MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise

Construction of a genetic toggle switch in Escherichia coli

Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000) · Nature · doi:10.1038/35002131 · Cited by 4,310 · see citing works

The impact of microRNAs on protein output

Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592 · see citing works

c-Myc-regulated microRNAs modulate E2F1 expression

O’Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,812 · see citing works

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

Raj, A., & van Oudenaarden, A. (2008) · Cell · doi:10.1016/j.cell.2008.09.050 · Cited by 2,593 · see citing works

Biological robustness

Kitano, H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1471 · Cited by 2,278 · see citing works

Stochasticity in gene expression: from theories to phenotypes

Kærn, M., Elston, T. C., Blake, W. J., & Collins, J. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1615 · Cited by 2,271 · see citing works

Noise in eukaryotic gene expression

Blake, W. J., Kærn, M., Cantor, C. R., & Collins, J. J. (2003) · Nature · doi:10.1038/nature01546 · Cited by 1,636 · see citing works

Roles for MicroRNAs in Conferring Robustness to Biological Processes

Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564 · see citing works

Regulation of noise in the expression of a single gene

Özbudak, E. M., Thattai, M., Kurtser, I., Grossman, A. D., & van Oudenaarden, A. (2002) · Nature Genetics · doi:10.1038/ng869 · Cited by 1,559 · see citing works

MicroRNA control of signal transduction

Inui, M., Martello, G., & Piccolo, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2868 · Cited by 1,262 · see citing works

Histone variants — ancient wrap artists of the epigenome

Talbert, P. B., & Henikoff, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2861 · Cited by 844 · see citing works

Negative Autoregulation Speeds the Response Times of Transcription Networks

Rosenfeld, N., Elowitz, M. B., & Alon, U. S. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00994-4 · Cited by 714 · see citing works

Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

Becskei, A., Séraphin, B., & Serrano, L. G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2528 · Cited by 687 · see citing works

MicroRNA-Mediated Feedback and Feedforward Loops Are Recurrent Network Motifs in Mammals

Tsang, J., Zhu, J., & van Oudenaarden, A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.018 · Cited by 652 · see citing works

Variability in gene expression underlies incomplete penetrance

Raj, A., Rifkin, S. A., Andersen, E. C., & van Oudenaarden, A. (2010) · Nature · doi:10.1038/nature08781 · Cited by 642 · see citing works

MicroRNAs can generate thresholds in target gene expression

Mukherji, S., Ebert, M. S., Zheng, G. X. Y., Tsang, J. S., Sharp, P. A., & van Oudenaarden, A. (2011) · Nature Genetics · doi:10.1038/ng.905 · Cited by 628 · see citing works

LNA: a versatile tool for therapeutics and genomics

Petersen, M. Å., & Wengel, J. (2003) · Trends in biotechnology · doi:10.1016/s0167-7799(02)00038-0 · Cited by 612 · see citing works

An E2F/miR-20a Autoregulatory Feedback Loop

Sylvestre, Y., Guire, V. D., Querido, E., Mukhopadhyay, U. K., Bourdeau, V., Major, F., Ferbeyre, G., & Chartrand, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608939200 · Cited by 610 · see citing works

Emerging properties of animal gene regulatory networks

Davidson, E. H. (2010) · Nature · doi:10.1038/nature09645 · Cited by 579 · see citing works

Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state

Brown, B. D., Gentner, B., Cantore, A., Colleoni, S., Amendola, M., Zingale, A., Baccarini, A., Lazzari, G., Galli, C., & Naldini, L. (2007) · Nature Biotechnology · doi:10.1038/nbt1372 · Cited by 559 · see citing works

Canalization of development by microRNAs

Hornstein, E., & Shomron, N. (2006) · Nature Genetics · doi:10.1038/ng1803 · Cited by 511 · see citing works

Enhancement of cellular memory by reducing stochastic transitions

Açar, M., Becskei, A., & van Oudenaarden, A. (2005) · Nature · doi:10.1038/nature03524 · Cited by 484 · see citing works

Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability

Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484 · cited 1× · see citing works

Positive autoregulation of the myogenic determination gene MyoD1

Thayer, M. J., Tapscott, S. J., Davis, R. L., Wright, W. E., Lassar, A. B., & Weintraub, H. M. (1989) · Cell · doi:10.1016/0092-8674(89)90838-6 · Cited by 471 · see citing works

The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans

Abbott, A. L., Alvarez-Saavedra, E., Miska, E. A., Lau, N. C., Bartel, D. P., Horvitz, H. R., & Ambros, V. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.009 · Cited by 467 · see citing works

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

Li, X., Cassidy, J. J., Reinke, C., Fischboeck, S., & Carthew, R. W. (2009) · Cell · doi:10.1016/j.cell.2009.01.058 · Cited by 445 · see citing works

Prediction and measurement of an autoregulatory genetic module

Isaacs, F. J., Hasty, J., Cantor, C. R., & Collins, J. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332628100 · Cited by 436 · see citing works

Variability in gene expression underlies incomplete penetrance

van Oudenaarden, A., Rifkin, S. A., Raj, A., & Andersen, E. C. (2010) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 424 · see citing works

MicroRNAs and gene regulatory networks: managing the impact of noise in biological systemsPreprint

Herranz, H., & Cohen, S. M. (2010) · Genes & Development · doi:10.1101/gad.1937010 · Cited by 362 · see citing works

An engineered epigenetic transgene switch in mammalian cells

Kramer, B. P., Viretta, A. U., Baba, M. D., Aubel, D., Weber, W., & Fussenegger, M. (2004) · Nature Biotechnology · doi:10.1038/nbt980 · Cited by 336 · see citing works

Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability

Alvarez-Saavedra, E., & Horvitz, H. R. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.051 · Cited by 295 · see citing works

A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells

Deans, T. L., Cantor, C. R., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.05.045 · Cited by 275 · see citing works

Impulse Control: Temporal Dynamics in Gene Transcription

Yosef, N., & Regev, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.015 · Cited by 259 · see citing works

The Role of Incoherent MicroRNA-Mediated Feedforward Loops in Noise Buffering

Osella, M., Bosia, C., Corà, D., & Caselle, M. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001101 · Cited by 256 · see citing works

Microfluidic devices for measuring gene network dynamics in single cells

Bennett, M. R., & Hasty, J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2625 · Cited by 243 · see citing works

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacityPreprint

Martinez, N. J., Ow, M. C., Barrasa, M. I., Hammell, M., Sequerra, R., Doucette‐Stamm, L., Roth, F. P., Ambros, V., & Walhout, A. J. M. (2008) · Genes & Development · doi:10.1101/gad.1678608 · Cited by 232 · see citing works

Dynamical modeling and multi-experiment fitting with PottersWheel

Maiwald, T., & Timmer, J. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn350 · Cited by 231 · see citing works

Designing Synthetic Regulatory Networks Capable of Self-Organizing Cell Polarization

Chau, A. H., Walter, J. M., Gerardin, J., Tang, C., & Lim, W. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.040 · Cited by 188 · see citing works

Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template

Bleris, L. G., Xie, Z., Glass, D. S., Adadey, A., Sontag, E. D., & Benenson, Y. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.49 · Cited by 175 · see citing works

Design Principles of Regulatory Networks: Searching for the Molecular Algorithms of the Cell

Lim, W. A., Lee, C. M., & Tang, C. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.12.020 · Cited by 157 · see citing works

Absolute rate theories of epigenetic stability

Walczak, A. M., Onuchic, J. N., & Wolynes, P. G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509547102 · Cited by 127 · see citing works

Genetic and Epigenetic Determinants of Neurogenesis and Myogenesis

Fong, A. P., Yao, Z., Zhong, J. W., Cao, Y., Ruzzo, W. L., Gentleman, R. C., & Tapscott, S. J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.01.015 · Cited by 119 · see citing works

Regulatory Dynamics of Synthetic Gene Networks with Positive Feedback

Maeda, Y. T., & Sano, M. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.03.064 · Cited by 110 · see citing works

Negative Feedback Through mRNA Provides the Best Control of Gene-Expression Noise

Singh, A. (2011) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2011.2168826 · Cited by 97 · see citing works

Regulated and Multiple miRNA and siRNA Delivery Into Primary Cells by a Lentiviral Platform

Amendola, M., Passerini, L., Pucci, F., Gentner, B., Bacchetta, R., & Naldini, L. (2009) · Molecular Therapy · doi:10.1038/mt.2009.48 · Cited by 91 · see citing works

Vacuum-assisted cell loading enables shear-free mammalian microfluidic culture

Kolnik, M., Tsimring, L. S., & Hasty, J. (2012) · Lab on a Chip · doi:10.1039/c2lc40569e · Cited by 86 · see citing works

Accurate prediction of gene feedback circuit behavior from component properties

Rosenfeld, N., Young, J. W., Alon, U. S., Swain, P. S., & Elowitz, M. B. (2007) · Molecular Systems Biology · doi:10.1038/msb4100185 · Cited by 74 · see citing works

Exponential sensitivity of noise-driven switching in genetic networks

Mehta, P., Mukhopadhyay, R., & Wingreen, N. S. (2008) · Physical Biology · doi:10.1088/1478-3975/5/2/026005 · Cited by 54 · see citing works

Bistability and Oscillations in Gene Regulation Mediated by Small Noncoding RNAs

Liu, D., Chang, X., Liu, Z., Chen, L., & Wang, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017029 · Cited by 45 · see citing works

MicroRNA-Mediated Positive Feedback Loop and Optimized Bistable Switch in a Cancer Network Involving miR-17-92

Li, Y., Li, Y., Zhang, H., & Chen, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026302 · Cited by 45 · see citing works

MicroRNAs regulate and provide robustness to the myogenic transcriptional network

Gagan, J., Dey, B. K., & Dutta, A. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.02.001 · Cited by 42 · see citing works

Construction and Modelling of an Inducible Positive Feedback Loop Stably Integrated in a Mammalian Cell-Line

Siciliano, V., Menolascina, F., Marucci, L., et al. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002074 · Cited by 35 · see citing works

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works

Synergic functions of miRNAs determine neuronal fate of adult neural stem cells

Pons-Espinal, M., de Luca, E., Marzi, M. J., Beckervordersandforth, R., Armirotti, A., Nicassio, F., Fabel, K., Kempermann, G., & De Pietri Tonelli, D. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.02.012 · Cited by 59 · see citing works

Expression levels of microRNAs are not associated with their regulatory activities

Liang, Z. G., Zhou, H., Zheng, H., & Wu, J. (2011) · Biology Direct · doi:10.1186/1745-6150-6-43 · Cited by 24 · see citing works

Novel regulation and functional interaction of polycistronic miRNAs

Truscott, M., Islam, A. B. M. M. K., & Frolov, M. V. (2015) · RNA · doi:10.1261/rna.053264.115 · Cited by 65 · see citing works

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

Siomi, H., & Siomi, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.013 · Cited by 574 · see citing works

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080 · see citing works

Partially observed bipartite network analysis to identify predictive connections in transcriptional regulatory networks

Alvarez, A. A., & WOOLF, P. J. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-86 · Cited by 6 · see citing works