Magnaghi, L. R., Biesuz, R., Doria, F., Mella, M., Freccero, M., & Crespan, E. (2024) · ACS Omega · doi:10.1021/acsomega.4c06430 · Cited by 2
The histone deacetylase inhibitor Scriptaid targets G-quadruplexes
Sánchez-Martín, V., Ružić, D., Tello-Lopez, M. J., Ortiz-Morales, A., Murciano‐Calles, J., Soriano, M., Nikolic, K. M., & Garcia-Salcedo, J. A. (2025) · Open Biology · doi:10.1098/rsob.240183 · Cited by 2
Core-Extended Naphthalene Diimide Dyads as Light-Up Probes with Targeted Cytotoxicity Toward Tumor Cells
Pirota, V., Salvati, E., Risoldi, C., Manoli, F., Rizzo, A., Zizza, P., Biroccio, A., Freccero, M., Manet, I. G. J., & Doria, F. (2025) · Biomolecules · doi:10.3390/biom15020311 · Cited by 2
Attenuation of c-Myc expression in breast cancer by hesperidin-mediated stabilization of its promoter proximal G quadruplex region
Choudhury, S. D., Ghosh, S., Kumar, P., Bhardwaj, A., Singh, K., Singh, A., Kumar, A., Basu, B., Giri, R., & Choudhury, D. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143000 · Cited by 2
Antitumor platinum(II) complex 56MESS binds to DNA G-quadruplexes, downregulates expression of c-MYC and k-RAS oncogenes, and triggers DNA damage in cancer cells
Malina, J., Kostrhunová, H., Aldrich-Wright, J. R., & Brabec, V. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111534 · Cited by 2
In-depth analysis of the mode of action of resveratrol: genome-wide characterization of G-quadruplex binding properties
Soriano‐Lerma, A., Sánchez-Martín, V., Murciano‐Calles, J., Ortiz-González, M., Tello-Lopez, M. J., Pérez‐Carrasco, V., Linde-Rodríguez, Á., Ramírez-Macías, I., Gómez‐Pinto, I., López‐Aliaga, I., et al. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00747-1 · Cited by 2
G-quadruplex : acteurs majeurs de la duplication du génome humain
Poulet-Benedetti, J., Valton, A.-L., & Prioleau, M. (2017) · médecine/sciences · doi:10.1051/medsci/20173312013 · Cited by 2
Reprogramming the chemical reactivity of iron in cancer stem cells
Cañeque, T., Müller, S., Lafon, A., Sindikubwabo, F., Versini, A., Saier, L., Barutaut, M., Gaillet, C., & Rodriguez, R. (2018) · Comptes Rendus Chimie · doi:10.1016/j.crci.2018.03.012 · Cited by 2
Self-citation
Integration of DNA Repair, Antigenic Variation, Cytoadhesion, and Chance in Babesia Survival: A Perspective
Allred, D. R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.869696 · Cited by 2
Fluorescent‐Ligand‐Mediated Screening of G‐Quadruplex Structures Using a DNA Microarray
Iida, K., Nakamura, T., Yoshida, W., Tera, M., Nakabayashi, K., Hata, K., Ikebukuro, K., & Nagasawa, K. (2013) · Angewandte Chemie · doi:10.1002/ange.201305366 · Cited by 2
Platinum(II)‐Based Optical Probes for Imaging Quadruplex DNA Structures via Phosphorescence Lifetime Imaging Microscopy
Berrones‐Reyes, J. C., Sherin, P. S., Sarkar, A., Kuimova, M. K., & Vilar, R. (2023) · Angewandte Chemie · doi:10.1002/ange.202310402 · Cited by 2
EGFR suppression contributes to growth inhibitory activity of G-quadruplex ligands in non-small cell lung cancers
Lu, K., Wang, H.-C., Tu, Y.-C., Lou, P., Chang, T., & Lin, J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115788 · Cited by 2
Ligand-Mediated G-Quadruplex Induction in a Double-Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide
Asamitsu, S. (2020) · Springer theses · doi:10.1007/978-981-15-7716-1_3 · Cited by 2
Analysis of live cell data with G-DNABERT supports a role for G-quadruplexes in chromatin loopingPreprint
Konovalov, D., Umerenkov, D., Herbert, A. G., & Poptsova, M. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.21.599985 · Cited by 2
DDX41 dissolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell deathPreprint
Bi, H., Ren, K., Wang, P., Li, E., Han, X., Wang, W., Yang, J., Aydemir, I., Tao, K., Godley, L. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.14.617891 · Cited by 2
High-throughput combination screening of Pidnarulex and other G-quadruplex ligands in multi-cell type tumor spheroids
Dexheimer, T. S., Coussens, N. P., Silvers, T. E., Juneja, P., Jones, E., Gore, S. D., Kunkel, M. W., Doroshow, J. H., & Teicher, B. A. (2025) · SLAS DISCOVERY · doi:10.1016/j.slasd.2025.100284 · Cited by 1
Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways
Wang, Q., Li, H., Zheng, Q., Yang, J., Hou, K., Jiang, L., Jia, S., Wu, X., Dan, J., & Luo, Y. (2025) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaf053 · Cited by 1
G-quadruplex structures are key regulators of mammalian spermatogenesis
Li, S., Ma, Y., Shi, H., Wang, R. T., Li, C., Zhang, T., Zhu, C., Gu, Y., Song, Z., Guo, H., et al. (2026) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00839-y · Cited by 1
Red-light-activated and thermally-stable amido-dithienylethenes for the reversible control of G-quadruplex binding and anticancer activity
Allen, N. M., Bezzant, S., Oliveira, A. S. F., Ramos‐Soriano, J., & Galán, M. C. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109710 · Cited by 1
DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC
Psalmon, G., Pipier, A., Barbotte, M., Hudson, R. H. E., Neidle, S., & Monchaud, D. (2026) · Genome biology · doi:10.1186/s13059-026-04035-9 · Cited by 1
Structural insights into the binding of CX-5461 and MTR-106 to G-quadruplex DNA
Li, Y., Liu, K., Hu, X. X., Deng, J., Lan, W., Xue, H., Tang, W., & Cao, C. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag667 · Cited by 1
Mechanistic and structural elucidation of π–π end-stacking interactions of a novel SO 2 NH-anthraquinone derivative with telomeric G-quadruplex d-[TTAGGGT] 4 : integrated NMR, spectroscopic, electrochemical, and computational evidence
Sharma, R., Kundu, R., Sharma, A., Vatsal, M., & Awasthi, P. (2026) · RSC Advances · doi:10.1039/d6ra02891h · Cited by 1
The G-force in the genome: Unknowns on the functional flairs of DNA G-quadruplexes
Gallina, I., & Richter, S. N. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003874 · Cited by 1
Discovery of a novel mitochondrial G-quadruplex-targeted fluorogenic probe for real-time imaging of mtDNA dynamics and in vivo tumor visualization
Yan, W., Li, N., Fan, W., Yuan, Y., Yuan, H., Fan, Y., Zhang, M., Chao, N., He, J., Gao, J.-M., et al. (2026) · Dyes and Pigments · doi:10.1016/j.dyepig.2026.114064 · Cited by 1
MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy
Guo, Y., Shi, Y.-H., Huang, P., Tang, G.-X., Xu, S., Li, M., Yuan, J.-H., Chen, X., Huang, Z., Yan, Y.-Y., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.4238416 · Cited by 1
AIE molecular probes for biomedical applications
Wong, A. Y. H., Wang, F., Kam, C., & Chen, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824335-0.00011-8 · Cited by 1
Imaging Study of Small Molecules to G-Quadruplexes in Cells
Tseng, T., & Chang, T. (2022) · Springer eBooks · doi:10.1007/978-981-16-1313-5_32-1 · Cited by 1
Distinctive aspects of ligand binding to G4 DNA structure flanked by the double helix
Tevonyan, L. L., Fatkullin, T. M., Beniaminov, A. D., & Kaluzhny, D. N. (2024) · Biochimie · doi:10.1016/j.biochi.2024.12.005 · Cited by 1
Modular Construction of Dynamic Nucleodendrimers
Abet, V., Evans, R., Guibbal, F., Caldarelli, S., & Rodriguez, R. (2014) · Angewandte Chemie · doi:10.1002/ange.201402400 · Cited by 1
Self-citation
Non-standard and higher-order DNA structures: DNA–DNA recognition
Neidle, S., & Sanderson, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819677-9.00003-2 · Cited by 1
Targeting cellular DNA with Luminescent Ruthenium( II ) Polypyridyl Complexes
Gill, M. R., & Thomas, J. A. (2017) · doi:10.1002/9783527695225.ch11 · Cited by 1
The Role of BAZ2-dependent Chromatin Remodeling in Suppressing G4 DNA Structures and Associated Genomic InstabilityPreprint
Vandeuren, A. L., O’Dare, K., Wilson, R. H. C., van Eijk, P., Julio, L. R., MacLeod, S. G., Chee, E., Salpukas, A., Kriz, E. M., Lantz, G. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.10.627505 · Cited by 1
Transcriptome-wide mapping reveals a non-canonical RNA-dependent mechanism of platinum cancer drugsPreprint
Krishnaraj, A., Wei, X., Thakral, R., Guo, W., Subramaniyan, S. B., Zhang, X., Alley, K. R., Feng, A., Hoy, A., Kung, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.20.694502 · Cited by 1
Selective Disruption of Plasmodium falciparum mitochondrial DNA via G-Quadruplex-Binding Ligand RHPS4 Provides a Novel Antimalarial StrategyPreprint
Salim, M., Paloque, L., Reyser, T., Nardella, F., Augereau, J., Luo, Y., Britton, S., Mergny, J., Gervais, V., Benoit‐Vical, F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.07.698092 · Cited by 1
Self-citation
Characterization of G-Quadruplex DNA- and RNA-Binding Protein
Oyoshi, T. (2015) · Springer eBooks · doi:10.1007/978-4-431-55576-6_4
Biophysical and computational investigations into G-quadruplex structural polymorphism and interaction with small molecules.
Le, H. T. (2014) · doi:10.18297/etd/799
Four-strand DNA structure found in cells
Abbott, A. (2013) · Nature · doi:10.1038/nature.2013.12253
Molecular recognition in G-quadruplexes : from G-tetrad formation to protein binding
Cheong, V. V. (2014) · doi:10.32657/10356/65412
Quantitative Demonstration of DNA Quadruplex in Human Cells - A Step Forward to Cancer Biology
Chatterjee, S., Kar, R. G., & Quantitative, C. S. (2013) · Journal of Pioneering Medical Science
Development of metal complexes and affinity tags that interact selectively with G-quadruplex nucleic acids
Stafford, V. S. (2014) · doi:10.25560/42996
Effect of oxidative stress on human telomeric DNA structural dynamics and accessibility
Kim, G. (2015) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Overview of Next-Generation Sequencing Technologies and Its Application in Chemical Biology
Chandran, A. (2017) · Springer theses · doi:10.1007/978-981-10-6547-7_1
Helicases and Their Relevance to Aging
Crouch, J. D., Banerjee, T., Awate, S., Bharti, S. K., & Brosh, R. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00072-5
Fluorescence of carbazole derivatives for screening of human cancer
Tseng, T., Chen, W., Chu, I.-T., Wang, C., Chang, C., Lin, M., Lou, P., & Chang, T. (2019) · Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology · doi:10.1117/12.2509410
Study of G-quadruplex formation in the promoter region of zinc transporter hZIP1
Bodek, D. F. (2016) · Spiral (Imperial College London) · doi:10.25560/52782
DNA G-quadruplexes under the spotlight
Sleiman, M. H., & Ladame, S. (2015) · doi:10.4155/fseb12013.13.128
Existence of G-quadruplexes in cells
Britton, S., Bartoli, A., & Rodriguez, R. (2015) · doi:10.4155/fseb12013.13.110
Self-citation
How has the field of quadruplex ligands fared since 1997?
Qu, X., Chang, T., Suntharalingam, K., & Monchaud, D. (2015) · doi:10.4155/fseb12013.14.205
Biological mechanisms of action of G-quadruplex targeting agents
Hukezalie, K. R., Okaz, E., & Wong, J. M. Y. (2015) · doi:10.4155/fseb12013.14.174
Novel molecules targeting DNA G-quadruplexes: carbazole derivatives
Chang, T., Wang, Z., Tseng, T., & Chang, C. (2015) · doi:10.4155/fseb12013.13.96
Introduction
Asamitsu, S. (2020) · Springer theses · doi:10.1007/978-981-15-7716-1_1
Faculty Opinions recommendation of ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures.
Chan, N., & Chi, P. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735795446.793561884
Faculty Opinions recommendation of DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells.
Mergny, J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734702236.793565038
Faculty Opinions recommendation of Genetic interactions of G-quadruplexes in humans.
Mergny, J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736170098.793568156
Faculty Opinions recommendation of Quantitative visualization of DNA G-quadruplex structures in human cells.
Hocek, M. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717972977.793476134
Faculty Opinions recommendation of A guide to computational methods for G-quadruplex prediction.
Chaires, J. B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736969533.793568165
Faculty Opinions recommendation of A genetic map of the response to DNA damage in human cells.
Trinkle‐Mulcahy, L. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738284022.793578688
Chemie
(2012) · Nachrichten aus der Chemie · doi:10.1002/nadc.201290141
Engineering constrained peptides to target nucleic acids: G-quadruplex recognition and imaging
Yavorova, Y. M. (2021) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/157352
G-quadruplexes as key motifs in transcriptomics
Sánchez-Martín, V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91810-7.00003-0
WRNIP1 PREVENTS G4/R-LOOP-ASSOCIATED GENOMIC INSTABILITYPreprint
Valenzisi, P., Marabitti, V., Petrai, S., Giardinelli, F. R., Pichierri, P., & Franchitto, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.17.520882
Targeting DNA Junctions with Small Molecules for Therapeutic Applications in Oncology
Zell, J., & Monchaud, D. (2022) · Springer eBooks · doi:10.1007/978-981-16-1313-5_37-1
The CGG triplet repeat binding protein 1 counteracts DNA secondary structure-induced transcription-replication conflictsPreprint
Ummethum, H., Lalonde, M., Werner, M., Trauner, M., Chanou, A., Weiβ, M., Lee, C. S. K., Kruse, E., Ettinger, A. W., & Hamperl, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.09.531843
Small molecule chaperones facilitate the folding of long non-coding RNA GPreprint
Lejault, P., Prudent, L., Terrier, M.-P., & Perreault, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.04.535601
The VEGF G-quadruplex forming promoter is repaired via long-patch BERPreprint
Hussen, A. S., Kravitz, H. L., Freudenthal, B., & Whitaker, A. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.25.546439
Targeting DNA Junctions with Small Molecules for Therapeutic Applications in Oncology
Zell, J., & Monchaud, D. (2023) · Springer eBooks · doi:10.1007/978-981-19-9776-1_37
Imaging Study of Small Molecules to G-Quadruplexes in Cells
Tseng, T., & Chang, T. (2023) · Springer eBooks · doi:10.1007/978-981-19-9776-1_32
Exploring the Mechanisms of Telomerase Regulation in Saccharomyces cerevisiae
Fekete-Szücs, E. (2023) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.777966042
Aurka inhibition-based combination therapy approaches in glioblastoma.
Sak, M. (2023) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/4149
Clustering and analysis of g quadruplex sequences.
Neupane, A. (2023) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/4058
A rise in double-strand breaks sensitizes tumours to oxidative metabolism inhibitorsPreprint
Medina‐Jover, F., Figueras, A., Lahiguera, Á., Guillén, P., Espín, R., Pardo, M. Á., Pujana, M. Á., Berra, E., Villanueva, A., Bernat‐Peguera, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.19.572355
G‐quadruplexes
Lombardi, E. P. (2023) · Wiley eBooks · doi:10.1002/9781394264902.ch6
Potential protein kinase inhibitors that target G-quadruplex DNA structures in the human telomeric regions
Banjan, B., Koshy, A. J., Kalath, H., John, L., Soman, S., Raju, R., & Revikumar, A. (2024) · Molecular Diversity · doi:10.1007/s11030-023-10768-7
Dealing with Replication Stress at Telomeres
Coulon, S. (2024) · Wiley eBooks · doi:10.1002/9781394300808.ch6
Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum
Datta, N. (2024) · Canadian Journal for the Academic Mind · doi:10.25071/2817-5344/74
Resveratrol targets G-quadruplexes to exert its pharmacological effectsPreprint
Soriano‐Lerma, A., Sánchez-Martín, V., Murciano‐Calles, J., Ortiz-González, M., Tello-Lopez, M. J., Pérez‐Carrasco, V., Linde-Rodríguez, Á., Ramírez-Macías, I., Gómez‐Pinto, I., López‐Aliaga, I., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.29.605564
Cryo-EM structures of G4-stalled CMG reveal inchworm mechanism of DNA translocationPreprint
Batra, S., Allwein, B., Kumar, C., Devbhandari, S., Brüning, J.-G., Bahng, S., Lee, C., Marians, K. J., Hite, R. K., & Remus, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.02.616340
Click and combinatorial approaches to quadruplex ligand discovery
Dash, J., Saha, P., & Fatma, K. (2024) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2024.09.009
Roadmap for click and combinatorial approaches to quadruplex ligand discovery: 2024
Dash, J., Saha, U., & Basu, S. (2024) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2024.09.004
Characterization of pyridostatin and its interactions with c-MYC g-quadruplexes
Cuny, Z. G. (2017) · doi:10.54718/tjks9481 · Cited by 1
Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency
Zhang, T., Lin, L., Li, J., Li, C., Liang, S., Bai, X., Wang, F., Bao, Y., Guo, D., Bo, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202410603
Rescue from pyridostatin-stabilized telomeric G-quadruplexes by DNA cleavage and microhomology-mediated end joiningPreprint
Matmati, S., Rao, S., & Lingner, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.25.690390
Nature‐Inspired MYC Inhibitor Disrupts MYC‐Driven Glycolysis and Restricts Ovarian Tumor Growth
Singh, M., Yadav, A., Singh, U., Gupta, R., Cavarzerani, E., Canzonieri, V., Negi, D., Dagar, A., Sathyamoorthy, B., Rizzolio, F., et al. (2025) · ChemMedChem · doi:10.1002/cmdc.202500554
Additional file 6 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664490
Additional file 3 of G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes
Li, C., Yin, Z., Xiao, R., Huang, B., Cui, Y., Wang, H., Xiang, Y., Wang, L., Lei, L., Ye, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22605011
Additional file 11 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664514
Additional file 9 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664508
Additional file 2 of G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes
Li, C., Yin, Z., Xiao, R., Huang, B., Cui, Y., Wang, H., Xiang, Y., Wang, L., Lei, L., Ye, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22605008
Additional file 7 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664496
Additional file 4 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664481
Additional file 1 of G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes
Li, C., Yin, Z., Xiao, R., Huang, B., Cui, Y., Wang, H., Xiang, Y., Wang, L., Lei, L., Ye, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22605005
Additional file 8 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664502
Additional file 1 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664466
Additional file 10 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664511
Additional file 5 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664484
Additional file 12 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664517
Additional file 3 of TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Magis, A. D., Schult, P., Schönleber, A., Linke, R., Ludwig, K. U., Kümmerer, B. M., & Paeschke, K. (2024) · Figshare · doi:10.6084/m9.figshare.26664475

Authors: Rodriguez, R., Miller, K. M., Forment, J. V., Bradshaw, C. R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S., & Jackson, S. P.
Affiliations: University of Cambridge (GB)
Corresponding author: Balasubramanian, Shankar
Jackson, Stephen P
ORCID: Rodriguez, Raphaël
Miller, Kyle M
Forment, Josep V
Bradshaw, Charles R
Nikan, Mehran
Britton, Sébastien
Balasubramanian, Shankar
Venue: Nature Chemical Biology
Publisher: Springer Science and Business Media LLC
Published: 2012-02-05
Volume: 8
Issue: 3
Pages: 301-310
ISSN: 1552-4450 (ISSN-L)
1552-4469
DOI: 10.1038/nchembio.780
PMC: PMC3433707
OpenAlex: W2042374693
Cited by: 741
References: 50
Citations by year: 2026: 35 · 2025: 55 · 2024: 66 · 2023: 53 · 2022: 41 · 2021: 60 · 2020: 58 · 2019: 56 · 2018: 52 · 2017: 52 · 2016: 39 · 2015: 54 · 2014: 49 · 2013: 44 · 2012: 27
FWCI: 22.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Chemical Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Apollo (University of Cambridge) (submittedVersion)
Apollo
Funders: Wellcome Trust (092096/Z/10/Z, 086861/Z/08/Z, 086861, 092096)
Cancer Research UK (11961, C6/A11224, 11224, A11224, C9681/A11961)
Biotechnology and Biological Sciences Research Council (BB/G008337/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: pyridostatin, G-quadruplex, alternative DNA structures, DNA damage, γH2AX, cell cycle arrest, breast cancer, guanine-rich DNA, gene expression regulation, drug-DNA interaction, ChIP-seq
MeSH terms: Proto-Oncogene Mas, Aminoquinolines, Antineoplastic Agents, Breast Neoplasms, Cell Cycle, DNA, DNA Damage, Drug Screening Assays, Antitumor, Humans, Molecular Weight, Picolinic Acids, Structure-Activity Relationship, Tumor Cells, Cultured, Cell Proliferation, G-Quadruplexes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks