Synergic functions of miRNAs determine neuronal fate of adult neural stem cells
Open accessAbstract
Adult neurogenesis requires the precise control of neuronal versus astrocyte lineage determination in neural stem cells. While microRNAs (miRNAs) are critically involved in this step during development, their actions in adult hippocampal neural stem cells (aNSCs) has been unclear. As entry point to address that question we chose DICER, an endoribonuclease essential for miRNA biogenesis and other RNAi-related processes. By specific ablation of Dicer in aNSCs in vivo and in vitro, we demonstrate that miRNAs are required for the generation of new neurons, but not astrocytes, in the adult murine hippocampus. Moreover, we identify 11 miRNAs, of which 9 have not been previously characterized in neurogenesis, that determine neurogenic lineage fate choice of aNSCs at the expense of astrogliogenesis. Finally, we propose that the 11 miRNAs sustain adult hippocampal neurogenesis through synergistic modulation of 26 putative targets from different pathways.
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Synergistic effects of miRNAs have been shown to be important for biological processes such as neurogenesis and human embryonic stem cell pluripotency and differentiation.
“Synergistic effects of miRNAs have been shown to be important for biological processes, such as neurogenesis (104) and human embryonic stem cell pluripotency and differentiation (105).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [104]
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- Authors
- Pons-Espinal, M., de Luca, E., Marzi, M. J., Beckervordersandforth, R., Armirotti, A., Nicassio, F., Fabel, K., Kempermann, G., & De Pietri Tonelli, D.
- Affiliations
- Italian Institute of Technology (IT)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Center for Regenerative Therapies Dresden (DE)
- ORCID
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 8
- Issue
- 4
- Pages
- 1046-1061
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC5390108
- OpenAlex
- W2596618221
- Cited by
- 59
- References
- 61
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 2
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DZNE Pub (submittedVersion, cc-by-nc-nd)
- Funders
- Universität Zürich
- Cold Spring Harbor Laboratory
- Fondazione Cariplo (2015-0590)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- microRNA, adult neurogenesis, hippocampal neural stem cells, astrocyte lineage, Dicer, microRNA biogenesis, RNA interference, synergistic gene regulation, miRNA target genes
- MeSH terms
- Animals, Cells, Cultured, Hippocampus, Neurons, Gene Deletion, MicroRNAs, Ribonuclease III, Mice, DEAD-box RNA Helicases, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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