The tiger genome and comparative analysis with lion and snow leopard genomes
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Tigers and their close relatives (Panthera) are some of the world’s most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats’ hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species. Tigers are an endangered species and therefore understanding their genetic architecture could aid conservation efforts. Here, the authors report the first genome sequence of the Amur tiger and, through close species comparative genomic analysis, provide insight into the genome organization, evolutionary divergence and diversity of big cats.
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The enrichment of genes related to lipid metabolism is likely a signature of adaptation for accommodating the hypercarnivorous diet of felids.
“The enrichment of genes related to lipid metabolism is likely a signature of adaptation for accommodating the hypercarnivorous diet of felids (31), and mirrors similar signs of selection on lipid metabolic pathways in the genomes of polar bears (32).”
From Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication (2014) · cites this paper as [31]
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Self-citation
- Authors
- Cho, Y. S., Hu, L., Hou, H., Lee, H., Xu, J., Kwon, S., Oh, S., Kim, H.-M., Jho, S., Kim, S., Shin, Y.-A., Kim, B. C., Kim, H., Kim, C.-U., Luo, S.-J., Johnson, W. E., Koepfli, K.-P., Schmidt-Küntzel, A., Turner, J. A., Marker, L., Harper, C., Miller, S. M., Jacobs, W., Bertola, L. D., Kim, T. H., Lee, S., Zhou, Q., Jung, H.-J., Xu, X., Gadhvi, P., Xu, P., Xiong, Y., Luo, Y., Pan, S., Gou, C., Chu, X., Zhang, J., Liu, S., He, J., Chen, Y., Yang, L., Yang, Y., He, J., Liu, S., Wang, J., Kim, C. H., Kwak, H., Kim, J.-S., Hwang, S., Ko, J., Kim, C.-B., Kim, S., Bayarlkhagva, D., Paek, W. K., Kim, S.-J., O’Brien, S. J., Wang, J., & Bhak, J.
- Affiliations
- Genome Research Foundation (KR)
- BGI Group (China) (CN)
- Seoul National University (KR)
- Samsung (South Korea) (KR)
- Soongsil University (KR)
- Sangmyung University (KR)
- Peking University (CN)
- Smithsonian Conservation Biology Institute (US)
- St Petersburg University (RU)
- Cheetah Conservation Fund (NA)
- University of Pretoria (ZA)
- Tshwane University of Technology (ZA)
- Leiden University (NL)
- Theragen (KR)
- Korea Bioinformation Center (KR)
- National Science Museum (KR)
- Corresponding author
- Wang, Junyi
- O’Brien, Stephen J.
- Wang, Jun
- Bhak, Jong
- ORCID
- Cho, Yun Sung
- Hou, Haolong
- Lee, Hang
- Kim, Hak-Min
- Kim, Byung Chul
- Kim, Hyunmin
- Luo, Shu-Jin
- Johnson, Warren E.
- Koepfli, Klaus-Peter
- Turner, Jason A.
- Marker, Laurie
- Harper, Cindy
- Miller, Susan M.
- Bertola, Laura D.
- Kim, Tae Hyung
- Lee, Sunghoon
- Zhou, Qian
- Jung, Hyun-Ju
- Xu, Xiao
- Xu, Pengwei
- Luo, Yadan
- Pan, Shengkai
- Zhang, Jilin
- Liu, Sanyang
- He, Jing
- Chen, Ying
- Yang, Linfeng
- Wang, Junyi
- Kim, Jong-Soo
- Paek, Woon Kee
- O’Brien, Stephen J.
- Bhak, Jong
- Venue
- Nature Communications
- Published
- 2013-09-17
- Volume
- 4
- Issue
- 1
- Pages
- 2433-2433
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC3778509
- OpenAlex
- W2154096947
- Cited by
- 312
- References
- 53
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 18 · 2023: 21 · 2022: 61 · 2021: 28 · 2020: 31 · 2019: 18 · 2018: 19 · 2017: 21 · 2016: 21 · 2015: 27 · 2014: 15 · 2013: 1
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion, cc-by-nc-sa)
- RePEc: Research Papers in Economics (submittedVersion)
- KRIBB Repository (submittedVersion)
- UpSpace Institutional Repository (University of Pretoria) (submittedVersion, cc-by)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Research Foundation
- Ministry of Knowledge Economy
- Ministry of Science, ICT and Future Planning (2008-2004707, NRF-2008-2004707)
- National Research Foundation of Korea (2008-2004707, NRF-2008)
- Megagrants
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- Amur tiger, African lion, snow leopard, big cats, comparative genomics, de novo genome assembly, muscle strength, EGLN1, high-altitude adaptation, synteny conservation, endangered species conservation, Panthera
- MeSH terms
- Adaptation, Physiological, Amino Acid Sequence, Animals, Lions, Molecular Sequence Data, Mutation, Population Density, Genetic Variation, Genome, Synteny, Panthera, Tigers
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