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Cited by 958

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Quorum sensing triggers the stochastic escape of individual cells from Pseudomonas putida biofilms

Open access
Cárcamo-Oyarce, Gerardo, Lumjiaktase, Putthapoom, Kümmerli, Rolf, Eberl, Leo·2015·Nature Communications
DOI 10.1038/ncomms6945
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Abstract

The term ‘quorum sensing’ (QS) is generally used to describe the phenomenon that bacteria release and perceive signal molecules to coordinate cooperative behaviour in response to their population size. QS-based communication has therefore been considered a social trait. Here we show that QS signals (N-acyl-homoserine lactones, AHLs) are stochastically produced in young biofilms of Pseudomonas putida and act mainly as self-regulatory signals rather than inducing neighbouring cells. We demonstrate that QS induces the expression of putisolvin biosurfactants that are not public goods, thereby triggering asocial motility of induced cells out of microcolonies. Phenotypic heterogeneity is most prominent in the early stages of biofilm development, whereas at later stages behaviour patterns across cells become more synchronized. Our findings broaden our perspective on QS by showing that AHLs can control the expression of asocial (self-directed) traits, and that heterogeneity in QS can serve as a mechanism to drive phenotypic heterogeneity in self-directed behaviour.

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Metadata

Authors
Cárcamo-Oyarce, G., Lumjiaktase, P., Kümmerli, R., & Eberl, L.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2015-01-16
Volume
6
Issue
1
Pages
5945-5945
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms6945
OpenAlex
W2045387875
Cited by
958
References
37
FWCI
16.98
Type
journal article
Language
en
Open access
gold

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