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Single-cell landscape of immunological responses in patients with COVID-19
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Effector T cells in SARS-CoV-2-infected patients displayed high exhaustion and cytotoxicity scores, with severe patients showing the most exhausted state.
“In contrast, effector T cells in SARS-CoV-2-infected patients displayed high exhaustion and cytotoxicity scores, with severe patients showing the most exhausted state [45].”
From Systemic profiling of immune responses in healthy adults vaccinated with an RBD-targeting COVID-19 mRNA vaccine (2025) · cites this paper as [45]
Viral infections typically increase T cell cytotoxicity, they also lead to elevated exhaustion levels.
“While viral infections typically increase T cell cytotoxicity, they also lead to elevated exhaustion levels [45].”
From Systemic profiling of immune responses in healthy adults vaccinated with an RBD-targeting COVID-19 mRNA vaccine (2025) · cites this paper as [45]
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COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
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Metadata
- Authors
- Zhang, J.-Y., Wang, X.-M., Xing, X., Xu, Z., Zhang, C., Song, J.-W., Fan, X., Xia, P., Fu, J.-L., Wang, S.-Y., Xu, R.-N., Dai, X.-P., Shi, L., Huang, L., Jiang, T.-J., Shi, M., Zhang, Y., Zumla, A., Maeurer, M., Bai, F., & Wang, F.-S.
- Venue
- Nature Immunology
- Published
- 2020-08-12
- Volume
- 21
- Issue
- 9
- Pages
- 1107-1118
- ISSN
- 1529-2908
- 1529-2916
- Cited by
- 642
- References
- 10
- Language
- en
- Funders
- Ministry of Science and Technology of the People’s Republic of China (2020YFC0841900, 2020YFC0844000)
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