The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides
Open accessAbstract
Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assembly of genome and transcriptome sequencing data reveals a genome of 20.2 Mb containing 8,171 protein-coding genes, the majority of which have multiple introns. Genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. Transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. The multi-omic map of R. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways. The ability of oleaginous fungi to produce lipids for biofuels remains untapped, in part due to a lack of genetic information required to engineer industrial strains. Zhuet al. present the genome of R. toruloides, and identify transcriptomic and proteomic changes associated with lipid production.
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Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis
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Metadata
- Authors
- Zhu, Z., Zhang, S., Liu, H., Shen, H., Lin, X., Yang, F., Zhou, Y. J., Jin, G., Ye, M., Zou, H., & Zhao, Z. K.
- Venue
- Nature Communications
- Published
- 2012-10-09
- Volume
- 3
- Issue
- 1
- Pages
- 1112-1112
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2042206503
- Cited by
- 430
- References
- 9
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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