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ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

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van den Born, Erwin, Vågbø, Cathrine B., Songe-Møller, Lene, Leihne, Vibeke, Lien, Guro F., Leszczynska, Grazyna, Malkiewicz, Andrzej, Krokan, Hans E., Kirpekar, Finn, Klungland, Arne, Falnes, Pål Ø.·2011·Nature Communications

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Research works printed but not linked: 33

  1. Agris, P. F. Decoding the genome: a modified view. Nucleic Acids Res. 32, 223–238 (2004). · DOI · Paper page
  2. Sprinzl, M. & Vassilenko, K. S. Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res. 33, D139–D140 (2005). · DOI · Paper page
  3. Johansson, M. J., Esberg, A., Huang, B., Björk, G. R. & Byström, A. S. Eukaryotic wobble uridine modifications promote a functionally redundant decoding system. Mol. Cell Biol. 28, 3301–3312 (2008). · DOI · Paper page
  4. Nasvall, S. J., Chen, P. & Björk, G. R. The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. RNA 10, 1662–1673 (2004). · DOI
  5. Huang, B., Johansson, M. J. & Byström, A. S. An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 11, 424–436 (2005). · DOI · Paper page
  6. Kalhor, H. R. & Clarke, S. Novel methyltransferase for modified uridine residues at the wobble position of tRNA. Mol. Cell Biol. 23, 9283–9292 (2003). · DOI
  7. Loenarz, C. & Schofield, C. J. Expanding chemical biology of 2-oxoglutarate oxygenases. Nat. Chem. Biol. 4, 152–156 (2008). · DOI · Paper page
  8. Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930–935 (2009). · DOI · Paper page
  9. Tsukada, Y. et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 439, 811–816 (2006). · DOI · Paper page
  10. Falnes, P. O., Johansen, R. F. & Seeberg, E. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419, 178–182 (2002). · DOI · Paper page
  11. Trewick, S. C., Henshaw, T. F., Hausinger, R. P., Lindahl, T. & Sedgwick, B. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419, 174–178 (2002). · DOI · Paper page
  12. Gerken, T. et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469–1472 (2007). · DOI · Paper page
  13. Kurowski, M. A., Bhagwat, A. S., Papaj, G. & Bujnicki, J. M. Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB. BMC Genomics 4, 48 (2003). · DOI · Paper page
  14. Duncan, T. et al. Reversal of DNA alkylation damage by two human dioxygenases. Proc. Natl Acad. Sci. USA 99, 16660–16665 (2002). · DOI · Paper page
  15. Westbye, M. P. et al. Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. J. Biol. Chem. 283, 25046–25056 (2008). · DOI · Paper page
  16. Ringvoll, J. et al. Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J. 25, 2189–2198 (2006). · DOI
  17. Nordstrand, L. M. et al. Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS ONE 5, e13827 (2010). · DOI
  18. Pan, Z. et al. Impaired placental trophoblast lineage differentiation in Alkbh1(−/−) mice. Dev. Dyn. 237, 316–327 (2008). · DOI
  19. Sedgwick, B., Bates, P. A., Paik, J., Jacobs, S. C. & Lindahl, T. Repair of alkylated DNA: recent advances. DNA Repair (Amst.) 6, 429–442 (2007). · DOI · Paper page
  20. Fu, D. et al. Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Mol. Cell Biol. 30, 2449–2459 (2010). · DOI · Paper page
  21. Songe-Moller, L. et al. Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. Mol. Cell Biol. 30, 1814–1827 (2010). · DOI · Paper page
  22. Kawakami, M., Takemura, S., Kondo, T., Fukami, T. & Goto, T. Chemical structure of a new modified nucleoside located in the anticodon of Bombyx mori glycine tRNA2. J. Biochem. 104, 108–111 (1988). · DOI
  23. Fu, Y. et al. The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the Wobble position of tRNA. Angew. Chem. Int. Ed. Engl. 49, 8885–8888 (2010). · DOI
  24. Andersen, T. E., Kirpekar, F. & Haselmann, K. F. RNA fragmentation in MALDI mass spectrometry studied by H/D-exchange: mechanisms of general applicability to nucleic acids. J. Am. Soc. Mass Spectrom. 17, 1353–1368 (2006). · doi:10.1016/j.jasms.2006.05.018
  25. Begley, U. et al. Trm9-catalyzed tRNA modifications link translation to the DNA damage response. Mol. Cell 28, 860–870 (2007). · DOI · Paper page
  26. Dewez, M. et al. The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity. Proc. Natl Acad. Sci. USA 105, 5459–5464 (2008). · DOI
  27. Holt, C. E. & Bullock, S. L. Subcellular mRNA localization in animal cells and why it matters. Science 326, 1212–1216 (2009). · DOI · Paper page
  28. Ito, S. et al. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466, 1129–1133 (2010). · DOI · Paper page
  29. Nawrot, B. & Malkiewicz, A. The tRNA 'wobble position' uridines. III. The synthesis of 5-[S-methoxycarbonyl(hydroxy)metyl]uridine and its 2-thio analogue. Nucleosides Nucleotides 8, 1499–1512 (1989). · DOI
  30. Crain, P. F. Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry. Methods Enzymol. 193, 782–790 (1990). · DOI · Paper page
  31. Fissekis, J. D. & Sweet, F. Synthesis of 5-carboxymethyluridine. A nucleoside from transfer ribonucleic acid. Biochemistry 9, 3136–3142 (1970). · DOI
  32. Mengel-Jorgensen, J. & Kirpekar, F. Detection of pseudouridine and other modifications in tRNA by cyanoethylation and MALDI mass spectrometry. Nucleic Acids Res. 30, e135 (2002). · doi:10.1093/nar/gnf135
  33. van den Born, E., Posthuma, C. C., Gultyaev, A. P. & Snijder, E. J. Discontinuous subgenomic RNA synthesis in arteriviruses is guided by an RNA hairpin structure located in the genomic leader region. J. Virol. 79, 6312–6324 (2005). · DOI

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Metadata

Authors
van den Born, E., Vågbø, C. B., Songe-Møller, L., Leihne, V., Lien, G. F., Leszczynska, G., Malkiewicz, A., Krokan, H. E., Kirpekar, F., Klungland, A., & Falnes, P. Ø.
Venue
Nature Communications
Published
2011-02-01
Volume
2
Issue
1
Pages
172-172
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2129397714
Cited by
174
References
1
FWCI
6.58
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. https://app.cochat.ai/papers/10.1038/ncomms1173
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van den Born, E., Vågbø, C. B., Songe-Møller, L., Leihne, V., Lien, G. F., Leszczynska, G., Malkiewicz, A., Krokan, H. E., Kirpekar, F., Klungland, A., & Falnes, P. Ø. (2011). ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications. https://doi.org/10.1038/ncomms1173

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