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Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer
Open accessAbstract
Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for microRNA binding to protein-coding transcripts. However, the prevalence, functional significance and targets of lncRNA-mediated sponge regulation of cancer are mostly unknown. Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. We confirm the tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. Surprisingly, one of the two lncRNAs, TUG1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcriptional regulation, suggesting its sub-cellular localization-dependent function. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA.
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Self-citation
Metadata
- Authors
- Du, Z., Sun, T., Hacisuleyman, E., Fei, T., Wang, X., Brown, M., Rinn, J. L., Lee, M. G.-S., Chen, Y., Kantoff, P. W., & Liu, X. S.
- Venue
- Nature Communications
- Published
- 2016-03-15
- Volume
- 7
- Issue
- 1
- Pages
- 10982-10982
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2296934997
- Cited by
- 317
- References
- 43
- FWCI
- 18.20
- Type
- journal article
- Language
- en
- Open access
- gold
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