Senescent tumor cells lead the collective invasion in thyroid cancer
Open accessAbstract
Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show senescent tumour cells are frequently present in the front region of collective invasion of papillary thyroid carcinoma (PTC), as well as lymphatic channels and metastatic foci of lymph nodes. In in vitro invasion analysis, senescent tumour cells exhibit high invasion ability as compared with non-senescent tumour cells through SASP expression. Collective invasion in PTC is led by senescent tumour cells characterized by generation of a C-X-C-motif ligand (CXCL)12 chemokine gradient in the front region. Furthermore, senescent cells increase the survival of cancer cells via CXCL12/CXCR4 signalling. An orthotopic xenograft in vivo model also shows higher lymphatic vessels involvement in the group co-transplanted with senescent cells and cancer cells. These findings suggest that senescent cells are actively involved in the collective invasion and metastasis of PTC.
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Besides cancer cells, other cells in the tumor microenvironment such as fibroblasts and endothelial cells undergo cellular senescence or display senescence-like phenotypic alterations that promote cancer progression.
“Recent studies revealed that besides cancer cells (7), other cells in the tumor microenvironment (TME), such as fibroblasts (8–11) and endothelial cells (12–14), undergo cellular senescence or display senescence-like phenotypic alterations that promote cancer progression.”
From Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment (2023) · cites this paper as [7]
Cancer cells exhibit senescence-like phenotypes.
“we and other groups have reported that cancer cells exhibit senescence-like phenotypes (7, 42).”
From Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment (2023) · cites this paper as [7]
OIS cells can associate with nonsenescent cancer cells during metastasis to assist in cancer cell survival and invasion through SASP factors.
“However, OIS cells reportedly can also associate with nonsenescent cancer cells during metastasis to assist in cancer cell survival and invasion through SASP factors [42].”
From The role of cellular senescence and SASP in tumour microenvironment (2023) · cites this paper as [42]
In a murine model of papillary thyroid carcinoma, senescent cancer cells located at the front of collective invasion and in lymph nodes generate a CXCL12 gradient that promotes cancer invasion.
“In a murine model of papillary thyroid carcinoma, senescent cancer cells located in the front region of collective invasion site and lymph nodes generate a CXCL12 gradient propaedeutic for cancer invasion.197”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [197]
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- Authors
- Kim, Y. H., Choi, Y. W., Lee, J., Soh, E. Y., Kim, J.-H., & Park, T. J.
- Affiliations
- Ajou University (KR)
- Corresponding author
- Kim, Jang-Hee
- Park, Tae Jun
- Venue
- Nature Communications
- Published
- 2017-05-10
- Volume
- 8
- Issue
- 1
- Pages
- 15208-15208
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5436223
- OpenAlex
- W2612090342
- Cited by
- 253
- References
- 53
- Citations by year
- 2026: 22 · 2025: 27 · 2024: 39 · 2023: 42 · 2022: 27 · 2021: 37 · 2020: 33 · 2019: 12 · 2018: 13 · 2017: 1
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- AJOU Open Repository (Ajou University) (submittedVersion)
- Funders
- Clinical Trial Center, China Medical University Hospital
- National Research Foundation
- Ajou University
- National Research Foundation of Korea (NRF-2016R1D1A1B02010452, 2016R1D1A1B02010452)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- cellular senescence, senescence-associated secretory phenotype, papillary thyroid carcinoma, collective invasion, lymph node metastasis, chemokine gradients, tumor cell survival, lymphatic vessel invasion, tumor microenvironment
- MeSH terms
- Thyroid Epithelial Cells, Animals, Carcinoma, Papillary, Cell Movement, Cells, Cultured, Female, Humans, Lymphatic Metastasis, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness, Thyroid Neoplasms, Transplantation, Heterologous, Cellular Senescence, Receptors, CXCR4, Gene Expression Profiling, Cell Line, Tumor, Chemokine CXCL12
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