You Are What You Host: Microbiome Modulation of the Aging Process
Open accessAbstract
The critical impact that microbiota have on health and disease makes the interaction between host and microbiome increasingly important as we evaluate therapeutics. Here, we highlight growing evidence that, beyond disease, microbes also affect the most fundamental of host physiological phenotypes, the rate of aging itself.
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The gut microbial ecosystem changes with aging, with Bifidobacteria decreasing and facultative anaerobes such as Streptococci, Staphylococci, Enterococci and Enterobacteria increasing.
“The microbial composition and diversity of the gut ecosystem changes with aging [10], as Bifidobacteria have been reported to decrease [11], while facultative anaerobes, including Streptococci, Staphylococci, Enterococci and Enterobacteria, increase with age [12]”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [10]
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Gut microbiota and physical frailty through the mediation of sarcopenia
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“…growth, development, metabolism, and digestive physiology of the host, as well as protection from predators, and adaptive fitness to the environment they inhabit (Shin et al., 2011; Gomez et al., 2012; Nguyen and Clarke, 2012; Guinane and Cotter, 2013; Kostic et al., 2013; Heintz and Mair, 2014).”
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“…uthor M anuscript Growing evidence support the existence of a gut microbial–mammalian metabolic axis (Figure 2) and indicate that commensal microbes extend their effects on their host beyond disease to also affect the organismal rate of aging itself (Heintz and Mair, 2014; H. Li and W. Jia, 2013).”
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“Any lethal or detrimental effect on bacterial metabolism can be interpreted as potentially harmful for soil bacteria and for the human microbiome, and consequently for human health (Gilbert et al., 2013; David et al., 2014; Heintz and Mair, 2014).”
BackgroundLacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans
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Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders
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BackgroundBats Are an Untapped System for Understanding Microbiome Evolution in Mammals
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“To date, studies addressing the link between host aging and the microbiome in humans and lab animals have uncovered direct links between microbial metabolic products and life span of the host (54).”
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Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria
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Theaflavin-regulated Imd condensates control Drosophila intestinal homeostasis and aging
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- Authors
- Heintz, C., & Mair, W.
- Affiliations
- Harvard University (US)
- Corresponding author
- Mair, William
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 156
- Issue
- 3
- Pages
- 408-411
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3956044
- OpenAlex
- W2095090113
- Cited by
- 222
- References
- 25
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 15 · 2023: 14 · 2022: 16 · 2021: 23 · 2020: 16 · 2019: 23 · 2018: 24 · 2017: 25 · 2016: 20 · 2015: 21 · 2014: 12
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- National Institute on Aging (R01AG044346)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- microbiome, aging, host-microbe interactions, microbiota modulation, host physiology, age-related diseases, therapeutics
- MeSH terms
- Aging, Animals, Humans, Longevity, Models, Animal, Metagenome, Microbiota
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