Cited by 1,878Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysNuclear Receptors and Signaling

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Open access

Kobayashi, Eri H., Suzuki, Takafumi, Funayama, Ryo, Nagashima, Takeshi, Hayashi, Makiko, Sekine, Hiroki, Tanaka, Nobuyuki, Moriguchi, Takashi, Motohashi, Hozumi, Nakayama, Keiko, Yamamoto, Masayuki·2016·Nature Communications

DOI 10.1038/ncomms11624PMC PMC4879264

Open this paper in CoChat — free account Open PDF

Abstract

Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear. Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment. Further, we found that Nrf2-mediated inhibition is independent of the Nrf2-binding motif and reactive oxygen species level. Murine inflammatory models further demonstrated that Nrf2 interferes with IL6 induction and inflammatory phenotypes in vivo . Thus, contrary to the widely accepted view that Nrf2 suppresses inflammation through redox control, we demonstrate here that Nrf2 opposes transcriptional upregulation of proinflammatory cytokine genes. This study identifies Nrf2 as the upstream regulator of cytokine production and establishes a molecular basis for an Nrf2-mediated anti-inflammation approach.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ncomms11624

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · cited 1×
“The binding of Pol II was upregulated in LPS-treated cells at the TSS of IL6 (2), the gene body of IL6 (3) and the TSS of the IL1b gene (5), similar to the TSS of the Nqo1 gene in LPSþDEM-treated cells used as a positive control (Nqo1 TSS).”
Background
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Self-citation
Targeting the KEAP1-NRF2 system to prevent kidney disease progression
Nezu, M., Suzuki, N., & Yamamoto, M. (2017) · American Journal of Nephrology · doi:10.1159/000475890 · Cited by 3,447
Self-citation
Data, information, knowledge and principle: back to metabolism in KEGG
Kanehisa, M. I., Goto, S., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1076 · Cited by 3,103
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284

Flagged first, then by citations

Show all 58 references

Sorted by citations

Items 501–600 of 1,002

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion
Sigfridsson, E., Marangoni, M., Johnson, J. A., Hardingham, G. E., Fowler, J. H., & Horsburgh, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-30675-4 · Cited by 41
Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy
Jiang, Z., Bo, L., Meng, Y., Wang, C., Chen, T., Wang, C., Yu, X., & Deng, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0838-9 · Cited by 41
p-Hydroxybenzyl Alcohol Prevents Memory Deficits by Increasing Neurotrophic Factors and Decreasing Inflammatory Factors in a Mice Model of Alzheimer’s Disease
Ding, Y., Bao, X., Lao, L., Ling, Y., Wang, Q., & Xu, S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180910 · Cited by 41
17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts
Song, C., Kim, N., Kim, D.-H., Lee, H.-N., & Surh, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221650 · Cited by 41
Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.
Song, J., Meng, Y.-M., Wang, M., Li, L.-Z., Liu, Z., Zheng, K., Wu, L.-F., Liu, B.-L., Hou, F.-J., & Li, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104845 · Cited by 38
A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions
Lu, M., Zhang, X., Zhao, J., You, Q., & Jiang, Z. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101565 · Cited by 41
“We first examined the mRNA levels of IL-1β and IL-6, which can be transcriptionally repressed by Nrf2 [66].”
Background
Cymbopogon citratus (DC.) Stapf mitigates ER-stress induced by streptozotocin in rats via down-regulation of GRP78 and up-regulation of Nrf2 signaling
Elekofehinti, O. O., Onunkun, A. T., & Olaleye, T. M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113130 · Cited by 41
MicroRNA mediated regulation of the major redox homeostasis switch, Nrf2, and its impact on oxidative stress-induced ischemic/reperfusion injury
Padmavathi, G., & Ramkumar, K. M. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108725 · Cited by 40
Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses
Wang, Y., Zhang, X., Meng, F.-G., & Zeng, T. (2021) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2021.1894624 · Cited by 40
“One of the most important findings in this field is that nuclear factor erythroid 2-related factor 2 (Nrf2) can modulate the polarization of macrophages (Kobayashi et al. 2016; Wei et al. 2018).”
Background
Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response
Ying, Y.-T., Yang, J., Tan, X., Liu, R., Zhuang, Y., Xu, J.-X., & Ren, W. (2021) · Cells · doi:10.3390/cells10123426 · Cited by 40
“Taken together, contrary to the widely accepted view that Nrf2 has an antiinflammatory effect [37], our findings suggest that Nrf2 induction is required for pbMECs to mount an efficient inflammatory response.”
BackgroundResultInfluential
Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment
Feng, J., Read, O. J., & Dinkova‐Kostova, A. T. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.2183 · Cited by 42
“Cells 2023; 46(3): 142-152 145 II, in a ROS- and antioxidant/electrophile response element (ARE)-independent manner (Kobayashi et al., 2016), as well as by ARE-dependent induction of activating transcription factor 3 (ATF3), a negative regulator of IL-6 transcription (Hoetzenecker et al., 2012).”
Background
The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis
Occhiuto, C. J., Moerland, J. A., Leal, A. S., Gallo, K. A., & Liby, K. T. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.2191 · Cited by 43
“…mutations may influence the regulation of the NRF2 pathway in the tumor microenvironment (Best et al., 2018; Cristescu et al., 2018) and consequently influence therapeutic responses to chemotherapy and/or immunotherapy (Kobayashi et al., 2016; Taguchi and Yamamoto, 2017; Taniguchi et al., 2020).”
New Insights into Oxidative and Reductive Stress Responses and Their Relation to the Anticancer Activity of Selenium-Containing Compounds as Hydrogen Selenide Donors
Krakowiak, A., & Pietrasik, S. (2023) · Biology · doi:10.3390/biology12060875 · Cited by 43
“NRF2 also induces the expression of detoxification enzymes and suppresses the induction of pro-inflammatory cytokine genes [29,30].”
Background
Advances in developing noncovalent small molecules targeting Keap1
Barreca, M., Qin, Y., Cadot, M. E. H., Barraja, P., & Bach, A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103800 · Cited by 42
Role of NRF2 in Pathogenesis of Alzheimer’s Disease
Chu, C., Uruno, A., Katsuoka, F., & Yamamoto, M. (2024) · Antioxidants · doi:10.3390/antiox13121529 · Cited by 43
“…enhances the expression of NQO1 , an NRF2 target gene, whereas Keap1 depletion does not enhance it to the same extent in neurons [74] . interleukin 1 β (IL-1 β ), respectively, well as the expression of chemokine genes like CCL2 , which encodes monocyte chemoat-tractant protein 1 (MCP-1) [53].”
Self-citation
Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage‐mediated inflammation in adipocytes
Yang, H., Li, Y., Nishimura, A., Jheng, H., Yuliana, A., Ohue‐Kitano, R., Nomura, W., Takahashi, N., Kim, C.-S., Yu, R., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700064 · Cited by 40
“Furthermore, besides its anti-oxidant activity, transcriptional factor Nrf2 exhibited anti-inflammatory effect by directly regulating mRNA expression levels of proinflammatory cytokine genes [34].”
Background
A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model
Kim, H. J., Jang, B. K., Park, J., Choi, J., Park, S. J., Byeon, S. R., Pae, A. N., Lee, Y. S., Cheong, E., & Park, K. D. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111777 · Cited by 40
Nrf2—A Molecular Target for Sepsis Patients in Critical Care
Gunne, S., Heinicke, U., Parnham, M. J., Laux, V., Zacharowski, K. D., & von Knethen, A. (2020) · Biomolecules · doi:10.3390/biom10121688 · Cited by 41
“Moreover, Nrf2 has been shown to act not only by inducing antioxidant target genes, but also to directly bind in the proximity of pro-inflammatory genes such as IL-6 and IL-1β, inhibiting recruitment of RNA polymerase II [115,140].”
Background
Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease
Cardozo, L., Alvarenga, L., Ribeiro, M. M., Dai, L., Shiels, P. G., Stenvinkel, P., Lindholm, B., & Mafra, D. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa129 · Cited by 42
Imperatorin Interferes with LPS Binding to the TLR4 Co-Receptor and Activates the Nrf2 Antioxidative Pathway in RAW264.7 Murine Macrophage Cells
Huang, M.-H., Lin, Y.-H., Lyu, P. C., Liu, Y., Chang, Y., Chung, J., Lin, W., & Hsieh, W. (2021) · Antioxidants · doi:10.3390/antiox10030362 · Cited by 43
“Previous studies have provided evidence that Nrf2/Heme oxygenase-1 (HO-1) is an antioxidant pathway and that the transcription factor Nrf2 suppresses oxidative stress and induces anti-inflammatory effects in macrophages [13].”
Background
The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance
Choi, B.-H., Kim, J. M., & Kwak, M. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01316-8 · Cited by 40
Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice
Onoki, T., Izumi, Y., Takahashi, M., Murakami, S., Matsumaru, D., Ohta, N., Wati, S. M., Hatanaka, N., Katsuoka, F., Okutsu, M., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101966 · Cited by 39
“In addition to the thoroughly analyzed antioxidant function of NRF2, this protein has been demonstrated to exert anti-inflammatory functions [7,8], as well as regulating the metabolism and mitochondrial activity [9–12].”
BackgroundSelf-citation
Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling
Wang, P., Ni, M., Tian, Y., Wang, H., Qiu, J., You, W., Song, W., Shi, Y., Zhou, J., Cheng, F., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102427 · Cited by 41
Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence
Gentinetta, T., Belcher, J. D., Brügger‐Verdon, V., Adam, J., Ruthsatz, T., Bain, J., Schu, D. J., Ventrici, L., Edler, M., Lioe, H., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030630 · Cited by 41
“Alternatively, heme-mediated activation of the oxidantsensor Nrf2 transcription factor is known to activate various anti-inflammatory genes and inhibit some pro-inflammatory genes [24].”
Background
Nrf2 Signaling in Macrophages
Zhu, H., Jia, Z., & Li, Y. (2016) · doi:10.20455/ros.2016.875 · Cited by 39
How could we forget immunometabolism in SARS-CoV2 infection or COVID-19?
Kumar, V. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1840567 · Cited by 39
Clonal KEAP1 mutations with loss of heterozygosity share reduced immunotherapy efficacy and low immune cell infiltration in lung adenocarcinoma
Scalera, S., Ricciuti, B., Mazzotta, M., Calonaci, N., Alessi, J. V., Cipriani, L., Bon, G., Messina, B., Lamberti, G., Federico, A. D., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.12.002 · Cited by 41
The novel β-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer
Wang, S., Wang, Y., Li, Q., Li, X., Feng, X., & Zeng, K. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102896 · Cited by 40
Regulation of NLRPs by reactive oxygen species: A story of crosstalk
Ziehr, B. K., & MacDonald, J. A. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119823 · Cited by 43
Exosomes from mesenchymal stem cells: Potential applications in wound healing
Li, S., Li, Y., Zhu, K., He, W., Guo, X., Wang, T., Gong, S., & Zhu, Z. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123066 · Cited by 42
The role of natural products targeting macrophage polarization in sepsis-induced lung injury
Li, Y., Ai, S., Li, Y., Ye, W., Li, R., Xu, X., & Liu, Q. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01067-4 · Cited by 40
ZNF207-driven PRDX1 lactylation and NRF2 activation in regorafenib resistance and ferroptosis evasion
Yang, T., Zhang, S., Nie, K., Cheng, C., Peng, X., Huo, J., & Zhang, Y. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101274 · Cited by 43
Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo
Yoshida, E., Suzuki, T., Morita, M., Taguchi, K., Tsuchida, K., Motohashi, H., Doita, M., & Yamamoto, M. P. (2018) · Genes to Cells · doi:10.1111/gtc.12579 · Cited by 39
“…induction gives rise to a protective effect against a variety stresses, including ischemia–reperfusion injury (Nezu 390 | Genes to Cells YOSHIDA et Al. et al., 2017), carcinogenesis (Kensler & Wakabayashi, 2010) and inflammation (Keleku- Lukwete, Suzuki, & Yamamoto, 2017; Kobayashi et al., 2016).”
BackgroundSelf-citation
Gedunin Inhibits Oligomeric Aβ1–42-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling
Tom, S., Rane, A., Katewa, A., Chamoli, M., Matsumoto, R. R., Andersen, J. K., & Chinta, S. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1636-9 · Cited by 39
Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator
Choi, J., Shin, S. J., Kim, H. J., Park, J., Kim, H. J., Lee, E. H., Pae, A. N., Bahn, Y., & Park, K. D. (2019) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00163 · Cited by 39
Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature
Parisi, G. F., Carota, G., Castruccio Castracani, C., Spampinato, M., Manti, S., Papale, M., Di Rosa, M., Barbagallo, I., & Leonardi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052465 · Cited by 43
“Sci. 2021, 22, 2465 16 of 25 LPS Lipopolysaccharides MAP Mitogen-activated protein NF-kb Nuclear factor kappa-light-chain-enhancer of activated B cells Nfr2 Nuclear factor erythroid-2-related factor 2 NK Natural killer NLRP3 NOD-, LRR- and pyrin domain-containing protein 3 PHEIC Public Health Emergency of Internationa…”
BackgroundInfluential
Crosstalk between Nrf2 signaling pathway and inflammation in ischemic stroke: Mechanisms of action and therapeutic implications
Khassafi, N., Tameh, A. A., Mirzaei, H., Rafat, A., Barati, S., Khassafi, N., & Vahidinia, Z. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114655 · Cited by 38
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders
Kong, X., Xu, L., Mou, Z., Lyu, W., Shan, K., Wang, L., Liu, F., Rong, F., Li, J., & Wei, P. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.07.001 · Cited by 38
Syndecan‐4 involves in the pathogenesis of rheumatoid arthritis by regulating the inflammatory response and apoptosis of fibroblast‐like synoviocytes
Cai, P., Lu, Z., Jiang, T., Wang, Z., Yang, Y., Zheng, L. X., & Zhao, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29093 · Cited by 38
“Therefore, upregulation of Nrf2 expression can increase the antioxidant capacity of cells through eliminating excess free radicals and reduce inflammation levels (Kobayashi et al., 2016).”
Background
Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice
Gunderstofte, C., Iversen, M. B., Peri, S., Thielke, A. L., Balachandran, S., Holm, C. K., & Olagnier, D. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02101 · Cited by 38
“Additionally, Nrf2 was described as an important regulator of the inflammatory response (18) and functions as a transcriptional repressor of inflammatory genes in murine macrophages (19).”
Background
Influences of Nanoparticles Characteristics on the Cellular Responses: The Example of Iron Oxide and Macrophages
Dalzon, B., Torres, A., Reymond, S., Gallet, B., Saint-Antonin, F., Collin‐Faure, V., Moriscot, C., Fenel, D., Schoehn, G., Aude‐Garcia, C., et al. (2020) · Nanomaterials · doi:10.3390/nano10020266 · Cited by 38
Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions
Lu, M., Shao, H.-L., Liu, T., You, Q., & Jiang, Z. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112734 · Cited by 38
Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non–Small Cell Lung Carcinoma
Song, S., Nguyen, V. Q., Schrank, T. P., Mulvaney, K. M., Walter, V., Wei, D., Orvis, T., Desai, N. P., Zhang, J., Hayes, D. N., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0082 · Cited by 38
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia
Farfán, N., Carril, J., Redel, M., Zamorano, M., Araya, M., Monzón, E., Alvarado, R., Contreras, N., Tapia-Bustos, A., Quintanilla, M. E., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207800 · Cited by 41
“This finding can be associated with NRF2 activation, since NRF2 and p65 may antagonize each other [91,92].”
Background
Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction
Yin, Y., Xu, N., Shi, Y., Zhou, B., Sun, D., Ma, B., Xu, Z., Yang, J., & Li, C. (2021) · Marine Drugs · doi:10.3390/md19060346 · Cited by 40
“It has been reported that activation of Nrf2 prevents LPS-induced transcriptional upregulation of pro-inflammatory cytokines, including IL-6 and IL-1β [50].”
Background
The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks
Wu, S., Rao, G., Wang, R., Pang, Q., Zhang, X., Huang, R., Li, T., Tang, Z., & Hu, L. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112965 · Cited by 38
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells
Ogese, M. O., Faulkner, L., Jenkins, R., French, N. S., Copple, I. M., Antoine, D. J., Elmasry, M., Malik, H., Goldring, C. E., Park, B. K., et al. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx069 · Cited by 40
Nrf2 Promotes Inflammation in Early Myocardial Ischemia-Reperfusion via Recruitment and Activation of Macrophages
Zhang, H., Liu, Y., Cao, X., Wang, W., Cui, X., Yang, X., Wang, Y., & Shi, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763760 · Cited by 37
“A growing body of evidence suggests that Nrf2, as the upstream regulator of cytokine production, opposes transcriptional upregulation of proinflammatory cytokine genes and establishes a molecular basis for an Nrf2-mediated anti-inflammatory approach (36).”
Background
Roles of NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches
Hao, W., Li, M., Cai, Q., Wu, S., Li, X., He, Q., & Hu, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.889792 · Cited by 38
Neuropeptide Y Promotes Human M2 Macrophage Polarization and Enhances p62/SQSTM1-Dependent Autophagy and NRF2 Activation
Profumo, E., Maggi, E., Arese, M., Cristofano, C. D., Salvati, B., Saso, L., Businaro, R., & Buttari, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113009 · Cited by 37
“Several reports have demonstrated a crucial role of NRF2 in tuning the balance of M1/M2 macrophages, thus identifying NRF2 as a molecular target to control macrophage inflammatory response [68,69].”
Background
Metabolic regulation of type I interferon production
O’Carroll, S. M., Henkel, F. D. R., & O'Neill, L. A. J. (2024) · Immunological Reviews · doi:10.1111/imr.13318 · Cited by 37
“75,76 NRF2 negatively regulates Ifnb1 .”
Protective Role of Nuclear Factor Erythroid 2-Related Factor 2 Against Respiratory Syncytial Virus and Human Metapneumovirus Infections
Ivanciuc, T., Sbrana, E., Casola, A., & Garofalo, R. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00854 · Cited by 37
“Nrf2 has been shown to bind to the proximity of cytokine genes (including IL-6 and IL-1β) in macrophages and to inhibit RNA Pol II recruitment, a process independent of the Nrf2-binding to motif and ROS levels (45).”
The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Mylka, V., Deckers, J., Ratman, D., Cauwer, L. D., Thommis, J., Rycke, R. M. D., Impens, F., Libert, C., Tavernier, J. H., Berghe, W. V., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1495681 · Cited by 35
“Our data also complement a recent study showing that the upstream regulator NFE2L2 itself can repress Il6 and Il1b genes by direct binding to their promoters [42].”
Result
Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis
Garcia-Vilarato, E., DeLuca, J. A. A., Callaway, E. S., Allred, K. F., Davidson, L. A., Hensel, M. E., Menon, R., Ivanov, I. V., Safe, S. H., Jayaraman, A., et al. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00268.2019 · Cited by 37
Targeting defective pulmonary innate immunity – A new therapeutic option?
Belchamber, K. B. R., & Donnelly, L. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107500 · Cited by 37
NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands
Wati, S. M., Matsumaru, D., & Motohashi, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101603 · Cited by 39
“Based on previous reports describing that NRF2 has potent anti-inflammatory activity [22,35], we hypothesized that NRF2 activation exerts its antiaging function by suppressing the smoldering inflammation of salivary glands.”
BackgroundSelf-citation
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
Casares, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Appendino, G., Dinkova‐Kostova, A. T., Muñóz, E., & de la Vega, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101689 · Cited by 37
“69 Stabilization of NRF2 triggers the transcription of multiple enzymes involved in scavenging 70 ROS and in generating antioxidant molecules like glutathione [27] [28] while leading to a 71 reduction of pro-inflammatory cytokines such as IL-6 [29] [30].”
Redox Homeostasis in Muscular Dystrophies
Mosca, N., Petrillo, S., Bortolani, S., Monforte, M., Ricci, E., Piemonte, F., & Tasca, G. A. (2021) · Cells · doi:10.3390/cells10061364 · Cited by 36
“It is important to note that Nrf2 binds DNA in proximity of the genes encoding IL-1β and IL-18 to modulate their transcription [30], thereby supporting its direct inhibitory effect on NOD-like receptor protein 3 (NLRP3) inflammasome priming.”
Background
Oxidative Stress and Cancer Heterogeneity Orchestrate NRF2 Roles Relevant for Therapy Response
Gall‐Tros̆elj, K., Tomljanović, M., Jaganjac, M., Glavan, T. M., Gašparović, A. Č., Milković, L., Šunjić, S. B., Buttari, B., Profumo, E., Saha, S., et al. (2022) · Molecules · doi:10.3390/molecules27051468 · Cited by 38
Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review
Laurindo, L. F., de Maio, M. C., Minniti, G., Corrêa, N. D. G., Barbalho, S. M., Quesada, K. R., Guiguer, É. L., Sloan, K. P., Detregiachi, C. R. P., Araújo, A. C., et al. (2023) · Metabolites · doi:10.3390/metabo13020243 · Cited by 38
The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury
Mousavi, K., Niknahad, H., Li, H., Jia, Z., Manthari, R. K., Zhao, Y., Shi, X., Chen, Y., Ahmadi, A., Azarpira, N., et al. (2021) · Toxicology Research · doi:10.1093/toxres/tfab073 · Cited by 36
The Role of the NRF2 Pathway in Maintaining and Improving Cognitive Function
Gray, N. E., Farina, M., Tucci, P., & Saso, L. (2022) · Biomedicines · doi:10.3390/biomedicines10082043 · Cited by 36
“Moreover, NRF2 has been implicated in reducing the expression of the pro-inflammatory cytokines IL6 and IL1β through a binding site nearby the promoter that prevents the recruitment of RNA Polymerase II [27].”
Background
An enriched environment improves long-term functional outcomes in mice after intracerebral hemorrhage by mechanisms that involve the Nrf2/BDNF/glutaminase pathway
Jia, P., Wang, J., Ren, X., He, J., Wang, S., Xing, Y., Chen, D., Zhang, X., Zhou, S., Liu, X., et al. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221135419 · Cited by 36
Selection signatures for local and regional adaptation in Chinese Mongolian horse breeds reveal candidate genes for hoof health
Han, H., Randhawa, I. A. S., MacHugh, D. E., McGivney, B. A., Katz, L. M., Dugarjaviin, M., & Hill, E. W. (2023) · BMC Genomics · doi:10.1186/s12864-023-09116-8 · Cited by 36
“The NQO1 is a representative target of the nuclear factor, erythroid 2 like 2 (NFE2L2) transcription factor, which causes suppression of the macrophage inflammatory response [30]; inflammatory damage to the lamellae is one of the biological processes known to cause laminitis [31].”
Background
Targeting reactive oxygen species and fat acid oxidation for the modulation of tumor-associated macrophages: a narrative review
Teng, Y., Xu, L., Li, W., Liu, P., Tian, L., & Liu, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224443 · Cited by 38
NRF2 in neurodegenerative diseases
Cuadrado, A. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.09.004 · Cited by 36
Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis
Waslo, C. S., BOURDETTE, D. N., Gray, N. E., Wright, K. M., & Spain, R. (2019) · Current Treatment Options in Neurology · doi:10.1007/s11940-019-0566-1 · Cited by 38
The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer
Zhang, X., Wang, Y., Li, X., Yang, A., Li, Z., & Wang, D. (2019) · Aging · doi:10.18632/aging.102456 · Cited by 36
“Meanwhile, Nrf2 can interfere with the production of interleukins [70], and can directly inhibit the expression of NF-κB [71].”
Background
The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism
Reverte, M., Eren, R. O., Jha, B., Desponds, C., Snäkä, T., Prével, F., Isorce, N., Lye, L., Owens, K. L., Lopes, U. G., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009422 · Cited by 36
Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF‐κB, and PI3K/Akt Signaling Pathways
Yassin, N. Y. S., AbouZid, S. F., El-Kalaawy, A. M., Ali, T. M., Elesawy, B. H., & Ahmed, O. M. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7665169 · Cited by 36
Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia
Vallelian, F., Buzzi, R. M., Pfefferlé, M., Yalamanoglu, A., Dubach, I. L., Wassmer, A., Gentinetta, T., Hansen, K., Humar, R., Schulthess, N., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00932-1 · Cited by 33
PI3K/Akt/Nrf2 mediated cellular signaling and virus-host interactions: latest updates on the potential therapeutic management of SARS-CoV-2 infection
Lekshmi, V. S., Asha, K., Sanicas, M., Asi, A. D., Arya, U. M., & Kumar, B. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1158133 · Cited by 35
“These compounds were identified as Nrf2 activators that can inhibit the NF-κB pathway promoting resolution of inflammation, inhibiting viral replication, and thereby facilitating cytoprotection and tissue repair (Kobayashi et al., 2016).”
Background
Extracellular Vesicles From Mesenchymal Umbilical Cord Cells Exert Protection Against Oxidative Stress and Fibrosis in a Rat Model of Bronchopulmonary Dysplasia
Bisaccia, P., Magarotto, F., D’Agostino, S., Dedja, A., Barbon, S., Guidolin, D., Liboni, C., Angioni, R., Lazzari, G. D., Caicci, F., et al. (2023) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szad070 · Cited by 36
“25 It is known that the expression of Nrf2 , a transcription factor of antioxidant genes and a repressor of inflammation, 56 is present at low levels in myofibroblasts.”
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway
Wang, Q., Liu, T., Koci, M. D., Wang, Y., Fu, Y., Ma, M., Ma, Q., & Zhao, L. (2023) · Antioxidants · doi:10.3390/antiox12122027 · Cited by 35
NRF2 in age-related musculoskeletal diseases: Role and treatment prospects
Zhang, X., Li, H., Chen, L., Wu, Y., & Li, Y. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101180 · Cited by 38
“33”
Nanozymes with Broad-Spectrum Scavenging of Reactive Oxygen Species (ROS) Alleviate Inflammation in Acute Liver Injury
Wang, F., Yuan, H., Shen, J., Li, Z., Li, J., Luo, P., Zhang, Q., Huang, W., Wang, X., Ma, J., et al. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c01627 · Cited by 36
Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells
Li, F., Zhang, L., Zhang, X., Fang, Q., Xu, Y., & Wang, H. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.07.010 · Cited by 35
Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier
Cazalla, E., Cuadrado, A., & García‐Yagüe, Á. J. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00599-5 · Cited by 36
“This mechanism is independent of NRF2’s typical binding to the ARE enhancer [74].”
Influential
Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases
Wen, P., Sun, Z., Yang, D., Li, J., Li, Z., Zhao, M., Wang, D., Gou, F., Wang, J., Dai, Y., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07390-w · Cited by 38
The Regulatory Network of Transcription Factors in Macrophage Polarization
Liu, J., Wang, M., & Zhao, Y. X. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s494550 · Cited by 38
4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress
Ma, T., Zheng, Z., Guo, H., Lian, X., Rane, M. J., Cai, L., Kim, K. S., Kim, K., Zhang, Z., & Bi, L. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.03.007 · Cited by 35
Leocarpinolide B attenuates LPS-induced inflammation on RAW264.7 macrophages by mediating NF-κB and Nrf2 pathways
Linghu, K., Qiu, S., Zhao, G. D., Xiong, W., Lin, L., Zhang, Q., Bian, Z., Wang, Y., & Yu, H. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172854 · Cited by 35
Green tea polyphenols mitigate the plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways
Wang, D., Zhang, M., Wang, T., Liu, T., Guo, Y., & Granato, D. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111576 · Cited by 35
The role of Nrf2 in acute and chronic muscle injury
Bronisz-Budzyńska, I., Kozakowska, M., Podkalicka, P., Kachamakova‐Trojanowska, N., Łoboda, A., & Dulak, J. (2020) · Skeletal Muscle · doi:10.1186/s13395-020-00255-0 · Cited by 33
Ellagic acid protects against diabetic nephropathy in rats by regulating the transcription and activity of Nrf2
ALTAMIMI, J. Z., AlFaris, N. A., Alshammari, G. M., Alagal, R. I., ALJABRYN, D. H., Aldera, H., Alrfaei, B. M., Alkhateeb, M. A., & Yahya, M. A. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104397 · Cited by 34
Diallyl disulfide suppresses the lipopolysaccharide-driven inflammatory response of macrophages by activating the Nrf2 pathway
Zhang, X., Zhao, N., Guo, F., Wang, Y., Liu, S.-X., & Zeng, T. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112760 · Cited by 35
Dl‐3‐n‐Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia‐Reperfusion Injury through the Nrf2‐Mediated Antioxidant Response and TLR4/MyD88/NF‐κB Signaling Pathway
Gao, Y., Hu, M., Niu, X., Li, M., Xu, L., Xiao, Y., Zhang, J., Wang, H., Li, L., Chu, B., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8652741 · Cited by 35
“M0027; IL-6, cat. no.”
Influential
Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation
Salman, S., Guermonprez, C., Peno‐Mazzarino, L., Lati, E., Rousseaud, A., Declercq, L., & Kerdine‐Römer, S. (2023) · Antioxidants · doi:10.3390/antiox12030766 · Cited by 39
“Recently, it has been described that Nrf2 can also directly inhibit the transcription of pro-inflammatory cytokine genes such as IL-6 and IL-1β through direct DNA binding close to these genes, independently from ARE, contrary to the widely accepted view that Nrf2 inhibits inflammation through redox control [22].”
Background
Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening
Wakamori, S., Taguchi, K., Nakayama, Y., Ohkoshi, A., Sporn, M. B., Ogawa, T., Katori, Y., & Yamamoto, M. P. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.239 · Cited by 34
Self-citation
Bacterial Metabolite Reuterin Attenuated LPS-Induced Oxidative Stress and Inflammation Response in HD11 Macrophages
Xu, Y., Ding, X., Wang, Y., Li, D., Xie, L., Liang, S., Zhang, Y., Li, W., Fu, A., & Zhan, X. (2022) · Antioxidants · doi:10.3390/antiox11091662 · Cited by 34
“Previous research pointed out that transcriptional factor nuclear factor erythroid 2-related factor 2 (Nrf2) not only mediated the oxidative stress response by regulating the expression of antioxidative enzymes but also attenuated the proinflammatory response via inhibiting the transcription of IL-6 and IL-1β [46,47].”
Background
Oxidative Stress Linking Obesity and Cancer: Is Obesity a ‘Radical Trigger’ to Cancer?
Jovanović, M., Kovačević, S., Brkljačić, J. M., & Djordjevic, A. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098452 · Cited by 39
“In normal cells, Nrf2 will activate to amortize the inﬂammation ROS by negative regulation of IL - 6 and induction of PPARγ [ 103 ].”
Background
The pathogenic role of intestinal flora metabolites in diabetic nephropathy
Tian, E., Wang, F., Zhao, L., Sun, Y., & Yang, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1231621 · Cited by 35
“The nuclear factor erythroid 2-related factor 2 (NRF2) plays a key role in cellular defence against oxidative stress (Kobayashi et al., 2016).”
Background
Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders
Zaid, A. K. M. A., & Ariel, A. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115204 · Cited by 35
A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets
Soni, P., Kaidery, N. A., Sharma, S. M., Gazaryan, I. G., Nikulin, S. V., Hushpulian, D. M., & Thomas, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1390798 · Cited by 36
Silencing of long isoforms of nuclear factor erythroid 2 like 1 primes macrophages towards M1 polarization
Wang, H., Zhu, J., Liu, Z., Lv, H., Lv, P., Chen, F., Fu, J., Hou, Y., Zhao, R., Xu, Y., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.022 · Cited by 34
“Like NFE2L1, NFE2L2 was demonstrated to interfere with LPS-induced transcriptional upregulation of pro-inflammatory cytokines, including Il6 and Il1β [34].”
BackgroundResultInfluential
Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection
Seelige, R., Saddawi‐Konefka, R., Adams, N. M., Picarda, G. G. A., Sun, J. C.-Y., Benedict, C. A., & Bui, J. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-32011-2 · Cited by 34
Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer
Kang, J.-S., Nam, L. B., Yoo, O.-K., & Keum, Y. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114002 · Cited by 35
The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1β protein
Sabzevary‐Ghahfarokhi, M., Soltani, A., Luzza, F., Larussa, T., Rahimian, G., Shirzad, H., & Bagheri, N. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05753-4 · Cited by 34
Role of NRF2 and Sirtuin activators in COVID-19
Khan, H., Patel, S., & Majumdar, A. S. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108879 · Cited by 34
Schisandrin A regulates the Nrf2 signaling pathway and inhibits NLRP3 inflammasome activation to interfere with pyroptosis in a mouse model of COPD
Zeng, J., Liao, S., Liang, Z., Li, C., Luo, Y., Wang, K., Zhang, D., Lan, L., Hu, S., Li, W., et al. (2023) · European journal of medical research · doi:10.1186/s40001-023-01190-8 · Cited by 35
“The activation of Nrf2 not only alleviates the inflammatory response of COPD by inducing HO-1 but also prevents elevated levels of proinflammatory mediators, including IL-6 [38].”
BackgroundInfluential

Authors: Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., Hayashi, M., Sekine, H., Tanaka, N., Moriguchi, T., Motohashi, H., Nakayama, K., & Yamamoto, M.
Affiliations: Tohoku University (JP)
Miyagi Prefectural Hospital Organization (JP)
Institute of Development, Aging and Cancer, Tohoku University (JP)
Corresponding author: Kobayashi, Eri H.
Yamamoto, Masayuki
ORCID: Kobayashi, Eri H.
Suzuki, Takafumi
Funayama, Ryo
Nagashima, Takeshi
Hayashi, Makiko
Sekine, Hiroki
Moriguchi, Takashi
Motohashi, Hozumi
Nakayama, Keiko
Yamamoto, Masayuki
Venue: Nature Communications
Publisher: Springer Science and Business Media LLC
Published: 2016-05-23
Volume: 7
Issue: 1
Pages: 11624-11624
ISSN: 2041-1723 (ISSN-L)
DOI: 10.1038/ncomms11624
PMC: PMC4879264
OpenAlex: W2400239628
Cited by: 1,878
References: 58
Citations by year: 2026: 188 · 2025: 244 · 2024: 245 · 2023: 214 · 2022: 243 · 2021: 209 · 2020: 236 · 2019: 115 · 2018: 109 · 2017: 61 · 2016: 13
FWCI: 51.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Nature Communications (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
The Japanese Biochemical Society
Funders: Japan Agency for Medical Research and Development (CREST)
Ministry of Education, Culture, Sports, Science and Technology (23116002, 22118002, 24249015, CREST)
Japan Society for the Promotion of Science (15K14414, 15H04692, 16H05147, 26111002, 24249015, 25840001, CREST, 15K08257, 16K15228)
Core Research for Evolutional Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Nrf2, macrophages, inflammation, inflammatory cytokines, interleukin-6, IL-1β, transcriptional repression, RNA polymerase II recruitment, lipopolysaccharide, anti-inflammatory mechanism, oxidative stress response
MeSH terms: Animals, Gene Expression Regulation, Inflammation, Macrophages, Mice, Inbred C57BL, Mice, Inbred ICR, RNA Polymerase II, Cytokines, Mice, Knockout, Oxidative Stress, NF-E2-Related Factor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks